Research Topics
| L S WelageSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
Evaluation of omeprazole, lansoprazole, pantoprazole, and rabeprazole in the treatment of acid-related diseasesL S Welage
College of Pharmacy, University of Michigan, Ann Arbor 48109 1065, USA
J Am Pharm Assoc (Wash) 40:52-62; quiz 121-3. 2000..To review the comparative efficacy and safety of the proton pump inhibitors (PPIs)--omeprazole, lansoprazole, pantoprazole, and rabeprazole--in the management of acid-related diseases...
Pharmacologic features of proton pump inhibitors and their potential relevance to clinical practiceLynda S Welage
Department of Clinical Sciences, University of Michigan, College of Pharmacy, Department of Pharmacy Services, Michigan University Medical Center, Ann Arbor, MI, USA
Gastroenterol Clin North Am 32:S25-35. 2003..PK/PD principles can be used to optimize PPI therapy when considering issues related to administration, such as timing of drug delivery relative to the number of active pumps and the drug's AUC...
Overview of pharmacologic agents for acid suppression in critically ill patientsLynda S Welage
The University of Michigan, College of Pharmacy, 428 Church Street, Ann Arbor, MI 48109 1065, USA
Am J Health Syst Pharm 62:S4-S10. 2005....
Pharmacologic properties of proton pump inhibitorsLynda S Welage
Department of Clinical Sciences, University of Michigan College of Pharmacy, 428 Church Street, Ann Arbor, MI 48109, USA
Pharmacotherapy 23:74S-80S. 2003..Although they share a common core structure and mechanism of action, it is important to understand the general pharmacology of these agents and how they differ from histamine2-receptor antagonists in order to optimize PPI therapy...
Understanding the scientific issues embedded in the generic drug approval processL S Welage
Department of Clinical Sciences, College of Pharmacy, University of Michigan Health System, Ann Arbor 48109 1065, USA
J Am Pharm Assoc (Wash) 41:856-67. 2001..To review the major scientific issues embedded in the generic drug approval process...
Historical overview of generic medication policyF J Ascione
College of Pharmacy, University of Michigan, Ann Arbor 48109 1065, USA
J Am Pharm Assoc (Wash) 41:567-77. 2001..To provide a historical perspective on controversies surrounding the use of generic drugs...
Economics and structure of the generic pharmaceutical industryD M Kirking
Department of Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor 48109 1065, USA
J Am Pharm Assoc (Wash) 41:578-84. 2001..To review key economic trends of the generic medication market and analyze the changing structure of the generic medication industry...
Comparison of 3 vancomycin dosage regimens during hemodialysis with cellulose triacetate dialyzers: post-dialysis versus intradialytic administrationN A Mason
College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109 1065, USA
Clin Nephrol 60:96-104. 2003..Specifically, this study was designed to compare the pharmacokinetics of vancomycin when administered during the last 1-2 hours of dialysis (i.e. intra-dialytic administration) to that administered after completion of dialysis...
Influence of metoprolol dosage release formulation on the pharmacokinetic drug interaction with paroxetineStephen M Stout
University of Michigan College of Pharmacy, 428 Church St, Ann Arbor, MI 48109 1065, USA
J Clin Pharmacol 51:389-96. 2011..This could theoretically result in greater beta-blockade and lost cardioselectivity. The magnitude of the interaction was similar between metoprolol formulations, which may be attributable to low doses/drug input rates employed...
Drug product selection: legal issuesT P Christensen
College of Pharmacy, North Dakota State University, Fargo 58105, USA
J Am Pharm Assoc (Wash) 41:868-74. 2001..To review the potential legal liability of the pharmacist in the drug product selection process...
Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parametersChristopher P Landowski
College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA
J Pharmacol Exp Ther 306:778-86. 2003....
Mechanistic understanding of time-dependent oral absorption based on gastric motor activity in humansKazutaka Higaki
College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109, USA
Eur J Pharm Biopharm 70:313-25. 2008..Further, estimates of k(a) derived using the time-dependent absorption model were closer to the intrinsic absorption rate constant for caffeine...
Continuous infusion of pantoprazole with octreotide does not improve management of variceal hemorrhageCesar Alaniz
Department of Pharmacy Services, College of Pharmacy, University of Michigan Hospitals and Health Centers, Ann Arbor, Michigan 48109, USA
Pharmacotherapy 29:248-54. 2009..To assess the effect of a prolonged continuous infusion of pantoprazole on patient outcomes when the drug was combined with standard octreotide therapy in patients with variceal hemorrhage...
Proton pump inhibitor formulary considerations in the acutely ill. Part 1: Pharmacology, pharmacodynamics, and available formulationsJohn W Devlin
School of Pharmacy, Northeastern University, Boston, MA 02115 5000, USA
Ann Pharmacother 39:1667-77. 2005....
Proton pump inhibitor formulary considerations in the acutely ill. Part 2: Clinical efficacy, safety, and economicsJohn W Devlin
School of Pharmacy, Northeastern University Medical Intensive Care Unit, Tufts New England Medical Center, Boston, MA 02115 5000, USA
Ann Pharmacother 39:1844-51. 2005....
Prevention of stress ulceration: current trends in critical careRyan J Daley
Pharmacotherapy Department, Fletcher Allen Health Care, Burlington, VT, USA
Crit Care Med 32:2008-13. 2004....
The cost-effectiveness of proton pump inhibitors for bleeding peptic ulcers: The unanswered questionsJohn W Devlin
Crit Care Med 32:1415-6. 2004
Variability in cimetidine absorption and plasma double peaks following oral administration in the fasted state in humans: correlation with antral gastric motilityNarushi Takamatsu
Yamanouchi Pharmaceutical Co. Ltd, Shizuoka, Japan
Eur J Pharm Biopharm 53:37-47. 2002....
