Feng Wei

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint New tricks for an old slug: descending serotonergic system in pain
    Feng Wei
    Department of Neural and Pain Sciences, University of Maryland, Baltimore, MD 21201, USA
    Sheng Li Xue Bao 64:520-30. 2012
  2. pmc Activation of Erk in the anterior cingulate cortex during the induction and expression of chronic pain
    Feng Wei
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 20201, USA
    Mol Pain 4:28. 2008
  3. pmc Supraspinal glial-neuronal interactions contribute to descending pain facilitation
    Feng Wei
    Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 28:10482-95. 2008
  4. ncbi request reprint Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice
    Feng Wei
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201, USA
    J Neurosci 26:851-61. 2006
  5. pmc Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain
    Feng Wei
    Department of Neural and Pain Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 30:8624-36. 2010
  6. pmc Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors
    Kohei Shimizu
    Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 5:75. 2009
  7. pmc Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade
    Ming Gu
    Department of Neural and Pain Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 31:12823-36. 2011
  8. pmc Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain
    Wei Guo
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 6:40. 2010
  9. pmc Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain
    Wei Guo
    Department of Biomedical Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 27:6006-18. 2007
  10. pmc Transition to persistent orofacial pain after nerve injury involves supraspinal serotonin mechanisms
    Masamichi Okubo
    Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    J Neurosci 33:5152-61. 2013

Collaborators

Detail Information

Publications29

  1. ncbi request reprint New tricks for an old slug: descending serotonergic system in pain
    Feng Wei
    Department of Neural and Pain Sciences, University of Maryland, Baltimore, MD 21201, USA
    Sheng Li Xue Bao 64:520-30. 2012
    ....
  2. pmc Activation of Erk in the anterior cingulate cortex during the induction and expression of chronic pain
    Feng Wei
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 20201, USA
    Mol Pain 4:28. 2008
    ..We propose a synaptic model for explaining the roles of Erk activity during different phases of chronic pain. Our findings suggest that cortical activation of Erk may contribute to both induction and expression of chronic pain...
  3. pmc Supraspinal glial-neuronal interactions contribute to descending pain facilitation
    Feng Wei
    Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 28:10482-95. 2008
    ..These studies have addressed a novel contribution of supraspinal astrocytes and associated cytokines as well as central glial-neuronal interactions to the enhancement of descending facilitation of neuropathic pain...
  4. ncbi request reprint Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice
    Feng Wei
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201, USA
    J Neurosci 26:851-61. 2006
    ....
  5. pmc Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain
    Feng Wei
    Department of Neural and Pain Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 30:8624-36. 2010
    ..These results indicate that the descending 5-HT from the RVM is an important contributor to pain facilitation during the development of persistent pain, and may not mediate opioid-induced descending inhibition in acute pain...
  6. pmc Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors
    Kohei Shimizu
    Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 5:75. 2009
    ....
  7. pmc Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade
    Ming Gu
    Department of Neural and Pain Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 31:12823-36. 2011
    ..New pain therapies should focus on prime targets of descending facilitation-induced glial involvement, and in particular the blocking of intercellular signaling transduction between neuron and glia...
  8. pmc Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain
    Wei Guo
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 6:40. 2010
    ..Here we report a model of constant myogenic orofacial pain that lasts for months...
  9. pmc Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain
    Wei Guo
    Department of Biomedical Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 27:6006-18. 2007
    ..These findings provide evidence of astroglial activation by tissue injury, concomitant IL-1beta induction, and the coupling of NMDA receptor phosphorylation through IL-1 receptor signaling...
  10. pmc Transition to persistent orofacial pain after nerve injury involves supraspinal serotonin mechanisms
    Masamichi Okubo
    Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    J Neurosci 33:5152-61. 2013
    ....
  11. pmc Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury
    Bryan Chai
    Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 8:78. 2012
    ..Here we investigated the involvement of the RVM-Vi/Vc circuitry in mediating contralateral orofacial hyperalgesia after an injection of CFA into the masseter muscle...
  12. ncbi request reprint Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation
    Wei Guo
    Department of Biomedical Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 26:126-37. 2006
    ..Our findings also caution that application of BDNF for recovery from CNS disorders could lead to undesirable central pain...
  13. pmc Bone marrow stromal cells produce long-term pain relief in rat models of persistent pain
    Wei Guo
    Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, Maryland 21201 1586, USA
    Stem Cells 29:1294-303. 2011
    ..The findings prompt studies to elucidate the cellular mechanisms of the BMSC-induced pain relieving effect and translate these observations into clinical settings...
  14. ncbi request reprint Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia
    Wei Guo
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 24:9161-73. 2004
    ..The group ImGluR-NMDAR coupling cascade leads to phosphorylation of the NMDAR and appears necessary for the initiation of spinal dorsal horn sensitization and behavioral hyperalgesia after inflammation...
  15. ncbi request reprint Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zone
    Hu Wang
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Comp Neurol 498:390-402. 2006
    ..These findings provide further evidence to support a role of the trigeminal transition zone in response to orofacial deep injury...
  16. pmc Activation of group I mGlu receptors contributes to facilitation of NMDA receptor membrane current in spinal dorsal horn neurons after hind paw inflammation in rats
    Kun Yang
    Department of Neural and Pain Sciences, School of Dentistry and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Eur J Pharmacol 670:509-18. 2011
    ..These findings support the hypothesis that signal transduction coupling between group I mGlu receptors and NMDA receptors underlies the activation of NMDA receptors in spinal hyperexcitability and hyperalgesia...
  17. pmc Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia
    Feng Wei
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, University of Toronto, Toronto, M5S 1A8, Canada
    Mol Pain 2:21. 2006
    ..Our results suggest that neuronal CaMKII activity in the forebrain plays a role in persistent pain...
  18. ncbi request reprint Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: a microelectroporation study in adult rodents
    Feng Wei
    Department of Anesthesiology, Anatomy and Neurobiology, and Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:8402-9. 2003
    ..This new method will be useful for investigating gene function in specific brain regions of freely moving animals. Furthermore, this approach also may facilitate gene therapy in adult human brains...
  19. ncbi request reprint Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases
    Feng Wei
    Department of Anesthesiology, Washington University Pain Center, Washington University, St Louis, MO 63108, USA
    Neuron 36:713-26. 2002
    ..Intra-ACC administration of forskolin rescued behavioral allodynia defective in the AC1&8 DKO mice. Our studies suggest that AC1 and AC8 in the ACC selectively contribute to behavioral allodynia...
  20. ncbi request reprint Calcium calmodulin-dependent protein kinase IV is required for fear memory
    Feng Wei
    Washington University Pain Center, Departments of Anesthesiology, Anatomy, and Neurobiology and Psychiatry, St Louis, Missouri 63110, USA
    Nat Neurosci 5:573-9. 2002
    ..We propose that cognitive memory related to a noxious shock can be disassociated from behavioral responses to tissue injury and inflammation...
  21. ncbi request reprint Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:11107-16. 2005
    ..Our results demonstrate that the upregulation of NR2B receptors in the ACC contributes to behavioral sensitization caused by inflammation...
  22. ncbi request reprint Selective contribution of Egr1 (zif/268) to persistent inflammatory pain
    Shanelle W Ko
    Department of Physiology, University of Toronto, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Pain 6:12-20. 2005
    ..Our study suggests that the transcription factor Egr1 plays a selective role in nociceptive behavioral responses to persistent inflammatory pain but not to acute noxious stimuli...
  23. doi request reprint Missed lumbar disc herniations diagnosed with kinetic magnetic resonance imaging
    Jun Zou
    Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
    Spine (Phila Pa 1976) 33:E140-4. 2008
    ..A novel dynamic magnetic resonance imaging (MRI) system, kinetic MRI (kMRI), was used to study lumbar disc herniations...
  24. ncbi request reprint Expression of neutrophil gelatinase-associated lipocalin regulates epithelial morphogenesis in vitro
    Jane A Gwira
    Department of Medicine, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 280:7875-82. 2005
    ....
  25. ncbi request reprint Giardia lamblia: stable expression of green fluorescent protein mediated by giardiavirus
    Quan Liu
    Department of Veterinary Medicine, Jilin University, 5333 Xi an Road, Changchun 130062, People s Republic of China
    Exp Parasitol 109:181-7. 2005
    ..This plasmid was electroporated into G. lamblia and the transfectants persistently expressed GFP under G418 selection. This stable transfection system should provide a valuable tool for genetic study of G. lamblia...
  26. ncbi request reprint Structure activity relationships of aristolochic acid analogues: toxicity in cultured renal epithelial cells
    Premalatha Balachandran
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, Oxford, Mississippi 38677, USA
    Kidney Int 67:1797-805. 2005
    ..Recent studies showed that aristolochic acid (AA) could induce acute renal failure and tubular lesions in several species and available evidences demonstrate the unequivocal role of AA in so called Chinese herbs nephropathy...
  27. ncbi request reprint Endogenous facilitation: from molecular mechanisms to persistent pain
    Daphne A Robinson
    Department of Physiology, 1 King s College Circle, University of Toronto, Toronto, Canada M5S 1A8
    Curr Neurovasc Res 1:11-20. 2004
    ..We believe that understanding molecular and cellular mechanisms of endogenous facilitatory systems hold the hope for better future treatment of patients with chronic pain...
  28. ncbi request reprint Vaccination with allogeneic GM-CSF gene-modified lung cancer cells: antitumor activity comparing with that induced by autologous vaccine
    Hui Li
    Department of Immunology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China
    Cancer Biother Radiopharm 22:790-8. 2007
    ..The immunogenic and antitumor activity of allogeneic vaccine was compared with that of autologous cancer cell vaccine...
  29. ncbi request reprint CD4 +CD25 + regulatory T cells decreased the antitumor activity of cytokine-induced killer (CIK) cells of lung cancer patients
    Hui Li
    Department of Immunology, Cancer Institute and Hospital, Tianjin Medical University, Tianjin, 30060, China
    J Clin Immunol 27:317-26. 2007
    ..These results indicated that Tregs could inhibit the antitumor activity of CIK cells. The molecules TGF-beta and GITR may contribute to the suppressive function of CD(4) (+)CD(25) (+) cells...

Research Grants4

  1. Central glia/cytokines and descending facilitation in orofacial neuropathic pain
    Feng Wei; Fiscal Year: 2007
    ..The studies will advance our understanding of the mechanisms of orofacial neuropathic pain and facilitate the design of new therapeutic approaches. ..
  2. Central glia/cytokines and descending facilitation in orofacial neuropathic pain
    Feng Wei; Fiscal Year: 2010
    ..The studies will advance our understanding of the mechanisms of orofacial neuropathic pain and facilitate the design of new therapeutic approaches. ..