Li na Wei

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2
    Guangjin Li
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 310:384-90. 2003
  2. pmc Axonal mRNA transport and localized translational regulation of kappa-opioid receptor in primary neurons of dorsal root ganglia
    Jing Bi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 103:19919-24. 2006
  3. ncbi request reprint SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nat Struct Mol Biol 14:68-75. 2007
  4. pmc Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3' untranslated region: a role for microRNA23b
    Qifang Wu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    FASEB J 22:4085-95. 2008
  5. pmc p38 mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide
    Do Kyung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Neurochem 116:1077-87. 2011
  6. pmc NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance
    Ping Chih Ho
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Nat Immunol 13:379-86. 2012
  7. pmc RIP140 in thyroid hormone-repression and chromatin remodeling of Crabp1 gene during adipocyte differentiation
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Nucleic Acids Res 37:7085-94. 2009
  8. pmc PKCepsilon stimulated arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation
    Pawan Gupta
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
    PLoS ONE 3:e2658. 2008
  9. pmc Dual action of epidermal growth factor: extracellular signal-stimulated nuclear-cytoplasmic export and coordinated translation of selected messenger RNA
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455
    J Cell Biol 188:325-33. 2010
  10. pmc Coordinated repressive chromatin-remodeling of Oct4 and Nanog genes in RA-induced differentiation of embryonic stem cells involves RIP140
    Cheng Ying Wu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Nucleic Acids Res 42:4306-17. 2014

Collaborators

Detail Information

Publications92

  1. ncbi request reprint Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2
    Guangjin Li
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 310:384-90. 2003
    ..These data identify two RIDs of HDAC3 and the biological activity of the complex formed by TR2 and HDAC3 on the TR2 DNA target...
  2. pmc Axonal mRNA transport and localized translational regulation of kappa-opioid receptor in primary neurons of dorsal root ganglia
    Jing Bi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 103:19919-24. 2006
    ....
  3. ncbi request reprint SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nat Struct Mol Biol 14:68-75. 2007
    ....
  4. pmc Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3' untranslated region: a role for microRNA23b
    Qifang Wu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    FASEB J 22:4085-95. 2008
    ..We propose a mechanism in which miRNA23b blocks the association of MOR1 mRNA with polysomes, thereby arresting its translation and suppressing the production of MOR1 protein...
  5. pmc p38 mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide
    Do Kyung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Neurochem 116:1077-87. 2011
    ..These observations suggest that CHX directly induces MOR gene transcription by recruiting the active transcription factor Sox18 to the MOR promoter through PI3- and/or p38 MAPK pathways...
  6. pmc NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance
    Ping Chih Ho
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Nat Immunol 13:379-86. 2012
    ..Our results identify RelA as an adaptor with which SCF fine tunes NF-κB target genes by targeting the coactivator RIP140 and show an unexpected role for RIP140 degradation in resolving inflammation and endotoxin tolerance...
  7. pmc RIP140 in thyroid hormone-repression and chromatin remodeling of Crabp1 gene during adipocyte differentiation
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Nucleic Acids Res 37:7085-94. 2009
    ....
  8. pmc PKCepsilon stimulated arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation
    Pawan Gupta
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
    PLoS ONE 3:e2658. 2008
    ..Previously we identified three methylated arginine residues in RIP140, which rendered its export to the cytoplasm; but it was unclear what triggered RIP140 arginine methylation...
  9. pmc Dual action of epidermal growth factor: extracellular signal-stimulated nuclear-cytoplasmic export and coordinated translation of selected messenger RNA
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455
    J Cell Biol 188:325-33. 2010
    ..In summary, this study uncovers a coordinated, dual activity of EGF in facilitating nuclear export of a specific mRNA-protein complex as well as translational activation of the exported mRNA...
  10. pmc Coordinated repressive chromatin-remodeling of Oct4 and Nanog genes in RA-induced differentiation of embryonic stem cells involves RIP140
    Cheng Ying Wu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Nucleic Acids Res 42:4306-17. 2014
    ..Finally, in these RA-triggered repressive chromatin-remodeling processes, lysine acetylation of RIP140 is critical for its recruiting Brm. ..
  11. pmc Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1
    Pawan Gupta
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Nucleic Acids Res 35:2269-82. 2007
    ..This results in a biphasic effect of RA on the expression of TR2 in undifferentiated and differentiated cells, which is required for RA-stimulated preadipocyte proliferation...
  12. pmc HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3
    Pawan Gupta
    Institute of Microbial Technology, Chandigarh, India
    PLoS ONE 4:e4363. 2009
    ..These findings could provide new insights into the development of potential therapeutics and in understanding how orphan nuclear receptor activities can be regulated without ligands...
  13. ncbi request reprint Biological activities of receptor-interacting protein 140 in adipocytes and metabolic diseases
    Ping Chih Ho
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall 321 Church Street SE, Minneapolis, MN 55455 0217, USA
    Curr Diabetes Rev 8:452-7. 2012
    ....
  14. pmc Chromatin remodeling and epigenetic regulation of the CrabpI gene in adipocyte differentiation
    Li na Wei
    Department of Pharmacology, University of Minnesota Medical School, 6 122 Jackson Hall, 341 Church St SE, Minneapolis, MN 55655, USA
    Biochim Biophys Acta 1821:206-12. 2012
    ..Understanding the pathways regulating CrabpI in this specific context might help to illuminate the physiological role of CRABPI in vivo. This article is part of a special issue entitled: Retinoid and Lipid Metabolism...
  15. doi request reprint The RNA superhighway: axonal RNA trafficking of kappa opioid receptor mRNA for neurite growth
    Li na Wei
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, 55455, USA
    Integr Biol (Camb) 3:10-6. 2011
    ....
  16. ncbi request reprint Epigenetic control of the expression of opioid receptor genes
    Li na Wei
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Epigenetics 3:119-21. 2008
    ....
  17. pmc Post-transcriptional regulation of opioid receptors in the nervous system
    Li na Wei
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Front Biosci 9:1665-79. 2004
    ....
  18. pmc Transcriptional and epigenetic regulation of opioid receptor genes: present and future
    Li na Wei
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, 55455, USA
    Annu Rev Pharmacol Toxicol 51:75-97. 2011
    ..As the expression of OR proteins is ultimately controlled by extensive posttranscriptional processing, the pharmacological implication of OR gene regulation at the transcriptional level remains to be determined...
  19. ncbi request reprint Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 279:46464-73. 2004
    ..Our data suggested that NRSF can function as a repressor of MOR transcription in specific cells, via a mechanism dependent on the MOR NRSE...
  20. ncbi request reprint Regulation of c-myc gene by nitric oxide via inactivating NF-kappa B complex in P19 mouse embryonal carcinoma cells
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 278:29776-82. 2003
    ..In light of findings that NF-kappa B stimulates Myc oncoprotein expression in cancers, our findings suggest that NO should be investigated as a prospective therapeutic cancer agent...
  21. pmc Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter
    Ya Shan Chuang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Stem Cells 29:660-9. 2011
    ..The study also demonstrates a novel mode of chromatin remodeling, which occurs by repositioning and sequentially inserting nucleosomes into a specific region of the gene promoter to compact the chromatin in differentiating cells...
  22. ncbi request reprint Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity
    Mariya Farooqui
    Department of Pharmacology and Biochemistry, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Biochemistry 42:971-9. 2003
    ..Competition and mutation studies demonstrated an essential role for (1067)Asn and (1073)Met for a ligand-dependent interaction. A model was proposed to address the constitutive and agonist-dependent interaction of RIP140 with RAR/RXR...
  23. pmc Modulation of lysine acetylation-stimulated repressive activity by Erk2-mediated phosphorylation of RIP140 in adipocyte differentiation
    Ping Chih Ho
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455 0217, USA
    Cell Signal 20:1911-9. 2008
    ....
  24. ncbi request reprint Retinoic acid-induced chromatin remodeling of mouse kappa opioid receptor gene
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Neurosci 25:3350-7. 2005
    ....
  25. pmc Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression
    Pawan Gupta
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 105:11424-9. 2008
    ..To normally proliferating P19 stem cell culture, exposure to a physiological concentration of atRA triggers a rapid nongenomic signaling cascade to suppress Oct4 gene and regulate cell proliferation...
  26. ncbi request reprint Transcriptional regulation of mouse delta-opioid receptor gene by CpG methylation: involvement of Sp3 and a methyl-CpG-binding protein, MBD2, in transcriptional repression of mouse delta-opioid receptor gene in Neuro2A cells
    Guilin Wang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 278:40550-6. 2003
    ....
  27. doi request reprint Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA
    J Cell Mol Med 13:3591-615. 2009
    ..We conclude that MOR gene expression is epigenetically programmed in various brain regions and that MeCP2 assists the epigenetic program during DNA methylation and chromatin remodelling of the MOR promoter...
  28. pmc Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Pharmacol 78:58-68. 2010
    ..Subsequent recruitment of the activating transcription factor Sp1 to the remodeled promoter results in MOR up-regulation...
  29. pmc Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation
    M D Mostaqul Huq
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455 0217, USA
    EMBO J 25:5094-104. 2006
    ..This study uncovered a novel means to inactivate, or suppress, RIP140, and demonstrated protein arginine methylation as a critical type of modification for corepressor...
  30. ncbi request reprint Real-time analysis of molecular interaction of retinoid receptors and receptor-interacting protein 140 (RIP140)
    Yixin Chen
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 16:2528-37. 2002
    ..Finally, with a mutagenesis approach, we determined the effects of specific point mutations on the kinetics of RIP-C' interaction with RAR/RXR...
  31. ncbi request reprint Ligand-independent orphan receptor TR2 activation by phosphorylation at the DNA-binding domain
    Shaukat Ali Khan
    Department of Pharmacology, University of Minnesota Medical School, 321 Church Street SE, Minneapolis, MN 55455, USA
    Proteomics 6:123-30. 2006
    ..This study provides the first evidence for ligand-independent activation of TR2 orphan receptor through PTM at the DBD, which enhanced its DNA-binding ability and interaction with coactivator P/CAF...
  32. pmc Probing protein oligomerization in living cells with fluorescence fluctuation spectroscopy
    Yan Chen
    School of Physics and Astronomy, University of Minnesota, 116 Church Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 100:15492-7. 2003
    ..Resolving protein interactions in a cell is an important step in understanding cellular function on a molecular level. Brightness analysis promises to develop into an important tool for determining protein complex formation in cells...
  33. ncbi request reprint Molecular interaction of retinoic acid receptors with coregulators PCAF and RIP140
    Yixin Chen
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Mol Cell Endocrinol 226:43-50. 2004
    ..This study presents kinetic evidence for competition of RIP140 with PCAF for ligand-dependent interactions with RAR/RXR, and provides kinetic explanation for the suppressive activity of RIP140 in RA-activated gene expression...
  34. pmc Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Cell Biol 27:4720-36. 2007
    ..Here, we propose that an epigenetic mechanism consisting of DNA methylation and chromatin modification underlies the cell stage-specific mechanism of MOR gene expression...
  35. ncbi request reprint Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase
    Peter J Franco
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Mol Cell Endocrinol 206:1-12. 2003
    ..Both the N- and C-terminal portions of HDAC3 showed interaction with the TR2 DBD. Thus, multiple domains of HDAC3 form the interaction surface for the DBD of nuclear receptors...
  36. ncbi request reprint Induction of the mouse kappa-opioid receptor gene by retinoic acid in P19 cells
    Jinhua Li
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 277:39967-72. 2002
    ..Collectively, enhanced binding of Sp1 to promoter I of the KOR gene as a result of inhibiting the ERK pathway contributes to RA induction of this gene in P19...
  37. ncbi request reprint Post-translational modification of nuclear co-repressor receptor-interacting protein 140 by acetylation
    M D Mostaqul Huq
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 4:975-83. 2005
    ....
  38. ncbi request reprint Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation
    Xinli Hu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 279:319-25. 2004
    ....
  39. ncbi request reprint Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function
    M D Mostaqul Huq
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 6:677-88. 2007
    ..Our finding also provides the evidence for lysine methylation for the family of nuclear receptors for the first time...
  40. ncbi request reprint A novel signaling pathway of nitric oxide on transcriptional regulation of mouse kappa opioid receptor gene
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:7941-7. 2002
    ..A novel pathway mediating the potential interplay between NO and opioid systems is discussed...
  41. ncbi request reprint Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation
    M D Mostaqul Huq
    Department of Pharmacology, Molecular Biology and Biophysics, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota 55455, USA
    Nat Chem Biol 3:161-5. 2007
    ....
  42. pmc Activation of testicular orphan receptor 4 by fatty acids
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455 0217, USA
    Biochim Biophys Acta 1789:734-40. 2009
    ..The data suggest that TR4 might exert its physiological function by sensing certain lipids. Identifying these compounds could be useful for examining the physiological pathways in which TR4 and its target genes are involved...
  43. doi request reprint MicroRNA mir-346 targets the 5'-untranslated region of receptor-interacting protein 140 (RIP140) mRNA and up-regulates its protein expression
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biochem J 424:411-8. 2009
    ..This is the first report demonstrating post-transcriptional regulation of RIP140 mRNA, involving the enhancing effect of a specific miRNA that targets RIP140's 5'UTR...
  44. ncbi request reprint Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell 19:643-53. 2005
    ..This indicates new TRAP/Mediator functions in facilitating ultimate recruitment and function of RNA polymerase II and the general transcription machinery...
  45. ncbi request reprint Receptor interacting protein 140 as a thyroid hormone-dependent, negative co-regulator for the induction of cellular retinoic acid binding protein I gene
    Li na Wei
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson, Minneapolis, MN 55455, USA
    Mol Cell Endocrinol 218:39-48. 2004
    ..This study presents the first evidence that over-expressed RIP140 acts as a T3-dependent negative co-regulator for T3 induction of the endogenous CRABPI gene in P19 cells...
  46. ncbi request reprint Regulation of co-repressive activity of and HDAC recruitment to RIP140 by site-specific phosphorylation
    Pawan Gupta
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 4:1776-84. 2005
    ..The study provides insights into the modulation of RIP140 biological activity through a specific cellular signaling pathway that augments phosphorylation at specific residues of RIP140 molecule and alters its cofactor recruitment...
  47. ncbi request reprint Transcriptional regulation of mouse mu opioid receptor gene: Sp3 isoforms (M1, M2) function as repressors in neuronal cells to regulate the mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, 55455, USA
    Mol Pharmacol 67:1674-83. 2005
    ..These results suggest that the binding of the M1 and M2 isoforms of the Sp3 transcription factor to the Sp binding sequence may play a role in mouse MOR gene expression...
  48. pmc Gene repressive activity of RIP140 through direct interaction with CDK8
    Shawna D Persaud
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 25:1689-98. 2011
    ..This underlies the T(3)-triggered repression of CrabpI gene. This study illustrates a new gene-repressive mechanism of RIP140 that can affect the transcription machinery by directly interacting with CDK8...
  49. pmc uAUG-mediated translational initiations are responsible for human mu opioid receptor gene expression
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Cell Mol Med 14:1113-24. 2010
    ..This re-initiation resulted in negative expression of OPRM1 under normal conditions. These results indicate that re-initiation in MOR gene expression could play an important role in OPRM1 regulation...
  50. doi request reprint Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Biochim Biophys Acta 1783:1835-46. 2008
    ..We report here a novel function of NRSF that enhance the translation of the mu opioid receptor (MOR) gene through its RNA binding sequence, the neuron-restrictive silencer element (NRSE)...
  51. ncbi request reprint Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    FASEB J 21:3963-73. 2007
    ..Our data suggest that alphaCP3 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence. We demonstrate for the first time a role of alphaCP3 as a transcriptional repressor in MOR gene regulation...
  52. pmc Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:6392-403. 2006
    ....
  53. pmc Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid
    Shawna D Persaud
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cell Signal 25:19-25. 2013
    ..This is the first study to identify CRABPI as the mediator for non-canonical activation of ERK1/2 by atRA, and demonstrate a new functional role for CRABPI in modulating ESC cell cycle progression...
  54. pmc Kappa opioid receptor contributes to EGF-stimulated neurite extension in development
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 107:3216-21. 2010
    ..The result also reveals an action of EGF to augment posttranscriptional regulation of certain mRNAs during developmental stages...
  55. pmc Lysine methylation of nuclear co-repressor receptor interacting protein 140
    M D Mostaqul Huq
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Proteome Res 8:1156-67. 2009
    ..This study reveals a potential hierarchy of modifications, at least for lysine and arginine methylation, which bidirectionally regulate the functionality of a nonhistone protein...
  56. doi request reprint Modulation of retinoic acid receptor alpha activity by lysine methylation in the DNA binding domain
    M D Mostaqul Huq
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Proteome Res 7:4538-45. 2008
    ..This study uncovers a potential role for monomethylation at Lys (109) in coordinating the synergy between DBD and LBD for ligand-dependent activation of RAR alpha...
  57. pmc A negative regulatory pathway of GLUT4 trafficking in adipocyte: new function of RIP140 in the cytoplasm via AS160
    Ping Chih Ho
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cell Metab 10:516-23. 2009
    ....
  58. doi request reprint Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cell Mol Med 12:2319-33. 2008
    ..Our data suggest that PARP-1 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence. We demonstrate for the first time a role of PARP-1 as a transcriptional repressor in MOR gene regulation...
  59. ncbi request reprint Poly(C) binding protein family is a transcription factor in mu-opioid receptor gene expression
    Sung Su Kim
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Mol Pharmacol 68:729-36. 2005
    ..Chromatin immunoprecipitation assay confirmed the interaction of PCBPs with MOR promoter in vivo. In conclusion, we demonstrate that PCBPs act as a transcription factor and positively regulate MOR gene expression in NMB cells...
  60. ncbi request reprint The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor
    Hack Sun Choi
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 343:1132-40. 2006
    ..In NMB cells expressing human MOR gene, transfection of SV1 or SV2 reduced binding activity of the endogenous MOR. These data support a potential role of SV1 and SV2 proteins as possible biological modulator of human mu-opioid receptor...
  61. pmc MicroRNA 339 down-regulates μ-opioid receptor at the post-transcriptional level in response to opioid treatment
    Qifang Wu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    FASEB J 27:522-35. 2013
    ..Taken together, these results suggest that miR-339-3p may serve as a negative feedback modulator of MOR signals by regulating intracellular MOR biosynthesis...
  62. pmc Vimentin interacts with the 5'-untranslated region of mouse mu opioid receptor (MOR) and is required for post-transcriptional regulation
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA
    RNA Biol 10:256-66. 2013
    ..Our data suggest that vimentin functions as a repressor of MOR translation, dependent on 175-150 of the MOR 5'-UTR...
  63. ncbi request reprint Mapping of phosphorylation sites of nuclear corepressor receptor interacting protein 140 by liquid chromatography-tandem mass spectroscopy
    M D Mostaqul Huq
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, 55455, USA
    Proteomics 5:2157-66. 2005
    ..These phosphorylation sites can be the targets in future studies addressing post-translational modification of RIP140 with regards to its biological activities...
  64. pmc Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolites
    M D Mostaqul Huq
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, 55455, USA
    EMBO J 25:3203-13. 2006
    ..This study uncovered a novel crosstalk between cholesterol and RA biosynthesis...
  65. pmc Translational repression of mouse mu opioid receptor expression via leaky scanning
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nucleic Acids Res 35:1501-13. 2007
    ..These results support the hypothesis that uORFs in mouse MOR mRNA act as negative regulators through a ribosome leaky scanning mechanism. Such leaky scanning resulted in the suppression of mouse MOR under normal conditions...
  66. pmc Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells
    Yadav Wagley
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biochim Biophys Acta 1833:1476-88. 2013
    ..All these results suggest a regulatory role of the p38 MAPK and NF-κB pathways in MOR gene expression and aid to our better understanding of the MOR gene regulation...
  67. pmc Unraveling protein-protein interactions in living cells with fluorescence fluctuation brightness analysis
    Yan Chen
    School of Physics and Astronomy, University of Minnesota, Minneapolis, USA
    Biophys J 88:4366-77. 2005
    ..We explore binding between these proteins in the presence and absence of RXR agonist. Our results demonstrate that brightness analysis offers a quantitative method for determining protein interactions in cells...
  68. ncbi request reprint Regulation of mouse kappa opioid receptor gene expression by different 3'-untranslated regions and the effect of retinoic acid
    Xinli Hu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, 55455, USA
    Mol Pharmacol 62:881-7. 2002
    ..A negative regulatory pathway for KOR transcription involves a putative enhancer region in its 3'-UTR. KOR mRNAs using the second poly(A) is more stable than that using the first poly(A)...
  69. ncbi request reprint Protein kinase C-mediated phosphorylation of orphan nuclear receptor TR2: effects on receptor stability and activity
    Shaukat Ali Khan
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proteomics 5:3885-94. 2005
    ..Point mutations at Ser-568 or Ser-461 were prepared and evaluated for their biological activity. Ser-568, but not Ser-461, mutation significantly reduced PKC-mediated TR2 protein stability and its transcriptional activity...
  70. pmc The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    EMBO J 26:1522-31. 2007
    ..This study reports an adaptor protein Grb7 that transmits the stimulating signals of Netrin-1 to the translational machinery to rapidly regulate mRNA translation...
  71. ncbi request reprint Netrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNA
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Neurosci 26:9743-9. 2006
    ....
  72. pmc Stress-induced epigenetic regulation of κ-opioid receptor gene involves transcription factor c-Myc
    Shlomit Flaisher-Grinberg
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 109:9167-72. 2012
    ....
  73. pmc Negative regulation of adiponectin secretion by receptor interacting protein 140 (RIP140)
    Ping Chih Ho
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455 0217, USA
    Cell Signal 24:71-6. 2012
    ....
  74. pmc Cytoplasmic receptor-interacting protein 140 (RIP140) interacts with perilipin to regulate lipolysis
    Ping Chih Ho
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cell Signal 23:1396-403. 2011
    ..The study suggests that reducing nuclear export of RIP140 might be a useful means of controlling adipocyte lipolysis...
  75. ncbi request reprint Retinoids and receptor interacting protein 140 (RIP140) in gene regulation
    Li na Wei
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Curr Med Chem 11:1527-32. 2004
    ....
  76. pmc A proteomics approach for identification of single strand DNA-binding proteins involved in transcriptional regulation of mouse mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 7:1517-29. 2008
    ..We demonstrate novel roles as transcriptional regulators in Oprm1 regulation for hnRNP K and alphaCP binding to the single strand DNA element...
  77. ncbi request reprint A major species of mouse mu-opioid receptor mRNA and its promoter-dependent functional polyadenylation signal
    Qifang Wu
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Pharmacol 68:279-85. 2005
    ....
  78. pmc Regulation of stress granule dynamics by Grb7 and FAK signalling pathway
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    EMBO J 27:715-26. 2008
    ..This is the first reported pathway actively regulating the dynamics of SGs...
  79. pmc Endothelin-1 promotes cytoplasmic accumulation of RIP140 through a ET(A)-PLCβ-PKCε pathway
    Ping Chih Ho
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455 0217, USA
    Mol Cell Endocrinol 351:176-83. 2012
    ....
  80. ncbi request reprint Mouse kappa-opioid receptor mRNA differential transport in neurons
    Jing Bi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St, SE, Minneapolis, MN 55455, USA
    Mol Pharmacol 64:594-9. 2003
    ..This study demonstrates the biological activity of the UTRs of KOR mRNA isoforms in directing differential transport of mRNA in mammalian neurons...
  81. ncbi request reprint Tyrosine nitration on p65: a novel mechanism to rapidly inactivate nuclear factor-kappaB
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 4:300-9. 2005
    ..This study identified a novel and efficient pathway where NO rapidly inactivated NF-kappaB activity by inducing Tyr nitration on p65...
  82. pmc Poly(C)-binding proteins as transcriptional regulators of gene expression
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 380:431-6. 2009
    ..PCBPs can function as a signal-dependent and coordinated regulator of transcription in eukaryotic cells. We address the molecular mechanisms by which PCBPs binding to single- and double-stranded DNA mediates gene expression...
  83. ncbi request reprint Post-translational modifications of nuclear co-repressor RIP140: a therapeutic target for metabolic diseases
    M D Mostaqul Huq
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN55455, USA
    Curr Med Chem 15:386-92. 2008
    ..This could provide insights into potential, new therapeutic targets for diseases concerning adipocytes such as metabolic disorders...
  84. pmc Copb1-facilitated axonal transport and translation of kappa opioid-receptor mRNA
    Jing Bi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 104:13810-5. 2007
    ....
  85. ncbi request reprint DNA methylation-related chromatin modification in the regulation of mouse delta-opioid receptor gene
    Guilin Wang
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Mol Pharmacol 67:2032-9. 2005
    ..Taken together, these results demonstrate that the mDOR gene expression is regulated by DNA methylation-related chromatin modification, especially histone acetylation and deacetylation...
  86. ncbi request reprint Regulation of opioid receptor expression
    Li na Wei
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota 55455 0217, USA
    Curr Opin Pharmacol 2:69-75. 2002
    ..Reports have also shown polymorphisms of the mu opioid receptor gene, primarily in the regulatory region, suggesting a potential connection between this gene and the likelihood of opioid abuse in humans...
  87. pmc Cholesterol regulation of receptor-interacting protein 140 via microRNA-33 in inflammatory cytokine production
    Ping Chih Ho
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, 55455 0217, USA
    FASEB J 25:1758-66. 2011
    ....
  88. pmc RhoA/ROCK1 signaling regulates stress granule formation and apoptosis
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Cell Signal 22:668-75. 2010
    ..This study identifies a specific signaling pathway, mediated by RhoA and ROCK1, which determines cell fate by promoting SG formation or initiating apoptosis during stress...
  89. doi request reprint Differential use of an in-frame translation initiation codon regulates human mu opioid receptor (OPRM1)
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cell Mol Life Sci 66:2933-42. 2009
    ..The data suggest that MOP expression is controlled in part by initiation of the long form of MOP at the alternate site...
  90. pmc Long-term morphine treatment decreases the association of mu-opioid receptor (MOR1) mRNA with polysomes through miRNA23b
    Qifang Wu
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Pharmacol 75:744-50. 2009
    ..This suggests a potential link between MOR expression and morphine treatment at the post-transcriptional level in which a specific miRNA, miRNA23b, is involved...
  91. ncbi request reprint Retinoid receptors and their coregulators
    Li na Wei
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Annu Rev Pharmacol Toxicol 43:47-72. 2003
    ..Challenges remain to understand the specificity of action of RARs and RXRs and the formation of specific transcription complexes consisting of the receptors, coregulators, and other unknown factors...
  92. ncbi request reprint Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation
    M D Mostaqul Huq
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 5:2072-82. 2006
    ..This study uncovered, for the first time, a ligand-independent mechanism underlying the biological activity of TR4 that was mediated by MAPK-mediated receptor phosphorylation of AF-1 domain...

Research Grants35

  1. Studies of mouse kappa opioid receptor gene regulation
    Li na Wei; Fiscal Year: 2007
    ....
  2. NRIP1 in vitamin A signaling pathways
    Li na Wei; Fiscal Year: 2007
    ..Finally, it is our ultimate goal to determine if the unique property of NRIP1 bears a physiological relevance in terms of the specificity of vitamin A action on a particular gene promoter. ..
  3. Studies of mouse kappa opioid receptor gene regulation
    Li na Wei; Fiscal Year: 2005
    ..Additionally, the application of transgenic mouse models is essential for understanding the genetic basis of pharmacological problems that are related to the opioid receptor system. ..
  4. TR2 nuclear receptor in vitamin A signaling
    Li na Wei; Fiscal Year: 2006
    ....
  5. NRIP1 in vitamin A signaling pathways
    Li na Wei; Fiscal Year: 2005
    ..Finally, it is our ultimate goal to determine if the unique property of NRIP1 bears a physiological relevance in terms of the specificity of vitamin A action on a particular gene promoter. ..
  6. Studies of mouse kappa opioid receptor gene regulation
    Li na Wei; Fiscal Year: 2004
    ..Additionally, the application of transgenic mouse models is essential for understanding the genetic basis of pharmacological problems that are related to the opioid receptor system. ..
  7. NRIP1 in vitamin A signaling pathways
    Li na Wei; Fiscal Year: 2003
    ..Finally, it is our ultimate goal to determine if the unique property of NRIP1 bears a physiological relevance in terms of the specificity of vitamin A action on a particular gene promoter. ..
  8. TR2 nuclear receptor in vitamin A signaling
    Li na Wei; Fiscal Year: 2007
    ....
  9. TR2 NUCLEAR RECEPTOR IN VITAMIN A SIGNALING PATHWAYS
    Li na Wei; Fiscal Year: 2000
    ..abstract_text> ..
  10. NRIP1 in vitamin A signaling pathways
    Li na Wei; Fiscal Year: 2002
    ..Finally, it is our ultimate goal to determine if the unique property of NRIP1 bears a physiological relevance in terms of the specificity of vitamin A action on a particular gene promoter. ..
  11. MOUSE KAPPA OPIOID RECEPTOR GENE
    Li na Wei; Fiscal Year: 1999
    ....
  12. Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathways
    Li na Wei; Fiscal Year: 2010
    ..The studies will also delineate the role of nutrients, such as vitamin A, in the maintenance of human health. ..
  13. Studies of mouse kappa opioid receptor gene regulation
    Li na Wei; Fiscal Year: 2010
    ....
  14. Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathways
    Li na Wei; Fiscal Year: 2010
    ..The studies will also delineate the role of nutrients, such as vitamin A, in the maintenance of human health. ..
  15. Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathways
    Li na Wei; Fiscal Year: 2009
    ..The studies will also delineate the role of nutrients, such as vitamin A, in the maintenance of human health. ..
  16. TR2 nuclear receptor in vitamin A signaling
    Li na Wei; Fiscal Year: 2010
    ..abstract_text> ..
  17. Studies of mouse kappa opioid receptor gene regulation
    Li na Wei; Fiscal Year: 2009
    ....
  18. TR2 nuclear receptor in vitamin A signaling
    Li na Wei; Fiscal Year: 2009
    ..abstract_text> ..
  19. Studies of mouse kappa opioid receptor gene regulation
    Li na Wei; Fiscal Year: 2002
    ..Additionally, the application of transgenic mouse models is essential for understanding the genetic basis of pharmacological problems that are related to the opioid receptor system. ..
  20. TR2 NUCLEAR RECEPTOR IN VITAMIN A SIGNALING PATHWAYS
    Li na Wei; Fiscal Year: 2001
    ..abstract_text> ..
  21. MOUSE KAPPA OPIOID RECEPTOR GENE
    Li na Wei; Fiscal Year: 2000
    ....
  22. TR2 NUCLEAR RECEPTOR IN VITAMIN A SIGNALING PATHWAYS
    Li na Wei; Fiscal Year: 1999
    ..abstract_text> ..
  23. Studies of mouse kappa opioid receptor gene regulation
    Li na Wei; Fiscal Year: 2003
    ..Additionally, the application of transgenic mouse models is essential for understanding the genetic basis of pharmacological problems that are related to the opioid receptor system. ..
  24. NRIP1 in vitamin A signaling pathways
    Li na Wei; Fiscal Year: 2004
    ..Finally, it is our ultimate goal to determine if the unique property of NRIP1 bears a physiological relevance in terms of the specificity of vitamin A action on a particular gene promoter. ..
  25. TR2 nuclear receptor in vitamin A signaling
    Li na Wei; Fiscal Year: 2010
    ..abstract_text> ..
  26. NRIP1 in vitamin A signaling pathways
    Li na Wei; Fiscal Year: 2006
    ..Finally, it is our ultimate goal to determine if the unique property of NRIP1 bears a physiological relevance in terms of the specificity of vitamin A action on a particular gene promoter. ..
  27. MOUSE KAPPA OPIOID RECEPTOR GENE
    Li na Wei; Fiscal Year: 2001
    ....
  28. Studies of mouse kappa opioid receptor gene regulation
    Li na Wei; Fiscal Year: 2006
    ..Additionally, the application of transgenic mouse models is essential for understanding the genetic basis of pharmacological problems that are related to the opioid receptor system. ..
  29. TR2 NUCLEAR RECEPTOR IN VITAMIN A SIGNALING PATHWAYS
    Li na Wei; Fiscal Year: 2002
    ..abstract_text> ..
  30. TR2 NUCLEAR RECEPTOR IN VITAMIN A SIGNALING PATHWAYS
    Li na Wei; Fiscal Year: 2003
    ..abstract_text> ..