Huafeng Wei

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Effects of fetal exposure to isoflurane on postnatal memory and learning in rats
    Yujuan Li
    Department of Anesthesiology and Critical Care, University of Pennsylvania, 305 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Neuropharmacology 53:942-50. 2007
  2. pmc Anesthesia, calcium homeostasis and Alzheimer's disease
    Huafeng Wei
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Alzheimer Res 6:30-5. 2009
  3. ncbi request reprint Isoflurane and sevoflurane affect cell survival and BCL-2/BAX ratio differently
    Huafeng Wei
    Department of Anesthesia, 305 John Morgan Building, 3620 Hamilton Walk, University of Pennsylvania Health System, Philadelphia, PA 19104 4283, USA
    Brain Res 1037:139-47. 2005
  4. doi request reprint The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors
    Huafeng Wei
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 108:251-60. 2008
  5. ncbi request reprint A new tracheal tube and methods to facilitate ventilation and placement in emergency airway management
    Huafeng Wei
    Department of Anesthesia and Critical Care, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Resuscitation 70:438-44. 2006
  6. pmc Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity
    Huafeng Wei
    Department of Anesthesiology and Critical Care, University of Pennsylvania, 305 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Neurosci Lett 425:59-62. 2007
  7. pmc The common inhaled anesthetic isoflurane increases aggregation of huntingtin and alters calcium homeostasis in a cell model of Huntington's disease
    Qiujun Wang
    Department of Anesthesiology and Critical Care, University of Pennsylvania, 305 John Morgan Building, 3620 Hamilton Walk, Pennsylvania, PA 19104, USA
    Toxicol Appl Pharmacol 250:291-8. 2011
  8. pmc Anesthetic-induced neurodegeneration mediated via inositol 1,4,5-trisphosphate receptors
    Yifan Zhao
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, 305 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    J Pharmacol Exp Ther 333:14-22. 2010
  9. pmc Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies
    Hui Yang
    Department of Anesthesiology and Critical Care, University of Pennsylvania, PA, USA
    Anesthesiology 109:243-50. 2008
  10. pmc Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice
    Jun Peng
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurosci Lett 516:274-9. 2012

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc Effects of fetal exposure to isoflurane on postnatal memory and learning in rats
    Yujuan Li
    Department of Anesthesiology and Critical Care, University of Pennsylvania, 305 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Neuropharmacology 53:942-50. 2007
    ..These results show that isoflurane exposure during late pregnancy is not neurotoxic to the fetal brain and does not impair memory and learning in the juvenile or adult rat...
  2. pmc Anesthesia, calcium homeostasis and Alzheimer's disease
    Huafeng Wei
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Alzheimer Res 6:30-5. 2009
    ....
  3. ncbi request reprint Isoflurane and sevoflurane affect cell survival and BCL-2/BAX ratio differently
    Huafeng Wei
    Department of Anesthesia, 305 John Morgan Building, 3620 Hamilton Walk, University of Pennsylvania Health System, Philadelphia, PA 19104 4283, USA
    Brain Res 1037:139-47. 2005
    ..At equipotent concentrations, isoflurane, but not sevoflurane, induces cytotoxicity in both PC12 cells and primary cortical neurons and decreases the Bcl-2/Bax ratio...
  4. doi request reprint The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors
    Huafeng Wei
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 108:251-60. 2008
    ..The authors hypothesized that isoflurane activates inositol 1,4,5-trisphosphate (IP3) receptors on the endoplasmic reticulum (ER) membrane, causing excessive calcium release, triggering apoptosis...
  5. ncbi request reprint A new tracheal tube and methods to facilitate ventilation and placement in emergency airway management
    Huafeng Wei
    Department of Anesthesia and Critical Care, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Resuscitation 70:438-44. 2006
    ..In patients requiring emergency intubation, a JET with PetCO(2) monitoring catheter and the instructions for use may be a useful addition to the airway management devices...
  6. pmc Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity
    Huafeng Wei
    Department of Anesthesiology and Critical Care, University of Pennsylvania, 305 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Neurosci Lett 425:59-62. 2007
    ..4% isoflurane for 24 h. Overall, these results suggest that isoflurane may be both neuroprotective and neurotoxic, depending on the exposure concentrations and duration...
  7. pmc The common inhaled anesthetic isoflurane increases aggregation of huntingtin and alters calcium homeostasis in a cell model of Huntington's disease
    Qiujun Wang
    Department of Anesthesiology and Critical Care, University of Pennsylvania, 305 John Morgan Building, 3620 Hamilton Walk, Pennsylvania, PA 19104, USA
    Toxicol Appl Pharmacol 250:291-8. 2011
    ..Calcium release from the ER contributes to the anesthetic induced huntingtin aggregation in STHdh(Q111/Q111) striatal cells...
  8. pmc Anesthetic-induced neurodegeneration mediated via inositol 1,4,5-trisphosphate receptors
    Yifan Zhao
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, 305 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    J Pharmacol Exp Ther 333:14-22. 2010
    ....
  9. pmc Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies
    Hui Yang
    Department of Anesthesiology and Critical Care, University of Pennsylvania, PA, USA
    Anesthesiology 109:243-50. 2008
    ....
  10. pmc Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice
    Jun Peng
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurosci Lett 516:274-9. 2012
    ....
  11. doi request reprint A presenilin-1 mutation renders neurons vulnerable to isoflurane toxicity
    Ge Liang
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    Anesth Analg 106:492-500, table of contents. 2008
    ..Sevoflurane and desflurane have less ability to disrupt intracellular calcium homeostasis; and thus we predict they will cause less cytotoxicity...
  12. pmc Isoflurane causes greater neurodegeneration than an equivalent exposure of sevoflurane in the developing brain of neonatal mice
    Ge Liang
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 112:1325-34. 2010
    ..We hypothesized that isoflurane has a greater potency to induce neurodegeneration than sevoflurane in the developing brains of neonatal mice based on our previous studies in cell culture...
  13. pmc Dual effects of isoflurane on proliferation, differentiation, and survival in human neuroprogenitor cells
    Xuli Zhao
    Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Anesthesiology 118:537-49. 2013
    ..The cellular and molecular mechanisms mediating these dual effects are not clear, but the exposure level and duration of isoflurane appear to be determinant factors...
  14. pmc Anesthesia-induced neurodegeneration in fetal rat brains
    Shouping Wang
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pediatr Res 66:435-40. 2009
    ..3% isoflurane groups. Isoflurane at a concentration of 3% for 1 h increased neurodegeneration in the hippocampal CA1 area and the retrosplenial cortex in the developing brain of fetal rats...
  15. doi request reprint The cytoprotective effects of dantrolene: a ryanodine receptor antagonist
    Saadet Inan
    Department of Anesthesiology and Critical Care, University of Pennsylvania, 305 John Morgan Building, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Anesth Analg 111:1400-10. 2010
    ....
  16. ncbi request reprint Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity
    Roderic G Eckenhoff
    Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Anesthesiology 101:703-9. 2004
    ..The authors hypothesize that inhaled anesthetics contribute to these effects through a durable enhancement of peptide oligomerization...
  17. ncbi request reprint Rat brain DNA transcript profile of halothane and isoflurane exposure
    Jonathan Z Pan
    Department of Anesthesiology and Critical Care, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Pharmacogenet Genomics 16:171-82. 2006
    ..In addition, the data show different gene expression profiles for the two inhaled anesthetics, suggesting unique pharmacological targets and mechanisms in each case...
  18. pmc Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease
    Dmitri Baranov
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Anesth Analg 108:1627-30. 2009
    ..This special article represents a consensus view on the possible link between Alzheimer's disease and anesthesia and the steps required to test this more definitively...

Research Grants6

  1. Volatile anesthetics, calcium homeostasis and apoptosis
    Huafeng Wei; Fiscal Year: 2007
    ..We will examine neuronal apoptosis by histopathology, and learning and cognition change in animals after treatment of isoflurane or sevoflurane. ..
  2. Mechanisms of anesthesia mediaited neurotoxicity
    Huafeng Wei; Fiscal Year: 2010
    ..Ultimately we hope to develop a strategy to prevent these harmful effects. This research will increase our understanding of general anesthesia-mediated neurotoxicity and make a safer use of inhaled anesthetics to surgical patients. ..
  3. Mechanisms of anesthesia mediaited neurotoxicity
    Huafeng Wei; Fiscal Year: 2009
    ..Ultimately we hope to develop a strategy to prevent these harmful effects. This research will increase our understanding of general anesthesia-mediated neurotoxicity and make a safer use of inhaled anesthetics to surgical patients. ..