R H Weisbart

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb
    Richard H Weisbart
    Department of Medicine, Division of Rheumatology, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    Mol Immunol 39:783-9. 2003
  2. ncbi request reprint Antibody mediated transduction of therapeutic proteins into living cells
    James E Hansen
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    ScientificWorldJournal 5:782-8. 2005
  3. ncbi request reprint Antibody-mediated Hsp70 protein therapy
    James E Hansen
    Department of Medicine, San Fernando Valley Program, University of California Los Angeles, Los Angeles, CA 90095, USA
    Brain Res 1088:187-96. 2006
  4. doi request reprint A cell-penetrating bispecific antibody for therapeutic regulation of intracellular targets
    Richard H Weisbart
    Veterans Affairs Greater Los Angeles Health Care System, 161111 Plummer St, Sepulveda, CA 91343, USA
    Mol Cancer Ther 11:2169-73. 2012
  5. doi request reprint BRAF splice variants in rheumatoid arthritis synovial fibroblasts activate MAPK through CRAF
    Richard H Weisbart
    Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    Mol Immunol 55:247-52. 2013
  6. pmc BRAF drives synovial fibroblast transformation in rheumatoid arthritis
    Richard H Weisbart
    Department of Research, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, California 91343, USA
    J Biol Chem 285:34299-303. 2010
  7. ncbi request reprint Selective IgA immune unresponsiveness to Proteus mirabilis fumarate reductase A-chain in rheumatoid arthritis
    Richard H Weisbart
    Department of Medicine, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    J Rheumatol 32:1208-12. 2005
  8. ncbi request reprint An intracellular delivery vehicle for protein transduction of micro-dystrophin
    Richard H Weisbart
    Department of Research, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA
    J Drug Target 13:81-7. 2005
  9. ncbi request reprint Antibody-mediated transduction of p53 selectively kills cancer cells
    Richard H Weisbart
    Division of Rheumatology, Department of Medicine, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    Int J Oncol 25:1867-73. 2004
  10. ncbi request reprint Construction and expression of a bispecific single-chain antibody that penetrates mutant p53 colon cancer cells and binds p53
    Richard H Weisbart
    Department of Medicine, Division of Rheumatology, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    Int J Oncol 25:1113-8. 2004

Detail Information

Publications17

  1. ncbi request reprint Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb
    Richard H Weisbart
    Department of Medicine, Division of Rheumatology, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    Mol Immunol 39:783-9. 2003
    ..Myosin IIb is implicated in the specific targeting of mAb 3E10 to skeletal muscle...
  2. ncbi request reprint Antibody mediated transduction of therapeutic proteins into living cells
    James E Hansen
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    ScientificWorldJournal 5:782-8. 2005
    ....
  3. ncbi request reprint Antibody-mediated Hsp70 protein therapy
    James E Hansen
    Department of Medicine, San Fernando Valley Program, University of California Los Angeles, Los Angeles, CA 90095, USA
    Brain Res 1088:187-96. 2006
    ..These results provide the first evidence that the Fv fragment of mAb 3E10 is capable of delivering proteins to neurons and indicate its potential in the development of Hsp70 protein therapy...
  4. doi request reprint A cell-penetrating bispecific antibody for therapeutic regulation of intracellular targets
    Richard H Weisbart
    Veterans Affairs Greater Los Angeles Health Care System, 161111 Plummer St, Sepulveda, CA 91343, USA
    Mol Cancer Ther 11:2169-73. 2012
    ..The use of cell-penetrating bispecific antibodies in targeted molecular therapy will significantly broaden the spectrum of accessible intracellular targets and may have a profound impact in cancer therapy...
  5. doi request reprint BRAF splice variants in rheumatoid arthritis synovial fibroblasts activate MAPK through CRAF
    Richard H Weisbart
    Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    Mol Immunol 55:247-52. 2013
    ....
  6. pmc BRAF drives synovial fibroblast transformation in rheumatoid arthritis
    Richard H Weisbart
    Department of Research, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, California 91343, USA
    J Biol Chem 285:34299-303. 2010
    ..Our finding is the first to establish mechanisms for fibroblast transformation responsible for destruction of articular cartilage and bone in rheumatoid arthritis and establishes a new target for therapeutic intervention...
  7. ncbi request reprint Selective IgA immune unresponsiveness to Proteus mirabilis fumarate reductase A-chain in rheumatoid arthritis
    Richard H Weisbart
    Department of Medicine, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    J Rheumatol 32:1208-12. 2005
    ..To determine if selective immune unresponsiveness to microbial antigens is associated with predisposition to rheumatoid arthritis (RA)...
  8. ncbi request reprint An intracellular delivery vehicle for protein transduction of micro-dystrophin
    Richard H Weisbart
    Department of Research, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA
    J Drug Target 13:81-7. 2005
    ..In the absence of membrane beta-dystroglycan, it localized to the cytoplasm. Antibody-mediated transduction of micro-dystrophin into muscle cells is a potential therapy for dystrophin-deficient muscular dystrophies...
  9. ncbi request reprint Antibody-mediated transduction of p53 selectively kills cancer cells
    Richard H Weisbart
    Division of Rheumatology, Department of Medicine, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    Int J Oncol 25:1867-73. 2004
    ..Fv-p53 was shown to penetrate cancer cells engrafted in vivo. These results support continued efforts to evaluate the potential efficacy of Fv-p53 for the treatment of certain cancers in vivo...
  10. ncbi request reprint Construction and expression of a bispecific single-chain antibody that penetrates mutant p53 colon cancer cells and binds p53
    Richard H Weisbart
    Department of Medicine, Division of Rheumatology, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    Int J Oncol 25:1113-8. 2004
    ..Our study demonstrates the use of an antibody that penetrates living cells in the design of a bispecific single chain antibody to target and restore the function of an intracellular protein...
  11. ncbi request reprint Nuclear delivery of p53 C-terminal peptides into cancer cells using scFv fragments of a monoclonal antibody that penetrates living cells
    Richard H Weisbart
    Department of Medicine, Division of Rheumatology, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    Cancer Lett 195:211-9. 2003
    ..Our results demonstrate the potential efficacy of antibody scFv fragments as a nuclear delivery system in cancer cells...
  12. ncbi request reprint Novel protein transfection of primary rat cortical neurons using an antibody that penetrates living cells
    R H Weisbart
    Department of Medicine, Division of Rheumatology, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA
    J Immunol 164:6020-6. 2000
    ..These studies illustrate the potential of this method for the intracellular delivery of therapeutic proteins...
  13. ncbi request reprint Intranuclear protein transduction through a nucleoside salvage pathway
    James E Hansen
    Veterans Affairs Greater Los Angeles Healthcare System VAGLAHS, Sepulveda, California 91343, USA
    J Biol Chem 282:20790-3. 2007
    ....
  14. ncbi request reprint Antibody-mediated p53 protein therapy prevents liver metastasis in vivo
    James E Hansen
    Medical Center, Veterans Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, CA 91343, USA
    Cancer Res 67:1769-74. 2007
    ..mAb 3E10 Fv has significant clinical potential as a mediator of intracellular and intranuclear delivery of p53 for prevention and treatment of cancer metastasis...
  15. ncbi request reprint Novel structural features of autoantibodies in murine lupus: a possible superantigen binding site?
    D J Zack
    Department of Medicine, Veterans Affairs Medical Center, Sepulveda, California 91343
    Immunol Cell Biol 72:513-20. 1994
    ....
  16. pmc p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis
    Qiu Lan Ma
    Department of Medicine, UCLA, Los Angeles, California, USA
    J Biol Chem 283:14132-43. 2008
    ..Our results implicate aberrant PAK in Abeta oligomer-induced signaling and synaptic deficits in Alzheimer disease...
  17. ncbi request reprint Antiguanosine antibodies in murine and human lupus have the internal image of G-binding proteins
    Keith K Colburn
    J L Pettis Memorial Veterans Medical Center, Loma Linda University Medical School, Loma Linda, California, USA
    J Rheumatol 30:993-7. 2003
    ..Serum antiguanosine autoantibodies in human lupus correlate with nephritis and polyserositis in acute disease as well as in exacerbations of disease symptoms...