Ying Wei

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells
    Ying Wei
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143 0111, USA
    J Biol Chem 282:3929-39. 2007
  2. pmc Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding
    Ying Wei
    Department of Medicine and Pulmonary and Critical Care Division, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 168:501-11. 2005
  3. pmc Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis
    Arnau Ulsamer
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 287:5164-72. 2012
  4. ncbi request reprint Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins
    Chi Hui Tang
    Pulmonary and Critical Care Division, Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 121:3747-56. 2008
  5. pmc Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
    Kevin K Kim
    Pulmonary and Critical Care Division, Department of Medicine, and Cardiovascular Research Institute, UCSF, San Francisco, CA 94143, USA
    J Clin Invest 119:213-24. 2009
  6. pmc Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts
    Young Kim
    Pulmonary and Critical Care Division, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 184:309-22. 2009
  7. pmc Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, and Lung Biology Center, UCSF, San Francisco, California 94143, USA
    J Clin Invest 121:2855-62. 2011
  8. pmc Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact
    Feng Zhang
    Pulmonary and Critical Care Division, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0130, USA
    J Cell Biol 163:177-88. 2003
  9. pmc Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration
    Sai Duriseti
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158 2517, USA
    J Biol Chem 285:26878-88. 2010
  10. ncbi request reprint Urokinase receptor and integrin interactions
    Matthias C Kugler
    Department of Medicine, Pulmonary and Critical Care Division, and CVRI University of California, San Francisco, 94143, USA
    Curr Pharm Des 9:1565-74. 2003

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells
    Ying Wei
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143 0111, USA
    J Biol Chem 282:3929-39. 2007
    ..Thus urokinase receptor binding to alpha5beta1 is required for maximal responses to fibronectin and tumor cell invasion, and this operates through an enhanced Src/Rac/ERK signaling pathway...
  2. pmc Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding
    Ying Wei
    Department of Medicine and Pulmonary and Critical Care Division, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 168:501-11. 2005
    ..Direct binding and regulation of alpha5beta1 by uPAR implies a modified "bent" integrin conformation can function in an alternative activation state with this and possibly other cis-acting membrane ligands...
  3. pmc Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis
    Arnau Ulsamer
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 287:5164-72. 2012
    ....
  4. ncbi request reprint Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins
    Chi Hui Tang
    Pulmonary and Critical Care Division, Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 121:3747-56. 2008
    ..Taken together, the results indicate that uPAR-beta1-integrin interactions are essential to signals induced by integrin matrix ligands or uPA that support lung cancer cell invasion in vitro and progression in vivo...
  5. pmc Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
    Kevin K Kim
    Pulmonary and Critical Care Division, Department of Medicine, and Cardiovascular Research Institute, UCSF, San Francisco, CA 94143, USA
    J Clin Invest 119:213-24. 2009
    ..These findings demonstrate epithelial integrin-dependent profibrotic crosstalk between beta-catenin and Smad signaling and support the hypothesis that EMT is an important contributor to pathologic fibrosis...
  6. pmc Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts
    Young Kim
    Pulmonary and Critical Care Division, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 184:309-22. 2009
    ..These findings demonstrate that alpha3beta1 coordinates cross talk between beta-catenin and Smad signaling pathways as a function of extracellular contact cues and thereby regulates responses to TGF-beta1 activation...
  7. pmc Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, and Lung Biology Center, UCSF, San Francisco, California 94143, USA
    J Clin Invest 121:2855-62. 2011
    ....
  8. pmc Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact
    Feng Zhang
    Pulmonary and Critical Care Division, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0130, USA
    J Cell Biol 163:177-88. 2003
    ..These studies reveal an integrin- and Src-dependent pathway for SLUG expression and mesenchymal transition...
  9. pmc Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration
    Sai Duriseti
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158 2517, USA
    J Biol Chem 285:26878-88. 2010
    ..Our results indicate that these antagonistic antibodies have potential for the detection and treatment of uPAR-expressing tumors...
  10. ncbi request reprint Urokinase receptor and integrin interactions
    Matthias C Kugler
    Department of Medicine, Pulmonary and Critical Care Division, and CVRI University of California, San Francisco, 94143, USA
    Curr Pharm Des 9:1565-74. 2003
    ..Together these observations support the idea that uPAR:integrin interactions may be a focal point of intervention in pathobiology where integrin function is crucial, such as tumor metastasis...
  11. pmc Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors
    Barbara Sennino
    Comprehensive Cancer Center, Department of Anatomy, University of California San Francisco UCSF, San Francisco, CA 94143 0452, USA
    Cancer Discov 2:270-87. 2012
    ..These findings document that invasion and metastasis are promoted by selective inhibition of VEGF signaling and can be reduced by the concurrent inhibition of c-Met...
  12. ncbi request reprint Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways
    Supurna Ghosh
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 281:13021-9. 2006
    ....
  13. pmc Identification of functional subclasses in the DJ-1 superfamily proteins
    Ying Wei
    Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America
    PLoS Comput Biol 3:e10. 2007
    ..The computational prediction of the functional sites for protein structures of unknown function provides valuable clues for functional classification...
  14. ncbi request reprint Active site prediction for comparative model structures with thematics
    Ihsan A Shehadi
    Department of Chemistry, United Arab Emirates University, Al Ain, United Arab Emirates
    J Bioinform Comput Biol 3:127-43. 2005
    ..With a few exceptions, the predicted active sites in the comparative model structures are similar to that of the corresponding template structure...
  15. doi request reprint Identification of residues in DmsD for twin-arginine leader peptide binding, defined through random and bioinformatics-directed mutagenesis
    Catherine S Chan
    Department of Biological Sciences, 2500 University Drive Northwest, University of Calgary, Calgary, Alberta T2N 1N4, Canada
    Biochemistry 47:2749-59. 2008
    ..Our results illustrate the positions of important DmsD residues involved in binding the DmsA leader peptide and identify a "hot pocket" of residues important for leader binding on the structure of DmsD...