John T Welch

Summary

Affiliation: University at Albany
Country: USA

Publications

  1. pmc Reversible thermal denaturation of a 60-kDa genetically engineered beta-sheet polypeptide
    Igor K Lednev
    Department of Chemistry, University at Albany, State University of New York, Albany, New York, USA
    Biophys J 91:3805-18. 2006
  2. ncbi request reprint The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine
    John T Welch
    Department of Chemistry, University at Albany, SUNY, Albany, NY 12222, USA
    Bioorg Med Chem 15:6659-66. 2007
  3. ncbi request reprint Bilayer fibril formation by genetically engineered polypeptides: preparation and characterization
    Natalya I Topilina
    Department of Chemistry and College of Nanoscale Science and Engineering, The University at Albany, State University of New York, Albany, New York 12222, USA
    Biomacromolecules 7:1104-11. 2006
  4. ncbi request reprint Beta-sheet folding of 11-kDa fibrillogenic polypeptide is completely aggregation driven
    Natalya I Topilina
    Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Biopolymers 86:261-4. 2007
  5. doi request reprint Charge distribution and amyloid fibril formation: insights from genetically engineered model systems
    Natalya I Topilina
    Department of Chemistry, University at Albany, State University of New York, Albany, New York 12222, USA
    Biomacromolecules 11:1721-6. 2010
  6. doi request reprint A de novo designed 11 kDa polypeptide: model for amyloidogenic intrinsically disordered proteins
    Natalya I Topilina
    Department of Chemistry, State University of New York, Albany, NY 12222, USA
    Biopolymers 93:607-18. 2010
  7. doi request reprint Genetic engineering combined with deep UV resonance Raman spectroscopy for structural characterization of amyloid-like fibrils
    Vitali Sikirzhytski
    Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, USA
    J Am Chem Soc 130:5852-3. 2008
  8. ncbi request reprint Design and preparation of beta-sheet forming repetitive and block-copolymerized polypeptides
    Seiichiro Higashiya
    Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, USA
    Biomacromolecules 8:1487-97. 2007
  9. pmc Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs
    Silvana C Ngo
    Department of Chemistry, University at Albany SUNY, Albany, NY 12222, USA
    Antimicrob Agents Chemother 51:2430-5. 2007
  10. ncbi request reprint Inhibition of dipeptidyl peptidase IV (DPP IV) by 2-(2-amino-1-fluoro-propylidene)-cyclopentanecarbonitrile, a fluoroolefin containing peptidomimetic
    Kake Zhao
    Department of Chemistry, University at Albany, Albany, NY 12222, USA
    Bioorg Med Chem 11:207-15. 2003

Research Grants

Collaborators

  • Igor L Medintz
  • Igor K Lednev
  • Natalya I Topilina
  • Seiichiro Higashiya
  • Vladimir V Ermolenkov
  • Silvana C Ngo
  • Vitali Sikirzhytski
  • Kake Zhao
  • Vitali Sikirzhytsky
  • Dmitri Zagorevskii
  • Woo Jin Chung
  • Oren Zimhony
  • Halimah Sayahi
  • William R Jacobs
  • Alain E Kaloyeros
  • Autumn Carlsen
  • Kathleen A Dunn
  • Eric T Eisenbraun
  • Robert E Geer
  • Christopher Kossow
  • Narender Rana
  • Christopher C Wells
  • Takashi Funaki
  • Dong Sung Lim

Detail Information

Publications11

  1. pmc Reversible thermal denaturation of a 60-kDa genetically engineered beta-sheet polypeptide
    Igor K Lednev
    Department of Chemistry, University at Albany, State University of New York, Albany, New York, USA
    Biophys J 91:3805-18. 2006
    ..The polypeptide sequence suggests an important balance between the absence of strong nonnative contacts (salt bridges or hydrophobic collapse) and limited repulsion of charged side chains...
  2. ncbi request reprint The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine
    John T Welch
    Department of Chemistry, University at Albany, SUNY, Albany, NY 12222, USA
    Bioorg Med Chem 15:6659-66. 2007
    ....
  3. ncbi request reprint Bilayer fibril formation by genetically engineered polypeptides: preparation and characterization
    Natalya I Topilina
    Department of Chemistry and College of Nanoscale Science and Engineering, The University at Albany, State University of New York, Albany, New York 12222, USA
    Biomacromolecules 7:1104-11. 2006
    ..The ordered self-assembly of designed, extremely repetitive, high molecular weight peptides is a harbinger of the utility of similar materials in nanoscience and engineering applications...
  4. ncbi request reprint Beta-sheet folding of 11-kDa fibrillogenic polypeptide is completely aggregation driven
    Natalya I Topilina
    Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Biopolymers 86:261-4. 2007
    ..The strong dependence of lag time on polypeptide concentration established the limiting step in aggregation as initiation of beta-sheet folding...
  5. doi request reprint Charge distribution and amyloid fibril formation: insights from genetically engineered model systems
    Natalya I Topilina
    Department of Chemistry, University at Albany, State University of New York, Albany, New York 12222, USA
    Biomacromolecules 11:1721-6. 2010
    ....
  6. doi request reprint A de novo designed 11 kDa polypeptide: model for amyloidogenic intrinsically disordered proteins
    Natalya I Topilina
    Department of Chemistry, State University of New York, Albany, NY 12222, USA
    Biopolymers 93:607-18. 2010
    ..The lag phase of polypeptide folding is concentration dependent leading to the conclusion that beta-sheet folding of the 11-kDa amyloidogenic polypeptide is completely aggregation driven...
  7. doi request reprint Genetic engineering combined with deep UV resonance Raman spectroscopy for structural characterization of amyloid-like fibrils
    Vitali Sikirzhytski
    Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, USA
    J Am Chem Soc 130:5852-3. 2008
    ..The relationship between Raman frequencies and Ramachandran dihedral angles of the polypeptide backbone indicates the nature of the beta-sheet and turn structural elements...
  8. ncbi request reprint Design and preparation of beta-sheet forming repetitive and block-copolymerized polypeptides
    Seiichiro Higashiya
    Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, USA
    Biomacromolecules 8:1487-97. 2007
    ....
  9. pmc Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs
    Silvana C Ngo
    Department of Chemistry, University at Albany SUNY, Albany, NY 12222, USA
    Antimicrob Agents Chemother 51:2430-5. 2007
    ..The results were validated utilizing a radiolabeled fatty acid synthesis assay. This assay showed that FASI was inhibited by PZA and pyrazinoic acid as well as by a series of PZA analogs...
  10. ncbi request reprint Inhibition of dipeptidyl peptidase IV (DPP IV) by 2-(2-amino-1-fluoro-propylidene)-cyclopentanecarbonitrile, a fluoroolefin containing peptidomimetic
    Kake Zhao
    Department of Chemistry, University at Albany, Albany, NY 12222, USA
    Bioorg Med Chem 11:207-15. 2003
    ..69 and 6.03 microM, respectively. In contrast to earlier reported fluoroolefin containing inhibitors, the nitriles underwent no detectable degradation at pH 7.6 under buffered conditions...
  11. ncbi request reprint Designer variable repeat length polypeptides as scaffolds for surface immobilization of quantum dots
    Igor L Medintz
    Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, DC 20375, USA
    J Phys Chem B 110:10683-90. 2006
    ..The versatility of this capture strategy is highlighted by the creation of a variety of one- and two-dimensional polypeptide-QD structures as well as a self-assembled surface-immobilized FRET-based nutrient sensor...

Research Grants1

  1. A New Target for Anti-tuberculosis Agents, FAS 1
    John Welch; Fiscal Year: 2003
    ..abstract_text> ..