Adriana Weinberg

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Cytomegalovirus-specific cell-mediated immunity in HIV-infected children on HAART
    Adriana Weinberg
    Section of Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    AIDS Res Hum Retroviruses 22:283-8. 2006
  2. ncbi Varicella-Zoster virus-specific cell-mediated immunity in HIV-infected children receiving highly active antiretroviral therapy
    Adriana Weinberg
    Section of Pediatric Infectious Diseases, and Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    J Infect Dis 190:267-70. 2004
  3. ncbi Regulatory T cells generated during cytomegalovirus in vitro stimulation of mononuclear cells from HIV-infected individuals on HAART correlate with decreased lymphocyte proliferation
    Renee D Jesser
    Department of Pediatric Infectious Diseases, University of Colorado Health Sciences Center, 4200 E 9th Avenue, UCHSC School of Medicine, Denver, CO 80262, USA
    Virology 352:408-17. 2006
  4. pmc Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Denver, Colorado, USA
    AIDS 22:2267-77. 2008
  5. pmc Optimization and limitations of use of cryopreserved peripheral blood mononuclear cells for functional and phenotypic T-cell characterization
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Denver, CO, USA
    Clin Vaccine Immunol 16:1176-86. 2009
  6. ncbi Risk of transmission of herpesviruses through cord blood transplantation
    Adriana Weinberg
    University of Colorado School of Medicine, Denver, Colorado, USA
    Biol Blood Marrow Transplant 11:35-8. 2005
  7. pmc How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients
    Kathryn L Springer
    Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 E 9th Ave, C 227, Denver, CO 80220, USA
    J Clin Microbiol 43:208-13. 2005
  8. ncbi Cytomegalovirus-specific immunity and protection against viremia and disease in HIV-infected patients in the era of highly active antiretroviral therapy
    Adriana Weinberg
    University of Colorado School of Medicine, Denver, 80262, USA
    J Infect Dis 193:488-93. 2006
  9. ncbi Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine
    Julie Patterson-Bartlett
    Department of Pediatrics of the University of Colorado School of Medicine, Denver, CO 80262, USA
    Vaccine 25:7087-93. 2007
  10. ncbi Administration of live varicella vaccine to HIV-infected children with current or past significant depression of CD4(+) T cells
    Myron J Levin
    University of Colorado School of Medicine, Denver, Denver, CO 80262, USA
    J Infect Dis 194:247-55. 2006

Detail Information

Publications44

  1. ncbi Cytomegalovirus-specific cell-mediated immunity in HIV-infected children on HAART
    Adriana Weinberg
    Section of Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    AIDS Res Hum Retroviruses 22:283-8. 2006
    ....
  2. ncbi Varicella-Zoster virus-specific cell-mediated immunity in HIV-infected children receiving highly active antiretroviral therapy
    Adriana Weinberg
    Section of Pediatric Infectious Diseases, and Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    J Infect Dis 190:267-70. 2004
    ..After developing HZ, only the 2 HAART-compliant patients developed VZV-CMI. Thus, VZV-specific immune reconstitution in HIV infection may require antigenic reexposure, in addition to control of HIV replication...
  3. ncbi Regulatory T cells generated during cytomegalovirus in vitro stimulation of mononuclear cells from HIV-infected individuals on HAART correlate with decreased lymphocyte proliferation
    Renee D Jesser
    Department of Pediatric Infectious Diseases, University of Colorado Health Sciences Center, 4200 E 9th Avenue, UCHSC School of Medicine, Denver, CO 80262, USA
    Virology 352:408-17. 2006
    ..These data indicate that FoxP3- and TGFbeta1-expressing regulatory T cells contribute to decreased immunity in HAART recipients...
  4. pmc Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Denver, Colorado, USA
    AIDS 22:2267-77. 2008
    ..The goal of HAART is to promote reconstitution of CD4+ T cells and other immune responses. We evaluated the extent and the kinetics of immune reconstitution in HIV-infected children over 144 weeks of successful HAART...
  5. pmc Optimization and limitations of use of cryopreserved peripheral blood mononuclear cells for functional and phenotypic T-cell characterization
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Denver, CO, USA
    Clin Vaccine Immunol 16:1176-86. 2009
    ....
  6. ncbi Risk of transmission of herpesviruses through cord blood transplantation
    Adriana Weinberg
    University of Colorado School of Medicine, Denver, Colorado, USA
    Biol Blood Marrow Transplant 11:35-8. 2005
    ..Our data show that screening prospective CB donors with anti-CMV immunoglobulin M practically eliminates the risk of CB CMV transmission, but HHV-6 warrants CB testing by polymerase chain reaction...
  7. pmc How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients
    Kathryn L Springer
    Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 E 9th Ave, C 227, Denver, CO 80220, USA
    J Clin Microbiol 43:208-13. 2005
    ..Novel antivirals or combination therapy may be required for the treatment of drug-resistant CMV in HCT recipients and perhaps in other severely immunocompromised patients...
  8. ncbi Cytomegalovirus-specific immunity and protection against viremia and disease in HIV-infected patients in the era of highly active antiretroviral therapy
    Adriana Weinberg
    University of Colorado School of Medicine, Denver, 80262, USA
    J Infect Dis 193:488-93. 2006
    ..CMV viremia did not appear to boost CMV-specific immunity. ELISPOT assays may be used to identify HIV-infected patients who might benefit from anti-CMV prophylactic interventions...
  9. ncbi Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine
    Julie Patterson-Bartlett
    Department of Pediatrics of the University of Colorado School of Medicine, Denver, CO 80262, USA
    Vaccine 25:7087-93. 2007
    ..The vaccine significantly increased VZV-specific Th1, memory, early effector, and cutaneous homing receptor-bearing T cells...
  10. ncbi Administration of live varicella vaccine to HIV-infected children with current or past significant depression of CD4(+) T cells
    Myron J Levin
    University of Colorado School of Medicine, Denver, Denver, CO 80262, USA
    J Infect Dis 194:247-55. 2006
    ..The licensed, live attenuated varicella vaccine is safe and immunogenic in HIV-infected children with minimal symptoms and good preservation of CD4(+) T cells (Centers for Disease Control and Prevention immunologic category 1)...
  11. pmc Immunity to human immunodeficiency virus (HIV) in children with chronic HIV infection receiving highly active antiretroviral therapy
    Adriana Weinberg
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Clin Diagn Lab Immunol 10:821-5. 2003
    ..We concluded that the association between HIV CMI and CMV CMI indicates that the same factors govern responsiveness to either antigen...
  12. pmc Distinctive in vitro effects of T-cell growth cytokines on cytomegalovirus-stimulated T-cell responses of HIV-infected HAART recipients
    Julie Patterson
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    Virology 378:48-57. 2008
    ..Overall, compared to other gamma-chain cytokines, IL-15 had the most favorable profile for boosting antiviral cell-mediated immunity...
  13. ncbi Development of resistance to acyclovir during chronic infection with the Oka vaccine strain of varicella-zoster virus, in an immunosuppressed child
    Myron J Levin
    Section of Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Infect Dis 188:954-9. 2003
    ..This is the first report of Oka-strain varicella virus causing severe disease after reactivation and of resistance to acyclovir during an infection caused by this virus...
  14. pmc Reactivation of latent viruses in individuals receiving rituximab for new onset type 1 diabetes
    Jing Lu Kroll
    Divison of Adult Infectious Diseases, University of Colorado School of Medicine, Aurora, USA
    J Clin Virol 57:115-9. 2013
    ..However, like with any immunosuppressive therapy, there is a concern of opportunistic viral reactivations with the use of rituximab, including herpes and polyomaviruses...
  15. ncbi Excess apoptosis of mononuclear cells contributes to the depressed cytomegalovirus-specific immunity in HIV-infected patients on HAART
    Adriana Weinberg
    Department of Pediatrics of the University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Virology 330:313-21. 2004
    ..This effect was not observed in uninfected controls, further indicating that the down regulatory effect of apoptosis on cell-mediated immunity (CMI) was specifically associated with the HIV-infected status...
  16. pmc Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine
    M J Levin
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 197:825-35. 2008
    ..The trial included an immunology substudy to determine the relationship of VZV-specific immune responses to vaccination and clinical outcome...
  17. pmc Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine
    Adriana Weinberg
    University of Colorado Denver, Denver, CO, USA
    J Infect Dis 200:1068-77. 2009
    ....
  18. ncbi Cytomegalovirus infection in the era of HAART: fewer reactivations and more immunity
    Kathryn L Springer
    Departments of Medicine and Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    J Antimicrob Chemother 54:582-6. 2004
    ....
  19. ncbi Ex vivo effect of estrogen and progesterone compared with dexamethasone on cell-mediated immunity of HIV-infected and uninfected subjects
    Laura M Enomoto
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Acquir Immune Defic Syndr 45:137-43. 2007
    ..Overall, HCT concentrations of estrogen and progesterone downregulated ex vivo VZV CMI of HIV-infected and uninfected subjects...
  20. ncbi Antimicrobial-specific cell-mediated immune reconstitution in children with advanced human immunodeficiency virus infection receiving highly active antiretroviral therapy
    Adriana Weinberg
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Infect Dis 39:107-14. 2004
    ..Additional factors for immune reconstitution were low HIV load, high CD4+ cell percentages, and low levels of activated CD8+ cells...
  21. ncbi Susceptibility of herpes simplex virus isolates to nucleoside analogues and the proportion of nucleoside-resistant variants after repeated topical application of penciclovir to recurrent herpes labialis
    Young Kyoo Shin
    Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver, Colorado, USA
    J Infect Dis 187:1241-5. 2003
    ..We conclude that antiviral-resistant variants, which are readily detected in HSV isolates from peripheral lesions, do not accumulate in the sensory ganglia of immunocompetent patients receiving multiple courses of nucleoside analogues...
  22. doi Cytotoxicity of glioblastoma cells mediated ex vivo by varicella-zoster virus-specific T cells
    Jennifer Canniff
    Department of Pediatrics, University Colorado Denver School of Medicine, Denver, CO, USA
    J Neurovirol 17:448-54. 2011
    ..The protective effect of prior VZV infection against the incidence of glioma may be mediated by CTL that recognizes epitopes shared by VZV and glioma cells...
  23. pmc Human herpesviruses 6 and 7 and central nervous system infection in children
    Asad Ansari
    University of Colorado School of Medicine, Denver, Colorado 90262, USA
    Emerg Infect Dis 10:1450-4. 2004
    ..HHV-6 was likely pathogenic in two patients with meningitis who lacked evidence of another microbiologic cause. HHV-6 and HHV-7 are uncommon causes of CNS infection in children. HHV-6 may occasionally cause meningitis in young infants...
  24. ncbi Antibody responses to hepatitis A virus vaccine in HIV-infected children with evidence of immunologic reconstitution while receiving highly active antiretroviral therapy
    Adriana Weinberg
    Department of Pediatrics and Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 193:302-11. 2006
    ..We investigated the safety and immunogenicity of 2 doses of hepatitis A virus (HAV) vaccine followed by a booster dose in HIV-infected children receiving stable highly active antiretroviral therapy...
  25. ncbi Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis
    Adriana Weinberg
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 187:777-84. 2003
    ..016). The incidence of foscarnet resistance after 6, 9, and 12 months of therapy was 13%, 24%, and 37%, respectively...
  26. ncbi Dual infections of the central nervous system with Epstein-Barr virus
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Medical School, Denver, CO 80262, USA
    J Infect Dis 191:234-7. 2005
    ..EBV lytic-cycle mRNA was detected in the cerebrospinal fluid of 5 of 6 tested samples, indicating EBV replication in the CNS during coinfection...
  27. pmc Quality assurance program for peripheral blood mononuclear cell cryopreservation
    Adriana Weinberg
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    Clin Vaccine Immunol 14:1242-4. 2007
    ..S. laboratory for analysis. Cell viability and recovery significantly increased over time. A wet-laboratory training session conducted at the central laboratory significantly improved the quality of the cryopreserved PBMC...
  28. ncbi Relationship of Kaposi sarcoma (KS)-associated herpesvirus viremia and KS disease in Zimbabwe
    Thomas B Campbell
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Clin Infect Dis 36:1144-51. 2003
    ..These findings provide evidence that KSHV viremia is common in advanced AIDS-KS in Zimbabwe and suggest a relationship between KSHV lytic replication and untreated HIV-1 infection...
  29. ncbi Sensitivity of diagnostic tests for influenza varies with the circulating strains
    Adriana Weinberg
    Clinical Virology Laboratory, University of Colorado Hospital, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Clin Virol 33:172-5. 2005
    ..Effective strategies to combat the spread of influenza viruses rely on accurate diagnosis of the infection, which is greatly affected by the sensitivity of the assays used...
  30. pmc Molecular methods for cytomegalovirus surveillance in bone marrow transplant recipients
    Adriana Weinberg
    Departments of Pediatrics, University of Colorado, Denver, Colorado 80262, USA
    J Clin Microbiol 40:4203-6. 2002
    ..These data suggest that WB or PBLs might be the preferred sample for use for surveillance for CMV in immunocompromised patients...
  31. ncbi Human fibroblasts transfected with cytomegalovirus immediate-early genes show increased MHC class I expression and are targets for natural killer cell-mediated cytotoxicity
    Ann Christine Nyquist
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
    Viral Immunol 15:147-54. 2002
    ..Transfection of CMV genes provides an experimental model for molecular studies of CMV- and allograft-specific cell-mediated immunity and modulation...
  32. pmc Impaired immunity to recall antigens and neoantigens in severely immunocompromised children and adolescents during the first year of effective highly active antiretroviral therapy
    Mona Rigaud
    New York University School of Medicine, New York, NY, USA
    J Infect Dis 198:1123-30. 2008
    ....
  33. ncbi Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response
    Andrea Kovacs
    Maternal Child and Adolescent Center for Infectious Disease and Virology, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    J Infect Dis 192:296-302. 2005
    ..For VL rebounders still in the study, CD4 cell counts remained increased for 32 weeks after VL rebound. Sustained immunologic benefits can be achieved even with partial VL response in children with advanced disease...
  34. pmc Reliability of CD4 quantitation in human immunodeficiency virus-positive children: implications for definition of immunologic response to highly active antiretroviral therapy
    Vincent J Carey
    Center for Biostatistics in AIDS Research, Harvard University School of Public Health, Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, Massachusetts 02115, USA
    Clin Diagn Lab Immunol 12:640-3. 2005
    ..Replicates of CD4% measures could be used to improve precision of interpretation of CD4% measures...
  35. ncbi Cytomegalovirus viremia, mortality, and end-organ disease among patients with AIDS receiving potent antiretroviral therapies
    David A Wohl
    Division of Infectious Diseases, The University of North Carolina, Chapel Hill, NC 27599, USA
    J Acquir Immune Defic Syndr 38:538-44. 2005
    ..To determine the association of cytomegalovirus (CMV) viremia with CMV disease and death in patients with AIDS...
  36. ncbi Cytomegalovirus-specific IFN-gamma production is associated with protection against cytomegalovirus reactivation in HIV-infected patients on highly active antiretroviral therapy
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA
    AIDS 17:2445-50. 2003
    ..To identify the predictors of cytomegalovirus reactivation in AIDS patients on highly active antiretroviral therapy (HAART)...
  37. pmc Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates
    Gillian M Scott
    Virology Research, POWH and UNSW Research Laboratories, Level 3 Clinical Sciences Building, Prince of Wales Hospital, Avoca Street, Randwick, NSW 2031, Australia
    Antimicrob Agents Chemother 51:89-94. 2007
    ..The additive effect of multiple mutations on antiviral susceptibility suggests that increasing antiviral-resistant phenotypes can result from different virus-antiviral interactions...
  38. ncbi History of chickenpox and shingles and prevalence of antibodies to varicella-zoster virus and three other herpesviruses among adults with glioma and controls
    Margaret Wrensch
    Department of Neurological Surgery, School of Medicine, University of California, San Francisco, CA 94102, USA
    Am J Epidemiol 161:929-38. 2005
    ..Cohort studies may help to clarify the nature of the association between immunity to and/or clinical manifestations of varicella-zoster virus and glioblastoma...
  39. pmc Adherence to antiretrovirals among US women during and after pregnancy
    Arlene D Bardeguez
    Department of Obstetrics, Gynecology and Women s Health, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103 1709, USA
    J Acquir Immune Defic Syndr 48:408-17. 2008
    ..Antiretrovirals (ARVs) are recommended for maternal health and to reduce HIV-1 mother-to-child transmission, but suboptimal adherence can counteract its benefits...
  40. pmc Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children
    Myron J Levin
    University of Colorado School of Medicine, Aurora, CO 80045 0508, United States
    Vaccine 26:4210-7. 2008
    ..LAIV should be further evaluated for a role in immunizing HIV-infected children...
  41. pmc Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus
    Sunwen Chou
    Division of Infectious Diseases, Oregon Health and Science University, VA Medical Center, Portland, OR 97239, United States
    J Clin Virol 43:107-9. 2008
    ..The levels of resistance conferred by specific mutations are variable, ranging from insignificant resistance to triple-drug resistance...
  42. ncbi Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021
    Ross E McKinney
    Department of Pediatrics, Duke University Medical Center, Box 3461, Durham, NC 27710, USA
    Pediatrics 120:e416-23. 2007
    ..Compliance with complex antiretroviral therapy regimens is a problem for HIV-1-infected children and their families. Simple, safe, and effective regimens are important for long-term therapeutic success...
  43. doi Introduction to the special issue dedicated to the 11th International CMV and Beta Herpesvirus Workshop
    Adriana Weinberg
    Department of Infectious Disease, University of Colorado, 4200 E 9th Avenue, Mail Stop C227, Denver, CO 80262, United States
    J Clin Virol 41:173. 2008
  44. pmc Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens
    Sunwen Chou
    Divisionof Infectious Disease, Oregon Health Science University, VA Medical Center, Portland, OR 97239, USA
    Antimicrob Agents Chemother 51:4160-2. 2007
    ..Bacterial artificial chromosome CMV clones containing pol mutation L845P were nonviable unless repaired with the wild-type sequence...