Research Topics
| Dongguang WeiSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Survival and neural differentiation of adult neural stem cells transplanted into the mature inner earZhengqing Hu
Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Exp Cell Res 302:40-7. 2005..The results illustrate that adult NSCs can survive and differentiate in the injured inner ear. It also demonstrates the feasibility of gene transfer to generate specific progeny for cell replacement therapy in the inner ear...- Survival, synaptogenesis, and regeneration of adult mouse spiral ganglion neurons in vitroDongguang Wei
Center for Hearing and Communication Research, Karolinska Institutet, Stockholm, Sweden
Dev Neurobiol 67:108-22. 2007..The authors also demonstrate that the adult mammalian inner ear retains progenitor cells, which could commit neurogenesis... 
Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damageDongguang Wei
Department of Anesthesiology and Pain Medicine, Center for Neuroscience, Program in Communication and Sensory Science, University of California, 1544 Newton Court, Davis, CA 95618, USA
Proc Natl Acad Sci U S A 105:21000-5. 2008..This study suggests that the functional plasticity of renewable cells and conditions that promote functional reprogramming can be used for cell therapy in the auditory setting...- A cell therapy approach to substitute neural elements in the inner earMats Ulfendahl
Karolinska Institutet, Center for Hearing and Communication Research, Department of Otolaryngology, Karolinska University Hospital, S 177 76 Stockholm, Sweden
Physiol Behav 92:75-9. 2007..In addition, it is possible that the physical properties of the cochlea, e.g., fluid-filled compartments and very limited space for cell proliferation, are unfavorable, at least in the normal cochlea... - Kv7-type channel currents in spiral ganglion neurons: involvement in sensorineural hearing lossPing Lv
Department of Anesthesiology and Pain Medicine, School of Medicine, University of California, Davis, California 95618, USA
J Biol Chem 285:34699-707. 2010..Thus, this study provides evidence of the cellular etiology and mechanisms of SGN degeneration in DFNA2... - Regeneration of the mammalian inner ear sensory epitheliumDongguang Wei
Center for Neuroscience, Program in Communication Science, Department of Anesthesiology and Pain Medicine, University of California, Davis, California 95618, USA
Curr Opin Otolaryngol Head Neck Surg 17:373-80. 2009..This review will focus on 'self-repair' of the mammalian inner ear sensory epithelium, including recruiting the in-situ proliferation and differentiation of endogenous cells at the damaged site and the autologous transplantation.. - Release and elementary mechanisms of nitric oxide in hair cellsPing Lv
Center for Neuroscience, Department of Anesthesiology and Pain Medicine, Program in Communication Sciences, University of California, Davis, Davis, CA 95616, USA
J Neurophysiol 103:2494-505. 2010..Finally, NO increases the magnitude of Ca(2+)-activated K(+) currents via direct NO nitrosylation. We conclude that NO-mediated inhibition serves as a component of efferent nerve modulation of hair cells... - Developmental expression and localization of KCNJ10 K+ channels in the guinea pig inner earZhe Jin
Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Neuroreport 17:475-9. 2006..Differential expression of KCNJ10 channel protein suggests roles for KCNJ10 channels in inner ear development and onset of auditory function... - Conservation of hearing by simultaneous mutation of Na,K-ATPase and NKCC1Rodney C Diaz
Department of Otolaryngology Head and Neck Surgery, University of California Davis School of Medicine, 1515 Newton Court, Davis, CA 95618, USA
J Assoc Res Otolaryngol 8:422-34. 2007..These observations provide insight into the detailed mechanisms of EP generation, and results of combination-knockout experiments may have important implications in the future treatment of drug-induced and age-related hearing losses... - Roles of alternative splicing in the functional properties of inner ear-specific KCNQ4 channelsTonghui Xu
Center for Neuroscience and Communication Science Program, University of California, Davis, California 95618, USA
J Biol Chem 282:23899-909. 2007..Furthermore, the dominant negative KCNQ4 mutant stifles the activity of KCNQ2-5, raising the possibility of a global disruption of KCNQ channel activity and the ensuing auditory phenotype... 
Endogenous electric currents might guide rostral migration of neuroblastsLin Cao
Department of Dermatology, University of California, Davis, 3301 C Street, Sacramento, California 95816, USA
EMBO Rep 14:184-90. 2013..The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration...- Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemiaHong Qiu
Division of Cardiovascular Medicine, Department of Internal Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
Cardiovasc Res 95:336-45. 2012..However, the key question that remains unanswered is whether cardiac-generated eicosanoids are the cause or the consequence of cardiac cell damage in MI...