Guy L Weinberg

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Local anesthetic cardiac toxicity can present as late-onset hypotension, bradycardia, and asystole
    Guy L Weinberg
    Anesthesiology 101:553. 2004
  2. ncbi request reprint Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart
    Guy L Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA
    Reg Anesth Pain Med 31:296-303. 2006
  3. ncbi request reprint Metabolic context affects hemodynamic response to bupivacaine in the isolated rat heart
    Lucas B Edelman
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, Chicago, IL, United States
    Chem Biol Interact 172:48-53. 2008
  4. pmc Sevoflurane reduces clinical disease in a mouse model of multiple sclerosis
    Paul E Polak
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA
    J Neuroinflammation 9:272. 2012
  5. pmc Intravenous lipid emulsion in clinical toxicology
    Leelach Rothschild
    Department of Anesthesiology, University of Illinois at Chicago, UIC Medical Center, Chicago, Illinois, USA
    Scand J Trauma Resusc Emerg Med 18:51. 2010
  6. doi request reprint Pioglitazone attenuates acute cocaine toxicity in rat isolated heart: potential protection by metabolic modulation
    Guy L Weinberg
    Department of Anesthesiology, University of Illinois, College of Medicine at Chicago, Illinois, USA
    Anesthesiology 114:1389-95. 2011
  7. doi request reprint Treatment of local anesthetic systemic toxicity (LAST)
    Guy L Weinberg
    University of Illinois College of Medicine, Jesse Brown VA Medical Center, Chicago, IL 60612, USA
    Reg Anesth Pain Med 35:188-93. 2010
  8. doi request reprint Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose
    Guy L Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago and Jesse Brown Veterans Administration Medical Center, Chicago, Illinois 60612, USA
    Anesthesiology 108:907-13. 2008
  9. ncbi request reprint Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats
    G L Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, USA
    Anesthesiology 88:1071-5. 1998
  10. ncbi request reprint Lipid rescue resuscitation from local anaesthetic cardiac toxicity
    Guy Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine, Chicago, and University of Illinois Hospital 60612, USA
    Toxicol Rev 25:139-45. 2006

Research Grants

  1. TZD Treatment of Cocaine Toxicity
    Guy Weinberg; Fiscal Year: 2005

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Local anesthetic cardiac toxicity can present as late-onset hypotension, bradycardia, and asystole
    Guy L Weinberg
    Anesthesiology 101:553. 2004
  2. ncbi request reprint Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart
    Guy L Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA
    Reg Anesth Pain Med 31:296-303. 2006
    ..The mechanism of lipid rescue is unknown. These studies address the possibility that lipid infusion reduces cardiac bupivacaine content in the context of cardiac toxicity...
  3. ncbi request reprint Metabolic context affects hemodynamic response to bupivacaine in the isolated rat heart
    Lucas B Edelman
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, Chicago, IL, United States
    Chem Biol Interact 172:48-53. 2008
    ..3+/-2.0 s versus 15.8+/-3.1; P<0.04). Fatty acid metabolism was shown to predispose the isolated heart to bupivacaine toxicity, confirming that the local anesthetic exerts specific effects on lipid processes in cardiomyocytes...
  4. pmc Sevoflurane reduces clinical disease in a mouse model of multiple sclerosis
    Paul E Polak
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA
    J Neuroinflammation 9:272. 2012
    ....
  5. pmc Intravenous lipid emulsion in clinical toxicology
    Leelach Rothschild
    Department of Anesthesiology, University of Illinois at Chicago, UIC Medical Center, Chicago, Illinois, USA
    Scand J Trauma Resusc Emerg Med 18:51. 2010
    ..Future studies will shape the evolving recommendations for lipid emulsion in the setting of non-local anesthetic drug overdose...
  6. doi request reprint Pioglitazone attenuates acute cocaine toxicity in rat isolated heart: potential protection by metabolic modulation
    Guy L Weinberg
    Department of Anesthesiology, University of Illinois, College of Medicine at Chicago, Illinois, USA
    Anesthesiology 114:1389-95. 2011
    ..The authors tested whether cocaine depresses mitochondrial acylcarnitine exchange and if a drug that enhances glucose metabolism could protect against cocaine-induced cardiac dysfunction...
  7. doi request reprint Treatment of local anesthetic systemic toxicity (LAST)
    Guy L Weinberg
    University of Illinois College of Medicine, Jesse Brown VA Medical Center, Chicago, IL 60612, USA
    Reg Anesth Pain Med 35:188-93. 2010
    ..We also recommend avoiding vasopressin and using epinephrine only in small doses. Vigilance, preparedness, and quick action will improve outcomes of this dreaded complication...
  8. doi request reprint Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose
    Guy L Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago and Jesse Brown Veterans Administration Medical Center, Chicago, Illinois 60612, USA
    Anesthesiology 108:907-13. 2008
    ..The authors compared resuscitation with lipid, epinephrine, and saline control in a rat model of bupivacaine-induced cardiac toxicity to determine whether lipid provides a benefit over epinephrine...
  9. ncbi request reprint Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats
    G L Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, USA
    Anesthesiology 88:1071-5. 1998
    ..The authors also measured the partitioning of bupivacaine between the lipid and aqueous phases of a plasma-lipid emulsion mixture...
  10. ncbi request reprint Lipid rescue resuscitation from local anaesthetic cardiac toxicity
    Guy Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine, Chicago, and University of Illinois Hospital 60612, USA
    Toxicol Rev 25:139-45. 2006
    ..An educational website has been established to help disseminate information about lipid emulsion therapy and to serve as a medium for physicians to share experiences or thoughts on the method and local anaesthetic toxicity...
  11. ncbi request reprint The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation
    Guy Weinberg
    Department of Anesthesiology, University of Illinois at Chicago College of Medicine and the Chicago VA Hospital Westside Division, Chicago, Illinois 60612, USA
    Anesth Analg 98:790-5, table of contents. 2004
    ..The dogs regained normal hemodynamic variables after lipid infusion. The findings suggest such that bupivacaine may protect the heart against ischemic acidosis...
  12. ncbi request reprint Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity
    Guy Weinberg
    Department of Anesthesiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
    Reg Anesth Pain Med 28:198-202. 2003
    ..The present studies were undertaken to determine if this method is similarly effective in a non-rodent model using a larger animal...
  13. ncbi request reprint Current concepts in resuscitation of patients with local anesthetic cardiac toxicity
    Guy L Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine, Chicago, Illinois 60618, USA
    Reg Anesth Pain Med 27:568-75. 2002
  14. ncbi request reprint Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria
    G L Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, 60612, USA
    Anesthesiology 92:523-8. 2000
    ..The authors previously reported that secondary carnitine deficiency may sensitize the heart to bupivacaine-induced arrhythmias. In this study, the authors tested whether bupivacaine inhibits carnitine metabolism in cardiac mitochondria...
  15. doi request reprint Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect
    David B Hiller
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, Chicago, Illinois, USA
    Anesthesiology 111:498-505. 2009
    ..We compared escalating doses of epinephrine on recovery with lipid infusion in a rat model of bupivacaine overdose...
  16. doi request reprint Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin-induced cardiac arrest
    Guido Di Gregorio
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, USA
    Crit Care Med 37:993-9. 2009
    ..Lipid emulsion infusion is an emerging antidotal therapy for toxin-induced cardiac arrest. To compare the efficacy of resuscitation from bupivacaine-induced asystole using lipid emulsion infusion vs. vasopressin, alone and with epinephrine...
  17. ncbi request reprint Adding bupivacaine to high-potassium cardioplegia improves function and reduces cellular damage of rat isolated hearts after prolonged, cold storage
    James D Ross
    Department of Physiology and Biophysics, University of Illinois College of Medicine at Chicago, and Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA
    Anesthesiology 105:746-52. 2006
    ..Bupivacaine retards myocardial acidosis during ischemia. The authors measured function of rat isolated hearts after prolonged storage to determine whether bupivacaine improves cardiac protection compared with standard cardioplegia alone...
  18. ncbi request reprint Epinephrine induces rapid deterioration in pulmonary oxygen exchange in intact, anesthetized rats: a flow and pulmonary capillary pressure-dependent phenomenon
    Vijay Krishnamoorthy
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, Chicago, Illinois, USA
    Anesthesiology 117:745-54. 2012
    ..Previous studies indicate epinephrine adversely affects arterial oxygenation when administered in a rat model of local anesthetic overdose. The authors tested whether epinephrine alone exerts similar effects in the intact animal...
  19. ncbi request reprint Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis
    Paul E Polak
    Department of Anesthesiology, University of Illinois, and Jesse Brown Veteran s Affairs Research Division, Chicago, IL 60612, USA
    J Neuroimmunol 168:65-75. 2005
    ..RTPCR analysis showed that GW0742 increased expression of some myelin genes. These data demonstrate that PPARdelta agonists, like other PPAR ligands, can exert protective actions in an autoimmune model of demyelinating disease...
  20. ncbi request reprint Safety of high volume lipid emulsion infusion: a first approximation of LD50 in rats
    David B Hiller
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, IL 60612, USA
    Reg Anesth Pain Med 35:140-4. 2010
    ..We hypothesize that high volumes of lipid could have undesirable effects and sought to identify the dose required to kill 50% of the animals (LD(50)) of large volume lipid administration...
  21. doi request reprint Lipid resuscitation for local anesthetic toxicity: is it really lifesaving?
    Ulana Leskiw
    University of Illinois at Chicago College of Medicine, Illinois 60612, USA
    Curr Opin Anaesthesiol 22:667-71. 2009
    ..This review discusses subsequent clinical reports, relevant laboratory studies and topics for further research...
  22. doi request reprint Local anesthetic systemic toxicity: prevention and treatment
    Pilar Mercado
    Department of Anesthesiology, University of Illinois at Chicago, 3200 West UICH MC 515, 1740 West Taylor Street, Chicago, IL 60612, USA
    Anesthesiol Clin 29:233-42. 2011
    ..This article discusses the mechanisms and clinical presentation, prevention, treatment, and future trends of local anesthetic systemic toxicity. The adverse effects of lipid emulsion therapy are also included...
  23. ncbi request reprint Bupivacaine, but not lidocaine, disrupts cardiolipin-containing small biomimetic unilamellar liposomes
    Hayat Onyuksel
    Department of Biopharmaceutical Sciences, University of Illinois at Chicago, IL 60612 4325, USA
    Chem Biol Interact 169:154-9. 2007
    ..We suggest that these interactions underlie, in part, bupivacaine-induced cardiotoxicity...
  24. ncbi request reprint Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis
    Douglas L Feinstein
    Department of Anesthesiology, University of Illinois, 11819 West Polk Street, MC519, Chicago, IL 60612, USA
    Ann Neurol 51:694-702. 2002
    ..Pioglitazone also reduced the antigen-dependent interferon-gamma production from EAE-derived T cells. These results suggest that orally administered PPARgamma agonists could provide therapeutic benefit in demyelinating disease...
  25. ncbi request reprint Noradrenergic regulation of inflammatory gene expression in brain
    Douglas L Feinstein
    Department of Anesthesiology, University of Illinois, Chicago, IL, USA
    Neurochem Int 41:357-65. 2002
    ....
  26. ncbi request reprint Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties
    Vitaliy Gavrilyuk
    Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612, USA
    J Neurochem 92:1140-9. 2005
    ..Changes in DST11 levels in diseased brain could therefore contribute to the progression of inflammatory damage...
  27. ncbi request reprint Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis
    Patricia Murphy
    Department of Anesthesiology, University of Illinois, 1819 West Polk Street, Chicago, IL 60612, USA
    J Neurosci Res 67:461-70. 2002
    ..These results indicate that ansamycins can exert potent anti-inflammatory effects on brain glial cells which may provide therapeutic benefit in neuroinflammatory diseases...
  28. ncbi request reprint Peroxisome proliferator-activated receptor gamma thiazolidinedione agonists increase glucose metabolism in astrocytes
    Cinzia Dello Russo
    Veterans Affairs Chicago Health Care System West Side Division, Chicago, Illinois, 60680, USA
    J Biol Chem 278:5828-36. 2003
    ..These results demonstrate that TZDs modify astrocyte metabolism and mitochondrial function, which could be beneficial in neurological conditions where glucose availability is reduced...
  29. ncbi request reprint Norepinephrine increases I kappa B alpha expression in astrocytes
    Vitaliy Gavrilyuk
    Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 277:29662-8. 2002
    ..These results demonstrate that I kappa B alpha expression is regulated by NE at both transcriptional and post-transcriptional levels, which could contribute to the observed anti-inflammatory properties of NE in vitro and in vivo...
  30. ncbi request reprint Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine
    Archie J Sirianni
    Department of Anesthesiology, Riddle Memorial Hospital, Media, PA, USA
    Ann Emerg Med 51:412-5, 415.e1. 2008
    ..An infusion of lipid emulsion was followed rapidly by restoration of effective circulation. Toxicologic studies are consistent with the lipid sink theory of antidotal efficacy...
  31. doi request reprint Clinical patterns and outcome in epithelioid hemangioendothelioma with or without pulmonary involvement: insights from an internet registry in the study of a rare cancer
    Kenneth Lau
    University of Illinois College of Medicine at Chicago, Illinois, USA
    Chest 140:1312-8. 2011
    ..The natural history of EHE is highly variable. This study uses an Internet registry to identify clinical patterns with prognostic significance in EHE...
  32. ncbi request reprint Lipid resuscitation: a life-saving antidote for local anesthetic toxicity
    S Bern
    Department of Anesthesiology, University of Illinois Hospital, 1740 W Taylor, Chicago, IL 60612, USA
    Curr Pharm Biotechnol 12:313-9. 2011
    ..Increased physician awareness and education, as well as optimized treatment protocols, will significantly reduce the rate of morbidity and mortality from local anesthetic toxicity...
  33. ncbi request reprint Metabolic modulation for cardiac protection
    Guy L Weinberg
    Expert Rev Cardiovasc Ther 5:135-8. 2007
  34. doi request reprint Lipid infusion therapy: translation to clinical practice
    Guy L Weinberg
    Anesth Analg 106:1340-2. 2008

Research Grants1

  1. TZD Treatment of Cocaine Toxicity
    Guy Weinberg; Fiscal Year: 2005
    ..We will also establish an isolated heart model to study the potential for clinical application of TZDs to treat acute cocaine cardiac toxicity. ..