David Weiss

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc The Escherichia coli cell division protein and model Tat substrate SufI (FtsP) localizes to the septal ring and has a multicopper oxidase-like structure
    Michael Tarry
    Department of Biochemistry, University of Oxford, UK
    J Mol Biol 386:504-19. 2009
  2. pmc Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL
    D S Weiss
    Department of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 181:508-20. 1999
  3. ncbi request reprint Bacterial cell division and the septal ring
    David S Weiss
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Mol Microbiol 54:588-97. 2004
  4. pmc The Escherichia coli cell division protein FtsW is required to recruit its cognate transpeptidase, FtsI (PBP3), to the division site
    Keri L N Mercer
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 184:904-12. 2002
  5. pmc A predicted ABC transporter, FtsEX, is needed for cell division in Escherichia coli
    Kari L Schmidt
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 186:785-93. 2004
  6. pmc Discovery and characterization of three new Escherichia coli septal ring proteins that contain a SPOR domain: DamX, DedD, and RlpA
    S J Ryan Arends
    Department of Microbiology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    J Bacteriol 192:242-55. 2010
  7. pmc Genetic analysis of the cell division protein FtsI (PBP3): amino acid substitutions that impair septal localization of FtsI and recruitment of FtsN
    Mark C Wissel
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 186:490-502. 2004
  8. pmc Probing the catalytic activity of a cell division-specific transpeptidase in vivo with beta-lactams
    Christian Eberhardt
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 185:3726-34. 2003
  9. pmc The transmembrane helix of the Escherichia coli division protein FtsI localizes to the septal ring
    Mark C Wissel
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Bacteriol 187:320-8. 2005
  10. pmc ATP-binding site lesions in FtsE impair cell division
    S J Ryan Arends
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Bacteriol 191:3772-84. 2009

Collaborators

  • Gregory Phillips
  • DAVID POPHAM
  • Jean Marc Ghigo
  • Charles C Kim
  • S J Ryan Arends
  • Mark C Wissel
  • Sanjeev Mariathasan
  • Denise M Monack
  • Michael Tarry
  • Ryan J Kustusch
  • Anna Brotcke
  • Vishva M Dixit
  • Shan Wang
  • Yvette Weinrauch
  • Lorea Manterola
  • Kari L Schmidt
  • Volker Brinkmann
  • Christian Eberhardt
  • Keri L N Mercer
  • Anna Sedelnikova
  • Renada J Scott
  • Silvana Rolong
  • Kyle Williams
  • Pietro Roversi
  • Susan M Lea
  • Ben C Berks
  • Evan Piette
  • Frank Sargent
  • Meron Roose-Girma
  • Karen O'Rourke
  • Wyne P Lee
  • Jacqueline McBride
  • Kim Newton
  • Emilio Garcia
  • Patrick Chain
  • Stephanie Malfatti
  • Jennifer L Wendt
  • Alberto Sola-Landa
  • Elaine B Newman
  • Ignacio Moriyon
  • Ignacio López-Goñi
  • Edgardo Moreno
  • Calista J Mitchell
  • Klaus Brandenburg
  • Jörg Howe
  • Michel H J Koch
  • Beatrix Fauler
  • Arturo Zychlinsky
  • Becky Graham
  • Yvonne Uhlemann
  • Nicholas D Peterson
  • Ulrike Reichard
  • Christian Goosmann
  • Lars Kuerschner

Detail Information

Publications18

  1. pmc The Escherichia coli cell division protein and model Tat substrate SufI (FtsP) localizes to the septal ring and has a multicopper oxidase-like structure
    Michael Tarry
    Department of Biochemistry, University of Oxford, UK
    J Mol Biol 386:504-19. 2009
    ....
  2. pmc Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL
    D S Weiss
    Department of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 181:508-20. 1999
    ..Septal localization depended upon every other division protein tested (FtsZ, FtsA, FtsQ, and FtsL). We conclude that FtsI is a late recruit to the division site, and that its localization depends on an intact membrane anchor...
  3. ncbi request reprint Bacterial cell division and the septal ring
    David S Weiss
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Mol Microbiol 54:588-97. 2004
    ..Finally, two murein hydrolases, AmiC and EnvC, have been shown to localize to the septal ring of Escherichia coli, where they play an important role in separation of daughter cells...
  4. pmc The Escherichia coli cell division protein FtsW is required to recruit its cognate transpeptidase, FtsI (PBP3), to the division site
    Keri L N Mercer
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 184:904-12. 2002
    ....
  5. pmc A predicted ABC transporter, FtsEX, is needed for cell division in Escherichia coli
    Kari L Schmidt
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 186:785-93. 2004
    ..We conclude that FtsEX participates directly in the process of cell division and is important for assembly or stability of the septal ring, especially in salt-free media...
  6. pmc Discovery and characterization of three new Escherichia coli septal ring proteins that contain a SPOR domain: DamX, DedD, and RlpA
    S J Ryan Arends
    Department of Microbiology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    J Bacteriol 192:242-55. 2010
    ..One interaction partner is FtsQ, and several synthetic phenotypes suggest that DamX is a negative regulator of FtsQ function...
  7. pmc Genetic analysis of the cell division protein FtsI (PBP3): amino acid substitutions that impair septal localization of FtsI and recruitment of FtsN
    Mark C Wissel
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 186:490-502. 2004
    ..Although separated by approximately 150 residues in the primary sequence, these amino acids are close together in the folded protein and might constitute a site of FtsI-FtsN interaction...
  8. pmc Probing the catalytic activity of a cell division-specific transpeptidase in vivo with beta-lactams
    Christian Eberhardt
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 185:3726-34. 2003
    ..We suggest that there might be allosteric activation of substrate binding...
  9. pmc The transmembrane helix of the Escherichia coli division protein FtsI localizes to the septal ring
    Mark C Wissel
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Bacteriol 187:320-8. 2005
    ..These residues cluster on one side of an alpha-helix, which we propose interacts directly with another division protein to recruit FtsI to the septal ring...
  10. pmc ATP-binding site lesions in FtsE impair cell division
    S J Ryan Arends
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Bacteriol 191:3772-84. 2009
    ..This structure is not what one would expect of a substrate-specific transmembrane channel, leading us to suggest that FtsEX is not really a transporter even though it probably has to hydrolyze ATP to support cell division...
  11. pmc Inhibiting cell division in Escherichia coli has little if any effect on gene expression
    S J Ryan Arends
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 186:880-4. 2004
    ..These results extend previous evidence that there is no division checkpoint in E. coli, and progression through the cell cycle is not regulated by the transcription of different genes during different parts of the cell cycle...
  12. ncbi request reprint A deficiency in S-adenosylmethionine synthetase interrupts assembly of the septal ring in Escherichia coli K-12
    Shan Wang
    Biology Department, Concordia University, 1455 de Maisonneuve Ave, Montreal, Quebec H3G 1M8, Canada
    Mol Microbiol 58:791-9. 2005
    ..The requirement for S-adenosylmethionine suggests that some methylation reaction is required before a complete septal ring can be assembled...
  13. pmc Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, South San Francisco, CA 94080, USA
    J Exp Med 202:1043-9. 2005
    ....
  14. pmc The lipopolysaccharide of Brucella abortus BvrS/BvrR mutants contains lipid A modifications and has higher affinity for bactericidal cationic peptides
    Lorea Manterola
    Departamento de Microbiologia y Parasitologia, Universidad de Navarra, c Irunlarrea no 1, 31008 Pamplona, Spain
    J Bacteriol 187:5631-9. 2005
    ..Accordingly, disruption of BvrS/BvrR damages the outer membrane, thus contributing to the severe attenuation manifested by bvrS and bvrR mutants...
  15. ncbi request reprint Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
    ..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
  16. pmc Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis
    Anna Brotcke
    Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Fairchild Bldg D041, Stanford, CA 94305, USA
    Infect Immun 74:6642-55. 2006
    ..We have identified five new Francisella virulence genes, and our results suggest that characterizations of additional MglA-regulated genes will yield further insights into the pathogenesis of this bacterium...
  17. ncbi request reprint Phosphorylation of the recombinant rho1 GABA receptor
    Anna Sedelnikova
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0021, USA
    Int J Dev Neurosci 20:237-46. 2002
    ..This study is a first and necessary step towards elucidating the regulation of rho1 GABA receptors by phosphorylation...
  18. ncbi request reprint Neutrophil extracellular traps kill bacteria
    Volker Brinkmann
    Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Science 303:1532-5. 2004
    ..NETs appear to be a form of innate response that binds microorganisms, prevents them from spreading, and ensures a high local concentration of antimicrobial agents to degrade virulence factors and kill bacteria...

Research Grants8

  1. Discovery and characterization of new bacterial cell division genes
    David S Weiss; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The studies proposed here will lead to a greater understanding of bacterial cell division. That knowledge can be used to develop new antibiotics. ..
  2. ASSEMBLY OF THE DIVISION SEPTUM IN ESCHERICHIA COLI
    David Weiss; Fiscal Year: 2003
    ..In this regard, it is worth noting that four of the proteins to be studied here (FtsI and the three transglycosylases) are primary targets of beta-lactam antibiotics. ..
  3. Discovery and characterization of new bacterial cell division genes
    David Weiss; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: The studies proposed here will lead to a greater understanding of bacterial cell division. That knowledge can be used to develop new antibiotics. ..