Research Topics
Genomes and Genes
| Arthur WeissSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expressionJeroen P Roose
Department of Medicine, University of California, San Francisco, USA
PLoS Biol 1:E53. 2003..Our data suggest that physiologic gene expression programs depend upon tonic activity of signaling pathways independent of receptor ligation...- Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signalingT Sosinowski
Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California 94143 0795, USA
J Exp Med 191:463-74. 2000..These results suggest that SLAP is a negative regulator of TCR signaling... - Antigen receptor signaling in the rheumatic diseasesJulie Zikherman
Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, 513 Parnassus Avenue San Francisco, CA 94143, USA
Arthritis Res Ther 11:202. 2009..Impaired and enhanced T-cell receptor signaling are both associated with distinct inflammatory diseases in mice. Mechanisms by which these pathways contribute to disease in mouse models and patients are under active investigation... 
Discovering the TCR beta-chain by subtractionArthur Weiss
Howard Hughes Medical Institute, Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco 94143, USA
J Immunol 175:2769-70. 2005
The right team at the right time to go for a home run: tyrosine kinase activation by the TCRArthur Weiss
Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Departments of Medicine and of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
Nat Immunol 11:101-4. 2010..The TCR signals via cytoplasmic tyrosine kinases. Art Weiss recounts discoveries that led to early understanding of these events...- A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activityByron B Au-Yeung
Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Department of Microbiology and Immunology, University of California San Francisco, California, USA
Nat Immunol 11:1085-92. 2010..Our results indicate Zap70 is a likely therapeutic target... - ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemiaLiguang Chen
Division of Hematology Oncology, Department of Medicine, University of California, San Diego, 9500 Gilman Dr, UCSD School of Medicine, La Jolla, CA 92093, USA
Blood 105:2036-41. 2005.... - Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent mannerLeonard L Dragone
Division of Pediatric Immunology Rheumatology, Department of Pediatrics, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 103:18202-7. 2006..These data suggest that SLAP has a conserved function in B and T cells by adapting c-Cbl to the antigen-receptor complex and targeting it for degradation... - Regulation of thymocyte positive selection and motility by GIT2Hyewon Phee
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Nat Immunol 11:503-11. 2010.... - A proline-rich motif in the C terminus of Akt contributes to its localization in the immunological synapseLawrence P Kane
Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
J Immunol 172:5441-9. 2004..Therefore, multiple mechanisms are involved in the proper targeting of Akt during the early events of T cell activation... - PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune backgroundJulie Zikherman
University of California, San Francisco, 94143, USA
J Immunol 182:4093-106. 2009..These studies suggest that Pep(-/-) T cells in the context of a susceptible microenvironment can drive hyperresponsive CD45 E613R B cells to break tolerance... - A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivityLih Yun Hsu
Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California San Francisco Children s Hospital, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 206:2527-41. 2009..By uncoupling the relative contribution from T regulatory cells and TCR repertoire during thymic selection, our data help to identify events that may be important, but alone are insufficient, for the development of autoimmune disease... - Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytesJeroen P Roose
Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0795, USA
Mol Cell Biol 27:2732-45. 2007..We hypothesize that this mechanism enables lymphocytes to maximally respond to physiologically low levels of stimulation... - Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor responseSebastian Deindl
Department of Molecular and Cell Biology, California Institute of Quantitative Biosciences, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 106:20699-704. 2009..Taken together, our results directly correlate the stability of the autoinhibitory interface with the activation of these key events in the T cell response... - Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for TecMichael G Tomlinson
Department of Medicine and Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
Mol Cell Biol 24:2455-66. 2004..We hypothesize that Tec functions in activated and effector T lymphocytes to induce the expression of genes regulated by NFAT transcription factors... - SRC-like adaptor protein regulates B cell development and functionLeonard L Dragone
Division of Pediatric Immunology Rheumatology, Department of Pediatrics, University of California, San Francisco, CA 94143, USA
J Immunol 176:335-45. 2006..These data suggest that SLAP regulates BCR levels and signal strength during lymphocyte development... - Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1Hyewon Phee
Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, 94143, USA
Nat Immunol 6:608-17. 2005..These data indicate that a pathway involving the GIT-PIX-PAK1 complex has a crucial function in PAK1 activation by recruiting PAK1 to the immunological synapse... - Structural basis for the inhibition of tyrosine kinase activity of ZAP-70Sebastian Deindl
Department of Molecular and Cell Biology, Department of Chemistry, and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
Cell 129:735-46. 2007..These interactions are inconsistent with ITAM binding, suggesting that destabilization of this autoinhibited ZAP-70 conformation is the first step in kinase activation... - Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signalingJing W Zhu
Departments of Medicine and of Microbiology and Immunology, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, CA 94143, USA
Immunity 28:183-96. 2008.... - Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcriptionLawrence P Kane
Department of Medicine The Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
Mol Cell Biol 22:5962-74. 2002..These findings suggest that the activation of different signaling pathways by MAP3Ks may be regulated separately and may provide evidence for how such discrimination by one member of this kinase family occurs... - B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiencyVikas A Gupta
Department of Medicine, Biomedical Sciences Graduate Program, Medical Scientist Training Program, University of California San Francisco, San Francisco, CA 94143, USA
J Exp Med 205:2755-61. 2008..These results reveal a requirement for careful control of B cell signaling and cell death in preventing inappropriate lymphocyte activation and autoimmunity... - Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complexMargaret D Myers
Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California San Francisco, 94143, USA
Nat Immunol 7:57-66. 2006..These studies indicate that SLAP links the E3 ligase activity of c-Cbl to the TCR, allowing for stage-specific regulation of TCR expression... - SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinaseMichael G Tomlinson
Department of Medicine and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA
J Biol Chem 279:55089-96. 2004..These data suggest that SHIP phosphatases can interact with and functionally inactivate Tec by de-phosphorylation of local PtdIns 3,4,5-P(3) and inhibition of Tec membrane localization... - The juxtamembrane wedge negatively regulates CD45 function in B cellsMichelle L Hermiston
Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143, USA
Immunity 23:635-47. 2005..Together, the results support a role for CD45 as a rheostat, with both positive and negative regulatory functions, that fine-tunes the signal transduction threshold at multiple checkpoints in B cell development... - A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cellsJeroen P Roose
Department of Medicine, UCSF, 533 Parnassus Avenue, Room U-330, San Francisco, CA 94143, USA
Mol Cell Biol 25:4426-41. 2005..Conversely, active PKCtheta depends on RasGRP1 sufficiency to effectively trigger downstream events. Last, DAG-PKC-RasGRP1-driven Ras-Erk activation in T cells is a unique signaling event, not simply compensated for by SOS activity... - STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell developmentAndre Limnander
Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California at San Francisco, San Francisco, California, USA
Nat Immunol 12:425-33. 2011..Conversely, overexpression of STIM1 conferred a competitive disadvantage to developing B cells. Our findings establish Ca(2+)-dependent Erk signaling as a critical proapoptotic pathway that mediates the negative selection of B cells... - Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinasesS Clare Chung
Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 177:317-28. 2007..The action of kinases on Icrac activation does not arise from control of the expression level of the stromal interaction molecule 1 and Orai1 proteins... - Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinasesTomas Brdicka
Department of Medicine, The Rosalind Russell Medical Research Center for Arthritis and Howard Hughes Medical Institute, University of California at San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143 0795, USA
Mol Cell Biol 25:4924-33. 2005..Similar regulation was also noted for the related Syk kinase. These findings suggest that a general autoinhibitory mechanism employed by RTKs is also used by some cytoplasmic tyrosine kinases... - Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine productionDavid G T Hesslein
Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 103:7012-7. 2006..These findings indicate that CD45-dependent regulation of ITAM-dependent signaling pathways is essential for NK cell-mediated cytokine production but not cytolytic activity... - CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic developmentJulie Zikherman
Division of Rheumatology, University of California San Francisco, San Francisco, CA 94143, USA
Immunity 32:342-54. 2010..High physiologic expression of CD45 is thus required for two reasons-to downmodulate inducible TCR signaling during positive selection and to counteract Csk during basal TCR signaling... - ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemiaLaura Z Rassenti
Chronic Lymphocytic Leukemia Research Consortium, University of California, San Diego, La Jolla 92093, USA
N Engl J Med 351:893-901. 2004..001). CONCLUSIONS: Although the presence of an unmutated IgV(H) gene is strongly associated with the expression of ZAP-70, ZAP-70 is a stronger predictor of the need for treatment in B-cell CLL... - Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarizationMichelle R Kuhne
Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Center for Medical Research in Arthritis, University of California, San Francisco, CA 94143, USA
J Immunol 171:860-6. 2003..Moreover, our studies revealed that a calcium-dependent event not requiring calcineurin or calcium/calmodulin-dependent kinase is required for TCR-induced polarization of the MTOC... - Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fateSoren Beinke
Department of Medicine, Division of Rheumatology, The Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, and Graduate Program in Biomedical Sciences, University of California, San Francisco, CA 94143 0795, USA
Proc Natl Acad Sci U S A 107:16234-9. 2010..Thus, PYK2 facilitates LFA-1-dependent CD8 T-cell responses and promotes CD8 T-cell short-lived effector fate, suggesting that PYK2 may be an interesting therapeutic target to suppress exacerbated CD8 T-cell responses... - Distinct roles for Syk and ZAP-70 during early thymocyte developmentEmil H Palacios
Department of Medicine, The Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, CA 94143, USA
J Exp Med 204:1703-15. 2007..We propose that pre-TCR signaling continues during DN4 and later stages, with ZAP-70 dynamically replacing Syk for continued pre-TCR signaling... - Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responsesMichelle L Hermiston
Department of Pediatrics, Medicine, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:546-51. 2009..Together, the data support a role for the CD45 wedge in regulation of T cell responses in vivo and suggest that its effects depend on cellular context... - Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissuesRobert Schmalzigaug
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Histochem Cytochem 55:1039-48. 2007.... - Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4Ajay Nirula
Department of Medicine, The Rosalind Russell Medical Research Center for Arthritis and the Howard Hughes Medical Institute, University of California at San Francisco, CA 94143, USA
J Exp Med 203:1733-44. 2006..These findings together define a pathway linking the kinases PDK1 and PKA in the induction of the Th2 cytokine IL-4... - ZAP-70: an essential kinase in T-cell signalingHaopeng Wang
Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
Cold Spring Harb Perspect Biol 2:a002279. 2010..Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor... - Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradationMargaret D Myers
Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA 94143, USA
J Cell Biol 170:285-94. 2005..These studies reveal a unique mechanism by which SLAP contributes to the regulation of TCR expression during a distinct stage of thymocyte development... - The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3Lawrence P Kane
Department of Medicine, The Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
Immunol Rev 192:7-20. 2003..These pathways have been associated with TCR/CD28 costimulation, and they have also been implicated as targets of Akt... - Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cellsJoseph Lin
Department of Medicine, University of California, San Francisco 94143, USA
J Immunol 173:2324-30. 2004..Together, these expression data along with previous biochemical data suggest that CD148 may play an important regulatory role to control an immune response... - Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signalingJamie R Schoenborn
Rosalind Russell Medical Research Center for Arthritis, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143, USA
Sci Signal 4:ra59. 2011..Our results also suggest a role for Csk in the termination or dampening of TCR signals... - CD45: a critical regulator of signaling thresholds in immune cellsMichelle L Hermiston
Department of Pediatrics, University of California, San Francisco, 94143, USA
Annu Rev Immunol 21:107-37. 2003..Perturbation of this function may contribute to autoimmunity, immunodeficiency, and malignancy. Moreover, recent advances suggest that modulation of CD45 function can have therapeutic benefit in many disease states... - The structure, regulation, and function of ZAP-70Byron B Au-Yeung
Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143 0795, USA
Immunol Rev 228:41-57. 2009..Thus, the critical importance of ZAP-70 in TCR signaling and its predominantly T-cell-restricted expression pattern make ZAP-70 an attractive drug target for the inhibition of pathological T-cell responses in disease... - Alternative splicing of CD45: the tip of the icebergJulie Zikherman
Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA
Immunity 29:839-41. 2008..In this issue of Immunity, Wu et al. (2008) identify hnRNPLL as a critical regulator of both signal-induced exon skipping in CD45 and global alternative-transcript expression in memory T cells... - Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signalingSusan E Levin
Departments of Medicine and Microbiology and Immunology, Biomedical Sciences Graduate Program, and Howard Hughes Medical Institute, University of California San Francisco, 5134 Parnassus Avenue, San Francisco, CA 94143, USA
J Biol Chem 283:15419-30. 2008..Thus, we have developed the first specific chemical means of inhibiting ZAP-70 in cells, which serves as a valuable tool for studying the function of ZAP-70 in T cells... - Function of the Src-family kinases, Lck and Fyn, in T-cell development and activationEmil H Palacios
Rosalind Russell Medical Research Center for Arthritis, Department of Medicine and The Howard Hughes Medical Institute, University of California, San Francisco 94143 0795, USA
Oncogene 23:7990-8000. 2004..SFKs are required for each of these TCR-based signals, and Lck seems to be the major contributor... - Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoformsZheng Xu
Department of Medicine and The Howard Hughes Medical Institute, University of California, San Francisco, CA 94143-0795, USA
Nat Immunol 3:764-71. 2002..Our results not only demonstrate the biological significance of alternative splicing in the immune system, but also suggest a model for regulating RPTP dimerization and function... - Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiationPietro G Andres
Division of Gastroenterology, Department of Medicine, University of California, San Francisco, California 94143, USA
Nat Immunol 5:435-42. 2004..Thus, different mechanisms underlie the induction of distinct T cell functional responses by CD28... - Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic miceCedric Louvet
Diabetes Center and the Department of Medicine, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 105:18895-900. 2008..Thus, long-term efficacy and tolerance is likely to depend on inhibiting a combination of tyrosine kinases supporting the use of selective kinase inhibitors as a new, potentially very attractive approach for the treatment of T1D... - T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalizationVictoria L Crotzer
The GW Hooper Foundation, Department of Microbiology, University of California San Francisco, 94143, USA
J Exp Med 199:981-91. 2004..Thus, we propose that CHC phosphorylation and dephosphorylation are involved in TCR internalization and that this is a regulatory mechanism linking TCR signaling to endocytosis... - The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cellsZheng Xu
Department of Medicine and Howard Hughes Meidcal Institute, University of California, San Francisco, California 94143 0795, USA
Cell Growth Differ 13:285-96. 2002..In summary, our results suggest that PTEN suppresses cell growth, promotes apoptosis, and decreases cell size by negatively regulating the phosphoinositide 3-kinase/Akt pathway in Jurkat T cells... - The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T-mediated virulencePriya Balachandran
Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, San Francisco, California 94143, USA
J Clin Invest 117:419-27. 2007..To the best of our knowledge, this represents the first identification of a mammalian gene product that is specifically required for in vivo resistance to disease mediated by a type III-secreted effector... - The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signalingJoseph Lin
Department of Medicine, Biomedical Sciences Graduate Program, University of California at San Francisco, 533 Parnassus Avenue, Box no 0795, San Francisco, CA 94143 0795, USA
J Cell Biol 162:673-82. 2003..Upon T cell-APC disengagement, CD148 can then access and dephosphorylate substrates to down-regulate prolongation of signaling... - Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureusJing W Zhu
Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, San Francisco, CA 94143, USA
Immunity 35:757-69. 2011..Moreover, our results suggest that CD45 and CD148 preferentially target different SFK members (Hck and Fgr versus Lyn, respectively) to positively and negatively regulate GPCR pathways... - Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune diseaseJulie Zikherman
Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, UCSF, San Francisco, California, USA
J Clin Invest 121:4618-21. 2011..These data provide new insight as to how noncoding PTPN2 SNPs identified in GWAS could drive human autoimmune diseases... - Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survivalJulie Zikherman
Division of Rheumatology, Department of Medicine, Rosalind Russell Medical Research Center for Arthritis and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 109:E3-12. 2012..Taken together, our findings reveal how CD45 function diverges in T cells and B cells, as well as how autoreactive B cells are censored as they transit development... - Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemiaLiguang Chen
Division of Hematology Oncology, Department of Medicine, University of California, San Diego for the CLL Research Consortium, San Diego, CA, USA
Blood 100:4609-14. 2002.... - Twisting tails exposed: the evidence for TCR conformational changeSusan E Levin
Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
J Exp Med 201:489-92. 2005..In this commentary, the evidence for TCR conformational change is reviewed and potential mechanisms for its initiation are explored... - It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activationLawrence P Kane
Dept of Medicine, The Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 9143-0795, USA
Trends Immunol 23:413-20. 2002..Although many questions remain, recent years have witnessed significant progress in understanding the signal transduction pathways leading from the TCR and CD28 to Rel/NF-kappaB-dependent transcription... - Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expressionEvan Markegard
Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e25540. 2011..We postulate that basal LAT-diacylglycerol-RasGRP signals fulfill a regulatory function in peripheral T lymphocytes by maintaining proper gene expression programs... - Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatasesMichelle L Hermiston
Department of Pediatrics, The Howard Hughes Medical Institute, University of California, San Francisco, California 94143-0795, USA
J Clin Invest 109:9-14. 2002 - Jurkat T cells and development of the T-cell receptor signalling paradigmRobert T Abraham
Program in Signal Transduction Research at The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Rev Immunol 4:301-8. 2004 - Overview of the Alliance for Cellular SignalingAlfred G Gilman
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Nature 420:703-6. 2002..One goal is to catalyse complementary research in individual laboratories; to facilitate this, all alliance data are freely available for use by the entire research community... - ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemiaLiguang Chen
Moores UCSD Cancer Center, University of California San Diego, 3855 Health Sciences Drive No 0820, La Jolla, CA 92093, USA
Blood 111:2685-92. 2008..We conclude that ZAP-70 most likely acts as an adapter protein that facilitates B-cell receptor (BCR) signaling in CLL cells independent of its tyrosine kinase activity or its ability to interact with c-Cbl... - Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domainsLorian C Hartgroves
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, United Kingdom
J Biol Chem 278:20389-94. 2003..Taken together our data suggest a synergistic assembly of multimolecular TCR.LAT signal transduction complexes in T cell plasma membrane domains... - Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulationLauren I Richie Ehrlich
Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 17:809-22. 2002..Most surprisingly, we find an intracellular pool of lck associated with recycling endosomes that translocates to mature synapses within 10 min of calcium flux. This bolus of lck may contribute to intermediate-late signal transduction... - The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytesMichael Mingueneau
Centre d immunologie de Marseille Luminy, Universite de la Mediterrannee, Case 906, Institut National de la Santé et de la Recherche Médicale U631, and Centre National de la Recherche Scientifique UMR6102, 13288 Marseille Cedex 9, France
Nat Immunol 9:522-32. 2008..Our results identify previously unknown functions for the evolutionarily conserved CD3epsilon PRS at the CD4+CD8+ developmental stage and suggest a rather limited function in mature T cells...