Edward Weinman

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Gastrointestinal phosphate handling in CKD and its association with cardiovascular disease
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD Department of Veteran Affairs, Baltimore, Md Electronic address
    Am J Kidney Dis 62:1006-11. 2013
  2. pmc NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Renal Physiol 303:F321-7. 2012
  3. pmc Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells
    Edward J Weinman
    University of Maryland School of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD 21202, USA
    Am J Physiol Renal Physiol 300:F231-5. 2011
  4. pmc Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Invest 117:3412-20. 2007
  5. ncbi request reprint The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    Annu Rev Physiol 68:491-505. 2006
  6. ncbi request reprint Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21202, USA
    Am J Physiol Renal Physiol 290:F838-43. 2006
  7. pmc PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP
    Edward J Weinman
    Dept of Medicine, Div of Nephrology, Univ of Maryland School of Medicine, Baltimore, MD 21202, USA
    Am J Physiol Renal Physiol 297:F1560-5. 2009
  8. pmc The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a
    Edward J Weinman
    Department of Medicine, Division of Nephrology, University of Maryland, School of Medicine, 22, South Greene Street, Baltimore, MD 21202, USA
    J Physiol 567:27-32. 2005
  9. ncbi request reprint NHERF-1 is required for renal adaptation to a low-phosphate diet
    Edward J Weinman
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Rm N3W143, UHM, 22 South Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 285:F1225-32. 2003
  10. ncbi request reprint Expression of NHERF-1, NHERF-2, PDGFR-alpha, and PDGFR-beta in normal human kidneys and in renal transplant rejection
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Pathobiology 70:314-23. 2002

Research Grants

  1. Na+-H+ Transport in Renal Apical Membranes
    Edward Weinman; Fiscal Year: 2006
  2. SODIUM-H+ TRANSPORT IN RENAL APICAL MEMBRANES
    Edward Weinman; Fiscal Year: 2002
  3. NHERF-1 and PTH regulation of the renal transport of phosphate.
    Edward J Weinman; Fiscal Year: 2010

Collaborators

Detail Information

Publications51

  1. pmc Gastrointestinal phosphate handling in CKD and its association with cardiovascular disease
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD Department of Veteran Affairs, Baltimore, Md Electronic address
    Am J Kidney Dis 62:1006-11. 2013
    ....
  2. pmc NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Renal Physiol 303:F321-7. 2012
    ..The current review outlines the experimental observations supporting the operation of this unique regulatory system...
  3. pmc Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells
    Edward J Weinman
    University of Maryland School of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD 21202, USA
    Am J Physiol Renal Physiol 300:F231-5. 2011
    ....
  4. pmc Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Invest 117:3412-20. 2007
    ..These results indicate that PTH-mediated inhibition of renal phosphate transport involves phosphorylation of S77 of the NHERF-1 PDZ I domain and the dissociation of NHERF-1/Npt2a complexes...
  5. ncbi request reprint The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    Annu Rev Physiol 68:491-505. 2006
    ..This review summarizes the emerging data on the biochemical mechanisms, physiologic outcomes, and potential clinical implications of the assembly and disassembly of receptor/NHERF complexes...
  6. ncbi request reprint Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21202, USA
    Am J Physiol Renal Physiol 290:F838-43. 2006
    ..These studies indicate defects in the renal tubule transport of phosphate, calcium, and uric acid in NHERF-1(-/-) male and female mice that could account for the increased deposition of calcium in the papilla of null mice...
  7. pmc PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP
    Edward J Weinman
    Dept of Medicine, Div of Nephrology, Univ of Maryland School of Medicine, Baltimore, MD 21202, USA
    Am J Physiol Renal Physiol 297:F1560-5. 2009
    ..Treatment with PTH, presumably by dissociating NHERF-1/Npt2a complexes, transiently increases the mobility of Npt2a, suggesting that freeing of Npt2a from the cytoskeleton precedes PTH-mediated endocytosis...
  8. pmc The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a
    Edward J Weinman
    Department of Medicine, Division of Nephrology, University of Maryland, School of Medicine, 22, South Greene Street, Baltimore, MD 21202, USA
    J Physiol 567:27-32. 2005
    ..These studies indicate a unique requirement for NHERF-1 in cAMP regulation of NHE3 and in the trafficking of Npt2a...
  9. ncbi request reprint NHERF-1 is required for renal adaptation to a low-phosphate diet
    Edward J Weinman
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Rm N3W143, UHM, 22 South Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 285:F1225-32. 2003
    ..These experiments demonstrate that full renal adaptation to a low-phosphate diet requires NHERF-1, which serves to increase BBM expression of Npt2...
  10. ncbi request reprint Expression of NHERF-1, NHERF-2, PDGFR-alpha, and PDGFR-beta in normal human kidneys and in renal transplant rejection
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Pathobiology 70:314-23. 2002
    ..In renal transplant rejection, there is increased expression of both PDGFR subtypes consistent with a role for PDGF in injury or repair...
  11. ncbi request reprint NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes
    Edward J Weinman
    Department of Medicine, Division Nephrology, University of Maryland School of Medicine, Room N3W143, UHM, 22 South Greene Street, Baltimore, MD 21201, USA
    FEBS Lett 536:141-4. 2003
    ..As the protein levels for NHE3, NHERF-2, PKA and ezrin were not changed in the NHERF-1 (-/-) BBMs, the data suggest a unique role for NHERF-1 in cAMP-mediated inhibition of NHE3 activity in the renal proximal tubule of the mouse...
  12. ncbi request reprint Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells
    E J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Renal Physiol 281:F374-80. 2001
    ....
  13. ncbi request reprint Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex
    E J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Kidney Int 60:450-4. 2001
    ..NHERF and related PDZ-containing proteins may serve as adapters for regulation of renal transporters...
  14. ncbi request reprint Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells
    E J Weinman
    Department of Medicine, University of Maryland School of Medicine and the Medical Service, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    J Biol Chem 276:42339-46. 2001
    ....
  15. ncbi request reprint Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media
    Rochelle Cunningham
    Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, Maryland, USA
    Am J Physiol Renal Physiol 289:F933-8. 2005
    ..These studies also suggest that there is a blunted phosphaturic effect of PTH in cells adapted to low-phosphate media...
  16. pmc Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:13454-60. 2010
    ..These studies suggest a novel role for the PDZ adapter protein NHERF-1 in coordinating dopamine signals that inhibit renal phosphate transport...
  17. pmc Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:25134-8. 2010
    ..The phosphorylation of Thr(95) facilitates the phosphorylation of Ser(77). This, in turn, results in the dissociation of NHERF-1 from Npt2a and a decrease in phosphate transport in renal proximal tubule cells...
  18. ncbi request reprint Na+-dependent phosphate transporters in the murine osteoclast: cellular distribution and protein interactions
    Mohammed A Khadeer
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 284:C1633-44. 2003
    ..Taken together, our data suggest that association of Npt2a with NHERF-1, ezrin, and actin, and of PiT-1 with actin, may be responsible for membrane sorting and regulation of these Na/P(i) cotransporters in the osteoclast...
  19. doi request reprint Role of NHERF and scaffolding proteins in proximal tubule transport
    Rochelle Cunningham
    Division of Nephrology, Department of Medicine, University of Maryland, School of Medicine, Room N3W143, UHM, 22 South Greene Street, Baltimore, MD 21201, USA
    Urol Res 38:257-62. 2010
    ..This review focuses primarily on NHERF-1, as the prototypical PDZ protein and will give a brief summary of its role in phosphate transport and the development of some forms of nephrolithiasis...
  20. ncbi request reprint NHERF and regulation of the renal sodium-hydrogen exchanger NHE3
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Pflugers Arch 450:137-44. 2005
    ..In this review, we trace the discovery of NHERF-1 and NHERF-2, and update our current understanding of the relation between these proteins and the regulation and trafficking of NHE3...
  21. ncbi request reprint Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 279:37815-21. 2004
    ..NHERF-1(-/-) cells also do not adapt to alterations in the phosphate content of the media indicating that the defect resides within the cells of the proximal tubule and is not dependent on systemic factors...
  22. ncbi request reprint Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus
    Rakhilya Murtazina
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 282:25141-51. 2007
    ....
  23. ncbi request reprint Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Renal Physiol 291:F896-901. 2006
    ..Together, these results highlight the requirement for NHERF-1 for physiological control of Npt2a trafficking and suggest that the Npt2a/NHERF-1 complex represents a unique PTH-responsive pool of Npt2a in renal microvilli...
  24. ncbi request reprint Parathyroid hormone regulation of NA+,K+-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cells
    Syed Jalal Khundmiri
    Department of Medicine, University of Louisville, Kidney Disease Program, Louisville, KY 40202, USA
    J Am Soc Nephrol 16:2598-607. 2005
    ..These results demonstrate that NHERF-1 is necessary for PTH-mediated inhibition of Na+,K+-ATPase activity and that the inhibition is mediated through the PDZ1, not PDZ2, domain...
  25. ncbi request reprint ANG II signaling in vasa recta pericytes by PKC and reactive oxygen species
    Zhong Zhang
    Department of Medicine, University of Maryland at Baltimore, Baltimore, MD 21201 1595, USA
    Am J Physiol Heart Circ Physiol 287:H773-81. 2004
    ..We conclude that ANG II and PKC activation increases DVR pericyte [Ca(2+)](cyt), divalent ion conductance into the cytoplasm, and ROS generation...
  26. ncbi request reprint Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, N3W143, Baltimore, MD 21201, USA
    J Am Soc Nephrol 18:1419-25. 2007
    ..These findings indicate that NHERF-1 exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the BBM abundance of mURAT1 and possibly other BBM uric acid transporters...
  27. ncbi request reprint ClC-5: role in endocytosis in the proximal tubule
    YingHong Wang
    Dept of Physiology, WBSB Rm 208, The Johns Hopkins Univ School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
    Am J Physiol Renal Physiol 289:F850-62. 2005
    ..Our data from the mutants suggest that defective targeting and trafficking of mutant ClC-5 to the endosomes are a major determinant in the lack of normal endocytosis in Dent's disease...
  28. doi request reprint Novel regulatory function for NHERF-1 in Npt2a transcription
    Syed Jalal Khundmiri
    Department of Medicine, Univ of Louisville, Kidney Disease Program, 570 S Preston St, Suite 102, Louisville, KY 40202, USA
    Am J Physiol Renal Physiol 294:F840-9. 2008
    ..Our data demonstrate for the first time that NHERF-1 regulates Npt2a transcription and membrane insertion...
  29. ncbi request reprint Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse
    James B Wade
    Dept of Physiology, 655 W, Baltimore St, Univ of Maryland, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 285:C1494-503. 2003
    ..These findings suggest that the organized subcellular distribution of the NHERF isoforms may play a role in the specific interactions mediating physiological control of transporter function...
  30. doi request reprint Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice
    Rochelle Cunningham
    Univ of Maryland School of Medicine, 22 S Greene St, N3W143, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 294:F1001-7. 2008
    ....
  31. pmc Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells
    Rochelle Cunningham
    Dept of Medicine, Division of Nephrology, Univ of Maryland, School of Medicine, Rm N3W143, UHM, 22 South Greene St, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 296:F355-61. 2009
    ..Our results also suggest that activation of MAPK is not critically involved in PTH- or dopamine-mediated inhibition of phosphate transport in mouse renal proximal tubule cells in culture...
  32. ncbi request reprint Acute renal failure and nephrotic range proteinuria due to amyloidosis in an HIV-infected patient
    Kirk M Chan-Tack
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Med Sci 332:364-7. 2006
    ..Clinical diagnosis, based on CD4 count, viral load, and degree of proteinuria, may not predict the pathological diagnosis in HIV-positive patients...
  33. ncbi request reprint Expression of TRPC4 channel protein that interacts with NHERF-2 in rat descending vasa recta
    Whaseon Lee-Kwon
    Division of Nephrology, Department of Medicine, Univ Maryland School of Medicine, N3W143, UMH, 22 S Greene St, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 288:C942-9. 2005
    ..These findings suggest that TRPC4 and NHERF-2 may play a role in interactions related to Ca2+ signaling...
  34. ncbi request reprint A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Biochemistry 42:12662-8. 2003
    ..Together, the data suggested that the PDZ interaction between the NHE3 C-terminus and a NHERF-1 PDZ domain enhanced the regulation of sodium-hydrogen exchange by cAMP-elevating hormones...
  35. ncbi request reprint Pyelonephritis and acute renal failure
    Anita Nahar
    Division of Nephrology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Am J Med Sci 328:121-3. 2004
    ..These cases represented initial diagnostic dilemmas for the admitting physicians and demonstrate the varied clinical presentations of acute renal failure as a direct consequence of bacterial infiltration of the renal parenchyma...
  36. ncbi request reprint The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1
    C Chris Yun
    Department of Medicine, Division of Digestive Disease, Emory University, Atlanta, Georgia, USA
    J Am Soc Nephrol 13:2823-30. 2002
    ..This interaction allows the integration of genomic regulation and activation of SGK1 and NHERF2 in the control of ROMK1 activity and renal K(+) excretion...
  37. ncbi request reprint Regulation of ion transport by the NHERF family of PDZ proteins
    Shirish Shenolikar
    Department Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Physiology (Bethesda) 19:362-9. 2004
    ....
  38. pmc Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells
    Yong Pan
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Fannin Street, Houston, Texas 77054, USA
    Breast Cancer Res 10:R5. 2008
    ....
  39. ncbi request reprint Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B
    Christoph Boehmer
    Department of Physiology I, University of Tubingen, Tubingen D 72076, Germany
    Biochem Biophys Res Commun 313:998-1003. 2004
    ..The action of the kinases and NHERF-2 may link urinary citrate excretion to proximal tubular H(+) secretion...
  40. ncbi request reprint Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells
    Eleanor DeLand Lederer
    Louisville Veterans Administration Medical Center, Louisville, Kentucky, USA
    J Am Soc Nephrol 14:1711-9. 2003
    ..These experiments also suggest that the mechanism for retrieval of NaPi IIa transporters from the apical membrane in response to cAMP does not require NHERF...
  41. ncbi request reprint Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50)
    W Bruce Sneddon
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 278:43787-96. 2003
    ..These results demonstrate that NHERF1 acts as a molecular switch that legislates the conditional efficacy of PTH fragments. Distinct endocytic pathways are determined by NHERF1 that are operative for the PTH1R in kidney and bone cells...
  42. ncbi request reprint Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice
    Paola Capuano
    Institute of Physiology, Univ of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Am J Physiol Cell Physiol 292:C927-34. 2007
    ..These data suggest that NHERF1 in the proximal tubule is important for PTH-induced internalization of NaP(i)-IIa and, specifically, couples the apical PTHR to PLC...
  43. ncbi request reprint kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins
    Peng Huang
    Department of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 279:25002-9. 2004
    ..This study provides the first direct evidence that a G protein-coupled receptor through association with NHERF-1/EBP-50 stimulates NHE3...
  44. ncbi request reprint Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF-1
    Jennifer M Bomberger
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 280:23926-35. 2005
    ..These results, using both endogenous and overexpressed cellular models, indicate a novel function for NHERF-1 and RAMP3 in the internalization of the AM receptor and suggest additional regulatory mechanisms for receptor trafficking...
  45. ncbi request reprint Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity in human airway 16HBE14o- cells and rescues DeltaF508 CFTR functional expression in cystic fibrosis ce
    Lorenzo Guerra
    Department of General and Environmental Physiology, University of Bari, Via Amendola 165 A, Bari 70126, Italy
    J Biol Chem 280:40925-33. 2005
    ....
  46. ncbi request reprint Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets
    James W Voltz
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:33879-87. 2007
    ....
  47. ncbi request reprint Cell-matrix interactions modulate transepithelial phosphate transport in P(i)-deprived OK cells
    Mario Barac-Nieto
    Department of Physiology, Kuwait University, Safat, Kuwait
    Am J Physiol Cell Physiol 293:C1272-7. 2007
    ..These Matrigel-induced changes led to an increase in net transepithelial apical to basolateral P(i) transport...
  48. pmc PDZ-domain interactions and apical expression of type IIa Na/P(i) cotransporters
    Nati Hernando
    Institute of Physiology, University of Zurich, Wintherthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 99:11957-62. 2002
    ..These data suggest an involvement of PDZ-interactions on the apical expression of type IIa cotransporters...
  49. pmc The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells
    Rosa A Cardone
    Department of General and Environmental Physiology, University of Bari, 70126 Bari, Italy
    Mol Biol Cell 18:1768-80. 2007
    ..We conclude that NHERF1 overexpression enhances the invasive phenotype in breast cancer cells, both alone and in synergy with exposure to the tumor microenvironment, via the coordination of PKA-gated RhoA/p38 signaling...
  50. ncbi request reprint Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice
    Nellie Broere
    Department of Biochemistry, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands
    J Biol Chem 282:37575-84. 2007
    ....
  51. ncbi request reprint Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia
    David A Spector
    Division of Renal Medicine, The Johns Hopkins Bayview Medical Center, Baltimore 21224, USA
    Am J Physiol Renal Physiol 282:F1034-42. 2002
    ..AQPs in genitourinary tract urothelia likely play a role in the regulation of epithelial cell volume and osmolality and may play a role in bulk water movement across urothelia...

Research Grants14

  1. Na+-H+ Transport in Renal Apical Membranes
    Edward Weinman; Fiscal Year: 2006
    ....
  2. SODIUM-H+ TRANSPORT IN RENAL APICAL MEMBRANES
    Edward Weinman; Fiscal Year: 2002
    ..The physiologic effect of NHE- RF/ezrin binding will be studied in PS120 cells expressing loss-of- function NHE-RF mutants or polypeptides representing the ERM region of ezrin. ..
  3. NHERF-1 and PTH regulation of the renal transport of phosphate.
    Edward J Weinman; Fiscal Year: 2010
    ..These observations may provide mechanistic insights into the processes that regulate the binding of target proteins to adaptors such as NHERF-1 and provide broader insights into the pathophysiology of NHERF-1 related diseases. ..