Adriana Weinberg

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Cytomegalovirus-specific immunity and protection against viremia and disease in HIV-infected patients in the era of highly active antiretroviral therapy
    Adriana Weinberg
    University of Colorado School of Medicine, Denver, 80262, USA
    J Infect Dis 193:488-93. 2006
  2. ncbi Quantitative CSF PCR in Epstein-Barr virus infections of the central nervous system
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Health Sciences Center, Campus Box C227, Denver, CO 80263, USA
    Ann Neurol 52:543-8. 2002
  3. ncbi Molecular methods for cytomegalovirus surveillance in bone marrow transplant recipients
    Adriana Weinberg
    Departments of Pediatrics, University of Colorado, Denver, Colorado 80262, USA
    J Clin Microbiol 40:4203-6. 2002
  4. ncbi Optimization and limitations of use of cryopreserved peripheral blood mononuclear cells for functional and phenotypic T-cell characterization
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Denver, CO, USA
    Clin Vaccine Immunol 16:1176-86. 2009
  5. ncbi Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Denver, Colorado, USA
    AIDS 22:2267-77. 2008
  6. ncbi Immunity to human immunodeficiency virus (HIV) in children with chronic HIV infection receiving highly active antiretroviral therapy
    Adriana Weinberg
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Clin Diagn Lab Immunol 10:821-5. 2003
  7. ncbi Evaluation of R-Mix shell vials for the diagnosis of viral respiratory tract infections
    Adriana Weinberg
    University of Colorado Health Sciences Center, Campus Box C227, 4200 E 9th Avenue, Denver, CO 80262, USA
    J Clin Virol 30:100-5. 2004
  8. ncbi Antimicrobial-specific cell-mediated immune reconstitution in children with advanced human immunodeficiency virus infection receiving highly active antiretroviral therapy
    Adriana Weinberg
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Infect Dis 39:107-14. 2004
  9. ncbi Excess apoptosis of mononuclear cells contributes to the depressed cytomegalovirus-specific immunity in HIV-infected patients on HAART
    Adriana Weinberg
    Department of Pediatrics of the University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Virology 330:313-21. 2004
  10. ncbi Dual infections of the central nervous system with Epstein-Barr virus
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Medical School, Denver, CO 80262, USA
    J Infect Dis 191:234-7. 2005

Research Grants

  1. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2007

Detail Information

Publications91

  1. ncbi Cytomegalovirus-specific immunity and protection against viremia and disease in HIV-infected patients in the era of highly active antiretroviral therapy
    Adriana Weinberg
    University of Colorado School of Medicine, Denver, 80262, USA
    J Infect Dis 193:488-93. 2006
    ..CMV viremia did not appear to boost CMV-specific immunity. ELISPOT assays may be used to identify HIV-infected patients who might benefit from anti-CMV prophylactic interventions...
  2. ncbi Quantitative CSF PCR in Epstein-Barr virus infections of the central nervous system
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Health Sciences Center, Campus Box C227, Denver, CO 80263, USA
    Ann Neurol 52:543-8. 2002
    ..These studies demonstrate the utility of quantitative CSF PCR and establish the presence of lytic cycle EBV mRNA in CSF of patients with EBV-associated neurological disease...
  3. ncbi Molecular methods for cytomegalovirus surveillance in bone marrow transplant recipients
    Adriana Weinberg
    Departments of Pediatrics, University of Colorado, Denver, Colorado 80262, USA
    J Clin Microbiol 40:4203-6. 2002
    ..These data suggest that WB or PBLs might be the preferred sample for use for surveillance for CMV in immunocompromised patients...
  4. ncbi Optimization and limitations of use of cryopreserved peripheral blood mononuclear cells for functional and phenotypic T-cell characterization
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Denver, CO, USA
    Clin Vaccine Immunol 16:1176-86. 2009
    ....
  5. ncbi Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Denver, Colorado, USA
    AIDS 22:2267-77. 2008
    ..The goal of HAART is to promote reconstitution of CD4+ T cells and other immune responses. We evaluated the extent and the kinetics of immune reconstitution in HIV-infected children over 144 weeks of successful HAART...
  6. ncbi Immunity to human immunodeficiency virus (HIV) in children with chronic HIV infection receiving highly active antiretroviral therapy
    Adriana Weinberg
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Clin Diagn Lab Immunol 10:821-5. 2003
    ..We concluded that the association between HIV CMI and CMV CMI indicates that the same factors govern responsiveness to either antigen...
  7. ncbi Evaluation of R-Mix shell vials for the diagnosis of viral respiratory tract infections
    Adriana Weinberg
    University of Colorado Health Sciences Center, Campus Box C227, 4200 E 9th Avenue, Denver, CO 80262, USA
    J Clin Virol 30:100-5. 2004
    ..In contrast, R-Mix harvested at 24h did not seem a very useful diagnostic tool. The utility of R-Mix harvested at 120 h, which accelerated the diagnosis of 16% of positive specimens in study phase 2, needs further investigation...
  8. ncbi Antimicrobial-specific cell-mediated immune reconstitution in children with advanced human immunodeficiency virus infection receiving highly active antiretroviral therapy
    Adriana Weinberg
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Infect Dis 39:107-14. 2004
    ..Additional factors for immune reconstitution were low HIV load, high CD4+ cell percentages, and low levels of activated CD8+ cells...
  9. ncbi Excess apoptosis of mononuclear cells contributes to the depressed cytomegalovirus-specific immunity in HIV-infected patients on HAART
    Adriana Weinberg
    Department of Pediatrics of the University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Virology 330:313-21. 2004
    ..This effect was not observed in uninfected controls, further indicating that the down regulatory effect of apoptosis on cell-mediated immunity (CMI) was specifically associated with the HIV-infected status...
  10. ncbi Dual infections of the central nervous system with Epstein-Barr virus
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Medical School, Denver, CO 80262, USA
    J Infect Dis 191:234-7. 2005
    ..EBV lytic-cycle mRNA was detected in the cerebrospinal fluid of 5 of 6 tested samples, indicating EBV replication in the CNS during coinfection...
  11. ncbi Risk of transmission of herpesviruses through cord blood transplantation
    Adriana Weinberg
    University of Colorado School of Medicine, Denver, Colorado, USA
    Biol Blood Marrow Transplant 11:35-8. 2005
    ..Our data show that screening prospective CB donors with anti-CMV immunoglobulin M practically eliminates the risk of CB CMV transmission, but HHV-6 warrants CB testing by polymerase chain reaction...
  12. ncbi Evaluation of three immunoassay kits for rapid detection of influenza virus A and B
    Adriana Weinberg
    University of Colorado Health Sciences Center, 4200 E 9th Ave, Campus Box C227, Denver, CO 80220, USA
    Clin Diagn Lab Immunol 12:367-70. 2005
    ..Overall, NOW provided the most accurate diagnoses and had user-friendly technical characteristics. However, the low overall sensitivity of the RIIAs indicates that these can be used as screening tools only...
  13. ncbi In vitro cell-mediated immune responses of human immunodeficiency virus-infected and -uninfected individuals to whole cytomegalovirus antigens and their subunits
    A Weinberg
    University of Colorado School of Medicine, Denver, Colorado, USA
    Clin Vaccine Immunol 15:1398-409. 2008
    ..These data show that LPA and the inducible IFN-gamma production elicited by CMV whole lysates may be used to assess modifications of the immune competency of HIV-infected individuals...
  14. ncbi Sensitivity of diagnostic tests for influenza varies with the circulating strains
    Adriana Weinberg
    Clinical Virology Laboratory, University of Colorado Hospital, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Clin Virol 33:172-5. 2005
    ..Effective strategies to combat the spread of influenza viruses rely on accurate diagnosis of the infection, which is greatly affected by the sensitivity of the assays used...
  15. ncbi Quality assurance program for peripheral blood mononuclear cell cryopreservation
    Adriana Weinberg
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    Clin Vaccine Immunol 14:1242-4. 2007
    ..S. laboratory for analysis. Cell viability and recovery significantly increased over time. A wet-laboratory training session conducted at the central laboratory significantly improved the quality of the cryopreserved PBMC...
  16. ncbi Factors that affect in vitro measurement of the susceptibility of herpes simplex virus to nucleoside analogues
    Adriana Weinberg
    Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO, United States
    J Clin Virol 38:139-45. 2007
    ..To identify factors that contribute to variability of HSV antiviral susceptibility breakpoints...
  17. ncbi Antibody responses to hepatitis A virus vaccine in HIV-infected children with evidence of immunologic reconstitution while receiving highly active antiretroviral therapy
    Adriana Weinberg
    Department of Pediatrics and Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 193:302-11. 2006
    ..We investigated the safety and immunogenicity of 2 doses of hepatitis A virus (HAV) vaccine followed by a booster dose in HIV-infected children receiving stable highly active antiretroviral therapy...
  18. ncbi Varicella-Zoster virus-specific cell-mediated immunity in HIV-infected children receiving highly active antiretroviral therapy
    Adriana Weinberg
    Section of Pediatric Infectious Diseases, and Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    J Infect Dis 190:267-70. 2004
    ..After developing HZ, only the 2 HAART-compliant patients developed VZV-CMI. Thus, VZV-specific immune reconstitution in HIV infection may require antigenic reexposure, in addition to control of HIV replication...
  19. ncbi The value of polymerase chain reaction for the diagnosis of viral respiratory tract infections in lung transplant recipients
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Clin Virol 25:171-5. 2002
    ..Respiratory viruses cause severe infections in lung transplant recipients, which require rapid and accurate diagnosis for appropriate management...
  20. ncbi In vitro hydroxyurea decreases Th1 cell-mediated immunity
    A Weinberg
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Clin Diagn Lab Immunol 8:702-5. 2001
    ..These findings suggest that HU-containing therapeutic regimens might decrease Th1-cell-mediated immune responses in vivo...
  21. ncbi Effect of cryopreservation on measurement of cytomegalovirus-specific cellular immune responses in HIV-infected patients
    A Weinberg
    University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Acquir Immune Defic Syndr 25:109-14. 2000
    ..These data indicate that cryopreserved cells are suitable for longitudinal studies of the CMV-specific immune response in HIV-infected patients and uninfected controls...
  22. ncbi Viability and functional activity of cryopreserved mononuclear cells
    A Weinberg
    University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Clin Diagn Lab Immunol 7:714-6. 2000
    ..Preparations with viability greater than or equal to 70% had consistent proliferative responses and were suitable for functional analyses...
  23. ncbi Alloreactive cytotoxic CD4+ responses elicited by cytomegalovirus-infected endothelial cells: role of MHC class I antigens
    A Weinberg
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
    Viral Immunol 13:37-47. 2000
    ..This model offers a framework for understanding the role of CMV infection in graft rejection and for devising preventative strategies...
  24. ncbi Comparison of PCR, antigenemia assay, and rapid blood culture for detection and prevention of cytomegalovirus disease after lung transplantation
    A Weinberg
    Diagnostic Virology Laboratory of the Department of Pediatrics and Respiratory Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Microbiol 38:768-72. 2000
    ..CMV DNA (as detected by PCR), but not antigenemia, persisted in patients who later developed recurrent CMV disease. The data indicate that lung transplant recipients will benefit from monitoring of CMV disease by plasma CMV PCR...
  25. ncbi Effect of shipment, storage, anticoagulant, and cell separation on lymphocyte proliferation assays for human immunodeficiency virus-infected patients
    A Weinberg
    University of Colorado School of Medicine, Denver, Colorado, USA
    Clin Diagn Lab Immunol 5:804-7. 1998
    ..However, if on-site testing is not available, optimal transportation conditions should be established for specific antigens...
  26. ncbi Inconsistent reconstitution of cytomegalovirus-specific cell-mediated immunity in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy
    A Weinberg
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Infect Dis 184:707-12. 2001
    ....
  27. ncbi The role of immune reconstitution in cytomegalovirus infection
    Adriana Weinberg
    Departments of Pediatrics and Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box C227, Denver, CO 80262, USA
    BioDrugs 16:89-95. 2002
    ..In addition, there is a continuous effort to develop CMV-specific immune-based therapies including vaccines and immune modulators such as cytokines, which may be of supplemental benefit in the control of CMV disease...
  28. ncbi Anti-influenza serum and mucosal antibody responses after administration of live attenuated or inactivated influenza vaccines to HIV-infected children
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA
    J Acquir Immune Defic Syndr 55:189-96. 2010
    ..Live-attenuated influenza vaccine (LAIV) prevents more cases of influenza in immune-competent children than the trivalent inactivated vaccine (TIV). We compared the antibody responses to LAIV or TIV in HIV-infected children...
  29. ncbi Cytomegalovirus-specific cell-mediated immunity in HIV-infected children on HAART
    Adriana Weinberg
    Section of Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    AIDS Res Hum Retroviruses 22:283-8. 2006
    ....
  30. ncbi Kinetics and determining factors of the virologic response to antiretrovirals during pregnancy
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Infect Dis Obstet Gynecol 2009:621780. 2009
    ..In conclusion, the virologic responses of pregnant and nonpregnant adults share similar characteristics...
  31. ncbi Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatment
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Acquir Immune Defic Syndr 52:17-24. 2009
    ..We sought to identify the immunologic and virologic factors associated with a robust response to hepatitis A virus (HAV) vaccine in children on highly active antiretroviral treatment...
  32. ncbi Cytomegalovirus-specific IFN-gamma production is associated with protection against cytomegalovirus reactivation in HIV-infected patients on highly active antiretroviral therapy
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA
    AIDS 17:2445-50. 2003
    ....
  33. ncbi Regulatory T cells generated during cytomegalovirus in vitro stimulation of mononuclear cells from HIV-infected individuals on HAART correlate with decreased lymphocyte proliferation
    Renee D Jesser
    Department of Pediatric Infectious Diseases, University of Colorado Health Sciences Center, 4200 E. 9th Avenue, UCHSC School of Medicine, Denver, CO 80262, USA
    Virology 352:408-17. 2006
    ..These data indicate that FoxP3- and TGFbeta1-expressing regulatory T cells contribute to decreased immunity in HAART recipients...
  34. ncbi A phase I-II study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicella
    Anne A Gershon
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Pediatr Infect Dis J 28:653-5. 2009
    ..There were no serious adverse events. Two years after vaccination 82% of subjects remained VZV-antibody positive and 60% had VZV-specific cell-mediated immunity. No child developed herpes zoster...
  35. ncbi Influence of age and nature of primary infection on varicella-zoster virus-specific cell-mediated immune responses
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA
    J Infect Dis 201:1024-30. 2010
    ..We studied the relationship between VZV cell-mediated immunity and age after varicella or VZV vaccination in healthy and human immunodeficiency virus (HIV)-infected individuals...
  36. ncbi Kinetics of viral shedding and immune responses in adults following administration of cold-adapted influenza vaccine
    Laura L Hammitt
    Section of Infectious Diseases, Department of Pediatrics, University of Colorado Denver, Denver, CO, United States
    Vaccine 27:7359-66. 2009
    ..PBMCs from subjects receiving CAIV showed a higher proportion of functional, tissue-tropic T-cells (CD4+CD69+CD18+MIP1alpha+) specific for homotypic and heterosubtypic strains of influenza by flow cytometry...
  37. ncbi Development of resistance to acyclovir during chronic infection with the Oka vaccine strain of varicella-zoster virus, in an immunosuppressed child
    Myron J Levin
    Section of Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Infect Dis 188:954-9. 2003
    ..This is the first report of Oka-strain varicella virus causing severe disease after reactivation and of resistance to acyclovir during an infection caused by this virus...
  38. ncbi Regulatory function of cytomegalovirus-specific CD4+CD27-CD28- T cells
    Adriana Tovar-Salazar
    University of Colorado Denver School of Medicine, Aurora, CO, USA
    Virology 398:158-67. 2010
    ..The CMV-CD4+CD27-CD28- TR may contribute to the downregulation of CMV-specific and nonspecific immune responses of CMV-infected individuals...
  39. ncbi Safety and immunogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine in HIV-infected children 7 to 12 years old
    Myron J Levin
    Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, USA
    J Acquir Immune Defic Syndr 55:197-204. 2010
    ..Quadrivalent human papillomavirus vaccine (QHPV) is > 95% effective in preventing infection with vaccine-type human papillomavirus. The safety and immunogenicity of QHPV are unknown in HIV-infected children...
  40. ncbi Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine
    Julie Patterson Bartlett
    Department of Pediatrics of the University of Colorado School of Medicine, Denver, CO 80262, USA
    Vaccine 25:7087-93. 2007
    ..The vaccine significantly increased VZV-specific Th1, memory, early effector, and cutaneous homing receptor-bearing T cells...
  41. ncbi Immune correlates of herpes zoster in HIV-infected children and youth
    Adriana Weinberg
    University of Colorado Denver, Aurora, Colorado, USA
    J Virol 86:2878-81. 2012
    ..In contrast, high nonspecific regulatory and activated T cells were associated with an increased risk of HZ...
  42. ncbi How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients
    Kathryn L Springer
    Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 E. 9th Ave, C-227, Denver, CO 80220, USA
    J Clin Microbiol 43:208-13. 2005
    ..Novel antivirals or combination therapy may be required for the treatment of drug-resistant CMV in HCT recipients and perhaps in other severely immunocompromised patients...
  43. ncbi Safety and immunogenicity of a live attenuated varicella vaccine in VZV-seropositive HIV-infected adults
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Aurora, CO, USA
    Hum Vaccin 6:318-21. 2010
    ..We evaluated the safety and immunogenicity of a live attenuated varicella-zoster virus (VZV) vaccine as a candidate for protecting HIV-infected adults against herpes-zoster...
  44. ncbi Administration of live varicella vaccine to HIV-infected children with current or past significant depression of CD4(+) T cells
    Myron J Levin
    University of Colorado School of Medicine, Denver, Denver, CO 80262, USA
    J Infect Dis 194:247-55. 2006
    ..The licensed, live attenuated varicella vaccine is safe and immunogenic in HIV-infected children with minimal symptoms and good preservation of CD4(+) T cells (Centers for Disease Control and Prevention immunologic category 1)...
  45. ncbi Distinctive in vitro effects of T-cell growth cytokines on cytomegalovirus-stimulated T-cell responses of HIV-infected HAART recipients
    Julie Patterson
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    Virology 378:48-57. 2008
    ..Overall, compared to other gamma-chain cytokines, IL-15 had the most favorable profile for boosting antiviral cell-mediated immunity...
  46. ncbi Human herpesviruses 6 and 7 and central nervous system infection in children
    Asad Ansari
    University of Colorado School of Medicine, Denver, Colorado 90262, USA
    Emerg Infect Dis 10:1450-4. 2004
    ..HHV-6 was likely pathogenic in two patients with meningitis who lacked evidence of another microbiologic cause. HHV-6 and HHV-7 are uncommon causes of CNS infection in children. HHV-6 may occasionally cause meningitis in young infants...
  47. ncbi Humoral, mucosal, and cell-mediated immunity against vaccine and nonvaccine genotypes after administration of quadrivalent human papillomavirus vaccine to HIV-infected children
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    J Infect Dis 206:1309-18. 2012
    ..To characterize the immunogenicity of a quadrivalent human papillomavirus vaccine (QHPV) in human immunodeficiency virus (HIV)-infected children, we studied their immune responses to 3 or 4 doses...
  48. ncbi Optimization of storage and shipment of cryopreserved peripheral blood mononuclear cells from HIV-infected and uninfected individuals for ELISPOT assays
    Adriana Weinberg
    Infectious Diseases, University of Colorado Denver, Aurora, CO, United States
    J Immunol Methods 363:42-50. 2010
    ..However, ELISPOT values significantly decreased with the duration of storage at -70°C both in HIV-infected and uninfected donors. ELISPOT results also decreased with PBMC viability <70%...
  49. ncbi Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis
    Adriana Weinberg
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 187:777-84. 2003
    ..016). The incidence of foscarnet resistance after 6, 9, and 12 months of therapy was 13%, 24%, and 37%, respectively...
  50. ncbi Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine
    M J Levin
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 197:825-35. 2008
    ..The trial included an immunology substudy to determine the relationship of VZV-specific immune responses to vaccination and clinical outcome...
  51. ncbi Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children
    Myron J Levin
    University of Colorado School of Medicine, Aurora, CO 80045 0508, United States
    Vaccine 26:4210-7. 2008
    ..LAIV should be further evaluated for a role in immunizing HIV-infected children...
  52. ncbi Susceptibility of herpes simplex virus isolates to nucleoside analogues and the proportion of nucleoside-resistant variants after repeated topical application of penciclovir to recurrent herpes labialis
    Young Kyoo Shin
    Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver, Colorado, USA
    J Infect Dis 187:1241-5. 2003
    ..We conclude that antiviral-resistant variants, which are readily detected in HSV isolates from peripheral lesions, do not accumulate in the sensory ganglia of immunocompetent patients receiving multiple courses of nucleoside analogues...
  53. ncbi Ex vivo effect of estrogen and progesterone compared with dexamethasone on cell-mediated immunity of HIV-infected and uninfected subjects
    Laura M Enomoto
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Acquir Immune Defic Syndr 45:137-43. 2007
    ..Overall, HCT concentrations of estrogen and progesterone downregulated ex vivo VZV CMI of HIV-infected and uninfected subjects...
  54. ncbi Use of PCR for the diagnosis of herpesvirus infections of the central nervous system
    Roberta L Debiasi
    Department of Pediatrics, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, 80262, Denver, CO 80262, USA
    J Clin Virol 25:S5-11. 2002
    ..This review summarizes the role of CSF PCR in the diagnosis and therapeutic management of herpesvirus infections of the nervous system, particularly those caused by HSV and VZV...
  55. ncbi Lopinavir exposure with an increased dose during pregnancy
    Mark Mirochnick
    Department of Pediatrics, Boston University School of Medicine, and Infectious Disease Division, Children s Hospital Boston, Boston, MA 02118, USA
    J Acquir Immune Defic Syndr 49:485-91. 2008
    ..The goal of this study was to determine LPV exposure during the third trimester of pregnancy and 2 weeks postpartum with a higher LPV/RTV dose...
  56. ncbi Resistance to antiretrovirals in HIV-infected pregnant women
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    J Clin Virol 45:39-42. 2009
    ..Antiretrovirals suppress HIV replication and prevent mother-to-child-transmission of HIV (PMTCT). Resistance to antiretrovirals may reduce the efficacy of PMTCT and/or complicate treatment of maternal or infant infection...
  57. ncbi Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine
    Adriana Weinberg
    University of Colorado Denver, Denver, CO, USA
    J Infect Dis 200:1068-77. 2009
    ....
  58. ncbi Human fibroblasts transfected with cytomegalovirus immediate-early genes show increased MHC class I expression and are targets for natural killer cell-mediated cytotoxicity
    Ann Christine Nyquist
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
    Viral Immunol 15:147-54. 2002
    ..Transfection of CMV genes provides an experimental model for molecular studies of CMV- and allograft-specific cell-mediated immunity and modulation...
  59. ncbi Dynamics of regulatory T-cells during pregnancy: effect of HIV infection and correlations with other immune parameters
    Kelly Richardson
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 6:e28172. 2011
    ..We studied Treg subpopulations in HIV-infected and uninfected women during pregnancy and their relationship with inflammation, activation and cell-mediated immunity (CMI)...
  60. ncbi Cytomegalovirus infection in the era of HAART: fewer reactivations and more immunity
    Kathryn L Springer
    Departments of Medicine and Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    J Antimicrob Chemother 54:582-6. 2004
    ....
  61. ncbi Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021
    Ross E McKinney
    Department of Pediatrics, Duke University Medical Center, Box 3461, Durham, NC 27710, USA
    Pediatrics 120:e416-23. 2007
    ..Compliance with complex antiretroviral therapy regimens is a problem for HIV-1-infected children and their families. Simple, safe, and effective regimens are important for long-term therapeutic success...
  62. ncbi Reduced immunogenicity of influenza vaccines in HIV-infected compared with uninfected pregnant women is associated with regulatory T cells
    Kelly Richardson
    Department of Pediatrics, University of Colorado Denver, Aurora, USA
    AIDS 25:595-602. 2011
    ..To evaluate the immunogenicity of influenza vaccines in HIV-infected pregnant women and the factors that may determine this response...
  63. ncbi Recurrences of cytomegalovirus retinitis in a human immunodeficiency virus-infected patient, despite potent antiretroviral therapy and apparent immune reconstitution
    S C Johnson
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Infect Dis 32:815-9. 2001
    ..In addition, lymphoproliferative responses to CMV antigens were absent despite evidence of reactivity to Candida antigen and pokeweed mitogen. The clinical significance of this case and of other recently reported cases is discussed...
  64. ncbi Live virus survives excimer laser ablation
    M J Taravella
    Department of Ophthalmology, University of Colorado Health Sciences Center, Denver, USA
    Ophthalmology 106:1498-9. 1999
    ..To determine whether live virus can withstand excimer laser ablation and pose a possible health hazard to medical personnel...
  65. ncbi Cytokine production in varicella-zoster virus-stimulated cultures of human blood lymphocytes
    A R Hayward
    Department of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA
    J Infect Dis 178:S95-8. 1998
    ..48, P = .03). Nevertheless, correlations between levels of these cytokines and RCF did not reach statistically significant levels...
  66. ncbi Treatment of multidrug-resistant cytomegalovirus retinitis with systemically administered leflunomide
    M E Levi
    Department of Medicine, Division of Infectious Disease, University of Colorado School of Medicine, Denver, Colorado 80224, USA
    Transpl Infect Dis 8:38-43. 2006
    ..These initial findings suggest that leflunomide may be useful in the treatment of CMV disease, including retinitis in patients after solid organ transplantation...
  67. ncbi Immunization of HIV-infected children with varicella vaccine
    M J Levin
    University of Colorado School of Medicine, Denver, USA
    J Pediatr 139:305-10. 2001
    ..CONCLUSION: On the basis of its safety and immunogenicity, varicella vaccine should be considered in the childhood vaccines given to mildly affected HIV-infected children...
  68. ncbi Cytotoxicity of glioblastoma cells mediated ex vivo by varicella-zoster virus-specific T cells
    Jennifer Canniff
    Department of Pediatrics, University Colorado Denver School of Medicine, Denver, CO, USA
    J Neurovirol 17:448-54. 2011
    ..The protective effect of prior VZV infection against the incidence of glioma may be mediated by CTL that recognizes epitopes shared by VZV and glioma cells...
  69. ncbi Relationship of Kaposi sarcoma (KS)-associated herpesvirus viremia and KS disease in Zimbabwe
    Thomas B Campbell
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Clin Infect Dis 36:1144-51. 2003
    ..These findings provide evidence that KSHV viremia is common in advanced AIDS-KS in Zimbabwe and suggest a relationship between KSHV lytic replication and untreated HIV-1 infection...
  70. ncbi Effect of menstrual cycle variation in female sex hormones on cellular immunity and regulation
    Adriana Weinberg
    Department of Pediatrics, The University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA
    J Reprod Immunol 89:70-7. 2011
    ..In conclusion, the increase in progesterone levels during the menstrual cycle was associated with higher Treg frequencies and lower CMI...
  71. ncbi Evaluation of a commercial PCR kit for diagnosis of cytomegalovirus infection of the central nervous system
    A Weinberg
    Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver, Colorado, USA
    J Clin Microbiol 36:3382-4. 1998
    ..The AMPLICOR kit showed sensitivity and specificity of 95 and 100%, respectively, versus the home-grown assay, indicating its utility in this clinical setting...
  72. ncbi Introduction to the special issue dedicated to the 11th International CMV and Beta Herpesvirus Workshop
    Adriana Weinberg
    Department of Infectious Disease, University of Colorado, 4200 E. 9th Avenue, Mail Stop C227, Denver, CO 80262, United States
    J Clin Virol 41:173. 2008
  73. ncbi Development of acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum
    M J Levin
    Section of Infectious Diseases Department of Pediatrics University of Colorado School of Medicine Denver, CO, USA
    Pediatr Infect Dis J 20:1094-7. 2001
    ....
  74. ncbi The varicella-autoantibody syndrome
    C Josephson
    Departments of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pediatr Res 50:345-52. 2001
    ..0002). Autoantibodies were transient. Transient antiphospholipid and coagulation protein autoantibodies were common with VZV infection, but were not predictive of thrombotic complications...
  75. ncbi Safety and immunogenicity of varicella-zoster virus vaccine in pediatric liver and intestine transplant recipients
    A Weinberg
    Dept. Pediatrics, University of Colorado Health Services Center, Denver, CO, USA
    Am J Transplant 6:565-8. 2006
    ..Varivax was safe and immunogenic in pediatric liver and intestine transplant recipients. Larger studies are needed to establish the efficacy and role of varicella vaccination after transplantation...
  76. ncbi Screening positive urine pregnancy tests for sexually transmitted diseases expedites the treatment of infected adolescent gravidas
    C Stevens-Simon
    Department of Pediatrics, University of Colorado Health Science Center, The Children's Hospital, Denver 80218, USA
    J Matern Fetal Neonatal Med 11:391-5. 2002
    ....
  77. ncbi Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates
    Gillian M Scott
    Virology Research, POWH and UNSW Research Laboratories, Level 3 Clinical Sciences Building, Prince of Wales Hospital, Avoca Street, Randwick, NSW 2031, Australia
    Antimicrob Agents Chemother 51:89-94. 2007
    ..The additive effect of multiple mutations on antiviral susceptibility suggests that increasing antiviral-resistant phenotypes can result from different virus-antiviral interactions...
  78. ncbi Model for assessment of proficiency of human immunodeficiency virus type 1 sequencing-based genotypic antiretroviral assays
    Diana D Huang
    Department of Immunology Microbiology, Rush Medical College, 1653 W Congress Parkway, Chicago, IL 60612, USA
    J Clin Microbiol 43:3963-70. 2005
    ..These criteria are applicable to all sequence-based genotyping platforms and have been used as a baseline for assessing the performance of genotyping for the determination of antiretroviral resistance in our ongoing proficiency program...
  79. ncbi Evaluation of three influenza A and B rapid antigen detection kits--update
    Adriana Weinberg
    Clin Diagn Lab Immunol 12:1010. 2005
  80. ncbi Development of herpes simplex virus disease in patients who are receiving cidofovir
    David L Wyles
    Division of Infectious Diseases, University of California, San Diego, CA, USA
    Clin Infect Dis 41:676-80. 2005
    ..In vitro resistance to cidofovir has been reported with use of laboratory HSV strains; clinical failure of cidofovir therapy for HSV disease has also been reported with an isolate that was susceptible by in vitro testing...
  81. ncbi Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens
    Sunwen Chou
    Divisionof Infectious Disease, Oregon Health Science University, VA Medical Center, Portland, OR 97239, USA
    Antimicrob Agents Chemother 51:4160-2. 2007
    ..Bacterial artificial chromosome CMV clones containing pol mutation L845P were nonviable unless repaired with the wild-type sequence...
  82. ncbi Cytomegalovirus viremia, mortality, and end-organ disease among patients with AIDS receiving potent antiretroviral therapies
    David A Wohl
    Division of Infectious Diseases, The University of North Carolina, Chapel Hill, NC 27599, USA
    J Acquir Immune Defic Syndr 38:538-44. 2005
    ..To determine the association of cytomegalovirus (CMV) viremia with CMV disease and death in patients with AIDS...
  83. ncbi Susceptibilities of herpes simplex viruses to penciclovir and acyclovir in eight cell lines
    Jeffry J Leary
    GlaxoSmithKline, The Antimicrobial and Host Defense Center of Excellence for Drug Discovery, Department of Host Defense, Collegeville, Pennsylvania, USA
    Antimicrob Agents Chemother 46:762-8. 2002
    ..Comparison experiments with a yield reduction format indicated that the use of assays of this type might allow some of the cell-specific properties observed in plaque reduction assays to be avoided...
  84. ncbi Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response
    Andrea Kovacs
    Maternal Child and Adolescent Center for Infectious Disease and Virology, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    J Infect Dis 192:296-302. 2005
    ..For VL rebounders still in the study, CD4 cell counts remained increased for 32 weeks after VL rebound. Sustained immunologic benefits can be achieved even with partial VL response in children with advanced disease...
  85. ncbi Reliability of CD4 quantitation in human immunodeficiency virus-positive children: implications for definition of immunologic response to highly active antiretroviral therapy
    Vincent J Carey
    Center for Biostatistics in AIDS Research, Harvard University School of Public Health, Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, Massachusetts 02115, USA
    Clin Diagn Lab Immunol 12:640-3. 2005
    ..Replicates of CD4% measures could be used to improve precision of interpretation of CD4% measures...
  86. ncbi Vaccination against Herpes Zoster and Postherpetic Neuralgia
    Michael N Oxman
    VA San Diego Healthcare System, San Diego, California, USA
    J Infect Dis 197:S228-36. 2008
    ..VZV vaccines can boost VZV-CMI. Therefore, we tested the hypothesis that VZV vaccination would protect older adults against HZ and PHN...
  87. ncbi Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus
    Sunwen Chou
    Division of Infectious Diseases, Oregon Health and Science University, VA Medical Center, Portland, OR 97239, United States
    J Clin Virol 43:107-9. 2008
    ..The levels of resistance conferred by specific mutations are variable, ranging from insignificant resistance to triple-drug resistance...
  88. ncbi History of chickenpox and shingles and prevalence of antibodies to varicella-zoster virus and three other herpesviruses among adults with glioma and controls
    Margaret Wrensch
    Department of Neurological Surgery, School of Medicine, University of California, San Francisco, CA 94102, USA
    Am J Epidemiol 161:929-38. 2005
    ..Cohort studies may help to clarify the nature of the association between immunity to and/or clinical manifestations of varicella-zoster virus and glioblastoma...
  89. ncbi Impaired immunity to recall antigens and neoantigens in severely immunocompromised children and adolescents during the first year of effective highly active antiretroviral therapy
    Mona Rigaud
    New York University School of Medicine, New York, NY, USA
    J Infect Dis 198:1123-30. 2008
    ....
  90. ncbi Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells
    Ofer Levy
    Division Infectious Diseases, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 188:948-53. 2003
    ....
  91. ncbi Adherence to antiretrovirals among US women during and after pregnancy
    Arlene D Bardeguez
    Department of Obstetrics, Gynecology and Women s Health, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103 1709, USA
    J Acquir Immune Defic Syndr 48:408-17. 2008
    ..Antiretrovirals (ARVs) are recommended for maternal health and to reduce HIV-1 mother-to-child transmission, but suboptimal adherence can counteract its benefits...

Research Grants2

  1. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2007
    ..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. ..