Research Topics
Genomes and GenesSpecies | Joel L WeissfeldSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Flexible sigmoidoscopy in the randomized prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial: added yield from a second screening examinationJoel L Weissfeld
UPMC Cancer Pavilion POB II, Pittsburgh, PA 15232, USA
J Natl Cancer Inst 104:280-9. 2012..We report outcomes from the PLCO screening FSG program and evaluate the increased yield produced by a second FSG...
Flexible sigmoidoscopy in the PLCO cancer screening trial: results from the baseline screening examination of a randomized trialJoel L Weissfeld
University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
J Natl Cancer Inst 97:989-97. 2005..Here we report findings from the baseline screening flexible sigmoidoscopy examination...- A case-cohort study of human herpesvirus 8 seropositivity and incident prostate cancer in TobagoAlicia C McDonald
Department of Epidemiology, University of Pittsburgh, A542 Crabtree Hall, 130 DeSoto Street, Pittsburgh, Pennsylvania, 15261, USA
Infect Agent Cancer 6:25. 2011..abstract:.. - Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polypsRobert E Schoen
Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
Gastroenterology 129:464-75. 2005..We evaluated the relationship of insulin, IGF-I, insulin-like growth factor binding protein (IGFBP) 3, and visceral adipose tissue (VAT) in subjects with adenomatous polyps, the precursor lesion of colorectal cancer... - Radiographic emphysema predicts low bone mineral density in a tobacco-exposed cohortJESSICA BON
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Am J Respir Crit Care Med 183:885-90. 2011..Whereas emphysema has been independently associated with vascular disease and other comorbidities, its association with BMD has not been well studied... 
Baseline mammographic breast density and the risk of invasive breast cancer in postmenopausal women participating in the NSABP study of tamoxifen and raloxifene (STAR)Reena S Cecchini
NSABP Biostatistical Center, One Sterling Plaza, Pittsburgh, PA 15213, USA
Cancer Prev Res (Phila) 5:1321-9. 2012....- Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking-related lung cancerShama C Buch
Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
Mol Carcinog 51:E11-20. 2012..Additionally, combining genotype information for SNPs in these pathways may assist in classifying current and ex-cigarette smokers according to lung cancer risk... - Physicians encouraging colorectal screening: a randomized controlled trial of enhanced office and patient management on compliance with colorectal cancer screeningBruce S Ling
Department of Medicine, University of Pittsburgh, Pennsylvania, USA
Arch Intern Med 169:47-55. 2009..Colorectal cancer screening is underused. Our objective was to evaluate methods for promoting colorectal cancer screening in primary care practice... - Colorectal cancers not detected by screening flexible sigmoidoscopy in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening TrialRobert E Schoen
Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
Gastrointest Endosc 75:612-20. 2012.... - Comorbidity as a mediator of survival disparity between younger and older women diagnosed with metastatic breast cancerSu Yon Jung
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Hypertension 59:205-11. 2012..The study findings suggest that hypertension should be included in the comorbidity information for decision-making support programs... - Utilization of surveillance colonoscopy in community practiceRobert E Schoen
Department of Medicine, University of Pittsburgh Medical Center, and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213 2582, USA
Gastroenterology 138:73-81. 2010..The burden and cost of surveillance colonoscopy are significant. The aim of this study was to examine the use of surveillance colonoscopy on a community-wide basis... - Smoking behavior 1 year after computed tomography screening for lung cancer: Effect of physician referral for abnormal CT findingsMindi A Styn
Department of Health and Community Systems, University of Pittsburgh School of Nursing, PA, USA
Cancer Epidemiol Biomarkers Prev 18:3484-9. 2009..Focusing on outcomes related to the reporting of CT abnormality, we examined the natural history of smoking in the Pittsburgh Lung Screening Study... - Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopyRobert E Schoen
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
N Engl J Med 366:2345-57. 2012..The benefits of endoscopic testing for colorectal-cancer screening are uncertain. We evaluated the effect of screening with flexible sigmoidoscopy on colorectal-cancer incidence and mortality... - The Pittsburgh Lung Screening Study (PLuSS): outcomes within 3 years of a first computed tomography scanDavid O Wilson
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15232, USA
Am J Respir Crit Care Med 178:956-61. 2008..The role of computed tomography (CT) screening for lung cancer is controversial, currently under study, and not yet fully elucidated... - Using the transtheoretical model to stage screening behavior for colorectal cancerJeanette M Trauth
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Health Educ Behav 30:322-36. 2003..This study appears to be one of the first applications of this theory to understanding CRC screening behavior in a community intervention... - Adherence to repeat screening flexible sigmoidoscopy in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening TrialJoel L Weissfeld
University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
Cancer 94:2569-76. 2002..In the current prospective study, the authors used adherence to repeat testing to assess the acceptability of screening flexible sigmoidoscopy... - High bone density is associated with prostate cancer in older Afro-Caribbean men: Tobago prostate surveyClareann H Bunker
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Cancer Causes Control 17:1083-9. 2006..To test the hypothesis that bone mineral density (BMD), a possible surrogate of lifetime exposure to hormone/growth factor/vitamin D/calcium exposure, is higher in prostate cancer cases than controls... - Yield of advanced adenoma and cancer based on polyp size detected at screening flexible sigmoidoscopyRobert E Schoen
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvani 15213 2582, USA
Gastroenterology 131:1683-9. 2006..To examine the yield at colonoscopy when a given size lesion is observed, we assessed the yield of advanced adenoma and cancer at colonoscopy based on the size of the abnormality detected at flexible sigmoidoscopy (FSG)... - ADRB2 gene variants, dual-energy x-ray absorptiometry body composition, and hypertension in Tobago men of African descentTracey Samantha Beason
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Metabolism 60:698-705. 2011..50). In a high-obesity and high-hypertension risk population with ancestry in common with African Americans, genetic variation defined by 2 common ADRB2 amino acid substitutions was not associated with body composition or hypertension... - Lung cancer serum biomarker discovery using label-free liquid chromatography-tandem mass spectrometryXuemei Zeng
Mass Spectrometry Platform, Cancer Biomarkers Facility, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
J Thorac Oncol 6:725-34. 2011..Given the clinical burden from lung cancer and the relatively favorable survival associated with early-stage lung cancer, biomarkers for early detection of lung cancer are of important potential clinical benefit... - Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymesShama C Buch
Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Head Neck 30:1139-47. 2008..Genetic variation in xenobiotic metabolizing enzymes may explain differing susceptibilities to the cancer causing effects of tobacco and alcohol... - Age-period-cohort analysis of cancers not related to tobacco, screening, or HIV: sex and race differencesYueh Ying Han
Department of Epidemiology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Cancer Causes Control 21:1227-36. 2010..To identify trends in a residual category of cancers not typically associated with tobacco, screening, or human immunodeficiency virus (HIV) infection... - Quantitative computed tomography analysis, airflow obstruction, and lung cancer in the pittsburgh lung screening studyDavid O Wilson
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Thorac Oncol 6:1200-5. 2011..To study the relationship between emphysema, airflow obstruction, and lung cancer in a high-risk population, we performed quantitative analysis of screening computed tomography (CT) scans... - Factors associated with mortality after breast cancer metastasisSu Yon Jung
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 714 Parran Hall, Pittsburgh, PA 15261, USA
Cancer Causes Control 23:103-12. 2012..The purpose of the present study was to identify factors related to survival in breast cancer patients after diagnosis with metastatic disease... - Serum biomarker profiles as diagnostic tools in lung cancerBrian M Nolen
University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213, USA
Cancer Biomark 10:3-12. 2011..A minimally-invasive biomarker-based test that could further characterize CT-positive patients based on risk of malignancy would greatly enhance its clinical efficacy... - Body mass index and the risk for developing invasive breast cancer among high-risk women in NSABP P-1 and STAR breast cancer prevention trialsReena S Cecchini
National Surgical Adjuvant Breast and Bowel Project NSABP Operations and Biostatistical Center, One Sterling Plaza, 201 N Craig St, Suite 350, Pittsburgh, PA 15213, USA
Cancer Prev Res (Phila) 5:583-92. 2012.... - Association of radiographic emphysema and airflow obstruction with lung cancerDavid O Wilson
Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 178:738-44. 2008..To study the relationship between emphysema and/or airflow obstruction and lung cancer in a high-risk population... - Comparison of survival outcomes between patients with malignant mixed mullerian tumors and high-grade endometrioid, clear cell, and papillary serous endometrial cancersAshley Sinclair Felix
Division of Cancer Prevention and Population Science, University of Pittsburgh Cancer Institute, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, and Department of Obstetrics and Gynecologic Oncology, Magee Women s Hospital of UPMC Health System, Pittsburgh, PA 15232, USA
Int J Gynecol Cancer 21:877-84. 2011..The goal of this study was to compare recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) among EC subtypes... - Results of repeat sigmoidoscopy 3 years after a negative examinationRobert E Schoen
Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
JAMA 290:41-8. 2003..The necessary frequency of endoscopic colorectal cancer screening after a negative examination is uncertain... - Use of fertility drugs and risk of ovarian cancer: results from a U.S.-based case-control studyMichelle L Kurta
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cancer Epidemiol Biomarkers Prev 21:1282-92. 2012..We used data from a large case-control study to determine whether fertility drug use significantly impacts ovarian cancer risk when taking into account parity, gravidity, and cause of infertility... - The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening studyMindi A Styn
Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 150:254-61. 2009..The association between DRD2 TaqIA and smoking cessation supports the hypothesis that genetic variation in the dopamine pathway influences smoking cessation... - Effects of ERCC2 Lys751Gln (A35931C) and CCND1 (G870A) polymorphism on outcome of advanced-stage squamous cell carcinoma of the head and neck are treatment dependentShilong Zhong
University of Pittsburgh Cancer Institute with Center for Clinical Pharmacology, Pittsburgh, PA, USA
Cancer Epidemiol Biomarkers Prev 20:2429-37. 2011..By grouping patients according to stage and radiation treatment, we compared SCCHN survival with regard to ERCC2 A35931C (Lys751Gln, rs13181) and CCND1 G870A (Pro241Pro, rs9344) genotypes... - A multiplexed serum biomarker immunoassay panel discriminates clinical lung cancer patients from high-risk individuals found to be cancer-free by CT screeningWilliam L Bigbee
Mass Spectrometry Platform, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
J Thorac Oncol 7:698-708. 2012..Clinical decision making in the setting of computed tomography (CT) screening could benefit from accessible biomarkers that help predict the level of lung cancer risk in high-risk individuals with indeterminate pulmonary nodules... - Relationship of visceral adipose tissue to recurrence of adenomatous polypsDavid A Sass
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Am J Gastroenterol 99:687-93. 2004..CONCLUSION: In this study, no association between visceral adipose tissue and adenomatous polyp recurrence was observed. Further study and exploration of the role of VAT in adenoma progression is required... - Analysis of colorectal cancer occurrence during surveillance colonoscopy in the dietary Polyp Prevention TrialAjay Pabby
Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Gastrointest Endosc 61:385-91. 2005..CONCLUSIONS: Interval cancer occurs despite colonoscopy. Improved quality of colonoscopy may have reduced cancer prevalence or resulted in earlier cancer detection in over 50% of prevalent cancers in the dietary Polyp Prevention Trial... - The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary diseaseJessica M Bon
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 4:e6865. 2009..A cross-sectional study was performed to examine the association of serum biomarkers with radiographic airway and parenchymal phenotypes of COPD... - Informed decision-making and colorectal cancer screening: is it occurring in primary care?Bruce S Ling
VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15213, USA
Med Care 46:S23-9. 2008..The degree to which providers communicate the information necessary to prepare patients for participation in this process is not known... - Peroxisome proliferator-activated receptor-gamma polymorphism, body mass and prostate cancer risk: evidence for gene-environment interactionJoseph M Zmuda
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Oncology 70:185-9. 2006..Peroxisome proliferator-activated receptor (PPAR)-gamma has been implicated in prostate cancer. In the present case-control study, we tested if a common Pro12Ala polymorphism in PPAR-gamma is associated with the risk of prostate cancer... - Pulmonary nodule detection with low-dose CT of the lung: agreement among radiologistsJoseph K Leader
Department of Radiology, Imaging Research Division, University of Pittsburgh, 300 Halket St, Ste 4200, Pittsburgh, PA 15213, USA
AJR Am J Roentgenol 185:973-8. 2005..The purpose of our study was to assess relative intra- and interobserver agreement in detecting pulmonary nodules when interpreting low-dose chest CT screening examinations... - Factors associated with Type I and Type II endometrial cancerAshley S Felix
Division of Cancer Prevention and Population Science, University of Pittsburgh Cancer Institute, 5150 Centre Avenue, Suite 4 C, Pittsburgh, PA 15232, USA
Cancer Causes Control 21:1851-6. 2010..We investigated risk factors for Type II (n = 176) vs. Type I (n = 1,576) endometrial cancer (EC) in cases treated at Magee-Womens Hospital between 1996 and 2008... - CYP2A6 Genotype and Smoking Behavior in Current Smokers Screened for Lung CancerMindi A Styn
1Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania, USA
Subst Use Misuse 48:490-4. 2013..016). Reduced metabolism genotypes appeared unrelated to quitting. Though related to smoking dose, CYP2A6 may not influence cessation... - Nonsteroidal anti-inflammatory drug use and serum total estradiol in postmenopausal womenAlana G Hudson
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cancer Epidemiol Biomarkers Prev 17:680-7. 2008..These cross-sectional findings suggest that NSAID use may be associated with lower circulating estradiol levels, potentially representing one mechanism through which NSAIDs exert protective effects on breast cancer... - A population-based, community estimate of total colon examination: the impact on compliance with screening for colorectal cancerRobert E Schoen
Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA
Am J Gastroenterol 97:446-51. 2002..CONCLUSION: The prevalence of TCE in this population was significant, and including TCE substantially increased measured compliance with colorectal cancer screening. Self-reported use of colonoscopy was validated as accurate... - Transvaginal ultrasound measurement of endometrial thickness as a biomarker for estrogen exposureAnita S Y Sit
Graduate School of Public Health, Magee Women s Hospital, University of Pittsburgh, Pennsylvania, USA
Cancer Epidemiol Biomarkers Prev 13:1459-65. 2004.... - Hormone replacement therapy formulations and risk of epithelial ovarian carcinomaAnita S Y Sit
Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15213, USA
Gynecol Oncol 86:118-23. 2002..049). No significant differences in EOC risk were observed for other HRT formulations. CONCLUSIONS: Our results did not suggest any consistent pattern of altered risk for EOC and the overall use of HRT by specific formulations of HRT... - The effect of delays in treatment for breast cancer metastasis on survivalSu Yon Jung
Department of Epidemiology, Graduate School of Public Health, Epidemiology Data Coordinating Center, University of Pittsburgh, 130 DeSoto Street, 127 Parran Hall, Pittsburgh, PA 15261, USA
Breast Cancer Res Treat 130:953-64. 2011..The findings of this study support targeted efforts to ensure prompt treatment initiation in patients diagnosed with metastatic breast cancer... - Association of physical activity and visceral adipose tissue in older women and menSteven E Riechman
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Obes Res 10:1065-73. 2002..However, few investigations used computed tomography (CAT) scanning for precise measures of abdominal fat... - Generational risks for cancers not related to tobacco, screening, or treatment in the United StatesYueh Ying Han
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cancer 116:940-8. 2010.... - Association of the EGFR intron 1 CA repeat length with lung cancer riskWeiping Zhang
Department of Pharmacology, University of Pittsburgh Cancer Institute, SPORE in Lung Cancer, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
Mol Carcinog 46:372-80. 2007..Our study, which is preliminary, demonstrates for the first time that shorter EGFR-CA repeats associate with lung cancer risk. The number of EGFR-CA repeats identifies a possible susceptible population to lung cancer... - Lack of association between adipose tissue distribution and IGF-1 and IGFBP-3 in men and womenRobert E Schoen
Departments of Epidemiology, Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
Cancer Epidemiol Biomarkers Prev 11:581-6. 2002..The lack of association between obesity and the IGF-1 axis suggests that the IGF-1 axis is not a likely mediator between VAT and disease... - Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokersYang Liu
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
BMC Cancer 7:74. 2007..We compare the results with the smoking status of the patients and the mutation status of the K-ras, p53, and EGFR genes determined previously on these same lung tumors... - Size and morphology of the trachea before and after lung volume reduction surgeryJoseph K Leader
Department of Radiology, Imaging Research Division, University of Pittsburgh, 300 Halket St, Ste 4200, Pittsburgh, PA 15213, USA
AJR Am J Roentgenol 183:315-21. 2004..The purpose of this investigation was to determine the effect of lung volume reduction surgery on measured tracheal features... - Lung cancer serum biomarker discovery using glycoprotein capture and liquid chromatography mass spectrometryXuemei Zeng
University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
J Proteome Res 9:6440-9. 2010..Strong positive correlations between glycopeptide mass chromatograms and ELISA-measured protein abundance was observed for all of the selected glycoproteins... - Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancerMalini Srinivasan
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
J Steroid Biochem Mol Biol 123:30-6. 2011.... - Non-cardiac findings on coronary electron beam computed tomography scanningJeffrey G Schragin
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Thorac Imaging 19:82-6. 2004..With the relatively high detection of significant, non-cardiac pathology in this increasingly common screening procedure, consideration should be given for radiologists to interpret the scans... - Detecting cholangiocarcinoma in patients with primary sclerosing cholangitisEduardo Siqueira
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Gastrointest Endosc 56:40-7. 2002....