Michael Weiner

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA Department of Radiology, University of California, San Francisco, CA, USA Department of Medicine, University of California, San Francisco, CA, USA Department of Psychiatry, University of California, San Francisco, CA, USA Department of Neurology, University of California, San Francisco, CA, USA Electronic address
    Alzheimers Dement 10:S226-35. 2014
  2. ncbi request reprint Military risk factors for cognitive decline, dementia and Alzheimer's disease
    Dallas P Veitch
    Center for Imaging of Neurodegenerative Diseases, Veterans Medical Center and Departments of Radiology, Medicine, Psychiatry and Neurology, University of California, San Francisco, San Francisco, CA, USA
    Curr Alzheimer Res 10:907-30. 2013
  3. doi request reprint The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Alzheimers Dement 9:e111-94. 2013
  4. doi request reprint Dementia in 2012: Further insights into Alzheimer disease pathogenesis
    Michael W Weiner
    Center for Imaging of Neurodegenerative Diseases, Department of Radiology, San Francisco VA Medical Center University of California San Francisco, 4150 Clement Street 114M, San Francisco CA, 94121 USA
    Nat Rev Neurol 9:65-6. 2013
  5. pmc Different associations of white matter lesions with depression and cognition
    Jun Young Lee
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    BMC Neurol 12:83. 2012
  6. pmc The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Alzheimers Dement 8:S1-68. 2012
  7. doi request reprint Magnetic resonance imaging and neuropsychological results from a trial of memantine in Alzheimer's disease
    Michael W Weiner
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, and University of California San Francisco, San Francisco, CA, USA
    Alzheimers Dement 7:425-35. 2011
  8. pmc The Alzheimer's disease neuroimaging initiative: progress report and future plans
    Michael W Weiner
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA, USA
    Alzheimers Dement 6:202-11.e7. 2010
  9. pmc Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease
    Prashanthi Vemuri
    Aging and Dementia Imaging Research Laboratory, Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Ann Neurol 67:308-16. 2010
  10. pmc Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes
    Gloria C Chiang
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Room M391, San Francisco, CA, 94143, USA
    Radiology 259:844-51. 2011

Research Grants

  1. Prediction of Cognitive Decline with MRI and MRS
    Michael Weiner; Fiscal Year: 2007
  2. Prediction of Cognitive Decline with MRI and MRS
    Michael Weiner; Fiscal Year: 2005
  3. Prediction of Cognitive Decline with MRI and MRS
    Michael Weiner; Fiscal Year: 2006
  4. Alzheimer's Disease Neuroimaging Initiative
    Michael Weiner; Fiscal Year: 2007
  5. Alzheimer's Disease Neuroimaging Initiative
    Michael Weiner; Fiscal Year: 2007
  6. Prediction of cognitive decline with structural, diffusion, and perfusion MRI
    Michael Weiner; Fiscal Year: 2009
  7. Prediction of Cognitive Decline with MRI and MRS
    Michael Weiner; Fiscal Year: 2005
  8. Prediction of Cognitive Decline with MRI and MRS
    Michael Weiner; Fiscal Year: 2004
  9. 1H MRSI OF AGING BRAIN AND SENILE DEMENTIA
    Michael Weiner; Fiscal Year: 1999
  10. 1H MRSI OF AGING BRAIN AND SENILE DEMENTIA
    Michael Weiner; Fiscal Year: 2000

Detail Information

Publications136 found, 100 shown here

  1. ncbi request reprint Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA Department of Radiology, University of California, San Francisco, CA, USA Department of Medicine, University of California, San Francisco, CA, USA Department of Psychiatry, University of California, San Francisco, CA, USA Department of Neurology, University of California, San Francisco, CA, USA Electronic address
    Alzheimers Dement 10:S226-35. 2014
    ..This study is a first step toward the design and statistical powering of an AD prevention trial using at-risk veterans as subjects, and provides the basis for a larger, more comprehensive study of dementia risk factors in veterans. ..
  2. ncbi request reprint Military risk factors for cognitive decline, dementia and Alzheimer's disease
    Dallas P Veitch
    Center for Imaging of Neurodegenerative Diseases, Veterans Medical Center and Departments of Radiology, Medicine, Psychiatry and Neurology, University of California, San Francisco, San Francisco, CA, USA
    Curr Alzheimer Res 10:907-30. 2013
    ....
  3. doi request reprint The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Alzheimers Dement 9:e111-94. 2013
    ..The ADNI study was extended by a 2-year Grand Opportunities grant in 2009 and a renewal of ADNI (ADNI-2) in October 2010 through to 2016, with enrollment of an additional 550 participants. ..
  4. doi request reprint Dementia in 2012: Further insights into Alzheimer disease pathogenesis
    Michael W Weiner
    Center for Imaging of Neurodegenerative Diseases, Department of Radiology, San Francisco VA Medical Center University of California San Francisco, 4150 Clement Street 114M, San Francisco CA, 94121 USA
    Nat Rev Neurol 9:65-6. 2013
    ..Increasing evidence implicated cell-to-cell transmission in the spread of tau and amyloid, highlighting novel targets for therapeutic intervention...
  5. pmc Different associations of white matter lesions with depression and cognition
    Jun Young Lee
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    BMC Neurol 12:83. 2012
    ....
  6. pmc The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Alzheimers Dement 8:S1-68. 2012
    ..The ADNI study was extended by a 2-year Grand Opportunities grant in 2009 and a renewal of ADNI (ADNI-2) in October 2010 through to 2016, with enrollment of an additional 550 participants...
  7. doi request reprint Magnetic resonance imaging and neuropsychological results from a trial of memantine in Alzheimer's disease
    Michael W Weiner
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, and University of California San Francisco, San Francisco, CA, USA
    Alzheimers Dement 7:425-35. 2011
    ..This study was designed to assess changes in brain volume and cognitive abilities in memantine-treated patients with Alzheimer's disease (AD) by using an exploratory, single-arm, delayed-start design...
  8. pmc The Alzheimer's disease neuroimaging initiative: progress report and future plans
    Michael W Weiner
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA, USA
    Alzheimers Dement 6:202-11.e7. 2010
    ..All data are available at UCLA/LONI/ADNI, without embargo. ADNI-like projects started in Australia, Europe, Japan, and Korea. ADNI provides significant new information concerning the progression of AD...
  9. pmc Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease
    Prashanthi Vemuri
    Aging and Dementia Imaging Research Laboratory, Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Ann Neurol 67:308-16. 2010
    ....
  10. pmc Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes
    Gloria C Chiang
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Room M391, San Francisco, CA, 94143, USA
    Radiology 259:844-51. 2011
    ..To determine whether automated temporoparietal brain volumes can be used to accurately predict future memory decline among a multicenter cohort of cognitively healthy elderly individuals...
  11. pmc A network diffusion model of disease progression in dementia
    Ashish Raj
    Department of Radiology, Weill Medical College of Cornell University, 515 E 71 Street, Suite S123, New York, NY 10044, USA
    Neuron 73:1204-15. 2012
    ..This work has many important implications, including dimensionality reduction, differential diagnosis, and especially prediction of future atrophy using baseline MRI morphometrics...
  12. pmc Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia
    William W Seeley
    UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143 1207, USA
    Arch Neurol 65:249-55. 2008
    ..Behavioral variant frontotemporal dementia (bvFTD) strikes hardest at the frontal lobes, but the sites of earliest injury remain unclear...
  13. pmc Voxel-based T2 relaxation rate measurements in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, VAMC San Francisco, California, USA
    Epilepsia 48:220-8. 2007
    ..Therefore, the aim of this study was to characterize extent and distribution pattern of extrahippocampal relaxation abnormalities in TLE with (TLE-MTS) and without MRI evidence of mesial-temporal sclerosis (TLE-no)...
  14. pmc Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  15. pmc Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular disease
    Beth Kuczynski
    Helen Wills Neuroscience Institute and the Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Arch Neurol 65:650-5. 2008
    ..Understanding how each disease contributes to dementia is essential from both a pathophysiologic and diagnostic perspective...
  16. ncbi request reprint Computational atlases of severity of white matter lesions in elderly subjects with MRI
    Stathis Hadjidemetriou
    NCIRE VA UCSF, 4150 Clement St, San Francisco, CA 94121, USA
    Med Image Comput Comput Assist Interv 11:450-8. 2008
    ..The lesion severities of the two groups have a significant statistical difference with the severity in the atlas of cerebrovascular disease being higher...
  17. pmc Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease
    Audrey Duarte
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, CA, USA
    Neurosci Lett 406:60-5. 2006
    ..The combination of the two patterns may explain the lack of correlations in MCI. Developmental versus pathological contributions to these relationships are discussed...
  18. pmc Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance
    Michael Ewers
    Department of Radiology, University of California, San Francisco, San Francisco, CA, USA
    Neurobiol Aging 33:1203-14. 2012
    ..5, 77.4))) and TMT-B test (prediction accuracy 64.6% (95% CI (55.5, 73.4%))). In conclusion, short-term conversion to AD is predicted by single marker models to a comparable degree as by multimarker models in amnestic MCI subjects...
  19. pmc Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Brain 134:1479-92. 2011
    ....
  20. pmc Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment
    Duygu Tosun
    Center for Imaging Neurodegenerative Diseases, Department of Veterans Affairs Medical Centre, 4150 Clement Street, Building 13, 114 M, San Francisco, CA 94121, USA
    Brain 134:1077-88. 2011
    ....
  21. pmc N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease
    Norbert Schuff
    Magnetic Resonance Unit VA Medical Center, Department of Radiology, University of California, San Francisco, CA 94121, USA
    Adv Exp Med Biol 576:241-62; discussion 361-3. 2006
  22. pmc Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment
    Judy Pa
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Ann Neurol 65:414-23. 2009
    ..The goal of the study was to compare clinical and neuroimaging characteristics of two single-domain MCI subgroups: amnestic MCI and dysexecutive MCI...
  23. doi request reprint Longitudinal effects of PTSD on memory functioning
    Kristin W Samuelson
    Mental Health Service, San Francisco Veteran s Affairs Medical Center, San Francisco, CA 94133, USA
    J Int Neuropsychol Soc 15:853-61. 2009
    ..Compared to veterans without PTSD, veterans with PTSD showed a greater decline in delayed facial recognition only, and this decline was extremely subtle...
  24. pmc Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease
    Michael Ewers
    University of California, VA Medical Center, Center for Neuroimaging of Neurodegenerative Diseases, San Francisco, San Francisco, CA 94121, USA
    Neurobiol Aging 33:1599-608. 2012
    ..There was no interaction between CSF signature and diagnosis or apolipoprotein E (ApoE) genotype. In conclusion, lower BMI is indicative of AD pathology as assessed with CSF-based biomarkers in demented and nondemented elderly subjects...
  25. ncbi request reprint Neuroanatomical correlates of impaired recognition of emotion in dementia
    Howard J Rosen
    University of California at San Francisco Department of Neurology, Memory and Aging Center, 350 Parnassus Avenue, Suite 706, Box 1207, San Francisco, CA 94143 1207, USA
    Neuropsychologia 44:365-73. 2006
    ....
  26. pmc Patterns of structural complexity in Alzheimer's disease and frontotemporal dementia
    Karl Young
    Department of Radiology, University of California San Francisco, and VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Hum Brain Mapp 30:1667-77. 2009
    ....
  27. pmc Voxel-based optimized morphometry (VBM) of gray and white matter in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis
    Suzanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, VAMC San Francisco, San Francisco, CA, USA
    Epilepsia 47:900-7. 2006
    ....
  28. pmc BMI and neuronal integrity in healthy, cognitively normal elderly: a proton magnetic resonance spectroscopy study
    Stefan Gazdzinski
    Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, San Francisco, California, USA
    Obesity (Silver Spring) 18:743-8. 2010
    ..Future studies need to evaluate whether these metabolite abnormalities are involved in the development and maintenance of weight problems...
  29. pmc Cortisol levels are positively correlated with hippocampal N-acetylaspartate
    Thomas C Neylan
    Mental Health Service, San Francisco Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Biol Psychiatry 54:1118-21. 2003
    ..This study examined the relationship of hypothalamic-pituitary-adrenal measures and hippocampal N-acetylaspartate (NAA) in posttraumatic stress disorder (PTSD) patients and control subjects...
  30. pmc Neuropsychological functioning in posttraumatic stress disorder and alcohol abuse
    Kristin W Samuelson
    Mental Health Service, San Francisco Veteran s Affairs Medical Center, San Francisco, CA, USA
    Neuropsychology 20:716-26. 2006
    ..By controlling for alcohol and depression, the authors can more conclusively demonstrate that verbal memory and attention differences are associated with PTSD...
  31. ncbi request reprint White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy
    An Tao Du
    Magnetic Resonance Unit 114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurobiol Aging 26:553-9. 2005
    ..Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy...
  32. pmc Requiring an amyloid-beta1-42 biomarker for prodromal Alzheimer's disease or mild cognitive impairment does not lead to more efficient clinical trials
    Lon S Schneider
    Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Alzheimers Dement 6:367-77. 2010
    ....
  33. pmc Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Radiology 259:834-43. 2011
    ..To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI)...
  34. pmc Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
    Juan Zhou
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Brain 133:1352-67. 2010
    ..Further developed, intrinsic connectivity network signatures may provide simple, inexpensive, and non-invasive biomarkers for dementia differential diagnosis and disease monitoring...
  35. pmc Longitudinal rates of lobar atrophy in frontotemporal dementia, semantic dementia, and Alzheimer's disease
    Casey E Krueger
    UCSF Department of Neurology, San Francisco, CA, USA
    Alzheimer Dis Assoc Disord 24:43-8. 2010
    ..Measuring specific regions of cerebral volume changes by serial neuroimaging may serve as a useful biomarker outcome measure for clinical trials in neurodegenerative diseases...
  36. pmc Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans
    Paul S Aisen
    Department of Neurosciences, University of California San Diego, CA, USA
    Alzheimers Dement 6:239-46. 2010
    ..The resulting data would provide valuable data on the earliest stages of AD, and support the development of interventions in these critically important populations...
  37. doi request reprint Regional cerebral volumes in veterans with current versus remitted posttraumatic stress disorder
    Linda Chao
    Department of Radiology, University of California, San Francisco 94121, USA
    Psychiatry Res 213:193-201. 2013
    ....
  38. pmc Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    E C Mormino
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Brain 132:1310-23. 2009
    ..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy...
  39. pmc Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease
    Clifford R Jack
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Alzheimers Dement 7:474-485.e4. 2011
    ..Hippocampal volumetry is the most widely studied quantitative magnetic resonance imaging measure in Alzheimer's disease and thus represents the most rational target for an initial effort at standardization...
  40. pmc Neuroanatomical correlates of cognitive self-appraisal in neurodegenerative disease
    Howard J Rosen
    Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
    Neuroimage 49:3358-64. 2010
    ..We hypothesize that emotional/physiological processing carried out by vmPFC is an important factor mediating self-appraisal accuracy in dementia...
  41. pmc A tensor based morphometry study of longitudinal gray matter contraction in FTD
    Simona M Brambati
    Memory and Aging Center, UCSF Department of Neurology, 350 Parnassus Ave, Suite 706, San Francisco, CA 94143, USA
    Neuroimage 35:998-1003. 2007
    ..These results suggest that TBM might be useful in tracking progression of regional atrophy in FTD...
  42. pmc Multisection proton MR spectroscopy for mesial temporal lobe epilepsy
    Aristides A Capizzano
    Department of Veterans Affairs Medical Center, Magnetic Resonance Spectroscopy Unit, University of California, San Francisco, USA
    AJNR Am J Neuroradiol 23:1359-68. 2002
    ..We investigated whether proton MR spectroscopy ((1)H-MRS) depicts metabolic changes beyond the hippocampus in cases of mTLE and whether these changes help lateralize the seizure focus...
  43. pmc Identification of the epileptogenic lobe in neocortical epilepsy with proton MR spectroscopic imaging
    Susanne G Mueller
    Department of Veterans Affairs DVA Medical Center, Magnetic Resonance Spectroscopy Unit, University of California, San Francisco, San Francisco, California 64115, USA
    Epilepsia 45:1580-9. 2004
    ..The aim of this study was to evaluate the usefulness of multislice magnetic resonance spectroscopic imaging (MRSI) in combination with tissue segmentation for the identification of the epileptogenic focus in neocortical epilepsy (NE)...
  44. pmc Heavy alcohol consumption in individuals with HIV infection: effects on neuropsychological performance
    Johannes C Rothlind
    Mental Health Service, DVA Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Int Neuropsychol Soc 11:70-83. 2005
    ....
  45. pmc Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort
    Anita Lakatos
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92617, USA
    Neurobiol Aging 31:1355-63. 2010
    ..Our results indicate that the mitochondrial haplogroup UK may confer genetic susceptibility to AD independently of the apolipoprotein E4 (APOE4) allele...
  46. pmc Standing on the shoulders of giants: improving medical image segmentation via bias correction
    Hongzhi Wang
    Department of Radiology, University of Pennsylvania, USA
    Med Image Comput Comput Assist Interv 13:105-12. 2010
    ..We apply this methodology on three segmentation problems/methods and show significant improvements for all of them...
  47. pmc Concordance and discordance between brain perfusion and atrophy in frontotemporal dementia
    Soichiro Shimizu
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Brain Imaging Behav 4:46-54. 2010
    ..Detection of discordance between brain perfusion and structure in FTD might aid diagnosis and staging of the disease...
  48. pmc Magnetic resonance spectroscopic imaging reconstruction with deformable shape-intensity models
    Xiao Ping Zhu
    Magnetic Resonance Unit, VA Medical Center, San Francisco, California 94121, USA
    Magn Reson Med 50:474-82. 2003
    ..1-fold with DSM without distorting spectral resolution, thus maintaining all spectral features of the raw, unfiltered data. In conclusion, DSM should be used to achieve high SNR in reconstructing MRSI data...
  49. pmc Evidence of neuronal injury outside the medial temporal lobe in temporal lobe epilepsy: N-acetylaspartate concentration reductions detected with multisection proton MR spectroscopic imaging--initial experience
    Peter Vermathen
    MR Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, USA
    Radiology 226:195-202. 2003
    ....
  50. pmc Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease
    Niklas Mattsson
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, California, United States of America Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America
    PLoS ONE 8:e85443. 2013
    ..Here we tested if baseline CSF α-synuclein affects brain atrophy rates and if these effects vary across brain regions, and across the cognitive spectrum from healthy elders (NL), to patients with mild cognitive impairment (MCI) and AD...
  51. pmc Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults
    Niklas Mattsson
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA Electronic address
    Neurobiol Aging 35:614-22. 2014
    ..Proteins interacting with CSF Aβ42 may be related to Aβ brain pathology, whereas proteins associated with atrophy even after adjusting for CSF Aβ42 may be related to Aβ-independent mechanisms. ..
  52. pmc Voxelwise genome-wide association study (vGWAS)
    Jason L Stein
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 53:1160-74. 2010
    ..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
  53. pmc An integrated multimodality MR brain imaging study: gray matter tissue loss mediates the association between cerebral hypoperfusion and Alzheimer's disease
    Duygu Tosun
    Imaging Neurodegenerative Diseases, VA Medical Center 114M, 4150 Clement St, San Francisco, CA 94121, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6981-4. 2009
    ....
  54. pmc Moderating effects of coping on the relationship between stress and the development of new brain lesions in multiple sclerosis
    David C Mohr
    University of California, VAMC, San Francisco, CA 94121, USA
    Psychosom Med 64:803-9. 2002
    ..This study examined the hypothesis that coping moderates the subsequent relationship between stress and the development of new brain lesions in MS...
  55. ncbi request reprint Patterns of cerebral atrophy in primary progressive aphasia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California at San Francisco, CA 94143 1207, USA
    Am J Geriatr Psychiatry 10:89-97. 2002
    ..Different clinical syndromes in PPA are associated with different patterns of atrophy. In the future, combined analysis of imaging and clinical characteristics may allow more accurate etiologic diagnosis...
  56. ncbi request reprint Cinguloparietal atrophy distinguishes Alzheimer disease from semantic dementia
    Adam L Boxer
    Memory and Aging Center and the Department of Neurology, University of California at San Francisco, 94143, USA
    Arch Neurol 60:949-56. 2003
    ..Progressive brain atrophy is associated with Alzheimer disease (AD) and other dementias. Regional differences in brain atrophy may reflect clinical features of disease...
  57. pmc ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia
    Linda L Chao
    Center for Imaging of Neurodegenerative Disease, San Francisco, CA, USA
    Alzheimer Dis Assoc Disord 24:19-27. 2010
    ..03). These results suggest that hypoperfusion as detected by ASL-MRI can predict subsequent clinical, functional, and cognitive decline and may be useful for identifying candidates for future Alzheimer disease treatment trials...
  58. pmc Automated MRI-based classification of primary progressive aphasia variants
    Stephen M Wilson
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
    Neuroimage 47:1558-67. 2009
    ..These results suggest that automated methods could assist in the differential diagnosis of PPA variants, enabling therapies to be targeted to likely underlying etiologies...
  59. pmc White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain 132:2579-92. 2009
    ..Taken together, the results suggest that white matter degradation measured with DTI may improve the diagnostic differentiation between FTD and Alzheimer's disease...
  60. pmc Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Hippocampus 19:558-64. 2009
    ....
  61. pmc Widespread extrahippocampal NAA/(Cr+Cho) abnormalities in TLE with and without mesial temporal sclerosis
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    J Neurol 258:603-12. 2011
    ..This reduces their value for focus lateralization and suggests a heterogeneous etiology of extrahippocampal spectroscopic metabolic abnormalities in TLE...
  62. pmc Rule violation errors are associated with right lateral prefrontal cortex atrophy in neurodegenerative disease
    Katherine L Possin
    Department of Neurology, University of California San Francisco, San Francisco, California, USA
    J Int Neuropsychol Soc 15:354-64. 2009
    ..These data underscore the importance of right lateral PFC in behavioral monitoring and highlight the potential of RV error assessment for identifying patients with damage to this region...
  63. pmc Subfield atrophy pattern in temporal lobe epilepsy with and without mesial sclerosis detected by high-resolution MRI at 4 Tesla: preliminary results
    Susanne G Mueller
    Department of Radiology, Center for Imaging of Neurodegenerative Diseases, University of California, San Francisco, California 94121, USA
    Epilepsia 50:1474-83. 2009
    ..The aim of this study was to test if distinct subfield atrophy patterns can be detected in temporal lobe epilepsy (TLE) with mesial temporal sclerosis (TLE-MTS) and without (TLE-no) hippocampal sclerosis...
  64. pmc Hippocampal volume differences in Gulf War veterans with current versus lifetime posttraumatic stress disorder symptoms
    Brigitte A Apfel
    Department of Psychiatry, University of California, San Francisco, California, USA
    Biol Psychiatry 69:541-8. 2011
    ..However, it is not known whether it is a risk factor for the development of PTSD or a consequence of PTSD. We sought to determine the effects of PTSD and depressive symptoms on hippocampal volume...
  65. pmc Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield
    Thomas C Neylan
    Mental Health Service, DVA Medical Center, San Francisco, California 94121, USA
    Biol Psychiatry 68:494-6. 2010
    ..Our objective was to determine whether insomnia severity in a sample of posttraumatic stress disorder (PTSD) patients and control subjects was associated with decreased volume in the CA3/dentate hippocampal subfield...
  66. pmc Effects of low-level exposure to sarin and cyclosarin during the 1991 Gulf War on brain function and brain structure in US veterans
    Linda L Chao
    Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 114 M, San Francisco, CA 94121, USA
    Neurotoxicology 31:493-501. 2010
    ..The goal of the current study is to determine the generalizability of these findings in another cohort of GW veterans with suspected GB/GF exposure...
  67. pmc Gray matter correlates of set-shifting among neurodegenerative disease, mild cognitive impairment, and healthy older adults
    Judy Pa
    Alzheimer Disease Research Center, Dept of Neurology, University of California, San Francisco, California, USA
    J Int Neuropsychol Soc 16:640-50. 2010
    ..Overall, these findings highlight the neuroanatomical correlates of set-shifting and the importance of controlling for component processes when investigating complex cognitive tasks...
  68. pmc Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study
    Helen Lavretsky
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Psychiatry 167:589-97. 2010
    ....
  69. pmc Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden
    Gil D Rabinovici
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Brain 133:512-28. 2010
    ..Our data are consistent with a model in which both early amyloid-beta accumulation and increased vulnerability to amyloid-beta pathology play critical roles in the pathogenesis of Alzheimer's disease in young patients...
  70. pmc Influences of lobar gray matter and white matter lesion load on cognition and mood
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, VAMC University of California San Francisco, 4150 Clement Street, San Francisco, CA, 94121, USA
    Psychiatry Res 181:90-6. 2010
    ..Cognitive function is associated with GM atrophy and depressed mood is associated with frontal WML. This indicates that although both often occur together, depressed mood and cognitive impairment have different pathological correlates...
  71. pmc Involvement of the thalamocortical network in TLE with and without mesiotemporal sclerosis
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, San Francisco, California, USA
    Epilepsia 51:1436-45. 2010
    ..This study investigated how structural abnormalities in the focus, ipsilateral thalamus and extrafocal cortical structures relate to each other in TLE with mesiotemporal sclerosis (TLE-MTS) and without hippocampal sclerosis (TLE-no)...
  72. doi request reprint Joint analysis of structural and perfusion MRI for cognitive assessment and classification of Alzheimer's disease and normal aging
    Duygu Tosun
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neuroimage 52:186-97. 2010
    ..Compared to reduced rCBF, regional cortical thinning better explained the variability in dementia severity. In conclusion, structural brain alterations compared to physiological variations are the dominant features of MRI in AD...
  73. pmc Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging
    Norbert Schuff
    Department of Veterans Affairs Medical Center, University of California at San Francisco, USA
    Alzheimers Dement 5:454-62. 2009
    ....
  74. pmc Improved pseudo-continuous arterial spin labeling for mapping brain perfusion
    Marzieh Nezamzadeh
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Magn Reson Imaging 31:1419-27. 2010
    ..Here, a new modification of pCASL, termed mpCASL is reported, in which the perturbation caused by the null pulse is reduced and perfusion mapping improved...
  75. pmc Patterns of cerebral hypoperfusion in amnestic and dysexecutive MCI
    Linda L Chao
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Alzheimer Dis Assoc Disord 23:245-52. 2009
    ..These data further suggest that cognitive impairment in MCI is related to cerebral hypoperfusion...
  76. pmc Atrophy in two attention networks is associated with performance on a Flanker task in neurodegenerative disease
    Tracy L Luks
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94143, USA
    Neuropsychologia 48:165-70. 2010
    ....
  77. pmc Detecting sarcasm from paralinguistic cues: anatomic and cognitive correlates in neurodegenerative disease
    Katherine P Rankin
    Memory and Aging Center, University of California San Francisco, Department of Neurology, San Francisco, CA 94143 1207, USA
    Neuroimage 47:2005-15. 2009
    ....
  78. pmc Characterization of white matter degeneration in elderly subjects by magnetic resonance diffusion and FLAIR imaging correlation
    Wang Zhan
    University of California San Francisco, VA Medical Center, Department of Radiology, Center of Imaging for Neurodegenerative Diseases, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Neuroimage 47:T58-65. 2009
    ..These results suggest that the different stages of WM degeneration in elderly subjects can be better characterized by regional DTI-FLAIR correlations than single modality alone...
  79. pmc K-Bayes reconstruction for perfusion MRI. I: concepts and application
    John Kornak
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, 4150 Clement Street 114M, San Francisco, CA 94121, USA
    J Digit Imaging 23:277-86. 2010
    ..The K-Bayes reconstructed images were demonstrated to provide reduced bias, increased precision, greater effect sizes, and higher resolution than those obtained using DFT...
  80. pmc Longitudinal MRI and cognitive change in healthy elderly
    Joel H Kramer
    Department of Neurology, San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
    Neuropsychology 21:412-8. 2007
    ..The association between WMSH and EXEC further highlights the cognitive sequealae associated with cerebrovascular disease in normal elderly...
  81. pmc Magnetic resonance imaging correlates of set shifting
    Joel H Kramer
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    J Int Neuropsychol Soc 13:386-92. 2007
    ..Follow-up analyses indicated that frontal contributions to shifting were not related to working memory. Results highlight the importance of carefully controlling for component cognitive processes when studying executive functioning...
  82. pmc Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia
    An Tao Du
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain 130:1159-66. 2007
    ..In conclusion, the characteristic patterns of cortical thinning in Alzheimer's disease and FTD suggest that cortical thickness may be a useful surrogate marker for these types of dementia...
  83. pmc Cognition and anatomy in three variants of primary progressive aphasia
    Maria Luisa Gorno-Tempini
    Department of Neurology, UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143, USA
    Ann Neurol 55:335-46. 2004
    ..Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes...
  84. pmc Clinical, cognitive and anatomical evolution from nonfluent progressive aphasia to corticobasal syndrome: a case report
    Maria Luisa Gorno-Tempini
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 1207, USA
    Neurocase 10:426-36. 2004
    ..This case demonstrates the clinical overlap between FTLD and CBS and shows that the two can appear in the same patient at different stages of the disease in relation to the progression of anatomical damage...
  85. pmc Structural anatomy of empathy in neurodegenerative disease
    Katherine P Rankin
    Memory and Aging Center, UCSF Department of Neurology, University of California San Francisco CA 94143 1207, USA
    Brain 129:2945-56. 2006
    ..The results suggest that the right anterior temporal and medial frontal regions are essential for real-life empathic behaviour...
  86. pmc Non-treatment-seeking heavy drinkers: effects of chronic cigarette smoking on brain structure
    Timothy C Durazzo
    Center for Neuroimaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Drug Alcohol Depend 87:76-82. 2007
    ....
  87. pmc Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging
    Xiaoping Zhu
    Department of Radiology, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Alzheimer Dis Assoc Disord 20:77-85. 2006
    ..However, the NAA and mI changes are not correlated with each other, suggesting that they represent different processes that might help staging of AD...
  88. pmc Attention, learning, and memory in posttraumatic stress disorder
    Thomas C Neylan
    Mental Health Service, San Francisco DVA Medical Center, San Francisco, California 94121, USA
    J Trauma Stress 17:41-6. 2004
    ..In this study, reduced hippocampal NAA did not appear to be associated with impaired declarative memory...
  89. pmc ERP evidence of impaired central nervous system function in virally suppressed HIV patients on antiretroviral therapy
    Linda L Chao
    Magnetic Resonance Unit, Department of Radiology, San Francisco Veterans Affairs Medical Center, and Department of Radiology, University of California, San Francisco, 94121, USA
    Clin Neurophysiol 115:1583-91. 2004
    ..To examine the effects of human immunodeficiency virus (HIV) on central nervous system (CNS) function in patients receiving antiretroviral therapy (ART) who have suppressed viral loads...
  90. pmc Neuroanatomical correlates of behavioural disorders in dementia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143 1207, USA
    Brain 128:2612-25. 2005
    ..Furthermore, the findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions...
  91. pmc Achieving sufficient spectral bandwidth for volumetric 1H echo-planar spectroscopic imaging at 4 Tesla
    Andreas Ebel
    Northern California Institute for Research and Education, VA Medical Center San Francisco, San Francisco, CA 94121, USA
    Magn Reson Med 54:697-701. 2005
    ..In this Note, limitations of the iFT method are discussed and an alternative, cyclic spectral unwrapping, is proposed, which is based on prior knowledge of typical in vivo spectral patterns...
  92. pmc Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla
    Lana G Kaiser
    Department of Radiology, University of California San Francisco, MR Unit VA Medical Center at San Francisco, San Francisco, California 94141, USA
    NMR Biomed 18:51-5. 2005
    ..Comparisons between old and young subjects showed higher concentration of scyllo-inositol and myo-inositol in older subjects and a trend for a correlation between scyllo-inositol and myo-inositol levels across subjects...
  93. ncbi request reprint Abnormal CNV in chronic heavy drinkers
    Linda L Chao
    Magnetic Resonance Unit, 116R San Francisco VA Medical Center, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Clin Neurophysiol 114:2081-95. 2003
    ..We used the contingent negative variation (CNV), a slow negative shift in the human electroencephalogram, to investigate the effects of heavy chronic alcohol use on frontal lobe function...
  94. pmc Chronic cigarette smoking and heavy drinking in human immunodeficiency virus: consequences for neurocognition and brain morphology
    Timothy C Durazzo
    Center for Neuroimaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, USA
    Alcohol 41:489-501. 2007
    ..Overall, the findings suggested that the direct and/or indirect effects of chronic cigarette smoking created an additional burden on the integrity of brain neurobiology and neurocognition in this cohort of HIV-positive heavy drinkers...
  95. pmc Sensitive and fast T1 mapping based on two inversion recovery images and a reference image
    Geon Ho Jahng
    University of California San Francisco, 4150 Clement Street, 114M San Francisco, California 94121, USA
    Med Phys 32:1524-8. 2005
    ..The proposed method should be useful for clinical studies because the T1 maps can be obtained within a few seconds...
  96. pmc Are treated alcoholics representative of the entire population with alcohol use disorders? A magnetic resonance study of brain injury
    Stefan Gazdzinski
    Center for Imaging of Neurodegenerative Diseases CIND, Veterans Administration Medical Center, San Francisco, CA 94121, USA
    Alcohol 42:67-76. 2008
    ....
  97. pmc Patterns of white matter atrophy in frontotemporal lobar degeneration
    Linda L Chao
    Center for Imaging of Neurodegenerative Diseases, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Arch Neurol 64:1619-24. 2007
    ..Structural magnetic resonance imaging (MRI) has been used to investigate the in vivo pathology of frontotemporal lobar degeneration. However, few neuroimaging studies have focused on white matter (WM) alterations in this disease...
  98. pmc Leon Thal's vision for the treatment and prevention of Alzheimer's disease
    Michael W Weiner
    Center for Imaging of Neurodegenerative Disease, VA Medical Center, University of California San Francisco, San Francisco, CA, USA
    Alzheimers Dement 4:S150-2. 2008
  99. pmc Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases, DVA Medical Center, San Francisco, CA 94121, USA
    Psychiatry Res 162:147-57. 2008
    ..NAA appears to be a more sensitive marker for neuronal abnormality in PTSD than brain volume. The alteration in the anterior cingulate cortex in PTSD has implications for fear conditioning and extinction...
  100. doi request reprint In-vivo investigation of the human cingulum bundle using the optimization of MR diffusion spectrum imaging
    Marzieh Nezamzadeh
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Eur J Radiol 75:e29-36. 2010
    ..This optimized DSI setting should be useful for detecting alterations along the cingulum bundle in Alzheimer disease and related neurodegenerative disorders...
  101. pmc Human brain: reliability and reproducibility of pulsed arterial spin-labeling perfusion MR imaging
    Geon Ho Jahng
    Department of Radiology, University of California San Francisco, 4150 Clement St, Rm 114M, San Francisco, CA 94121, USA
    Radiology 234:909-16. 2005
    ..5%), and (b) random noise rather than within-subject variability limited reliability and reproducibility. It was concluded that low signal-to-noise ratios substantially limit the reliability and reproducibility of perfusion measurements...

Research Grants26

  1. Prediction of Cognitive Decline with MRI and MRS
    Michael Weiner; Fiscal Year: 2007
    ..This project is expected to improve methods for predicting cognitive decline/dementia due to AD; these techniques should identify those subjects at high risk for AD, who are candidates for primary prevention. ..
  2. Prediction of Cognitive Decline with MRI and MRS
    Michael Weiner; Fiscal Year: 2005
    ..This project is expected to improve methods for predicting cognitive decline/dementia due to AD; these techniques should identify those subjects at high risk for AD, who are candidates for primary prevention. ..
  3. Prediction of Cognitive Decline with MRI and MRS
    Michael Weiner; Fiscal Year: 2006
    ..This project is expected to improve methods for predicting cognitive decline/dementia due to AD; these techniques should identify those subjects at high risk for AD, who are candidates for primary prevention. ..
  4. Alzheimer's Disease Neuroimaging Initiative
    Michael Weiner; Fiscal Year: 2007
    ..The results of this study will be extremely useful for design of future AD and MCI trials. ..
  5. Alzheimer's Disease Neuroimaging Initiative
    Michael Weiner; Fiscal Year: 2007
    ..The results of this study will be extremely useful for design of future AD and MCI trials. ..
  6. Prediction of cognitive decline with structural, diffusion, and perfusion MRI
    Michael Weiner; Fiscal Year: 2009
    ..This application uses MRI scanning to "predict cognitive decline" in nondemented elders and will lead to methods which identify subjects at risk, who can then be put on preventive treatment once it's available. ..
  7. Prediction of Cognitive Decline with MRI and MRS
    Michael Weiner; Fiscal Year: 2005
    ..This project is expected to improve methods for predicting cognitive decline/dementia due to AD; these techniques should identify those subjects at high risk for AD, who are candidates for primary prevention. ..
  8. Prediction of Cognitive Decline with MRI and MRS
    Michael Weiner; Fiscal Year: 2004
    ..This project is expected to improve methods for predicting cognitive decline/dementia due to AD; these techniques should identify those subjects at high risk for AD, who are candidates for primary prevention. ..
  9. 1H MRSI OF AGING BRAIN AND SENILE DEMENTIA
    Michael Weiner; Fiscal Year: 1999
    ....
  10. 1H MRSI OF AGING BRAIN AND SENILE DEMENTIA
    Michael Weiner; Fiscal Year: 2000
    ....
  11. 1H MRSI OF AMYOTROPHIC LATERAL SCLEROSIS
    Michael Weiner; Fiscal Year: 2000
    ..abstract_text> ..
  12. 1H MRSI OF AGING BRAIN AND SENILE DEMENTIA
    Michael Weiner; Fiscal Year: 2001
    ....
  13. 1H MRSI OF AMYOTROPHIC LATERAL SCLEROSIS
    Michael Weiner; Fiscal Year: 2001
    ..abstract_text> ..
  14. 1H MRSI OF AMYOTROPHIC LATERAL SCLEROSIS
    Michael Weiner; Fiscal Year: 2001
    ..abstract_text> ..
  15. 1H MRSI OF AGING BRAIN AND SENILE DEMENTIA
    Michael Weiner; Fiscal Year: 2002
    ....
  16. Varian 4 Tesla MRI/MRS for Neuro-degenerative Diseases
    Michael Weiner; Fiscal Year: 2002
    ..These expected results emphasize the practical outcome and significance of this research. ..
  17. 1H MRSI OF AMYOTROPHIC LATERAL SCLEROSIS
    Michael Weiner; Fiscal Year: 2002
    ..abstract_text> ..
  18. Prediction of Cognitive Decline with MRI and MRS
    Michael Weiner; Fiscal Year: 2003
    ..This project is expected to improve methods for predicting cognitive decline/dementia due to AD; these techniques should identify those subjects at high risk for AD, who are candidates for primary prevention. ..
  19. Prediction of cognitive decline with structural, diffusion, and perfusion MRI
    Michael W Weiner; Fiscal Year: 2010
    ..This application uses MRI scanning to "predict cognitive decline" in nondemented elders and will lead to methods which identify subjects at risk, who can then be put on preventive treatment once it's available. ..