Ivan Jeanne Weiler

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. doi request reprint Early-phase ERK activation as a biomarker for metabolic status in fragile X syndrome
    Ning Weng
    Beckman Institute, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1253-7. 2008
  2. doi request reprint Descartins, the memory molecules
    Ivan Jeanne Weiler
    Psychology Department and Beckman Institute, University of Illinois at Urbana Champaign, USA
    Dev Psychobiol 53:476-81. 2011
  3. pmc Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses
    Ivan Jeanne Weiler
    Beckman Institute, Neuroscience Program, and Departments of Psychology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 101:17504-9. 2004
  4. ncbi request reprint Fragile X mental retardation protein levels increase following complex environment exposure in rat brain regions undergoing active synaptogenesis
    Scott A Irwin
    Beckman Institute, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Neurobiol Learn Mem 83:180-7. 2005
  5. ncbi request reprint Effects of Fragile X syndrome and an FMR1 knockout mouse model on forebrain neuronal cell biology
    James D Churchill
    Beckman Institute, University of Illinois, Urbana, Illinois 61801, USA
    Microsc Res Tech 57:156-8. 2002
  6. pmc Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein
    Der I Kao
    Department of Cell and Developmental Biology, Beckman Institute, Neuroscience Program, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 107:15601-6. 2010
  7. pmc Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome
    Soong Ho Kim
    Beckman Institute, Neuroscience Program, and Departments of Psychology, Psychiatry, and Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 105:4429-34. 2008
  8. ncbi request reprint Fragile X mental retardation protein shifts between polyribosomes and stress granules after neuronal injury by arsenite stress or in vivo hippocampal electrode insertion
    Soong Ho Kim
    Beckman Institute, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Neurosci 26:2413-8. 2006
  9. ncbi request reprint Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond
    Aaron W Grossman
    Beckman Institute, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Neurosci 26:7151-5. 2006
  10. pmc The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting
    Georgina M Aldridge
    Beckman Institute, University of Illinois at Urbana Champaign, USA
    J Neurosci Methods 172:250-4. 2008

Collaborators

Detail Information

Publications15

  1. doi request reprint Early-phase ERK activation as a biomarker for metabolic status in fragile X syndrome
    Ning Weng
    Beckman Institute, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1253-7. 2008
    ....
  2. doi request reprint Descartins, the memory molecules
    Ivan Jeanne Weiler
    Psychology Department and Beckman Institute, University of Illinois at Urbana Champaign, USA
    Dev Psychobiol 53:476-81. 2011
    ..Recent studies have implicated ERK (extracellular receptor regulated kinase) as a central factor in regulating the kinetics of translation at the synapse...
  3. pmc Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses
    Ivan Jeanne Weiler
    Beckman Institute, Neuroscience Program, and Departments of Psychology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 101:17504-9. 2004
    ..This deficit in rapid neurotransmitter-controlled local translation of specific proteins may contribute to morphological and functional abnormalities observed in patients with fragile X syndrome...
  4. ncbi request reprint Fragile X mental retardation protein levels increase following complex environment exposure in rat brain regions undergoing active synaptogenesis
    Scott A Irwin
    Beckman Institute, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Neurobiol Learn Mem 83:180-7. 2005
    ....
  5. ncbi request reprint Effects of Fragile X syndrome and an FMR1 knockout mouse model on forebrain neuronal cell biology
    James D Churchill
    Beckman Institute, University of Illinois, Urbana, Illinois 61801, USA
    Microsc Res Tech 57:156-8. 2002
    ..1994) Cell 78:23-33]. These mice show molecular, morphological, and behavioral alterations consistent with phenotypes observed in FraX patients, making them good models to study the absence of FMRP expression...
  6. pmc Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein
    Der I Kao
    Department of Cell and Developmental Biology, Beckman Institute, Neuroscience Program, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 107:15601-6. 2010
    ..These data suggest that FMRP can mediate spatial mRNA delivery for local protein synthesis in response to synaptic stimulation...
  7. pmc Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome
    Soong Ho Kim
    Beckman Institute, Neuroscience Program, and Departments of Psychology, Psychiatry, and Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 105:4429-34. 2008
    ..We propose that overactivation of phosphatases in synapses may be a key deficit in FXS, which affects synaptic translation, transcription, and synaptic receptor regulation...
  8. ncbi request reprint Fragile X mental retardation protein shifts between polyribosomes and stress granules after neuronal injury by arsenite stress or in vivo hippocampal electrode insertion
    Soong Ho Kim
    Beckman Institute, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Neurosci 26:2413-8. 2006
    ....
  9. ncbi request reprint Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond
    Aaron W Grossman
    Beckman Institute, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Neurosci 26:7151-5. 2006
    ..Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein)...
  10. pmc The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting
    Georgina M Aldridge
    Beckman Institute, University of Illinois at Urbana Champaign, USA
    J Neurosci Methods 172:250-4. 2008
    ....
  11. ncbi request reprint Dendritic spine and dendritic field characteristics of layer V pyramidal neurons in the visual cortex of fragile-X knockout mice
    Scott A Irwin
    Neuroscience Program, University of Illinois, Urbana, Illinois 61801, USA
    Am J Med Genet 111:140-6. 2002
    ..They also support the validity of these mice as a model of fragile-X syndrome...
  12. pmc Neuropeptide Release is Impaired in a Mouse Model of Fragile X Mental Retardation Syndrome
    Suresh P Annangudi
    Beckman Institute, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    ACS Chem Neurosci 1:306-314. 2010
    ..Therefore, deficits associated with FXS may reflect this aberrant vesicle release, specifically involving docking and fusion of peptidergic DCVs, and may lead to defective maturation/maintenance of synaptic connections...
  13. ncbi request reprint A converging-methods approach to fragile X syndrome
    James D Churchill
    Beckman Institute, Neuroscience Program and Department of Psychology, University of Illinois, Urbana, IL 61801, USA
    Dev Psychobiol 40:323-38. 2002
    ..The developmental outcome in Fragile X is a nervous system that is relatively disorganized, resulting in disrupted perceptual, and cognitive social, behavior...
  14. ncbi request reprint NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes
    Barbara Bardoni
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 10142, 67404 Illkirch, C U de Strasbourg, France
    Exp Cell Res 289:95-107. 2003
    ..These findings suggest the involvement of NUFIP1 in the export and localization of mRNA and, in association with FMRP, in the regulation of local protein synthesis near synapses...
  15. ncbi request reprint RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice
    Kevin Y Miyashiro
    Department of Pharmacology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 37:417-31. 2003
    ..These data are consistent with spatially selective regulation of multiple biological pathways by FMRP...