DAVID WEIGLE

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Evaluation of leptin levels in subjects at risk for type 1 diabetes
    Lisa K Gilliam
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    J Autoimmun 26:133-7. 2006
  2. pmc Dietary n-3-polyunsaturated fatty acids and energy balance in overweight or moderately obese men and women: a randomized controlled trial
    Mario Kratz
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
    Nutr Metab (Lond) 6:24. 2009
  3. ncbi request reprint Defective dietary induction of uncoupling protein 3 in skeletal muscle of obesity-prone rats
    D S Weigle
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    Obes Res 8:385-91. 2000
  4. ncbi request reprint A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations
    David S Weigle
    University of Washington School of Medicine, Seattle, WA, USA
    Am J Clin Nutr 82:41-8. 2005
  5. ncbi request reprint Pharmacological therapy of obesity: past, present, and future
    David S Weigle
    Endocrinology, University of Washington School of Medicine and Harborview Medical Center, Seattle, Washington 98104, USA
    J Clin Endocrinol Metab 88:2462-9. 2003
  6. ncbi request reprint Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet
    David S Weigle
    University of Washington School of Medicine, Veterans Affairs Puget Sound Health Care System, and Harborview Medical Center, Seattle, Washington 98104, USA
    J Clin Endocrinol Metab 88:1577-86. 2003
  7. ncbi request reprint Modified macronutrient diets and weight loss--are food choice and variety more important than caloric restriction?
    David S Weigle
    Endocrinology, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
    Nat Clin Pract Endocrinol Metab 3:728-9. 2007
  8. ncbi request reprint Adaptation to altitude as a vehicle for experiential learning of physiology by university undergraduates
    David S Weigle
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    Adv Physiol Educ 31:270-8. 2007
  9. ncbi request reprint Plasma C-reactive protein concentration is not affected by isocaloric dietary fat reduction
    Mikhail S Koren
    University of Washington School of Medicine, Seattle, Washington, USA
    Nutrition 22:444-8. 2006
  10. pmc Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women
    Mario Kratz
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 87:347-53. 2008

Research Grants

Detail Information

Publications28

  1. ncbi request reprint Evaluation of leptin levels in subjects at risk for type 1 diabetes
    Lisa K Gilliam
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    J Autoimmun 26:133-7. 2006
    ....
  2. pmc Dietary n-3-polyunsaturated fatty acids and energy balance in overweight or moderately obese men and women: a randomized controlled trial
    Mario Kratz
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
    Nutr Metab (Lond) 6:24. 2009
    ..abstract:..
  3. ncbi request reprint Defective dietary induction of uncoupling protein 3 in skeletal muscle of obesity-prone rats
    D S Weigle
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    Obes Res 8:385-91. 2000
    ....
  4. ncbi request reprint A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations
    David S Weigle
    University of Washington School of Medicine, Seattle, WA, USA
    Am J Clin Nutr 82:41-8. 2005
    ..Ad libitum, low-carbohydrate diets decrease caloric intake and cause weight loss. It is unclear whether these effects are due to the reduced carbohydrate content of such diets or to their associated increase in protein intake...
  5. ncbi request reprint Pharmacological therapy of obesity: past, present, and future
    David S Weigle
    Endocrinology, University of Washington School of Medicine and Harborview Medical Center, Seattle, Washington 98104, USA
    J Clin Endocrinol Metab 88:2462-9. 2003
  6. ncbi request reprint Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet
    David S Weigle
    University of Washington School of Medicine, Veterans Affairs Puget Sound Health Care System, and Harborview Medical Center, Seattle, Washington 98104, USA
    J Clin Endocrinol Metab 88:1577-86. 2003
    ..Fat restriction avoids the increase in ghrelin levels caused by dietary energy restriction...
  7. ncbi request reprint Modified macronutrient diets and weight loss--are food choice and variety more important than caloric restriction?
    David S Weigle
    Endocrinology, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
    Nat Clin Pract Endocrinol Metab 3:728-9. 2007
  8. ncbi request reprint Adaptation to altitude as a vehicle for experiential learning of physiology by university undergraduates
    David S Weigle
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    Adv Physiol Educ 31:270-8. 2007
    ....
  9. ncbi request reprint Plasma C-reactive protein concentration is not affected by isocaloric dietary fat reduction
    Mikhail S Koren
    University of Washington School of Medicine, Seattle, Washington, USA
    Nutrition 22:444-8. 2006
    ..However, it remains unclear whether dietary fat has an effect independent from weight change on markers of inflammation...
  10. pmc Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women
    Mario Kratz
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 87:347-53. 2008
    ..Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents...
  11. ncbi request reprint Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial
    Laura Lewis Frank
    Fred Hutchinson Cancer Research Center, Cancer Prevention, Seattle, WA 98109 1024, USA
    Obes Res 13:615-25. 2005
    ..This study examined the effects of exercise on metabolic risk variables insulin, leptin, glucose, and triglycerides in overweight/obese postmenopausal women...
  12. ncbi request reprint Insulin, C-peptide, and leptin concentrations predict increased visceral adiposity at 5- and 10-year follow-ups in nondiabetic Japanese Americans
    Jenny Tong
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98108, USA
    Diabetes 54:985-90. 2005
    ....
  13. ncbi request reprint Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery
    David E Cummings
    Department of Medicine, University of Washington the Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    N Engl J Med 346:1623-30. 2002
    ..Because ghrelin is produced primarily by the stomach, weight loss after gastric bypass surgery may be accompanied by impaired ghrelin secretion...
  14. ncbi request reprint Elevated plasma ghrelin levels in Prader Willi syndrome
    David E Cummings
    Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center University of Washington, Seattle, Washington, USA
    Nat Med 8:643-4. 2002
  15. pmc Frequent intentional weight loss is associated with higher ghrelin and lower glucose and androgen levels in postmenopausal women
    Laura E Hooper
    Department of Epidemiology, University of Washington, USA
    Nutr Res 30:163-70. 2010
    ..01). No independent associations between the concentrations of leptin or estrogens and weight cycling were observed. This study suggests that frequent intentional weight loss may affect hormones involved in energy regulation...
  16. ncbi request reprint Changes in plasma amino Acid levels do not predict satiety and weight loss on diets with modified macronutrient composition
    Mikhail S Koren
    University of Washington School of Medicine, Seattle, Wash, USA
    Ann Nutr Metab 51:182-7. 2007
    ..We examined whether high-carbohydrate or high-protein diets induce satiety and weight loss by altering plasma concentrations of these amino acids...
  17. ncbi request reprint Effect of aging on the response of ghrelin to acute weight loss
    Michi Yukawa
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 54:648-53. 2006
    ..To determine whether the failure of the orexigenic hormone ghrelin to increase as it normally does with weight loss contributes to impaired weight recovery in older persons...
  18. ncbi request reprint Leptin levels are appropriate for body mass index in older men who experience involuntary weight loss
    Michi Yukawa
    Divisions of Gerontology and Geriatric Medicine and Endocrinology, University of Washington, Seattle, Washington 98104, USA
    J Am Geriatr Soc 50:1566-71. 2002
    ..To determine the relationship between leptin and unintentional weight loss in older adults...
  19. doi request reprint Peripheral ghrelin treatment stabilizes body weights of senescent male Brown Norway rats at baseline and after surgery
    Michi Yukawa
    Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, WA, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1453-60. 2008
    ....
  20. ncbi request reprint Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans
    Holly S Callahan
    University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 89:1319-24. 2004
    ..We conclude that the depth of postprandial ghrelin suppression is proportional to ingested caloric load but that recovery of plasma ghrelin is not a critical determinant of intermeal interval...
  21. pmc Exchanging carbohydrate or protein for fat improves lipid-related cardiovascular risk profile in overweight men and women when consumed ad libitum
    Mario Kratz
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Investig Med 58:711-9. 2010
    ..The impact of low-fat diets on the plasma lipoprotein profile is incompletely understood...
  22. doi request reprint Serum leptin concentrations and markers of immune function in overweight or obese postmenopausal women
    Julie A Meyers
    Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA
    J Endocrinol 199:51-60. 2008
    ..Our study does not support a link between leptin and other immune parameters among overweight or obese, but otherwise healthy postmenopausal women, perhaps because such effects are only present at low or deficient leptin concentrations...
  23. pmc Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy
    Mario Kratz
    Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    J Clin Endocrinol Metab 93:959-66. 2008
    ..The expression of adipogenic genes in sc adipose tissue has been reported to be lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is unclear whether this is a result or cause of lipoatrophy...
  24. ncbi request reprint Absence of hypersensitivity to glucocorticoids in antiretroviral-associated lipodystrophy
    Ian P Martin
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Obes Res 11:21-4. 2003
    ..The objective of this study was to determine whether tissue sensitivity to glucocorticoids is increased in subjects with lipodystrophy taking protease inhibitors...
  25. pmc Energy balance in congenital generalized lipodystrophy type I
    Sasha Taleban
    General Clinical Research Center, University of Washington, USA
    Metabolism 57:1155-61. 2008
    ..Appetite-regulating hormone levels in CGL-1 suggest that multiple factors act to control appetite in these individuals...
  26. doi request reprint The obesity epidemic: pharmacological challenges
    Stephen R Bloom
    Hammersmith Hospital, Imperial College, London, UK W120NN
    Mol Interv 8:82-98. 2008
    ..These high rates have led to dramatic increases in diseases such as type 2 diabetes, cardiovascular and respiratory diseases, depression, and some forms of cancer...
  27. ncbi request reprint Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans
    Jonathan Q Purnell
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Endocrinol Metab 88:5747-52. 2003
    ..Our data are consistent with the hypotheses that insulin may negatively regulate ghrelin and that high-density lipoprotein may be a carrier particle for circulating ghrelin...
  28. ncbi request reprint Circulating ghrelin levels are suppressed by meals and octreotide therapy in children with Prader-Willi syndrome
    Andrea M Haqq
    Division of Endocrinology, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Endocrinol Metab 88:3573-6. 2003
    ..Further investigation is warranted to determine whether long-term octreotide treatment causes sustained ghrelin suppression, changes eating behavior, and induces weight loss in this population...

Research Grants6

  1. METABOLIC CONSEQUENCES OF ANTIRETROVIRAL THERAPY
    DAVID WEIGLE; Fiscal Year: 2003
    ..Future trials of these medications, along with a great deal more basic research, are clearly justified by the increasing and sustained use of HAART to deal with the worldwide epidemic of HIV infection. ..
  2. STUDIES OF REGIONAL FAT DISTRIBUTION AND ENERGY BALANCE
    DAVID WEIGLE; Fiscal Year: 2005
    ..The applicant has successfully trained several young physician investigators in patient-oriented and basic research, and a plan to continue doing so is presented. ..