Matthew D Welch

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Cellular control of actin nucleation
    Matthew D Welch
    Department of Molecular and Cell Biology, 301 LSA, University of California, Berkeley 94720 3200, USA
    Annu Rev Cell Dev Biol 18:247-88. 2002
  2. pmc Motility determinants in WASP family proteins
    Defne Yarar
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Mol Biol Cell 13:4045-59. 2002
  3. ncbi request reprint Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor
    Erin D Goley
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 16:269-79. 2004
  4. pmc WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport
    Kenneth G Campellone
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Cell 134:148-61. 2008
  5. pmc Regulation of integrin trafficking, cell adhesion, and cell migration by WASH and the Arp2/3 complex
    Steve N Duleh
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cytoskeleton (Hoboken) 69:1047-58. 2012
  6. pmc Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli
    Kenneth G Campellone
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Biol Chem 287:20613-24. 2012
  7. pmc Expression of an epitope-tagged virulence protein in Rickettsia parkeri using transposon insertion
    Matthew D Welch
    Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
    PLoS ONE 7:e37310. 2012
  8. pmc Nuclear localization of actin requires AC102 in Autographa californica multiple nucleopolyhedrovirus-infected cells
    Kamal M Gandhi
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 3102, USA
    J Gen Virol 93:1795-803. 2012
  9. pmc Actin-based motility drives baculovirus transit to the nucleus and cell surface
    Taro Ohkawa
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 190:187-95. 2010
  10. pmc Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway
    Shawna C O Reed
    Microbiology Graduate Group, University of California, Berkeley, CA 94720, USA
    Cell Microbiol 14:529-45. 2012

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Cellular control of actin nucleation
    Matthew D Welch
    Department of Molecular and Cell Biology, 301 LSA, University of California, Berkeley 94720 3200, USA
    Annu Rev Cell Dev Biol 18:247-88. 2002
    ....
  2. pmc Motility determinants in WASP family proteins
    Defne Yarar
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Mol Biol Cell 13:4045-59. 2002
    ..Our results suggest that recruitment of factors, including profilin, by the proline-rich regions of WASP and Scar1 and the EVH1 domain of WASP stimulates cellular actin-based motility...
  3. ncbi request reprint Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor
    Erin D Goley
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 16:269-79. 2004
    ....
  4. pmc WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport
    Kenneth G Campellone
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Cell 134:148-61. 2008
    ..Thus, WHAMM is an important regulator of membrane dynamics functioning at the interface of the microtubule and actin cytoskeletons...
  5. pmc Regulation of integrin trafficking, cell adhesion, and cell migration by WASH and the Arp2/3 complex
    Steve N Duleh
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cytoskeleton (Hoboken) 69:1047-58. 2012
    ..2012 Wiley Periodicals, Inc...
  6. pmc Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli
    Kenneth G Campellone
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Biol Chem 287:20613-24. 2012
    ..These results reveal that EspF(U) acts as a scaffold to recruit multiple actin assembly factors whose functions are normally regulated by Cdc42...
  7. pmc Expression of an epitope-tagged virulence protein in Rickettsia parkeri using transposon insertion
    Matthew D Welch
    Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
    PLoS ONE 7:e37310. 2012
    ..parkeri strains expressing diverse fluorescent proteins. Expression of epitope-tagged proteins in Rickettsia will expand our ability to assess the regulation and function of important virulence factors...
  8. pmc Nuclear localization of actin requires AC102 in Autographa californica multiple nucleopolyhedrovirus-infected cells
    Kamal M Gandhi
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 3102, USA
    J Gen Virol 93:1795-803. 2012
    ..Deletion of Ac004 or he65 had no impact on actin translocation kinetics, timing of BV production or BV titres. These results implicate AC102 as a key player in baculovirus manipulation of actin...
  9. pmc Actin-based motility drives baculovirus transit to the nucleus and cell surface
    Taro Ohkawa
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 190:187-95. 2010
    ..Temporal coordination of actin-based nuclear and surface translocation likely enables rapid transmission to neighboring cells during infection in insects and represents a distinctive evolutionary strategy for overcoming host defenses...
  10. pmc Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway
    Shawna C O Reed
    Microbiology Graduate Group, University of California, Berkeley, CA 94720, USA
    Cell Microbiol 14:529-45. 2012
    ..Our results reveal a key role for the WAVE and Arp2/3 complexes, as well as a higher degree of variation than previously appreciated in actin nucleation pathways activated during Rickettsia invasion...
  11. pmc Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly
    Kenneth G Campellone
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA
    PLoS Pathog 4:e1000191. 2008
    ..These findings define the minimal set of bacterial effectors required for pedestal formation and the elements within those effectors that contribute to actin assembly via N-WASP-Arp2/3-mediated signaling pathways...
  12. pmc An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability
    Erin D Goley
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:8159-64. 2010
    ....
  13. ncbi request reprint Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation
    Adam C Martin
    Dept of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3202, USA
    Nat Cell Biol 8:826-33. 2006
    ..Our results suggest a critical feature of dendritic nucleation in which debranching and subsequent actin-filament remodelling and/or depolymerization are important for endocytic vesicle morphogenesis...
  14. pmc WASH and the Arp2/3 complex regulate endosome shape and trafficking
    Steve N Duleh
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Cytoskeleton (Hoboken) 67:193-206. 2010
    ....
  15. pmc The actin nucleation factor JMY is a negative regulator of neuritogenesis
    Elif Nur Firat-Karalar
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Biol Cell 22:4563-74. 2011
    ..This function of JMY requires its actin-nucleating activity. These findings highlight a previously unrecognized function for JMY as a modulator of neuritogenesis...
  16. pmc Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia
    Alisa W Serio
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell Host Microbe 7:388-98. 2010
    ..parkeri but not Listeria monocytogenes. Our results highlight key distinctions between the evolutionary strategies and molecular mechanisms employed by bacterial pathogens to assemble and organize actin...
  17. ncbi request reprint A Rickettsia WASP-like protein activates the Arp2/3 complex and mediates actin-based motility
    Robert L Jeng
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell Microbiol 6:761-9. 2004
    ..We propose that additional Rickettsia or host factors reorganize the Y-branched networks into parallel arrays in a manner similar to a recently proposed model of filopodia formation...
  18. pmc Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility
    Cat M Haglund
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Nat Cell Biol 12:1057-63. 2010
    ..These results suggest that Sca2 mimics formins to determine the unique organization of actin filaments in Rickettsia tails and drive bacterial motility, independently of host nucleators...
  19. pmc New mechanisms and functions of actin nucleation
    Elif Nur Firat-Karalar
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Curr Opin Cell Biol 23:4-13. 2011
    ..The mechanisms and functions of actin nucleators are proving to be more complex than previously considered, with extensive cooperation and overlap in their cellular roles...
  20. ncbi request reprint A role for cortactin in Listeria monocytogenes invasion of NIH 3T3 cells, but not in its intracellular motility
    Consuelo Barroso
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    Cell Motil Cytoskeleton 63:231-43. 2006
    ..Therefore, our findings suggest that cortactin plays a role in Listeria internalization, but not in the formation of actin clouds and tails, or in bacteria intracellular motility...
  21. pmc Pathogens and polymers: microbe-host interactions illuminate the cytoskeleton
    Cat M Haglund
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 195:7-17. 2011
    ..The study of pathogen interactions with the cytoskeleton has illuminated key cellular processes such as phagocytosis, macropinocytosis, membrane trafficking, motility, autophagy, and signal transduction...
  22. pmc A nucleator arms race: cellular control of actin assembly
    Kenneth G Campellone
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Rev Mol Cell Biol 11:237-51. 2010
    ..Formin nucleators with additional biochemical and cellular activities have also been uncovered. Finally, the Spire, cordon-bleu and leiomodin nucleators have revealed new ways of overcoming the kinetic barriers to actin polymerization...
  23. ncbi request reprint SnapShot: actin regulators II
    Anosha D Siripala
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Cell 128:1014. 2007
  24. ncbi request reprint SnapShot: actin regulators I
    Anosha D Siripala
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Cell 128:626. 2007
  25. ncbi request reprint Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein
    Erin D Goley
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Science 314:464-7. 2006
    ..Recompartmentalizing dynamic host actin may represent a conserved mode of pathogenesis and reflect viral manipulation of normal functions of nuclear actin...
  26. ncbi request reprint The ARP2/3 complex: an actin nucleator comes of age
    Erin D Goley
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Rev Mol Cell Biol 7:713-26. 2006
    ..A decade of study has begun to shed light on the molecular mechanisms by which this powerful machine controls the polymerization, organization and recycling of actin-filament networks, both in vitro and in the living cell...
  27. pmc Plasma membrane organization is essential for balancing competing pseudopod- and uropod-promoting signals during neutrophil polarization and migration
    Stéphane Bodin
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Mol Biol Cell 16:5773-83. 2005
    ....
  28. ncbi request reprint Actin-based motility of intracellular pathogens
    Edith Gouin
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    Curr Opin Microbiol 8:35-45. 2005
    ....
  29. pmc Formation of filopodia-like bundles in vitro from a dendritic network
    Danijela Vignjevic
    Northwestern University Medical School, Department of Cell and Molecular Biology, 303 E Chicago Ave, Ward 8 063, Chicago, IL 60611, USA
    J Cell Biol 160:951-62. 2003
    ..We propose a model for filopodial formation in which actin filaments of a preexisting dendritic network are elongated by inhibition of capping and subsequently cross-linked into bundles by fascin...
  30. ncbi request reprint Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton
    Edward A Miao
    Department of Microbiology, University of Washington, HSB K 140, Box 357710, Seattle, WA 98195 7710, USA
    Mol Microbiol 48:401-15. 2003
    ..However, a third intracellular virulence factor, spvB, which ADP-ribosylates actin, strongly inhibited VAP formation in HeLa cells, suggesting a more subtle effect for SspH2 and SseI on the actin cytoskeleton...
  31. pmc Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility
    Luisa M Stamm
    Program in Host Pathogen Interactions, University of California San Francisco, San Francisco, CA 94158, USA
    J Exp Med 198:1361-8. 2003
    ..marinum. These findings show that M. marinum can escape into the cytoplasm of infected macrophages, where it can recruit host cell cytoskeletal factors to induce actin polymerization leading to direct cell to cell spread...
  32. ncbi request reprint Identification of a bacterial factor required for actin-based motility of Burkholderia pseudomallei
    Mark P Stevens
    Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire, RG20 7NN, UK
    Mol Microbiol 56:40-53. 2005
    ....
  33. ncbi request reprint Turning on the Arp2/3 complex at atomic resolution
    Elizabeth L Borths
    Department of Chemistry, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Structure 10:131-5. 2002
    ..The recently published 2 A X-ray crystal structure of bovine Arp2/3 complex gives us atomic scale insight into Arp2/3-mediated actin nucleation, while cryo-EM work and functional studies begin to fill in exciting mechanistic details...