Research Topics
| R B WeiskopfSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humansRichard B Weiskopf
Department of Anesthesia and Perioperative Care, University of California, San Francisco, Box 0648, San Francisco, CA 94143 0648, USA
Anesth Analg 114:511-9. 2012..We tested the hypothesis that transfusion can cause mild pulmonary dysfunction that has not been noticed clinically and is not sufficiently severe to fit the definition of transfusion-related acute lung injury...
Acute isovolemic anemia does not impair peripheral or central nerve conductionRichard B Weiskopf
Department of Anesthesia, and Cardiovascular Research Institute, University of California, San Francisco, 94143 0648, USA
Anesthesiology 99:546-51. 2003..In this study, the authors tested the hypothesis that such changes relate to the slowing of afferent neural traffic...
Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemiaRichard B Weiskopf
Department of Anesthesia, University of California, San Francisco, California 94143 0648, USA
Anesthesiology 96:871-7. 2002....
Efficacy of acute normovolemic hemodilution assessed as a function of fraction of blood volume lostR B Weiskopf
Department of Anesthesia, University of California, San Francisco 94143 0648, USA
Anesthesiology 94:439-46. 2001....
The use of recombinant activated coagulation factor VII for spine surgeryRichard B Weiskopf
Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0648, USA
Eur Spine J 13:S83-8. 2004....
Heart rate increases linearly in response to acute isovolemic anemiaRichard B Weiskopf
Department of Anesthesia, The Cardiovascular Research Institute, University of California, San Francisco, California 94122, USA
Transfusion 43:235-40. 2003..The hypothesis that heart rate in humans increases in response to acute isovolemic anemia and that the increase is affected by gender was tested...
A procedure for rapid issue of red cells for emergency useRichard B Weiskopf
Department of Anesthesia and Physiology, University of California, San Francisco 94143 0648, USA
Arch Pathol Lab Med 129:492-6. 2005..These times may not be adequate to permit the red cells to provide sufficiently rapid delivery of oxygen in massively bleeding patients...
Extracellular potassium concentrations in red blood cell suspensions after irradiation and washingRichard B Weiskopf
Department of Anesthesia, University of California, San Francisco, California 94143 0648, USA
Transfusion 45:1295-301. 2005..AABB standards permit storage of washed RBCs at 4 degrees C for 24 hours. The [K(+)e] of washed RBCs during storage is not known. Experiments were performed to provide those data...
Human cardiovascular and metabolic response to acute, severe isovolemic anemiaR B Weiskopf
Department of Anesthesia, Cardiovascular Research Institute, University of California, San Francisco 94143 0648, USA
JAMA 279:217-21. 1998....
Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humansRichard B Weiskopf
Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, USA
Anesthesiology 104:911-20. 2006..The authors tested the hypothesis that erythrocytes stored for 3 weeks are as effective in supplying oxygen to human tissues as are erythrocytes stored for less than 5 h...
Repetitive rapid increases in desflurane concentration blunt transient cardiovascular stimulation in humansR B Weiskopf
Department of Anesthesia, University of California, San Francisco 94143 0648
Anesthesiology 81:843-9. 1994..We hypothesized that the initial increase in concentration would produce greater changes than subsequent increases...
Acute severe isovolemic anemia impairs cognitive function and memory in humansR B Weiskopf
Departments of Anesthesia, The Cardiovascular Research Institute, University of California, San Francisco, California 94143 0648, USA
Anesthesiology 92:1646-52. 2000..However, in those studies, sensitive, specific measures of critical organ function were not used. This study tested the hypothesis that acute severe decreases of hemoglobin concentration alters human cognitive function...
Cardiovascular effects of I653 in swineR B Weiskopf
Department of Anesthesia, University of California, San Francisco
Anesthesiology 69:303-9. 1988..2 MAC, 120 +/- 4 at 1.6 MAC). Systemic vascular resistance increased slightly at 1.6 MAC compared to the values at 0.8 and 1.2 MAC, but was always less than in the conscious condition.(ABSTRACT TRUNCATED AT 250 WORDS)..
Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humansJ M Leung
Department of Anesthesia, University of California, San Francisco
Anesthesiology 93:1004-10. 2000....
Recombinant human hemoglobin does not affect renal function in humans: analysis of safety and pharmacokineticsM K Viele
Department of Laboratory Medicine, University of California, San Francisco 94143 0100, USA
Anesthesiology 86:848-58. 1997..Historically, infusion in humans of acellular hemoglobin preparations has resulted in renal toxicity. This study was performed to evaluate the safety and pharmacokinetics of rHb1.1 when infused in humans...
Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation productsE I Eger
Department of Anesthesia, University of California, San Francisco 94143 0464, USA
Anesthesiology 87:517-26. 1997..The authors determined the kinetic characteristics of desflurane and sevoflurane and those of compound A [CH2F-O-C(=CF2)(CF3)], a nephrotoxic degradation product of sevoflurane...
Microarray kit analysis of cytokines in blood product units and segmentsRichard B Weiskopf
Department of Laboratory Medicine, and the Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143 0648, USA
Transfusion 49:2269-75. 2009....
Acute isovolemic anemia impairs central processing as determined by P300 latencyRichard B Weiskopf
Departments of Anesthesia and Physiology, Cardiovascular Research Institute, University of California, San Francisco, 94143 0648, USA
Clin Neurophysiol 116:1028-32. 2005..Acute anemia slows the responses to clinical tests of cognitive function. We tested the hypothesis that these slowed responses during acute severe isovolemic anemia in healthy unmedicated humans result from impaired central processing...
Changing from isoflurane to desflurane toward the end of anesthesia does not accelerate recovery in humansM A Neumann
Department of Anesthesia, University of California, San Francisco, 94143, USA
Anesthesiology 88:914-21. 1998..The authors tried to determine whether substituting desflurane for isoflurane in the last 30 min of a 120-min anesthetic would accelerate recovery...
Anemia and perioperative red blood cell transfusion: a matter of toleranceCaveh Madjdpour
Department of Anesthesiology, University Hospital (CHUV, Lausanne, Switzerland
Crit Care Med 34:S102-8. 2006..Therefore, knowing the compensatory mechanisms during acute anemia is crucial. This review focuses on acute anemia tolerance, its limits, and physiologic transfusion triggers in the perioperative period...
Visual loss after spinal surgeryRichard B Weiskopf
Anesthesiology 106:1250-1; author reply 1251-2. 2007
Volume replacement therapy during major orthopedic surgery using Voluven (hydroxyethyl starch 130/0.4) or hetastarchSweeta D Gandhi
Department of Anesthesiology, Clement J Zablocki Veterans Affairs Medical Center and the Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Anesthesiology 106:1120-7. 2007..4; Fresenius Kabi, Bad Homburg, Germany) and hetastarch (HES 670/0.75 in saline) for intravascular volume replacement therapy during major orthopedic surgery...
The role of data and safety monitoring in acute trauma resuscitation researchHoward R Champion
Uniformed Services University of Health Sciences, Bethesda, MD 20910, USA
J Am Coll Surg 204:73-83. 2007..Many of the difficulties conducting acute resuscitation research are exacerbated because multiinstitutional studies are needed to adequately power such research...
Hemodilution and candlesRichard B Weiskopf
Anesthesiology 97:773-5. 2002
Choosing the optimal endpoint(s) for a clinical trial on transfusionJean François Hardy
Department of Anesthesiology, University of Montreal, Notre Dame Hospital, Montreal, Quebec, Canada
Transfusion 45:1S. 2005
Intraoperative use of recombinant activated coagulation factor vIIRichard B Weiskopf
Anesthesiology 96:1287-9. 2002
A comparison of intrathecal opioid and intravenous analgesia for the incidence of cardiovascular, respiratory, and renal complications after abdominal aortic surgeryMarie Hélène Fléron
Department of Anesthesiology and Critical Care, CHU Pitie Salpetriere, Institut Mutualiste Montsouris, Paris, France
Anesth Analg 97:2-12, table of contents. 2003....
