M R Weir

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi Impact of salt intake on blood pressure and proteinuria in diabetes: importance of the renin-angiotensin system
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Miner Electrolyte Metab 24:438-45. 1998
  2. ncbi Antihypertensive drugs, dietary salt, and renal protection: how low should you go and with which therapy?
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Am J Kidney Dis 32:1-22. 1998
  3. ncbi Are drugs that block the renin-angiotensin system effective and safe in patients with renal insufficiency?
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Am J Hypertens 12:195S-203S. 1999
  4. ncbi The renin-angiotensin-aldosterone system: a specific target for hypertension management
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Am J Hypertens 12:205S-213S. 1999
  5. ncbi Long-term impact of discontinued or reduced calcineurin inhibitor in patients with chronic allograft nephropathy
    M R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    Kidney Int 59:1567-73. 2001
  6. ncbi Diabetes and hypertension: how low should you go and with which drugs?
    M R Weir
    Department of Medicine, University of Maryland, Baltimore 21201, USA
    Am J Hypertens 14:17S-26S. 2001
  7. ncbi Theoretical basis and clinical evidence for differential effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor subtype 1 blockers
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Curr Opin Nephrol Hypertens 9:403-11. 2000
  8. ncbi Dose-related antihypertensive effects of irbesartan in patients with mild-to-moderate hypertension
    J L Pool
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Hypertens 11:462-70. 1998
  9. doi Optimizing early de novo immunosuppression with sirolimus
    M R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Transplant Proc 40:S29-31. 2008
  10. ncbi Histologic grading of acute allograft rejection in pancreas needle biopsy: correlation to serum enzymes, glycemia, and response to immunosuppressive treatment
    J C Papadimitriou
    Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA
    Transplantation 66:1741-5. 1998

Detail Information

Publications40

  1. ncbi Impact of salt intake on blood pressure and proteinuria in diabetes: importance of the renin-angiotensin system
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Miner Electrolyte Metab 24:438-45. 1998
    ..Many of the coexisting cardiovascular risk factors associated with salt sensitivity may be explainable in part by the overactivity of the renin-angiotensin system...
  2. ncbi Antihypertensive drugs, dietary salt, and renal protection: how low should you go and with which therapy?
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Am J Kidney Dis 32:1-22. 1998
    ..The precise role of alterations in dietary salt consumption on progression of renal disease directly as well as on the effectiveness of various antihypertensive drugs has yet to be examined in clinical trials...
  3. ncbi Are drugs that block the renin-angiotensin system effective and safe in patients with renal insufficiency?
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Am J Hypertens 12:195S-203S. 1999
    ..Early clinical experience with these drugs in patients with renal disease suggests that there might be a lesser incidence of functional renal insufficiency and hyperkalemia compared with ACE inhibitors...
  4. ncbi The renin-angiotensin-aldosterone system: a specific target for hypertension management
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Am J Hypertens 12:205S-213S. 1999
    ....
  5. ncbi Long-term impact of discontinued or reduced calcineurin inhibitor in patients with chronic allograft nephropathy
    M R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    Kidney Int 59:1567-73. 2001
    ..Chronic allograft nephropathy is the major cause of progressive renal failure in renal transplant recipients. It has no definitive treatment...
  6. ncbi Diabetes and hypertension: how low should you go and with which drugs?
    M R Weir
    Department of Medicine, University of Maryland, Baltimore 21201, USA
    Am J Hypertens 14:17S-26S. 2001
    ..Despite the advantages of angiotensin converting enzyme inhibitors, most patients will require three to five medications to achieve optimal levels of goal SBP to attenuate the rate of progression of renal disease...
  7. ncbi Theoretical basis and clinical evidence for differential effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor subtype 1 blockers
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Curr Opin Nephrol Hypertens 9:403-11. 2000
    ....
  8. ncbi Dose-related antihypertensive effects of irbesartan in patients with mild-to-moderate hypertension
    J L Pool
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Hypertens 11:462-70. 1998
    ..Withdrawal of irbesartan did not result in rebound hypertension or adverse events. Thus, once-daily irbesartan is both an effective and safe antihypertensive agent for the treatment of mild-to-moderate hypertension...
  9. doi Optimizing early de novo immunosuppression with sirolimus
    M R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Transplant Proc 40:S29-31. 2008
    ..Because 1-year serum creatinine levels often provide an indication of long-term graft function, early evaluation of subtle degrees of graft dysfunction should prompt a graft biopsy to identify treatable causes...
  10. ncbi Histologic grading of acute allograft rejection in pancreas needle biopsy: correlation to serum enzymes, glycemia, and response to immunosuppressive treatment
    J C Papadimitriou
    Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA
    Transplantation 66:1741-5. 1998
    ..The correlation between clinical evidence of graft dysfunction (increased serum enzymes and glucose), severity of acute rejection on biopsy (rejection grade), and response to treatment has not been previously studied...
  11. doi Association of serum uric acid with graft survival after kidney transplantation: a time-varying analysis
    A Haririan
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Transplant 11:1943-50. 2011
    ..Its negative impact seems to be worse with lower eGFR...
  12. doi The detrimental effect of poor early graft function after laparoscopic live donor nephrectomy on graft outcomes
    J M Nogueira
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Transplant 9:337-47. 2009
    ..001). Risk factors for poor DGF included advanced donor age, high recipient BMI, sirolimus use and prolonged warm ischemia time. In conclusion, poor EGF following lapNx has a deleterious effect on long-term graft function and survival...
  13. ncbi Salt and blood pressure responses to calcium antagonism in hypertensive patients
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201 1595, USA
    Hypertension 30:422-7. 1997
    ..This effect does, however, appear to be largely confined to individuals who are salt sensitive...
  14. ncbi Valsartan alone or with a diuretic or ACE inhibitor as treatment for African American hypertensives: relation to salt intake
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Am J Hypertens 14:665-71. 2001
    ....
  15. ncbi Influence of race and dietary salt on the antihypertensive efficacy of an angiotensin-converting enzyme inhibitor or a calcium channel antagonist in salt-sensitive hypertensives
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Hypertension 31:1088-96. 1998
    ..These data demonstrate that controlling for salt sensitivity diminishes race-related differences in antihypertensive activity...
  16. doi Optimizing immunosuppression with sirolimus in the first year posttransplantation: experience in the United States
    M R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21202, USA
    Transplant Proc 41:S13-7. 2009
    ..Since 1-year serum creatinine level often provides an indication of long-term graft function, early evaluation of subtle degrees of graft dysfunction should prompt a graft biopsy to identify treatable causes...
  17. ncbi Morphological spectrum of polyoma virus disease in renal allografts: diagnostic accuracy of urine cytology
    R C Drachenberg
    Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Transplant 1:373-81. 2001
    ..We conclude that urine cytology is useful to evaluate renal transplant patients with PV reactivation because sloughed tubular cells are found in urine and positive urine samples are a consistent manifestation of PV renal involvement...
  18. ncbi Targeting mechanisms of hypertensive vascular disease with dual calcium channel and renin-angiotensin system blockade
    M R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA
    J Hum Hypertens 21:770-9. 2007
    ....
  19. doi How early should blood pressure control be achieved for optimal cardiovascular outcomes?
    M R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    J Hum Hypertens 25:211-7. 2011
    ..Although these studies were not conducted exclusively in high-risk patients, subgroup analyses have demonstrated that the observed outcomes in the overall study populations apply to the diabetic and CKD subsets...
  20. doi Can the early elimination of calcineurin inhibitors result in clinical benefits?
    M R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD21202, USA
    Transplant Proc 42:S16-20. 2010
    ..An important question is whether selective substitution of other drugs/biologicals for calcineurin inhibitors will permit adequate immunoprophylaxis, yet improve graft longevity...
  21. ncbi Pilot study to evaluate a water displacement technique to compare effects of diuretics and ACE inhibitors to alleviate lower extremity edema due to dihydropyridine calcium antagonists
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Hypertens 14:963-8. 2001
    ....
  22. ncbi Efficacy of candesartan cilexetil as add-on therapy in hypertensive patients uncontrolled on background therapy: a clinical experience trial. ACTION Study Investigators
    M R Weir
    Department of Medicine, University of Maryland, Baltimore 21201 1595, USA
    Am J Hypertens 14:567-72. 2001
    ..Thus, candesartan cilexetil either alone or as add-on therapy was highly effective for the control of systolic or diastolic hypertension regardless of demographic background when used in typical clinical practice settings...
  23. ncbi Diabetes and hypertension: blood pressure control and consequences
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Hypertens 12:170S-178S. 1999
    ..This combination of events is ideal for delaying progression of renal disease. However, the use of drugs that block the RAS is not a surrogate for maintaining tight control of blood pressure...
  24. ncbi Effect of dietary sodium on insulin sensitivity in older, obese, sedentary hypertensives
    D R Dengel
    Department of Medicine, University of Maryland School of Medicine, and Baltimore Veterans Administration Medical Center, USA
    Am J Hypertens 10:964-70. 1997
    ....
  25. ncbi Nocturnal reduction of blood pressure and the antihypertensive response to a diuretic or angiotensin converting enzyme inhibitor in obese hypertensive patients. TROPHY Study Group
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA. mweirumppalab.umd.edu
    Am J Hypertens 11:914-20. 1998
    ..6/-4.1 mm Hg, P = NS v placebo). Results of 24-h ABP data show that both lisinopril and HCTZ are effective therapies for obesity-related hypertension and that response to treatment is influenced by sex, race, and dipper/nondipper status...
  26. ncbi Risk for posttransplant Diabetes mellitus with current immunosuppressive medications
    M R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Kidney Dis 34:1-13. 1999
    ..Consequently, improved understanding of the effects of currently used immunosuppressive medicines on glycemic tolerance is of interest in clinical transplantation...
  27. ncbi The rationale for combination versus single-entity therapy in hypertension
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA. mweirumppa1.ab.umd.edu
    Am J Hypertens 11:163S-169S. 1998
    ..However, there is no published evidence that calcium antagonists reduce the cough associated with the ACE inhibitor...
  28. ncbi The inevitability of renal function loss in patients with hypercreatinemia
    J C Fink
    The Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201 1595, USA
    Am J Nephrol 21:386-9. 2001
    ..Hypercreatinemia, however, does not accurately discriminate between those renal insufficiency patients who are stable versus those at high risk for ESRD...
  29. ncbi Appropriate use of calcium antagonists in hypertension
    M R Weir
    Division of Nephrology, University of Maryland, School of Medicine, Baltimore, USA
    Hosp Pract (Minneap) 36:47-8, 53-5. 2001
    ..Although renin-angiotensin blockers are now the key components of such regimens, calcium antagonists can play an important role as well, given their demonstrated efficacy in controlling blood pressure...
  30. ncbi Antihypertensive therapy and quality of life. Influence of blood pressure reduction, adverse events, and prior antihypertensive therapy
    M R Weir
    Department of Medicine, University of Maryland Medical System, Baltimore 21201, USA
    Am J Hypertens 9:854-9. 1996
    ..Adverse events, but not systolic or diastolic blood pressure reduction correlated directly with changes in quality of life...
  31. ncbi The beta blockers: are they as protective in hypertension as in other cardiovascular conditions?
    D S Hanes
    Department of Medicine, Division of Nephrology, University of Maryland Hospital, Baltimore, MD, USA
    J Clin Hypertens (Greenwich) 3:236-43. 2001
    ..c)2001 Le Jacq Communications, Inc...
  32. ncbi CD103+ CTL accumulate within the graft epithelium during clinical renal allograft rejection
    G A Hadley
    Department of Surgery, University of Maryland at Baltimore, MSTF Room 400, 10 South Pine Street, Baltimore, MD 21201, USA
    Transplantation 72:1548-55. 2001
    ..Given the strong association of tubulitis with clinical rejection, these data are consistent with a role for the CD103+ CTL subset as an effector mechanism in renal allograft destruction...
  33. ncbi Insulin resistance and salt sensitivity. A renal hemodynamic abnormality?
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Hypertens 9:193S-199S. 1996
    ....
  34. ncbi Early withdrawal of calcineurin inhibitors and rescue immunosuppression with sirolimus-based therapy in renal transplant recipients with moderate to severe renal dysfunction
    R K Wali
    Division of Nephrology, Department of Medicine, Unniversity of Maryland School of Medicine, Baltimore, MD, USA
    Am J Transplant 7:1572-83. 2007
    ....
  35. ncbi Is it the low-protein diet or simply the salt restriction?
    M R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Kidney Int 71:188-90. 2007
    ....
  36. ncbi Comparison of enalapril and hydrochlorothiazide in mild hypertension and changes in plasma lipid concentrations during therapy
    M R Weir
    Department of Medicine, University of Maryland Hospital, Baltimore
    Clin Ther 10:712-24. 1988
    ..Further studies are needed to confirm these plasma lipid findings and to determine their clinical significance...
  37. ncbi Evidence-based treatment of hypertension in patients with diabetes mellitus
    M Onuigbo
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Diabetes Obes Metab 5:13-26. 2003
  38. pmc Low-dose combination therapy as first-line hypertension treatment for blacks and nonblacks
    L M Prisant
    Section of Cardiology, Medical College of Georgia, Augusta 30912 3105, USA
    J Natl Med Assoc 91:40-8. 1999
    ..The incidence of drug-related adverse events was similar between treatments; however, bisoprolol/6.25-mg HCTZ had a lower discontinuation rate due to lack of blood pressure control or adverse experiences in both blacks and nonblacks...
  39. ncbi Management of high-risk hypertensive patients with diabetes: potential role of angiotensin II receptor antagonists
    M A Weber
    State University of New York Downstate College of Medicine, Brooklyn, NY 11203, USA
    J Clin Hypertens (Greenwich) 3:225-35. 2001
    ..c)2001 Le Jacq Communications, Inc...
  40. ncbi Angiotensin-receptor blockers and diuretics--advantages of combination
    A Mimran
    Department of Medicine, University of Montpellier, Montpellier, France
    Blood Press 14:6-11. 2005
    ..The combination of an ARB and a thiazide diuretic may be of particular value in patient populations who tend to have poor BP control on monotherapy, or have additional cardiovascular or renal risk factors...