J V Weinstock

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Helminths and harmony
    J V Weinstock
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 1009, USA
    Gut 53:7-9. 2004
  2. ncbi request reprint IL-18 and IL-12 signal through the NF-kappa B pathway to induce NK-1R expression on T cells
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 170:5003-7. 2003
  3. ncbi request reprint Substance P regulates Th1-type colitis in IL-10 knockout mice
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 171:3762-7. 2003
  4. ncbi request reprint The possible link between de-worming and the emergence of immunological disease
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lab Clin Med 139:334-8. 2002
  5. ncbi request reprint Role of helminths in regulating mucosal inflammation
    Joel V Weinstock
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa, Iowa City, IA 52242 1009, USA
    Springer Semin Immunopathol 27:249-71. 2005
  6. ncbi request reprint TGF-beta and IL-10 regulation of IFN-gamma produced in Th2-type schistosome granulomas requires IL-12
    K Qadir
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 281:G940-6. 2001
  7. ncbi request reprint Interleukin 12 and antigen independently induce substance P receptor expression in T cells in murine schistosomiasis mansoni
    A M Blum
    Division of Gastroenterology-Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    FASEB J 15:950-7. 2001
  8. ncbi request reprint IL-4 regulates VIP receptor subtype 2 mRNA (VPAC2) expression in T cells in murine schistosomiasis
    A Metwali
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    FASEB J 14:948-54. 2000
  9. ncbi request reprint The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni
    A M Blum
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 162:6080-5. 1999
  10. ncbi request reprint T cell substance P receptor governs antigen-elicited IFN-gamma production
    Arthur M Blum
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 284:G197-204. 2003

Collaborators

Detail Information

Publications56

  1. pmc Helminths and harmony
    J V Weinstock
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 1009, USA
    Gut 53:7-9. 2004
  2. ncbi request reprint IL-18 and IL-12 signal through the NF-kappa B pathway to induce NK-1R expression on T cells
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 170:5003-7. 2003
    ..IL-10, a regulator of the Th1 response, blocks this activation. These data further suggest that SP and NK-1R, which promote IFN-gamma synthesis, are part of the Th1 pathway of immunity...
  3. ncbi request reprint Substance P regulates Th1-type colitis in IL-10 knockout mice
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 171:3762-7. 2003
    ..NK-1R antagonist reverses ongoing intestinal inflammation attesting to the importance of SP and its receptor in mucosal inflammation...
  4. ncbi request reprint The possible link between de-worming and the emergence of immunological disease
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lab Clin Med 139:334-8. 2002
  5. ncbi request reprint Role of helminths in regulating mucosal inflammation
    Joel V Weinstock
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa, Iowa City, IA 52242 1009, USA
    Springer Semin Immunopathol 27:249-71. 2005
    ..These effects by once ubiquitous organisms may have protected individuals from many of the emerging immune-mediated illnesses like IBD, multiple sclerosis, type I diabetes, and asthma...
  6. ncbi request reprint TGF-beta and IL-10 regulation of IFN-gamma produced in Th2-type schistosome granulomas requires IL-12
    K Qadir
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 281:G940-6. 2001
    ..We found substantial differences in control of granuloma IFN-gamma production and IL-12 circuitry in C57BL/6 and CBA mice...
  7. ncbi request reprint Interleukin 12 and antigen independently induce substance P receptor expression in T cells in murine schistosomiasis mansoni
    A M Blum
    Division of Gastroenterology-Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    FASEB J 15:950-7. 2001
    ..IL-12 induces SPr independently of TCR activation and IFN-gamma expression. SP and its receptor, which regulate IFN-gamma production, are probably part of the IL-12-Th1 circuit...
  8. ncbi request reprint IL-4 regulates VIP receptor subtype 2 mRNA (VPAC2) expression in T cells in murine schistosomiasis
    A Metwali
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    FASEB J 14:948-54. 2000
    ..However, rIL-4 could not suppress VPAC2 mRNA expression in Th1 cells. Thus, VPAC2 is an inducible CD4+ T cell receptor, and IL-4 down-modulates VPAC2 mRNA expression in Th2 cells...
  9. ncbi request reprint The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni
    A M Blum
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 162:6080-5. 1999
    ..These results provide further evidence that in murine schistosomiasis SPr is displayed commonly on granuloma inflammatory cells and is important for granuloma development and expression of IFN-gamma circuitry in this natural infection...
  10. ncbi request reprint T cell substance P receptor governs antigen-elicited IFN-gamma production
    Arthur M Blum
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 284:G197-204. 2003
    ..Splenocytes and granuloma cells from NK-1R KO mice made less IFN-gamma. The mice also made less IgG2a. Thus T cell NK-1R is important for IFN-gamma regulation...
  11. ncbi request reprint Localization and regulation of IFN-gamma production within the granulomas of murine schistosomiasis in IL-4-deficient and control mice
    E Rakasz
    Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    J Immunol 160:4994-9. 1998
    ..Thus, the Th2 granuloma of schistosomiasis has large numbers of activated Th1 or Th0 lymphocytes that are under tight restraint...
  12. ncbi request reprint SSTR2A is the dominant somatostatin receptor subtype expressed by inflammatory cells, is widely expressed and directly regulates T cell IFN-gamma release
    D E Elliott
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa College of Medicine, Iowa City, USA
    Eur J Immunol 29:2454-63. 1999
    ..We show that SOM acts directly on T cells to inhibit TCR-stimulated IFN-gamma release. Thus, SOM may directly regulate T cell IFN-gamma release at inflammatory sites...
  13. ncbi request reprint Intestinal helminths protect in a murine model of asthma
    Kunihiko Kitagaki
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 177:1628-35. 2006
    ..Helminthic colonization appears to protect against asthma and atopic disorders; the regulatory cytokine, IL-10, may be a critical player...
  14. pmc Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity
    Long Hang
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Tufts Medical Center, Boston, MA 02111, USA
    J Immunol 185:3184-9. 2010
    ..DCs have an important role in driving both murine and human IBD. Data suggest that phenotypic alternations in mucosal DC function are part of the regulatory process...
  15. ncbi request reprint CD4+ T cells from IL-10-deficient mice transfer susceptibility to NSAID-induced Rag colitis
    Arthur M Blum
    Division of Gastroenterology 4607 JCP Univ of Iowa Hospital and Clinics, 200 Hawkins Dr, Iowa City, IA 52242 1009, USA
    Am J Physiol Gastrointest Liver Physiol 287:G320-5. 2004
    ..In conclusion, only CD4(+) T cells from IL-10(-/-) animals leave Rag mice susceptible to NSAID-induced, Th1 colitis. Lamina propria T cells normally make large quantities of IL-10, suggesting that IL-10 from T cells may be protective...
  16. ncbi request reprint IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation
    Razvan Arsenescu
    Department of Internal Medicine, University of Kentucky, Lexington, KY 40515, USA
    J Immunol 174:3906-11. 2005
    ..Thus, macrophages are a source for SP at these sites of chronic inflammation, and IL-12 and STAT4 are regulators of macrophage SP mRNA expression...
  17. pmc Interleukin-4 receptor alpha chain and STAT6 signaling inhibit gamma interferon but not Th2 cytokine expression within schistosome granulomas
    Ahmed Metwali
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Infect Immun 70:5651-8. 2002
    ..Thus, conventional Th cells in Stat6 KO granulomas produce IFN-gamma and Th2 cytokines. Stat6 limits IFN-gamma production but is unnecessary for Th2-cell development or localization within the granuloma...
  18. pmc TGF-beta regulates T-cell neurokinin-1 receptor internalization and function
    Martin Beinborn
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, and Molecular Pharmacology Research Center, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 107:4293-8. 2010
    ....
  19. ncbi request reprint Cutting edge: hemokinin has substance P-like function and expression in inflammation
    Ahmed Metwali
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 172:6528-32. 2004
    ..Two distinct but functionally overlapping tachykinins govern inflammation through NK-1R at sites of chronic inflammation...
  20. ncbi request reprint Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease
    Robert W Summers
    Department of Internal Medicine, James A Clifton Center for Digestive Diseases, University of Iowa Health Care, Iowa City, Iowa, USA
    Am J Gastroenterol 98:2034-41. 2003
    ..Induction of a Th2 immune response by intestinal helminths diminishes Th1 responsiveness. This study evaluates the safety and effectiveness of helminthic ova in the treatment of active IBD...
  21. ncbi request reprint Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
    J N Kline
    Department of Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    J Immunol 160:2555-9. 1998
    ..Significantly, in a previously sensitized mouse, CpG ODN can prevent allergen-induced airway inflammation. These studies suggest that exposure to CpG DNA may protect against asthma...
  22. ncbi request reprint Helminths as governors of immune-mediated inflammation
    David E Elliott
    Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    Int J Parasitol 37:457-64. 2007
    ..This paper summarises work by multiple groups demonstrating that colonization with helminths alters immune reactivity and protects against disease from dysregulated inflammation...
  23. ncbi request reprint Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial
    Robert W Summers
    James A Clifton Center for Digestive Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Gastroenterology 128:825-32. 2005
    ..In animal models, helminths prevent or improve colitis by the induction of regulatory T cells and modulatory cytokines. This study determined the efficacy and safety of the helminth Trichuris suis in therapy of ulcerative colitis...
  24. ncbi request reprint Helminthic therapy: using worms to treat immune-mediated disease
    David E Elliott
    Division of Gastroenterology, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242 1009, USA
    Adv Exp Med Biol 666:157-66. 2009
    ..These helminth-host immune interactions have potentially important implications for the treatment of immune-mediated diseases...
  25. ncbi request reprint Is there a role for helminths in the therapy of inflammatory bowel disease?
    Robert W Summers
    James A Clifton Center for Digestive Disease, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Nat Clin Pract Gastroenterol Hepatol 2:62-3. 2005
  26. ncbi request reprint Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation
    M Nedim Ince
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    J Immunol 176:726-9. 2006
    ..Thus, during helminth infection, LPS challenge induces mucosal T cells to make TGFbeta through a TLR4-dependent process without promoting synthesis of proinflammatory cytokines...
  27. pmc Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation
    M Nedim Ince
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    Eur J Immunol 39:1870-8. 2009
    ..Thus, T cell TGF-beta signaling is essential for helminthic stimulation of mucosal IL-10 production, helminthic modulation of intestinal IFN-gamma generation and H. polygyrus-mediated suppression of chronic colitis...
  28. ncbi request reprint Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production
    David E Elliott
    Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    J Immunol 181:2414-9. 2008
    ..Ab-mediated blockade of IL-17 improves colitis in IL-10-deficient mice. Thus, helminth-associated inhibition of IL-17 production is most likely an important mechanism mediating protection from inappropriate intestinal inflammation...
  29. ncbi request reprint Helminths and mucosal immune modulation
    Joel V Weinstock
    Division of Gastroenterology, Department of Internal Medicine, Tufts New England Medical Center, 750 Washington Street, P O Box 233, Boston, MA 02111, USA
    Ann N Y Acad Sci 1072:356-64. 2006
    ..These effects of once ever-present helminths may have protected people from immune-mediated illnesses like inflammatory bowel disease...
  30. ncbi request reprint Exposure to schistosome eggs protects mice from TNBS-induced colitis
    David E Elliott
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 284:G385-91. 2003
    ..Intact signal transducer and activator of transcription 6 was required for attenuation of colitis. Exposure to helminths can decrease murine colonic inflammation...
  31. ncbi request reprint Helminths and the modulation of mucosal inflammation
    David E Elliott
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1009, USA
    Curr Opin Gastroenterol 21:51-8. 2005
    ..This review summarizes some of the recent findings showing that helminths induce regulatory circuits that could prevent and treat inflammatory bowel disease...
  32. ncbi request reprint Rapid development of colitis in NSAID-treated IL-10-deficient mice
    Daniel J Berg
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Gastroenterology 123:1527-42. 2002
    ..Prostaglandins are lipid mediators that may be important mediators of intestinal inflammation. In this study we assessed the role of prostaglandins in the regulation of mucosal inflammation in the IL-10(-/-) mouse model of IBD...
  33. ncbi request reprint Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice
    David E Elliott
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Eur J Immunol 34:2690-8. 2004
    ..polygyrus inhibits ongoing IL-10(-/-) colitis in part through blocking mucosal Th1 cytokine production. Resolution of inflammation is associated with increased IL-13 production and can be adoptively transferred by MLN T cells...
  34. ncbi request reprint The role of substance P, hemokinin and their receptor in governing mucosal inflammation and granulomatous responses
    Joel V Weinstock
    James A Clifton Center for Digestive Diseases, Department of Internal Medicine, University of Iowa Roy J and Lucille Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Front Biosci 9:1936-43. 2004
    ..Thus, substance P and hemokinin are inflammatory cytokines with overlapping functions that help control immune responses in granulomas and at mucosal surfaces, and probably elsewhere...
  35. ncbi request reprint IL-4 inhibits vasoactive intestinal peptide production by macrophages
    Ahmed Metwali
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 283:G115-21. 2002
    ..Thus macrophages can make VIP, which is subject to IL-4 regulation. However, in the Th2 granulomas, other cell types produce VIP, which compensates for loss of macrophages as a source of this molecule...
  36. ncbi request reprint Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection
    Ahmed Metwali
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    Am J Physiol Gastrointest Liver Physiol 291:G253-9. 2006
    ..Thus H. polygyrus induces a regulatory CD8+ lamina propria T cell that inhibits T cell proliferation and that appears to have a role in control of colitis...
  37. pmc Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine
    Tommy Setiawan
    Division of Gastroenterology 4611 JCP, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    Infect Immun 75:4655-63. 2007
    ..IL-10 is particularly important for limiting the Th1 response. The T-cell origin of these cytokines demonstrates mucosal regulatory T-cell induction...
  38. pmc Treatment of Helicobacter gastritis with IL-4 requires somatostatin
    Yana Zavros
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:12944-9. 2003
    ..Thus, a mechanism by which IL-4 resolves inflammation in the stomach is by stimulating the release of SOM from gastric D cells...
  39. ncbi request reprint Anti-interferon-inducible chemokine, CXCL10, reduces colitis by impairing T helper-1 induction and recruitment in mice
    Jae Geun Hyun
    Department of Internal Medicine, Division of Gastroenterology, Northwestern University School of Medicine, Chicago, Illinois 60611, USA
    Inflamm Bowel Dis 11:799-805. 2005
    ....
  40. ncbi request reprint The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice
    A Metwali
    Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    J Immunol 157:4546-53. 1996
    ..Thus the production of IL-4 early in the inflammatory response is not the only factor preventing Th1 expression in inflammation...
  41. pmc Trichuris suis therapy in Crohn's disease
    R W Summers
    James A Clifton Center for Digestive Diseases, Department of Internal Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Gut 54:87-90. 2005
    ..Helminths diminish immune responsiveness in naturally colonised humans and reduce inflammation in experimental colitis. Thus exposure to helminths may help prevent or even ameliorate Crohn's disease...
  42. ncbi request reprint Established T(H1) granulomatous responses induced by active Mycobacterium avium infection switch to T(H2) following challenge with Schistosoma mansoni
    Randy Sacco
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Clin Immunol 104:274-81. 2002
    ..avium is modulated subsequent to co-infection with S. mansoni. The dominance of the T(H2) response observed in this model could have clinical implications in areas where parasites and mycobacteria co-exist...
  43. pmc Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis
    Lindsey E Bazzone
    Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    Infect Immun 76:5164-72. 2008
    ....
  44. pmc ICOS costimulation expands Th2 immunity by augmenting migration of lymphocytes to draining lymph nodes
    Amanda G Tesciuba
    Department of Medicine, Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 181:1019-24. 2008
    ..Our data support a model in which ICOS costimulation augments the pool of lymphocytes in the draining lymph nodes, leading to an increase in the frequency of potentially reactive T and B cells...
  45. ncbi request reprint CD4+ TCR repertoire heterogeneity in Schistosoma mansoni-induced granulomas
    Laura H Hogan
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53706, USA
    J Immunol 169:6386-93. 2002
    ..Understanding the mechanism of T cell recruitment into granulomas has important implications for the rational design of immunotherapies for granulomatous diseases...
  46. pmc Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation
    Hozefa S Bandukwala
    Committee on Immunology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 204:1875-89. 2007
    ....
  47. pmc Interleukin-12 (IL-12) and IL-23 induction of substance p synthesis in murine T cells and macrophages is subject to IL-10 and transforming growth factor beta regulation
    Arthur Blum
    Division of Gastroenterology 233, Tufts New England Medical Center, Boston, MA 02111, USA
    Infect Immun 76:3651-6. 2008
    ..Hemokinin is another tachykinin with homology to substance P. Macrophages and T cells make hemokinin, but hemokinin production is not subject to IL-12 or IL-23 regulation...
  48. ncbi request reprint Why Trichuris suis should prove safe for use in inflammatory bowel diseases
    Robert W Summers
    Inflamm Bowel Dis 11:783-4. 2005
  49. pmc Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues
    James C Lo
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 112:1495-505. 2003
    ....
  50. pmc Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma
    Jiankun Tong
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 203:1173-84. 2006
    ....
  51. ncbi request reprint Mechanisms of disease: the hygiene hypothesis revisited
    Francisco Guarner
    University Hospital Vall d Hebron, Barcelona, Spain
    Nat Clin Pract Gastroenterol Hepatol 3:275-84. 2006
    ..The use of probiotics, prebiotics, helminths or microbe-derived immunoregulatory vaccines might, therefore, become a valuable approach to disease prevention...
  52. ncbi request reprint Substance P expression correlates with severity of diarrhea in cryptosporidiosis
    Prema Robinson
    Infectious Diseases Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Infect Dis 188:290-6. 2003
    ..This study demonstrates a direct correlation between SP levels and disease severity and may imply that SP plays a role in diarrhea mediation...
  53. ncbi request reprint Substance P receptor mediated maintenance of chronic inflammation in EAE
    Emily K Reinke
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison WI, United States
    J Neuroimmunol 180:117-25. 2006
    ....
  54. ncbi request reprint Reduced CTL response and increased viral burden in substance P receptor-deficient mice infected with murine gamma-herpesvirus 68
    Sherine F Elsawa
    Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
    J Immunol 170:2605-12. 2003
    ..These studies demonstrate that genetic elimination of substance P receptors in mice results in an increased gamma-herpesvirus burden and an altered host response...
  55. ncbi request reprint Therapeutic colonization with Trichuris suis
    Robert W Summers
    Arch Pathol Lab Med 130:1753; author reply 1753-4. 2006
  56. ncbi request reprint Granulomas in schistosome and mycobacterial infections: a model of local immune responses
    Matyas Sandor
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Room 5468, Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    Trends Immunol 24:44-52. 2003
    ..In addition, different activation pathways for macrophages residing in granulomas are discussed. Granulomas are unique inflammatory sites that offer a challenging and rewarding model to study immunity...