K Weinberg

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation
    K Weinberg
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital Los Angeles, CA 90027, USA
    Blood 97:1458-66. 2001
  2. doi request reprint Study of thymic size and function in children and adolescents with treatment refractory systemic sclerosis eligible for immunoablative therapy
    A Reiff
    Divisions of Rheumatology, Radiology and Bone Marrow Transplantation, Department of Pediatrics, University of Southern California, Keck School of Medicine, Children s Hospital Los Angeles, CA 90027, USA
    Clin Immunol 133:295-302. 2009
  3. ncbi request reprint Exclusion of candidate genetic loci for Duane retraction syndrome
    S Ott
    Division of Ophthalmology, Children s Hospital Los Angeles, University of Southern California School of Medicine, 90064, USA
    Am J Ophthalmol 127:358-60. 1999
  4. ncbi request reprint Successful hematopoietic stem cell transplantation for Niemann-Pick disease type B
    Ami J Shah
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital Los Angeles, CA 90027, USA
    Pediatrics 116:1022-5. 2005
  5. ncbi request reprint Successful immune reconstitution decreases leukemic relapse and improves survival in recipients of unrelated cord blood transplantation
    Robertson Parkman
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital Los Angeles, The Saban Research Institute, 4650 Sunset Boulevard, Mail Stop 62, Los Angeles, CA 90027, USA
    Biol Blood Marrow Transplant 12:919-27. 2006
  6. ncbi request reprint [Treatment progress of Duchenne Muscular Dystrophy (DMD)]
    Elzbieta Monika Smogorzewska
    Hematopoietic Stem Cell Processing Laboratory, Research Immunology, Children Hospital LA, Los Angeles, USA
    Med Wieku Rozwoj 8:25-32. 2004
  7. ncbi request reprint [Transplantation of genetically modified cells in the treatment of children with SCID: great hopes and recent disappointments]
    Elzbieta Monika Smogorzewska
    Research Immunology, Children Hospital LA, Los Angeles, CA 90027, USA
    Med Wieku Rozwoj 7:27-34. 2003
  8. ncbi request reprint Preponderant mitotic activity of nonleukemic cells plays an important role in failures to detect abnormal clone in childhood acute lymphoblastic leukemia
    Shi Qi Wu
    Department of Pediatrics, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, Mailstop 11, Los Angeles, CA 90027, U S A
    J Pediatr Hematol Oncol 25:520-5. 2003
  9. doi request reprint Progressive declines in neurocognitive function among survivors of hematopoietic stem cell transplantation for pediatric hematologic malignancies
    Ami J Shah
    Department of Pediatrics, Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital, Los Angeles, CA 90027, USA
    J Pediatr Hematol Oncol 30:411-8. 2008
  10. ncbi request reprint Second hematopoietic stem cell transplantation in pediatric patients: overall survival and long-term follow-up
    Ami J Shah
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital, Los Angeles, CA 90027, USA
    Biol Blood Marrow Transplant 8:221-8. 2002

Research Grants

  1. The Role of KGF in Thymopoiesis
    Kenneth Weinberg; Fiscal Year: 2006
  2. High-speed Flow Cytometer
    Kenneth Weinberg; Fiscal Year: 2003
  3. IL-7R and c-kit interactions in thymopoiesis
    Kenneth Weinberg; Fiscal Year: 2006
  4. ENHANCEMENT OF POST-BMT IMMUNE RECONSTITUTION BY IL-7
    Kenneth Weinberg; Fiscal Year: 2006

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation
    K Weinberg
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital Los Angeles, CA 90027, USA
    Blood 97:1458-66. 2001
    ..Collectively, these data suggest that thymopoiesis is inhibited by GVHD. Larger studies will be needed to determine the independent contributions of age and preparative regimen to post-transplant thymopoietic capacity...
  2. doi request reprint Study of thymic size and function in children and adolescents with treatment refractory systemic sclerosis eligible for immunoablative therapy
    A Reiff
    Divisions of Rheumatology, Radiology and Bone Marrow Transplantation, Department of Pediatrics, University of Southern California, Keck School of Medicine, Children s Hospital Los Angeles, CA 90027, USA
    Clin Immunol 133:295-302. 2009
    ..A thorough evaluation of immune and thymic functions to identify those patients prior to HSCT is recommended...
  3. ncbi request reprint Exclusion of candidate genetic loci for Duane retraction syndrome
    S Ott
    Division of Ophthalmology, Children s Hospital Los Angeles, University of Southern California School of Medicine, 90064, USA
    Am J Ophthalmol 127:358-60. 1999
    ..To report preliminary linkage analysis of a large Hispanic family showing autosomal dominant inheritance for Duane retraction syndrome...
  4. ncbi request reprint Successful hematopoietic stem cell transplantation for Niemann-Pick disease type B
    Ami J Shah
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital Los Angeles, CA 90027, USA
    Pediatrics 116:1022-5. 2005
    ..Five years after her second HSCT, her sphingomyelinase levels are within normal levels, she has no pulmonary symptoms, and aside from persistent graft versus host disease, she is doing well...
  5. ncbi request reprint Successful immune reconstitution decreases leukemic relapse and improves survival in recipients of unrelated cord blood transplantation
    Robertson Parkman
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital Los Angeles, The Saban Research Institute, 4650 Sunset Boulevard, Mail Stop 62, Los Angeles, CA 90027, USA
    Biol Blood Marrow Transplant 12:919-27. 2006
    ..Successful antigen-specific immune reconstitution after unrelated cord blood transplantation results in decreased leukemic relapse and improved overall survival...
  6. ncbi request reprint [Treatment progress of Duchenne Muscular Dystrophy (DMD)]
    Elzbieta Monika Smogorzewska
    Hematopoietic Stem Cell Processing Laboratory, Research Immunology, Children Hospital LA, Los Angeles, USA
    Med Wieku Rozwoj 8:25-32. 2004
    ..In the future it may be possible for mesenchymal cells to be isolated, ex vivo expanded and transplanted into patients with muscle diseases...
  7. ncbi request reprint [Transplantation of genetically modified cells in the treatment of children with SCID: great hopes and recent disappointments]
    Elzbieta Monika Smogorzewska
    Research Immunology, Children Hospital LA, Los Angeles, CA 90027, USA
    Med Wieku Rozwoj 7:27-34. 2003
    ..This case is being investigated to determine whether the genetic manipulations of the patient's HSC could be the reason for mutagenesis and how other factors could have contributed to this unfortunate event...
  8. ncbi request reprint Preponderant mitotic activity of nonleukemic cells plays an important role in failures to detect abnormal clone in childhood acute lymphoblastic leukemia
    Shi Qi Wu
    Department of Pediatrics, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, Mailstop 11, Los Angeles, CA 90027, U S A
    J Pediatr Hematol Oncol 25:520-5. 2003
    ..Therefore, karyotypically "normal" childhood ALL patients should undergo FISH studies to rule out the presence of t(12;21) and/or hyperdiploid clone...
  9. doi request reprint Progressive declines in neurocognitive function among survivors of hematopoietic stem cell transplantation for pediatric hematologic malignancies
    Ami J Shah
    Department of Pediatrics, Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital, Los Angeles, CA 90027, USA
    J Pediatr Hematol Oncol 30:411-8. 2008
    ..Although some patients have acute deficits that appear and improve over time, other patients have progressive declines in neurocognitive function that are chronic...
  10. ncbi request reprint Second hematopoietic stem cell transplantation in pediatric patients: overall survival and long-term follow-up
    Ami J Shah
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital, Los Angeles, CA 90027, USA
    Biol Blood Marrow Transplant 8:221-8. 2002
    ..Although toxicity is considerable following a second transplantation, the major causes of mortality continue to be relapse and infection...
  11. pmc Pre- and post-natal treatment of hemophagocytic lymphohistiocytosis
    Ami J Shah
    Division of Research Immunology, Childrens Hospital Los Angeles, California 90027, USA
    Pediatr Blood Cancer 52:139-42. 2009
    ..We report on the first patient to receive post-natal HSCT for HLH after receiving in utero chemotherapy for disease stabilization...
  12. ncbi request reprint Human CD34(+) and CD34(+)CD38(-) hematopoietic progenitors in sickle cell disease differ phenotypically and functionally from normal and suggest distinct subpopulations that generate F cells
    Lori Luck
    Division of Hematology Oncology, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Exp Hematol 32:483-93. 2004
    ..Sickle cell disease (SCD) is remarkable for stress erythropoiesis. We investigated the progenitor populations contributing to erythroid stress...
  13. ncbi request reprint Tolerance induction by lentiviral gene therapy with a nonmyeloablative regimen
    Noboru Mitsuhashi
    Childrens Hospital of Los Angeles, Department of Cardiothoracic Surgery, Los Angeles, CA 90027, USA
    Blood 107:2286-93. 2006
    ..Mice reconstituted with GalT accepted alphaGal+ heart grafts over 100 days. Transduction with lentiviral vectors results in chimerism at levels sufficient to induce long-term tolerance under nonmyeloablative conditions...
  14. pmc Localization of a gene for Duane retraction syndrome to chromosome 2q31
    B Appukuttan
    Division of Ophthalmology, Childrens Hospital Los Angeles, Los Angeles, CA, 90027, USA
    Am J Hum Genet 65:1639-46. 1999
    ..Coding sequences for these genes were normal or had genetic alterations unlikely to be responsible for the DRS phenotype. Identifying the gene responsible for DRS may lead to an improved understanding of early cranial-nerve development...
  15. ncbi request reprint Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation
    Dullei Min
    Division of Research Immunology BMT, Childrens Hospital Los Angeles, CA 90027, USA
    Blood 99:4592-600. 2002
    ..Furthermore, thymic injury and prolonged posttransplantation immune deficiency in BMT recipients can be prevented by KGF administration...
  16. pmc Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report
    Barbara C Engel
    Division of Research Immunology Bone Marrow Transplantation, General Clinical Research Center, Department of Pathology, Children s Hospital Los Angeles, CA 90027, and Baylor College of Medicine, Houston, TX, USA
    Blood 109:503-6. 2007
    ..The confounding effects of this preexisting marrow cytogenetic abnormality on the response to gene transfer highlights another challenge of gene therapy with the use of autologous hematopoietic stem cells...
  17. ncbi request reprint Gene therapy for adenosine deaminase deficiency
    R Parkman
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital Los Angeles, California, USA
    Annu Rev Med 51:33-47. 2000
    ....
  18. ncbi request reprint Severe combined immunodeficiency due to a specific defect in the production of interleukin-2
    K Weinberg
    Division of Research Immunology, Childrens Hospital Los Angeles, CA 90027
    N Engl J Med 322:1718-23. 1990
  19. pmc Identification, functional analysis and expression in a heterotopic heart transplant model of CXCL9 in the rat
    Noboru Mitsuhashi
    Division of Cardiothoracic Surgery, Department of Cardiothoracic Surgery, Children s Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Immunology 112:87-93. 2004
    ..These findings indicate that rat CXCL9 has an in vivo role in the infiltration of CD4+ T cells in the transplanted graft...
  20. doi request reprint Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations
    Yue Xin Ren
    Department of Pathology and Laboratory Medicine, Children s Hospital Los Angeles, CA 90027, USA
    Cancer Res 68:6587-97. 2008
    ..Our results show the critical role played by PAX-FKHR in determining the molecular, myogenic, and histologic phenotype of ARMS. More importantly, we identify MSCs as a progenitor that can give rise to ARMS...
  21. pmc Severe papillomavirus infection progressing to metastatic squamous cell carcinoma in bone marrow-transplanted X-linked SCID dogs
    Michael H Goldschmidt
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey St, Philadelphia, PA 19104, USA
    J Virol 80:6621-8. 2006
    ..Canine XSCID therefore provides an ideal animal model with which to study the role of the gammac-dependent signaling pathway in the response to papillomavirus infections and the progression of these viral infections to metastatic SCC...
  22. ncbi request reprint Transplantation of X-linked severe combined immunodeficient dogs with CD34+ bone marrow cells
    Brian J Hartnett
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Biol Blood Marrow Transplant 8:188-97. 2002
    ....
  23. ncbi request reprint Importance of interleukin-7 in the development of experimental graft-versus-host disease
    Brile Chung
    Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
    Biol Blood Marrow Transplant 14:16-27. 2008
    ..These experiments demonstrate that IL-7 is an important factor in the development of GVHD, presumably by supporting the survival, proliferation, and possibly activation of alloreactive donor-derived T cells in the recipients...
  24. pmc T cell repertoire development in XSCID dogs following nonconditioned allogeneic bone marrow transplantation
    William Vernau
    Department of Veterinary Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA
    Biol Blood Marrow Transplant 13:1005-15. 2007
    ..However, in contrast to transplanted XSCID boys who show a significant decline in their T cell diversity by 10 to 12 years following BMT, transplanted XSCID dogs maintain a polyclonal, diverse T cell repertoire through midlife...
  25. pmc Prevention of graft-versus-host disease by anti IL-7Ralpha antibody
    Brile Chung
    Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Blood 110:2803-10. 2007
    ..Blockade of IL-7R by anti-IL-7Ralpha antibody resulted in elimination of alloreactive T cells, prevention of GVHD, and improvement of donor T-cell reconstitution...
  26. ncbi request reprint The effects of Campath 1H upon graft-versus-host disease, infection, relapse, and immune reconstitution in recipients of pediatric unrelated transplants
    Ami J Shah
    Department of Pediatrics, Keck School of Medicine, Los Angeles, California, USA
    Biol Blood Marrow Transplant 13:584-93. 2007
    ..Further studies are warranted to assess if a lack of difference in infection rates are still demonstrated in larger cohorts...
  27. ncbi request reprint Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha
    Jiwei Wang
    Department of Pathology, Division of Research Immunology Bone Marrow Transplant, Childrens Hospital Los Angeles Research Institute, Los Angeles, California 90027, USA
    J Biol Chem 277:43369-76. 2002
    ....
  28. pmc Antigen-specific T-lymphocyte function after cord blood transplantation
    Geoff Cohen
    The EMMES Corporation, Rockville, Maryland, USA
    Biol Blood Marrow Transplant 12:1335-42. 2006
    ..These results indicate that naive T lymphocytes present in the HSC inoculum can contribute to the generation of antigen-specific T-lymphocyte immunity early after transplantation...
  29. ncbi request reprint Early use of drastic therapy
    Kenneth I Weinberg
    N Engl J Med 352:2124-6. 2005

Research Grants4

  1. The Role of KGF in Thymopoiesis
    Kenneth Weinberg; Fiscal Year: 2006
    ..The studies will provide important information regarding how the thymic microenvironment is maintained and recovered from cytotoxic injury, and how thymocytes influence the development of their microenvironment. ..
  2. High-speed Flow Cytometer
    Kenneth Weinberg; Fiscal Year: 2003
    ..In order to accommodate the new sorter, the FACS Core Laboratory will be remodeled and expanded with institutional funds. Combined institutional and grant support will be used to staff and maintain the new equipment. ..
  3. IL-7R and c-kit interactions in thymopoiesis
    Kenneth Weinberg; Fiscal Year: 2006
    ..abstract_text> ..
  4. ENHANCEMENT OF POST-BMT IMMUNE RECONSTITUTION BY IL-7
    Kenneth Weinberg; Fiscal Year: 2006
    ..The durability of the thymopoietic improvements induced by IL-7 or IL-7 stroma will be examined. Together, the studies will elucidate mechanisms by which IL-7 replacement can be used to treat thymic insufficiency. ..