Research Topics
| D WeintraubSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
Screening for impulse control symptoms in patients with de novo Parkinson disease: a case-control studyDaniel Weintraub
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Neurology 80:176-80. 2013..To determine the frequency and correlates of impulse control and related behavior symptoms in patients with de novo, untreated Parkinson disease (PD) and healthy controls (HCs)...
Impulse control and related disorders in Parkinson's diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neurodegener Dis 11:63-71. 2013..As empirically validated treatments for ICDs emerge, it will also be important to examine their efficacy and tolerability in individuals with comorbid PD...- Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating ScaleDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 2676, USA
Mov Disord 27:242-7. 2012..Preliminary results suggest that it can be used to support a diagnosis of these disorders, as well as to monitor changes in symptom severity over time... - Rivastigmine in Alzheimer's disease and Parkinson's disease dementia: an ADAS-cog factor analysisDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
Am J Alzheimers Dis Other Demen 26:443-9. 2011..Rivastigmine treatment is associated with improvement in memory and language in AD and PDD. The numerically greater response in PDD is consistent with greater cholinergic deficits in this disease state... - Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson diseaseD Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
Neurology 75:448-55. 2010.... - Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patientsDaniel Weintraub
University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Arch Neurol 67:589-95. 2010..An association between dopamine-replacement therapies and impulse control disorders (ICDs) in Parkinson disease (PD) has been suggested in preliminary studies... - Sertraline for the treatment of depression in Alzheimer disease: week-24 outcomesDaniel Weintraub
Section of Geriatric Psychiatry, University of Pennsylvania and Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
Am J Geriatr Psychiatry 18:332-40. 2010..The authors report the Week-24 outcomes of patients who participated in a 12-week efficacy study of sertraline for depression of AD... - Impulse control disorders in Parkinson's disease: prevalence and possible risk factorsDaniel Weintraub
Psychiatry and Neurology, University of Pennsylvania School of Medicine Parkinson s Disease Research, Education and Clinical Center and the Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, USA
Parkinsonism Relat Disord 15:S110-3. 2009..It is important that PD patients be aware that DA use may lead to the development of one or more ICDs, and clinicians monitor patients as part of routine clinical care... - Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson diseaseS Hoops
Departments of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Neurology 73:1738-45. 2009..The Montreal Cognitive Assessment (MoCA) is more sensitive than the commonly used Mini-Mental State Examination (MMSE) in detecting MCI and dementia in patients without PD, but its validity in PD has not been established... - Amantadine use associated with impulse control disorders in Parkinson disease in cross-sectional studyDaniel Weintraub
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Ann Neurol 68:963-8. 2010..Further research, including larger clinical trials, is needed to assess the role of amantadine in the development and treatment of ICDs in PD... - Patterns and trends in antipsychotic prescribing for Parkinson disease psychosisDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Arch Neurol 68:899-904. 2011..Antipsychotic (AP) use is common in Parkinson disease (PD), but APs can worsen parkinsonism, evidence for efficacy is limited, and use in patients with dementia increases mortality... - Parkinson's disease: the quintessential neuropsychiatric disorderDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mov Disord 26:1022-31. 2011.... - Neurodegeneration across stages of cognitive decline in Parkinson diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, 3615 Chestnut St, Ste 330, Philadelphia, PA 19104, USA
Arch Neurol 68:1562-8. 2011..To assess regions and patterns of brain atrophy in patients with Parkinson disease (PD) with normal cognition (PD-NC), mild cognitive impairment (PD-MCI), and dementia-level cognitive deficits (PDD)... - Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3339, USA
Brain 135:170-80. 2012..In addition, an Alzheimer's disease pattern of brain atrophy may be a preclinical biomarker of cognitive decline in Parkinson's disease... - CSF amyloid {beta} 1-42 predicts cognitive decline in Parkinson diseaseA Siderowf
Department of Neurology, 330 South 9th Street, Second Floor, Philadelphia, PA 19107, USA
Neurology 75:1055-61. 2010..Cognitive decline associated with Parkinson disease (PD) is common and highly disabling. Biomarkers that help identify patients at risk for cognitive decline would be useful additions to the clinical management of the disease... - Use of latent variable modeling to delineate psychiatric and cognitive profiles in Parkinson diseaseShahrzad Mavandadi
Mental Illness Research, Education and Clinical Center, Philadelphia VA Medical Center, Philadelphia, PA, USA
Am J Geriatr Psychiatry 17:986-95. 2009..The objective of this study was to use analytic-based approaches to classify psychiatric and cognitive symptoms in PD... - Involuntary emotional expression disorder (IEED) in Parkinson's diseaseLisa Phuong
Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
Parkinsonism Relat Disord 15:511-5. 2009..To estimate the frequency and correlates of involuntary emotional expression disorder (IEED) in Parkinson's disease (PD) using the Center for Neurologic Study-Lability Scale (CNS-LS) and recently-proposed diagnostic criteria for IEED... - Attitudes regarding the etiology and treatment of depression in Parkinson's disease: a qualitative studyKatherine Oehlberg
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 2676, USA
J Geriatr Psychiatry Neurol 21:123-32. 2008..This preliminary study suggests that many PD patients with clinically significant depressive symptoms attribute their depression to psychosocial factors and endorse nonpharmacologic treatment approaches... 
Pharmacologic management of psychosis in the elderly: a critical reviewNicholas Hoeh
University of Pennsylvania, Philadelphia 19104, USA
J Geriatr Psychiatry Neurol 16:213-8. 2003..This article reviews the efficacy of the pharmacologic management of psychotic symptoms in primary psychotic disorders, affective disorders, and neurodegenerative disorders...- Antidepressant treatment of veterans with Parkinson's disease and depression: analysis of a national samplePeijun Chen
Division of Geriatric Psychiatry, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
J Geriatr Psychiatry Neurol 20:161-5. 2007..Efforts to improve the care of depressed PD patients should focus instead on improving recognition, ensuring adequacy of treatment, and evaluating the efficacy of existing antidepressants... - Assessing the executive function deficits of patients with Parkinson's disease: utility of the Tower of London-DrexelWilliam C Culbertson
Drexel University, Neuropsychology Program, Philadelphia, PA 19104, USA
Assessment 11:27-39. 2004..Support was found for the convergent and divergent validity of the TOLDX. The clinical and theoretical implications of the findings are discussed... - Long-term follow-up of impulse control disorders in Parkinson's diseaseEugenia Mamikonyan
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mov Disord 23:75-80. 2008.... - [99mTc]TRODAT-1 SPECT imaging correlates with odor identification in early Parkinson diseaseA Siderowf
Parkinson Disease and Movement Disorders Center, Department of Neurology, University of Pennsylvania, Philadelphia, USA
Neurology 64:1716-20. 2005..In vivo imaging of the dopamine transporter with [99mTc]TRODAT-1 (TRODAT) and olfactory testing have both been proposed as potential biomarkers in Parkinson disease (PD)... - Montreal cognitive assessment performance in patients with Parkinson's disease with "normal" global cognition according to mini-mental state examination scoreSarra Nazem
Department of Psychiatry, University of Pennsyvania, Philadelphia, USA
J Am Geriatr Soc 57:304-8. 2009..To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson's disease (PD) with "normal" global cognition according to Mini-Mental State Examination (MMSE) score... - Suicidal and death ideation in Parkinson's diseaseSarra Nazem
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mov Disord 23:1573-9. 2008..Comorbid psychiatric disorders, more than PD-related disease variables, are associated with this ideation, highlighting the need for a comprehensive approach to the clinical care of PD patients... - Mild cognitive impairment is common in Parkinson's disease patients with normal Mini-Mental State Examination (MMSE) scoresEugenia Mamikonyan
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Parkinsonism Relat Disord 15:226-31. 2009..We report on the frequency and characteristics of cognitive deficits in PD patients with intact global cognition based on Mini-Mental State Examination (MMSE) performance... - Association between cognition and function in patients with Parkinson disease with and without dementiaEmily Rosenthal
Department of Neurology, Division of Geriatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
Mov Disord 25:1170-6. 2010..87 vs. 0.75, P = 0.0008). Cognition is associated with impairment in ADL function, even in nondemented patients with PD. However, sensitive cognitive assessment measures may be needed to identify these functionally relevant impairments... - Depression in veterans with Parkinson's disease: frequency, co-morbidity, and healthcare utilizationPeijun Chen
Division of Geriatric Psychiatry, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
Int J Geriatr Psychiatry 22:543-8. 2007..To determine the frequency of depression in Parkinson's disease (PD) in routine clinical care, and to examine its association with co-morbid psychiatric and medical conditions and healthcare utilization... - Probing the safety of medications in the frail elderly: evidence from a randomized clinical trial of sertraline and venlafaxine in depressed nursing home residentsDavid W Oslin
Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
J Clin Psychiatry 64:875-82. 2003..This unexpected finding demonstrates the need for systematic research on the safety of drugs in the frail elderly... - Presentation and management of psychosis in Parkinson's disease and dementia with Lewy bodiesDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, 3535 Market St, Rm. 3003, Philadelphia, PA 19104, USA
Am J Psychiatry 164:1491-8. 2007 - Frequency and correlates of co-morbid psychosis and depression in Parkinson's diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Parkinsonism Relat Disord 12:427-31. 2006..02), depression with mild-cognitive impairment (P=.03), and their co-occurrence with higher daily levodopa dosages (P<.01). These results suggest that psychosis and depression in PD are distinct neurobehavioral disorders... - Test characteristics of the 15-item geriatric depression scale and Hamilton depression rating scale in Parkinson diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, and the Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center 19104, USA
Am J Geriatr Psychiatry 14:169-75. 2006..The objective of this study was to compare the sensitivity, specificity, and diagnostic accuracy of the 15-item Geriatric Depression Scale (GDS-15) and the Hamilton Depression Rating Scale (HDRS) in patients with Parkinson disease (PD)... - Daily affect in Parkinson disease is responsive to life events and motor symptomsDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, and the Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center 19104, USA
Am J Geriatr Psychiatry 14:161-8. 2006..Specifically, it was intended to test the hypothesis that PD, even in the absence of depression, is associated with anhedonia... - Psychiatric complications in Parkinson diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 13:844-51. 2005..This article provides an overview of the epidemiology, pathophysiology, clinical presentation, and management of the most common psychiatric complications in PD... - Dimensions of executive function in Parkinson's diseaseDaniel Weintraub
Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
Dement Geriatr Cogn Disord 20:140-4. 2005..Executive impairment is common in Parkinson's disease (PD). However, it is unknown which dimensions of executive function are assessed by commonly used neuropsychological instruments and if clinical correlates of specific dimensions exist... - Antidepressant studies in Parkinson's disease: a review and meta-analysisDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mov Disord 20:1161-9. 2005..In addition, PD patients may benefit less from antidepressant treatment, particularly selective serotonin reuptake inhibitors, than do elderly patients without PD... - Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson's diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Nucl Med 46:227-32. 2005..We studied the correlation of striatal dopamine transporter (DAT) imaging with anxiety and depression symptoms in Parkinson's disease (PD)... - Evidence for impaired encoding and retrieval memory profiles in Parkinson diseaseDaniel Weintraub
Parkinson s Disease Research, Education and Clinical Center PADRECC, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
Cogn Behav Neurol 17:195-200. 2004..Specifically, we sought to ascertain whether the memory performance of PD patients can be categorized as fitting an unimpaired, an impaired retrieval, or an impaired encoding memory profile... - Recognition and treatment of depression in Parkinson's diseaseDaniel Weintraub
Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, USA
J Geriatr Psychiatry Neurol 16:178-83. 2003..Most depressed patients are untreated, and half of antidepressant users remain depressed, suggesting that even when delivered, treatment is often inadequate or ineffective... - Effect of increasing the dose and duration of sertraline trial in the treatment of depressed nursing home residentsDaniel Weintraub
Section of Geriatric Psychiatry, University of Pennsylvania, and Philadelphia VA Medical Center, USA
J Geriatr Psychiatry Neurol 16:109-11. 2003..Our findings suggest that an extended trial or high dosages of sertraline may benefit some depressed elderly patients with persistent depression after acute treatment... - Impulse control disorders in Parkinson's diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3003, Philadelphia, PA 19104, USA
Curr Neurol Neurosci Rep 6:302-6. 2006..As empirically validated treatments for ICDs are emerging, it will be important to examine their efficacy and tolerability in individuals with co-occurring PD and ICDs... - Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mov Disord 24:1461-7. 2009..A positive screen should be followed by a comprehensive, clinical interview to determine the range and severity of symptoms, as well as need for clinical management... - Phenylthiocarbamide (PTC) perception in Parkinson diseasePaul J Moberg
Parkinson s Disease Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cogn Behav Neurol 20:145-8. 2007..To examine phenylthiocarbamide (PTC) sensitivity in Parkinson disease (PD) patients and healthy volunteers to determine whether taster status represented a simple vulnerability marker for PD... - Parkinson's disease--Part 2: Treatment of motor symptomsDaniel Weintraub
Department of Neurological Sciences, University of Pennsylvania, 330 S 9th St, Philadelphia, PA 19107, USA
Am J Manag Care 14:S49-58. 2008..Cost-effectiveness is a major consideration for managed care and is also analyzed for many available treatment options... - Parkinson's disease--Part 3: Neuropsychiatric symptomsDaniel Weintraub
Department of Psychiatry and Neurology, University of Pennsylvania, 3615 Chestnut St, Philadelphia, PA 19104, USA
Am J Manag Care 14:S59-69. 2008..This article looks at useful screening measures to help clinicians recognize neuropsychiatric symptoms and offers suggestions for their effective treatment... - Intervening in the neuropsychiatric features of Parkinson's diseaseDaniel Weintraub
University of Pennsylvania School of Medicine, Department of Psychiatry, 3535 Market Sreet, Room 3003, Philadelphia, PA 19104, USA
Expert Rev Neurother 7:699-710. 2007..Nevertheless, the available information does suggest the outlines of management methods, pending expanded research to identify optimal strategies specific to Parkinson's disease... - Differences in depression symptoms in patients with Alzheimer's and Parkinson's diseases: evidence from the 15-item Geriatric Depression Scale (GDS-15)Daniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Int J Geriatr Psychiatry 22:1025-30. 2007..Depression occurs frequently in patients with both Alzheimer's disease (AD) and Parkinson's disease (PD), but there has been little comparison of depression symptoms in the two populations... - Effect of age on geriatric depression scale performance in Parkinson's diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mov Disord 22:1331-5. 2007..In conclusion, the GDS-15 has comparable validity in younger and older PD patients, suggesting its appropriateness as a depression screening instrument in PD patients of all ages... - Effect of psychiatric and other nonmotor symptoms on disability in Parkinson's diseaseDaniel Weintraub
Parkinson s Disease Research, Education and Clinical Center, Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
J Am Geriatr Soc 52:784-8. 2004..To examine the effect of depression and other nonmotor symptoms on functional ability in Parkinson's disease (PD)... - Association of dopamine agonist use with impulse control disorders in Parkinson diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, and Parkinson's Disease Research, Education, and Clinical Center, USA
Arch Neurol 63:969-73. 2006..Because dopamine agonists are increasingly being used for other indications, future research should assess the dopamine agonist-associated risk for ICDs in other populations... - Escitalopram for major depression in Parkinson's disease: an open-label, flexible-dosage studyDaniel Weintraub
University of Pennsylvania School of Medicine, Pennsylvania, USA
J Neuropsychiatry Clin Neurosci 18:377-83. 2006..In Parkinson's disease, either SSRIs may have limited antidepressant effects, or the use of existing depression diagnostic and rating instruments may be problematic... - Dopamine and impulse control disorders in Parkinson's diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania School of Medicine, Parkinson s Disease Research, Education and Clinical Center, Philadelphia, PA, USA
Ann Neurol 64:S93-100. 2008..As empirically validated treatments for ICDs are emerging, it will be important to examine their efficacy and tolerability in individuals with cooccurring PD and ICDs... - Parkinson's disease--Part 1: Pathophysiology, symptoms, burden, diagnosis, and assessmentDaniel Weintraub
University of Pennsylvania, Philadelphia, PA, USA
Am J Manag Care 14:S40-8. 2008..This article provides a brief review of the epidemiology, pathophysiology, clinical course, and burden of PD... - Psychiatric assessment of a nursing home population using audiovisual telecommunicationP Grob
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA
J Geriatr Psychiatry Neurol 14:63-5. 2001.... - Pharmacologic interventions for psychosis and agitation in neurodegenerative diseases: evidence about efficacy and safetyDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
Psychiatr Clin North Am 28:941-83, ix-x. 2005 - Drug Insight: impulse control disorders and dopamine therapies in Parkinson's diseaseMarc N Potenza
Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06519, USA
Nat Clin Pract Neurol 3:664-72. 2007.... - Decreased ventral striatal activity with impulse control disorders in Parkinson's diseaseHengyi Rao
Center for Functional Neuroimaging, Department of Neurology and Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mov Disord 25:1660-9. 2010..Thus, treatments for ICDs in non-PD patients warrant consideration in PD patients with ICDs... - Therapeutic options for emotional lability: current and emerging treatmentsDaniel Weintraub
University of Pennsylvania School of Medicine, Parkinson's Disease and Mental Illness Research, Education and Clinical Centers (PADRECC and MIRECC, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
Am J Geriatr Pharmacother 3:12-5; quiz 16-7. 2005 - Change in the rate of restraint use and falls on a psychogeriatric inpatient unit: impact of the health care financing administration's new restraint and seclusion standards for hospitalsDaniel Weintraub
Section on Geriatric Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Geriatr Psychiatry Neurol 15:91-4. 2002..If replicated, these findings of decreased restraint use without a concomitant increase in the number of falls demonstrate a change in practice patterns as a result of HCFA's action...