Maria L Wei

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Hermansky-Pudlak syndrome: a disease of protein trafficking and organelle function
    Maria L Wei
    Department of Dermatology, Veterans Affairs Medical Center 190, University of California, 4150 Clement St, San Francisco, USA
    Pigment Cell Res 19:19-42. 2006
  2. doi request reprint Multidrug resistance decreases with mutations of melanosomal regulatory genes
    Tong Xie
    Department of Dermatology, University of California San Francisco, San Francisco, California, USA
    Cancer Res 69:992-9. 2009
  3. ncbi request reprint Hermansky-Pudlak HPS1/pale ear gene regulates epidermal and dermal melanocyte development
    Thuyen Nguyen
    Department of Dermatology, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 127:421-8. 2007
  4. pmc Targeting protein-trafficking pathways alters melanoma treatment sensitivity
    Zhi Ming Huang
    Department of Dermatology, University of California, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 109:553-8. 2012
  5. ncbi request reprint Characterization of melanosomes in murine Hermansky-Pudlak syndrome: mechanisms of hypopigmentation
    Thuyen Nguyen
    Department of Dermatology, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 122:452-60. 2004
  6. pmc The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10
    Pooja Agarwal
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158 2517, USA
    Development 138:2555-65. 2011
  7. ncbi request reprint Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development
    Thuyen Nguyen
    Department of Dermatology, Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    J Invest Dermatol 119:1156-64. 2002

Research Grants

Collaborators

  • Jianxin Hu
  • Dorothy C Bennett
  • Dennis H Oh
  • Luanne L Peters
  • Thuyen Nguyen
  • Tong Xie
  • Zhi Ming Huang
  • Pooja Agarwal
  • Glenn L Millhauser
  • Stephanie Demetriou
  • Elena V Sviderskaya
  • Lily Zhong
  • Milka Chinen
  • Rebecca Scherzer
  • Mira P Patel
  • James E Cleaver
  • Philip J Chang
  • Brian L Black
  • Evdokia Dodou
  • Shan Mei Xu
  • David J McCulley
  • Melissa L Ehlers
  • Michael P Verzi
  • Joshua P Anderson
  • Melanie Hupe
  • Edward K Novak
  • Maryam Kermani
  • Joachim Fluhr
  • Richard T Swank

Detail Information

Publications7

  1. ncbi request reprint Hermansky-Pudlak syndrome: a disease of protein trafficking and organelle function
    Maria L Wei
    Department of Dermatology, Veterans Affairs Medical Center 190, University of California, 4150 Clement St, San Francisco, USA
    Pigment Cell Res 19:19-42. 2006
    ....
  2. doi request reprint Multidrug resistance decreases with mutations of melanosomal regulatory genes
    Tong Xie
    Department of Dermatology, University of California San Francisco, San Francisco, California, USA
    Cancer Res 69:992-9. 2009
    ..Together, these data provide the first direct evidence that melanosomal regulatory genes influence drug sensitivity and that the presence of mature melanosomes likely contributes to melanoma resistance to therapy...
  3. ncbi request reprint Hermansky-Pudlak HPS1/pale ear gene regulates epidermal and dermal melanocyte development
    Thuyen Nguyen
    Department of Dermatology, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 127:421-8. 2007
    ..The implications of these findings for the mechanisms governing physiologic variation in human pigmentation and for the pathogenesis of vitiligo are discussed...
  4. pmc Targeting protein-trafficking pathways alters melanoma treatment sensitivity
    Zhi Ming Huang
    Department of Dermatology, University of California, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 109:553-8. 2012
    ..Together, these results indicate that targeting protein-trafficking molecules markedly increases melanoma treatment sensitivity and influences the degree of melanosomes available for sequestration of therapeutic agents...
  5. ncbi request reprint Characterization of melanosomes in murine Hermansky-Pudlak syndrome: mechanisms of hypopigmentation
    Thuyen Nguyen
    Department of Dermatology, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 122:452-60. 2004
    ....
  6. pmc The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10
    Pooja Agarwal
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158 2517, USA
    Development 138:2555-65. 2011
    ....
  7. ncbi request reprint Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development
    Thuyen Nguyen
    Department of Dermatology, Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    J Invest Dermatol 119:1156-64. 2002
    ..In contrast, the hypopigmentation seen in the gunmetal strain is due to the retention of melanosomes in melanocytes, and inefficient transfer into keratinocytes...

Research Grants2

  1. Mechanisms of Hypopigmentation in Hermansky-Pudlak Syndrome
    MARIA WEI; Fiscal Year: 2007
    ..This proposal focuses on the immediate goals of determining the functions of selected HPS gene products in melanocytes and learning how these ubiquitous proteins regulate melanosome biogenesis and function. ..