Matthew Weir

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. doi request reprint A randomized, double-blind, forced-titration study to compare olmesartan medoxomil versus losartan potassium in patients with stage 1 and 2 hypertension
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Postgrad Med 123:80-7. 2011
  2. ncbi request reprint An in-depth review of the evidence linking dietary salt intake and progression of chronic kidney disease
    Charlotte Jones-Burton
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Nephrol 26:268-75. 2006
  3. doi request reprint Efficacy of amlodipine/olmesartan medoxomil ± hydrochlorothiazide in patients aged ≥ 65 or < 65 years with uncontrolled hypertension on prior monotherapy
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Postgrad Med 125:124-34. 2013
  4. doi request reprint Urinary sodium is a potent correlate of proteinuria: lessons from the chronic renal insufficiency cohort study
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Nephrol 36:397-404. 2012
  5. doi request reprint Debate from the 2012 ASH Annual Scientific Sessions: should blood pressure be reduced in hemodialysis patients? Con position
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Am Soc Hypertens 6:443-7. 2012
  6. doi request reprint Eosinophilia as an early indicator of pancreatic allograft rejection
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Transplant 26:238-41. 2012
  7. doi request reprint Renal outcomes in hypertensive Black patients at high cardiovascular risk
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Kidney Int 81:568-76. 2012
  8. ncbi request reprint Providing end-organ protection with renin-angiotensin system inhibition: the evidence so far
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    J Clin Hypertens (Greenwich) 8:99-105; quiz 106-7. 2006
  9. doi request reprint Hypertension and the kidney: perspectives on the relationship of kidney disease and cardiovascular disease
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    Clin J Am Soc Nephrol 4:2045-50. 2009
  10. doi request reprint Beta-blockers in the treatment of hypertension: are there clinically relevant differences?
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Postgrad Med 121:90-8. 2009

Collaborators

Detail Information

Publications125 found, 100 shown here

  1. doi request reprint A randomized, double-blind, forced-titration study to compare olmesartan medoxomil versus losartan potassium in patients with stage 1 and 2 hypertension
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Postgrad Med 123:80-7. 2011
    ..To evaluate the comparative efficacy and safety of once-daily olmesartan medoxomil (OM) and losartan potassium (LOS) in patients with hypertension...
  2. ncbi request reprint An in-depth review of the evidence linking dietary salt intake and progression of chronic kidney disease
    Charlotte Jones-Burton
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Nephrol 26:268-75. 2006
    ..Dietary salt has been debated for decades as having a potentially deleterious influence on human health...
  3. doi request reprint Efficacy of amlodipine/olmesartan medoxomil ± hydrochlorothiazide in patients aged ≥ 65 or < 65 years with uncontrolled hypertension on prior monotherapy
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Postgrad Med 125:124-34. 2013
    ..The treatment regimen was well tolerated irrespective of patient age. ..
  4. doi request reprint Urinary sodium is a potent correlate of proteinuria: lessons from the chronic renal insufficiency cohort study
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Nephrol 36:397-404. 2012
    ....
  5. doi request reprint Debate from the 2012 ASH Annual Scientific Sessions: should blood pressure be reduced in hemodialysis patients? Con position
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Am Soc Hypertens 6:443-7. 2012
    ..Achieving dry-weight during dialysis as opposed to a specific blood pressure level is the optimal strategy for reducing cardiovascular events in the hemodialysis patient...
  6. doi request reprint Eosinophilia as an early indicator of pancreatic allograft rejection
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Transplant 26:238-41. 2012
    ..A pancreas allograft biopsy indicated eosinophilic acute cellular rejection. Peripheral eosinophilia may be a useful early indicator of pancreas graft rejection preceding changes in serum pancreatic enzymes by approximately one month...
  7. doi request reprint Renal outcomes in hypertensive Black patients at high cardiovascular risk
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Kidney Int 81:568-76. 2012
    ..Blacks have a modestly higher increased risk for more advanced increases in serum creatinine than non-Blacks...
  8. ncbi request reprint Providing end-organ protection with renin-angiotensin system inhibition: the evidence so far
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    J Clin Hypertens (Greenwich) 8:99-105; quiz 106-7. 2006
    ..This includes composite or specific end points involving reduction of stroke, myocardial infarction, or development of end-stage renal disease...
  9. doi request reprint Hypertension and the kidney: perspectives on the relationship of kidney disease and cardiovascular disease
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    Clin J Am Soc Nephrol 4:2045-50. 2009
    ....
  10. doi request reprint Beta-blockers in the treatment of hypertension: are there clinically relevant differences?
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Postgrad Med 121:90-8. 2009
    ....
  11. ncbi request reprint A noninferiority comparison of valsartan/hydrochlorothiazide combination versus amlodipine in black hypertensives
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Hypertension 46:508-13. 2005
    ..5 mg) is as effective as high-dose amlodipine (10 mg) in reducing blood pressure in blacks with stage 1 and stage 2 hypertension, and valsartan/hydrochlorothiazide is better tolerated...
  12. doi request reprint Minimizing the risk of chronic allograft nephropathy
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    Transplantation 87:S14-8. 2009
    ..The avoidance of clinical inertia in pursuing subtle changes in graft function is critical. Modification in maintenance immunosuppression may benefit many patients with early evidence of graft deterioration...
  13. doi request reprint The renoprotective effects of RAS inhibition: focus on prevention and treatment of chronic kidney disease
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    Postgrad Med 121:96-103. 2009
    ..Ongoing clinical trials assessing treatment and prevention of CKD may resolve unanswered questions about RAS inhibition in patients with hypertension and/or diabetes...
  14. doi request reprint Optimizing early de novo immunosuppression with sirolimus
    M R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Transplant Proc 40:S29-31. 2008
    ..Because 1-year serum creatinine levels often provide an indication of long-term graft function, early evaluation of subtle degrees of graft dysfunction should prompt a graft biopsy to identify treatable causes...
  15. ncbi request reprint The efficacy and safety of initial use of irbesartan/hydrochlorothiazide fixed-dose combination in hypertensive patients with and without high cardiovascular risk
    Matthew R Weir
    University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 9:23-30. 2007
    ..Irbesartan/HCTZ provided consistent blood pressure lowering and tolerability regardless of age, obesity, and type 2 diabetes and greater efficacy in patients with high cardiovascular risk...
  16. ncbi request reprint Effects of renin-angiotensin system inhibition on end-organ protection: can we do better?
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medidne, Baltimore, Maryland 21201 1595, USA
    Clin Ther 29:1803-24. 2007
    ..Angiotensin receptor blockers (ARBs) selectively antagonize angiotensin II at AT 1 receptors and may also increase activation of the AT 2 receptor and modulate the effects of angiotensin II breakdown products...
  17. doi request reprint Mycophenolate mofetil-based immunosuppression with sirolimus in renal transplantation: a randomized, controlled Spare-the-Nephron trial
    Matthew R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Kidney Int 79:897-907. 2011
    ..Thus, compared with MMF/CNI treatment, a 2-year regimen of MMF/SRL resulted in similar measures of renal function but with fewer deaths and a trend to less BPAR and graft loss...
  18. ncbi request reprint Renin inhibitors: novel agents for renoprotection or a better angiotensin receptor blocker for blood pressure lowering?
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Nephrol Hypertens 16:416-21. 2007
    ..Direct renin inhibitors are the newest antihypertensive therapeutic class. The review describes their antihypertensive and antiproteinuric effects and possible renoprotective capabilities...
  19. ncbi request reprint Targeting mechanisms of hypertensive vascular disease with dual calcium channel and renin-angiotensin system blockade
    M R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA
    J Hum Hypertens 21:770-9. 2007
    ....
  20. ncbi request reprint Time to achieve blood-pressure goal: influence of dose of valsartan monotherapy and valsartan and hydrochlorothiazide combination therapy
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Hypertens 20:807-15. 2007
    ..Our objective was to assess time to achieve blood-pressure (BP) goal with incremental doses of valsartan alone, and together with hydrochlorothiazide (HCTZ), in patients with uncomplicated hypertension...
  21. ncbi request reprint Is it the low-protein diet or simply the salt restriction?
    M R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Kidney Int 71:188-90. 2007
    ....
  22. ncbi request reprint Microalbuminuria and cardiovascular disease
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin J Am Soc Nephrol 2:581-90. 2007
    ..Use of this (old) marker may allow improved use of medications and strategies for secondary prevention...
  23. doi request reprint Optimizing immunosuppression with sirolimus in the first year posttransplantation: experience in the United States
    M R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21202, USA
    Transplant Proc 41:S13-7. 2009
    ..Since 1-year serum creatinine level often provides an indication of long-term graft function, early evaluation of subtle degrees of graft dysfunction should prompt a graft biopsy to identify treatable causes...
  24. doi request reprint Antihypertensive effects of double the maximum dose of valsartan in African-American patients with type 2 diabetes mellitus and albuminuria
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21202, USA
    J Hypertens 28:186-93. 2010
    ..To determine whether higher than conventional doses of renin-angiotensin-aldosterone system blockade can improve BP reduction in African-American patients...
  25. ncbi request reprint Recognizing the link between chronic kidney disease and cardiovascular disease
    Matthew R Weir
    Division of Nephrology, University of Maryland, School of Medicine, Baltimore, MD, USA
    Am J Manag Care 17:S396-402. 2011
    ..CKD-related factors (eg, disorders of electrolyte and mineral metabolism, anemia, and vascular calcification) also contribute to mortality associated with CKD...
  26. doi request reprint Short-term effects of vitamin D receptor activation on serum creatinine, creatinine generation, and glomerular filtration
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Kidney Int 80:1016-7. 2011
    ..These observations may be explainable by an effect of vitamin D receptor activation on creatinine metabolism...
  27. pmc Hemodynamic correlates of proteinuria in chronic kidney disease
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine Medical Center, Baltimore, MD 21201, USA
    Clin J Am Soc Nephrol 6:2403-10. 2011
    ..Whether central measures of BP or vascular stiffness are associated with increased risk of proteinuria in patients with chronic kidney disease (CKD) is unknown...
  28. doi request reprint Varying patterns of the antihypertensive and antialbuminuric response to higher doses of renin-angiotensin-aldosterone system blockade in albuminuric hypertensive type 2 diabetes mellitus patients
    Matthew R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Hypertens 29:2031-7. 2011
    ..Nonetheless, not all patients successfully respond to RAAS blockade with a reduction in BP and UAER...
  29. doi request reprint Acute fall in glomerular filtration rate with renin-angiotensin system inhibition: a biomeasure of therapeutic success?
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Kidney Int 80:235-7. 2011
    ..This response is functional, not anatomical, and varies with volume status. The reduction in GFR with renin-angiotensin system inhibition may serve as a biomeasure of future therapeutic benefit...
  30. doi request reprint A titrate-to-goal study of switching patients uncontrolled on antihypertensive monotherapy to fixed-dose combinations of amlodipine and olmesartan medoxomil ± hydrochlorothiazide
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD, USA
    J Clin Hypertens (Greenwich) 13:404-12. 2011
    ....
  31. doi request reprint Acute kidney injury following cardiac surgery: role of perioperative blood pressure control
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Nephrol 33:438-52. 2011
    ..Although factors that predispose to postoperative renal dysfunction have been identified, this knowledge has not been associated with a substantial reduction in the incidence of this serious adverse event...
  32. doi request reprint Can the early elimination of calcineurin inhibitors result in clinical benefits?
    M R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD21202, USA
    Transplant Proc 42:S16-20. 2010
    ..An important question is whether selective substitution of other drugs/biologicals for calcineurin inhibitors will permit adequate immunoprophylaxis, yet improve graft longevity...
  33. doi request reprint Effects of high- and low-sodium diets on ambulatory blood pressure in patients with hypertension receiving aliskiren
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Cardiovasc Pharmacol Ther 15:356-63. 2010
    ..6%; P < .0001). Overall, 40.9% patients had ≥ 1 adverse event and the rates were similar between groups. In this study, aliskiren was well tolerated and a low-sodium diet accentuated its antihypertensive effect...
  34. doi request reprint How early should blood pressure control be achieved for optimal cardiovascular outcomes?
    M R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    J Hum Hypertens 25:211-7. 2011
    ..Although these studies were not conducted exclusively in high-risk patients, subgroup analyses have demonstrated that the observed outcomes in the overall study populations apply to the diabetic and CKD subsets...
  35. doi request reprint Potassium homeostasis and renin-angiotensin-aldosterone system inhibitors
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, Room N3W143, Baltimore, MD 21201, USA
    Clin J Am Soc Nephrol 5:531-48. 2010
    ..Moreover, these patients are likely to derive benefit from RAAS inhibition. Rather than denying them an effective treatment, electrolyte levels should be closely monitored in these patients...
  36. doi request reprint mTOR inhibition: the learning curve in kidney transplantation
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
    Transpl Int 23:447-60. 2010
    ..mTOR inhibitors also have been used as CNI-sparing agents both early and late post-transplant. Much debate remains over how to best utilize mTOR inhibition in kidney transplantation...
  37. ncbi request reprint Calcium channel blockers: their pharmacologic and therapeutic role in hypertension
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Cardiovasc Drugs 7:5-15. 2007
    ....
  38. doi request reprint Safety and feasibility of achieving lower systolic blood pressure goals in persons with type 2 diabetes: the SANDS trial
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 11:540-8. 2009
    ..The authors conclude that both standard and more aggressive systolic blood pressure reduction can be achieved with excellent safety and good tolerability in patients with type 2 diabetes mellitus...
  39. ncbi request reprint The role of combination antihypertensive therapy in the prevention and treatment of chronic kidney disease
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Hypertens 18:100S-105S. 2005
    ..Fixed-dose combination agents are useful in bringing high-risk hypertensive patients to appropriate BP goals, primarily by simplifying the complex medical regimens in these patients...
  40. ncbi request reprint Salt intake and progression of chronic kidney disease: an overlooked modifiable exposure? A commentary
    Matthew R Weir
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Kidney Dis 45:176-88. 2005
    ..Increased salt intake also attenuates the antihypertensive effects of most antihypertensive drugs. Consequently, salt intake must be considered a potential modifiable risk factor for the progression of kidney disease...
  41. ncbi request reprint Diabetes and hypertension: how low should you go and with which drugs?
    M R Weir
    Department of Medicine, University of Maryland, Baltimore 21201, USA
    Am J Hypertens 14:17S-26S. 2001
    ..Despite the advantages of angiotensin converting enzyme inhibitors, most patients will require three to five medications to achieve optimal levels of goal SBP to attenuate the rate of progression of renal disease...
  42. ncbi request reprint Valsartan alone or with a diuretic or ACE inhibitor as treatment for African American hypertensives: relation to salt intake
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Am J Hypertens 14:665-71. 2001
    ....
  43. ncbi request reprint Pilot study to evaluate a water displacement technique to compare effects of diuretics and ACE inhibitors to alleviate lower extremity edema due to dihydropyridine calcium antagonists
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Hypertens 14:963-8. 2001
    ....
  44. ncbi request reprint Optimizing target-organ protection in patients with diabetes mellitus: angiotensin-converting enzyme inhibitors or angiotensin receptor blockers?
    Wei X Lu
    Curr Hypertens Rep 5:192-8. 2003
    ....
  45. ncbi request reprint Blood pressure management in the kidney transplant recipient
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, 22 South Greene Street, Suite N3W143, Baltimore, MD 21201, USA
    Adv Chronic Kidney Dis 11:172-83. 2004
    ....
  46. ncbi request reprint Angiotensin II receptor blockers: the importance of dose in cardiovascular and renal risk reduction
    Matthew R Weir
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, 22 South Greene Street, Room N3W143, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 6:315-23; quiz 324-5. 2004
    ..Data from ongoing trials will provide additional insight...
  47. ncbi request reprint Opportunities for cardiovascular risk reduction with angiotensin II receptor blockers
    Matthew R Weir
    University of Maryland Hospital, Renal Division, N3W 143, Baltimore, MD 21202, USA
    Curr Hypertens Rep 4:333-5. 2002
  48. ncbi request reprint Microalbuminuria in type 2 diabetics: an important, overlooked cardiovascular risk factor
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    J Clin Hypertens (Greenwich) 6:134-41; quiz 142-3. 2004
    ..Consequently, the identification and normalization of urine microalbumin excretion should be an important consideration in patients with diabetes...
  49. ncbi request reprint Incidence of pedal edema formation with dihydropyridine calcium channel blockers: issues and practical significance
    Matthew R Weir
    Division of Nephrology, University of Maryland Hopsital, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 5:330-5. 2003
    ..A favorable tolerability profile is of particular importance for an antihypertensive medication, since hypertension is a chronic disorder necessitating long-term treatment and patient compliance...
  50. ncbi request reprint Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program
    Matthew R Weir
    Nephrology Division, University of Maryland Hospital, Baltimore, MD 21201, USA
    Am Heart J 146:591-604. 2003
    ..The totality of data is not consistent with an increased CV risk among patients taking rofecoxib...
  51. ncbi request reprint Late calcineurin inhibitor withdrawal as a strategy to prevent graft loss in patients with suboptimal kidney transplant function
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Nephrol 24:379-86. 2004
    ..Its etiology is multifactorial and may include both immunologic and nonimmunologic causes. In this observational cohort study we set out to see if calcineurin inhibitor withdrawal would reduce the likelihood of graft loss...
  52. ncbi request reprint Dietary salt, blood pressure, and microalbuminuria
    Matthew R Weir
    Division of Nephrology, University of Maryland Hospital, 22 South Greene Street, Baltimore, MD 21201 1595, USA
    J Clin Hypertens (Greenwich) 6:23-6. 2004
    ....
  53. ncbi request reprint Long-term impact of discontinued or reduced calcineurin inhibitor in patients with chronic allograft nephropathy
    M R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    Kidney Int 59:1567-73. 2001
    ..Chronic allograft nephropathy is the major cause of progressive renal failure in renal transplant recipients. It has no definitive treatment...
  54. ncbi request reprint Renal effects of nonselective NSAIDs and coxibs
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore 21201, USA
    Cleve Clin J Med 69:SI53-8. 2002
    ....
  55. ncbi request reprint Healthy diet and blood pressure
    Matthew Weir
    Division of Nephrology, University of Maryland Hospital, Baltimore, MD 21201 1595, USA
    J Clin Hypertens (Greenwich) 6:381-2. 2004
  56. ncbi request reprint Progressive renal and cardiovascular disease: optimal treatment strategies
    Matthew R Weir
    University of Maryland Medical System, 22 South Greene Street, Room N3W143, Baltimore, MD 21201 1595, USA
    Kidney Int 62:1482-92. 2002
  57. ncbi request reprint Efficacy of candesartan cilexetil as add-on therapy in hypertensive patients uncontrolled on background therapy: a clinical experience trial. ACTION Study Investigators
    M R Weir
    Department of Medicine, University of Maryland, Baltimore 21201 1595, USA
    Am J Hypertens 14:567-72. 2001
    ..Thus, candesartan cilexetil either alone or as add-on therapy was highly effective for the control of systolic or diastolic hypertension regardless of demographic background when used in typical clinical practice settings...
  58. ncbi request reprint Theoretical basis and clinical evidence for differential effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor subtype 1 blockers
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Curr Opin Nephrol Hypertens 9:403-11. 2000
    ....
  59. doi request reprint Cardiovascular events during differing hypertension therapies in patients with diabetes
    Michael A Weber
    Department of Medicine, SUNY Downstate College of Medicine, Brooklyn, New York 11203, USA
    J Am Coll Cardiol 56:77-85. 2010
    ..The aim of this study was to determine which combination therapy in patients with hypertension and diabetes most effectively decreases cardiovascular events...
  60. doi request reprint Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial
    George L Bakris
    Hypertensive Diseases Unit, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Lancet 375:1173-81. 2010
    ..We assessed the effects of these drug combinations on progression of chronic kidney disease...
  61. doi request reprint Telmisartan is more effective than losartan in reducing proteinuria in patients with diabetic nephropathy
    George Bakris
    Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Kidney Int 74:364-9. 2008
    ..We conclude that telmisartan is superior to losartan in reducing proteinuria in hypertensive patients with diabetic nephropathy, despite a similar reduction in blood pressure...
  62. ncbi request reprint Risk-based classification of hypertension and the role of combination therapy
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    J Clin Hypertens (Greenwich) 10:4-12. 2008
    ..All 3 sets of guidelines acknowledge the necessity of using > or =2 antihypertensive agents to attain BP goals in many patients...
  63. ncbi request reprint Combination therapy with Renin-Angiotensin-aldosterone receptor blockers for hypertension: how far have we come?
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 10:146-52. 2008
    ..Studies are now under way to determine the relative benefits of an RAAS blocker/diuretic compared with an RAAS blocker/calcium channel blocker as initial therapy...
  64. doi request reprint Acute kidney injury and cardiovascular outcomes in acute severe hypertension
    Lynda A Szczech
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Box 3646, Durham, NC 27710, USA
    Circulation 121:2183-91. 2010
    ....
  65. doi request reprint Chronic allograft dysfunction: can we use mammalian target of rapamycin inhibitors to replace calcineurin inhibitors to preserve graft function?
    Ravinder K Wali
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Organ Transplant 13:614-21. 2008
    ..Protocol biopsies have demonstrated that histological lesions of CNI toxicity can develop as early as 3 months posttransplantation...
  66. ncbi request reprint Pharmacological strategies for kidney function preservation: are there differences by ethnicity?
    Jay Lakkis
    Department of Medicine, Division of Nephrology, University of Maryland, School of Medicine, Baltimore, MD, USA
    Adv Ren Replace Ther 11:24-40. 2004
    ..The obesity and diabetes epidemics are unlikely to abate without innovative and ultimately effective public health approaches...
  67. ncbi request reprint Early steroid withdrawal in solitary pancreas transplantation results in equivalent graft and patient survival compared with maintenance steroid therapy
    Ghazal Vessal
    School of Pharmacy, University of Maryland, Baltimore, MD, USA
    Clin Transplant 21:491-7. 2007
    ..We conclude that early corticosteroid withdrawal in isolated pancreas transplantation results in fewer infections and can be achieved without an increased risk of rejection or graft loss over the first year...
  68. ncbi request reprint The tissue renin-angiotensin-aldosterone system in diabetes mellitus
    Donna S Hanes
    University of Maryland Hospital, Renal Division, N3W 143, 22 S Greene Street, Baltimore, MD 21202, USA
    Curr Hypertens Rep 6:98-105. 2004
    ..The purpose of this review is to highlight our current understanding of the role of the tissue RAS in the pathogenesis of diabetic end-organ damage and ongoing strategies to interfere pharmacologically...
  69. pmc Aortic PWV in chronic kidney disease: a CRIC ancillary study
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Hypertens 23:282-9. 2010
    ..Little data exist characterizing aortic stiffness in patients with chronic kidney disease (CKD) who are not receiving dialysis, and in particular the effect of reduced kidney function on aortic PWV...
  70. doi request reprint The impact of reduced immunosuppression on graft outcomes in elderly renal transplant recipients
    Melissa Badowski
    Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA
    Clin Transplant 23:930-7. 2009
    ..Our results suggest that reduction in overall IS in this group was associated with improved graft and patient survival...
  71. ncbi request reprint Evaluation of the dose response with valsartan and valsartan/hydrochlorothiazide in patients with essential hypertension
    Matthew R Weir
    Department of Medicine, Division of Nephrology, Univesity of Maryland School of Medicine, MD 21201, USA
    J Clin Hypertens (Greenwich) 9:103-12. 2007
    ..The rate of discontinuation due to adverse events was low with both monotherapy and combination treatment. Higher starting doses may enable patients to achieve greater initial BP reductions and reach BP goal more rapidly...
  72. pmc Cardiovascular disease among hispanics and non-hispanics in the chronic renal insufficiency cohort (CRIC) study
    Ana C Ricardo
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    Clin J Am Soc Nephrol 6:2121-31. 2011
    ..Hispanics are the largest minority group in the United States. The leading cause of death in patients with chronic kidney disease (CKD) is cardiovascular disease (CVD), yet little is known about its prevalence among Hispanics with CKD...
  73. pmc Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive study
    Kristine Yaffe
    Department of Psychiatry, School of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 58:338-45. 2010
    ....
  74. doi request reprint Renin inhibition and microalbuminuria development: meaningful predictor of kidney disease progression
    Lalitha De Silva
    University of Maryland School of Medicine, Baltimore, Maryland, USA
    Curr Opin Nephrol Hypertens 19:437-43. 2010
    ..We evaluate the data on the use of direct renin inhibitors (DRIs) for treatment of hypertension with microalbuminuria...
  75. ncbi request reprint Polyomavirus reactivation in native kidneys of pancreas alone allograft recipients
    Abdolreza Haririan
    Division of Nephrology, Department of Medicine, Wayne State University, School of Medicine, Detroit, MI, USA
    Transplantation 75:1186-90. 2003
    ..There are limited data on the status of viral activity in the native kidneys of non-renal solid organ recipients...
  76. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
    ....
  77. pmc Dry-weight: a concept revisited in an effort to avoid medication-directed approaches for blood pressure control in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Roudebush VA Medical Center, 1481 West 10th Street, 111N, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 5:1255-60. 2010
    ..Achieving and maintaining dry-weight appears to be an effective but forgotten strategy in controlling and maintaining normotension among hypertensive patients on hemodialysis...
  78. ncbi request reprint Should living-unrelated renal transplant recipients receive antibody induction? Results of a clinical experience trial
    Anne M Wiland
    Department of Pharmacy Services, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Transplantation 77:422-5. 2004
    ..These groups both had immediate graft function and similar maintenance immunosuppression...
  79. pmc Measured GFR does not outperform estimated GFR in predicting CKD-related complications
    Chi yuan Hsu
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    J Am Soc Nephrol 22:1931-7. 2011
    ..These results raise questions regarding the conventional view that iGFR is the "gold standard" measure of kidney function...
  80. ncbi request reprint The unique character of cardiovascular disease in chronic kidney disease and its implications for treatment with lipid-lowering drugs
    Joseph Nogueira
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Clin J Am Soc Nephrol 2:766-85. 2007
    ..In this article, the data that are pertinent to the CKD population are reviewed, and updated recommendations for use of LLD in the CKD population are provided...
  81. ncbi request reprint Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease
    Thomas C Dowling
    Department of Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Clin Pharmacol Ther 73:427-34. 2003
    ..Evaluation of drug metabolism in patients with end-stage renal disease is important because these patients use a large number of medications and are at risk of adverse reactions and drug-drug interactions...
  82. ncbi request reprint Pancreas allograft biopsy: safety of percutaneous biopsy-results of a large experience
    David K Klassen
    Department of Medicine, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
    Transplantation 73:553-5. 2002
    ..The safety and success rate of the procedure with current surgical techniques is unclear. We report the complications and success rate in 426 consecutive percutaneous pancreas allograft biopsies performed at a single center...
  83. doi request reprint A single center comparison of long-term outcomes of renal allografts procured laparoscopically versus historic controls procured by the open approach
    Joseph M Nogueira
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transpl Int 21:908-14. 2008
    ..We conclude that, despite having suffered early renal dysfunction, the lapNx cohort of renal allograft recipients enjoys similar long-term renal allograft survival as compared to openNx...
  84. doi request reprint The independent association between serum uric acid and graft outcomes after kidney transplantation
    Abdolreza Haririan
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W143, Baltimore, MD 21201, USA
    Transplantation 89:573-9. 2010
    ..We sought to evaluate the predictive value of mean uric acid (UA) level during the first 6 months posttransplant for graft survival and function...
  85. ncbi request reprint Selective cyclooxygenase-2 inhibition and cardiovascular effects: an observational study of a Medicaid population
    Fadia T Shaya
    Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
    Arch Intern Med 165:181-6. 2005
    ..This observational cohort study examines the cardiovascular risk of COX-2 inhibitors compared with nonspecific NSAIDs in Maryland Medicaid enrollees, a high-risk population...
  86. ncbi request reprint Effect of kidney transplantation on left ventricular systolic dysfunction and congestive heart failure in patients with end-stage renal disease
    Ravinder K Wali
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    J Am Coll Cardiol 45:1051-60. 2005
    ..We examined the impact of kidney transplantation on left ventricular ejection fraction (LVEF) in end-stage renal disease (ESRD) patients with congestive heart failure (CHF)...
  87. doi request reprint Cigarette smoking, kidney function, and mortality after live donor kidney transplant
    Joseph M Nogueira
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Kidney Dis 55:907-15. 2010
    ..The role of smoking as a risk factor for adverse renal outcomes after kidney transplant has not been well studied. We therefore undertook this investigation to assess the association of smoking with transplant outcomes...
  88. ncbi request reprint Histological grading of chronic pancreas allograft rejection/graft sclerosis
    John C Papadimitriou
    Department of Pathology, University of Maryland, School of Medicine, Baltimore MD, USA
    Am J Transplant 3:599-605. 2003
    ..87), substantial for Grade CII (0.61) and moderate for Grade CI (0.59). The proposed grading scheme provides a reliable and reproducible tool for the assessment of CR in percutaneous needle biopsies, with definite prognostic significance...
  89. pmc Reasons for discharges against medical advice: a qualitative study
    Eberechukwu Onukwugha
    Pharmaceutical Health Services Research Department, University of Maryland School of Pharmacy, 220 Arch Street, Baltimore, MD 21201, USA
    Qual Saf Health Care 19:420-4. 2010
    ..The objective of this study is to identify the reasons for DAMA based on patient and multicategory provider focus-group interviews (FGIs)...
  90. doi request reprint Renin angiotensin system inhibition in the older person: a review
    Maha A Mohamed
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene Street, N3W143, Baltimore, MD 21201, USA
    Clin Geriatr Med 25:245-57. 2009
    ..Herein, the author's review the mechanism of action of the renin angiotensin cascade and then discuss the clinical evidence surrounding the use of RAS-blocking drugs in the older population...
  91. pmc Clinical commentary: how to choose blood pressure goals and treatment: influence of estimated glomerular filtration rate and albuminuria
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Trans Am Clin Climatol Assoc 119:53-61; discussion 61-3. 2008
    ....
  92. doi request reprint Renal consequences of prostaglandin inhibition in heart failure
    Ayoola O Akinbamowo
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Heart Fail Clin 4:505-10. 2008
    ..This review summarizes the renal consequences of using prostaglandin inhibitors in subjects who have congestive heart failure...
  93. doi request reprint A study of renal outcomes in obese living kidney donors
    Joseph M Nogueira
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transplantation 90:993-9. 2010
    ..Little is known about the long-term outcomes of obese living kidney donors (OLKDs). We undertook this study to describe renal outcomes of OLKDs several years after donation...
  94. ncbi request reprint Retransplantation in patients with graft loss caused by polyoma virus nephropathy
    Emilio Ramos
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Transplantation 77:131-3. 2004
    ..The risk of recurrence does not seem to be increased in comparison with the first graft...
  95. ncbi request reprint Predictors of compliance with antihypertensive therapy in a high-risk medicaid population
    Fadia T Shaya
    Pharmaceutical Health Services Research Department, University of Maryland School of Pharmacy, 220 Arch St, 12th Floor, Baltimore, MD 21201, USA
    J Natl Med Assoc 101:34-9. 2009
    ..To identify predictors of compliance with antihypertensive combination therapy in a Medicaid population...
  96. ncbi request reprint Ethnic disparities, hospital quality, and discharges against medical advice among patients with cardiovascular disease
    Ebere Chukwu Onukwugha
    Pharmaceutical Health Services Research Department, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
    Ethn Dis 19:172-8. 2009
    ..Disparities in discharges AMA have not been examined among patients with cardiovascular disease, nor has the moderating role of hospital quality been studied...
  97. pmc Renal function and cardiovascular response to mental stress
    Stephen L Seliger
    University of Maryland School of Medicine, Maryland VA Healthcare System, Baltimore County, Baltimore, MD 21201, USA
    Am J Nephrol 28:304-10. 2008
    ..Chronic kidney disease (CKD) is also associated with sympathetic hyperactivity and vascular risk, but its relationship with CVR is unknown...
  98. pmc A study of renal outcomes in African American living kidney donors
    Joseph M Nogueira
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transplantation 88:1371-6. 2009
    ..Little is known about the long-term outcomes of African American living kidney donors (AALKDs). We undertook this study to describe renal outcomes of AALKDs several years after donation...
  99. ncbi request reprint Clinical course of polyoma virus nephropathy in 67 renal transplant patients
    Emilio Ramos
    Departments of Medicine, Pathology, Pharmacy Services, and Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Am Soc Nephrol 13:2145-51. 2002
    ..Although multiple factors probably play a role in the development of PVN, judicious use of immunosuppressive agents is indicated to minimize the occurrence of this infection...
  100. ncbi request reprint Pretransplant serum C-reactive protein and the risk of chronic allograft nephropathy in renal transplant recipients: a pilot case-control study
    Jeffrey C Fink
    Division of Nephrology, Department of Medicine, University of Maryland, Baltimore, MD, USA
    Am J Kidney Dis 39:1096-101. 2002
    ..Cohort studies in larger groups of transplant patients are needed to confirm a causal pathway between pretransplant inflammation, atherogenesis, and CAN...
  101. ncbi request reprint BK virus-associated nephropathy in renal allograft recipients: rescue therapy by sirolimus-based immunosuppression
    Ravinder K Wali
    Division of Nephrology, Department of Internal Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Transplantation 78:1069-73. 2004
    ..BK virus nephritis (BKN) in recipients of renal allografts has reemerged during the past 5 years. Despite increased incidence, therapeutic options remain limited and progression of the disease often leads to allograft failure...