Dongguang Wei

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear
    Zhengqing Hu
    Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Exp Cell Res 302:40-7. 2005
  2. ncbi request reprint Survival, synaptogenesis, and regeneration of adult mouse spiral ganglion neurons in vitro
    Dongguang Wei
    Center for Hearing and Communication Research, Karolinska Institutet, Stockholm, Sweden
    Dev Neurobiol 67:108-22. 2007
  3. pmc Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage
    Dongguang Wei
    Department of Anesthesiology and Pain Medicine, Center for Neuroscience, Program in Communication and Sensory Science, University of California, 1544 Newton Court, Davis, CA 95618, USA
    Proc Natl Acad Sci U S A 105:21000-5. 2008
  4. ncbi request reprint A cell therapy approach to substitute neural elements in the inner ear
    Mats Ulfendahl
    Karolinska Institutet, Center for Hearing and Communication Research, Department of Otolaryngology, Karolinska University Hospital, S 177 76 Stockholm, Sweden
    Physiol Behav 92:75-9. 2007
  5. pmc Kv7-type channel currents in spiral ganglion neurons: involvement in sensorineural hearing loss
    Ping Lv
    Department of Anesthesiology and Pain Medicine, School of Medicine, University of California, Davis, California 95618, USA
    J Biol Chem 285:34699-707. 2010
  6. pmc Regeneration of the mammalian inner ear sensory epithelium
    Dongguang Wei
    Center for Neuroscience, Program in Communication Science, Department of Anesthesiology and Pain Medicine, University of California, Davis, California 95618, USA
    Curr Opin Otolaryngol Head Neck Surg 17:373-80. 2009
  7. ncbi request reprint Developmental expression and localization of KCNJ10 K+ channels in the guinea pig inner ear
    Zhe Jin
    Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroreport 17:475-9. 2006
  8. pmc Release and elementary mechanisms of nitric oxide in hair cells
    Ping Lv
    Center for Neuroscience, Department of Anesthesiology and Pain Medicine, Program in Communication Sciences, University of California, Davis, Davis, CA 95616, USA
    J Neurophysiol 103:2494-505. 2010
  9. pmc Conservation of hearing by simultaneous mutation of Na,K-ATPase and NKCC1
    Rodney C Diaz
    Department of Otolaryngology Head and Neck Surgery, University of California Davis School of Medicine, 1515 Newton Court, Davis, CA 95618, USA
    J Assoc Res Otolaryngol 8:422-34. 2007
  10. ncbi request reprint Roles of alternative splicing in the functional properties of inner ear-specific KCNQ4 channels
    Tonghui Xu
    Center for Neuroscience and Communication Science Program, University of California, Davis, California 95618, USA
    J Biol Chem 282:23899-909. 2007

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear
    Zhengqing Hu
    Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Exp Cell Res 302:40-7. 2005
    ..The results illustrate that adult NSCs can survive and differentiate in the injured inner ear. It also demonstrates the feasibility of gene transfer to generate specific progeny for cell replacement therapy in the inner ear...
  2. ncbi request reprint Survival, synaptogenesis, and regeneration of adult mouse spiral ganglion neurons in vitro
    Dongguang Wei
    Center for Hearing and Communication Research, Karolinska Institutet, Stockholm, Sweden
    Dev Neurobiol 67:108-22. 2007
    ..The authors also demonstrate that the adult mammalian inner ear retains progenitor cells, which could commit neurogenesis...
  3. pmc Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage
    Dongguang Wei
    Department of Anesthesiology and Pain Medicine, Center for Neuroscience, Program in Communication and Sensory Science, University of California, 1544 Newton Court, Davis, CA 95618, USA
    Proc Natl Acad Sci U S A 105:21000-5. 2008
    ..This study suggests that the functional plasticity of renewable cells and conditions that promote functional reprogramming can be used for cell therapy in the auditory setting...
  4. ncbi request reprint A cell therapy approach to substitute neural elements in the inner ear
    Mats Ulfendahl
    Karolinska Institutet, Center for Hearing and Communication Research, Department of Otolaryngology, Karolinska University Hospital, S 177 76 Stockholm, Sweden
    Physiol Behav 92:75-9. 2007
    ..In addition, it is possible that the physical properties of the cochlea, e.g., fluid-filled compartments and very limited space for cell proliferation, are unfavorable, at least in the normal cochlea...
  5. pmc Kv7-type channel currents in spiral ganglion neurons: involvement in sensorineural hearing loss
    Ping Lv
    Department of Anesthesiology and Pain Medicine, School of Medicine, University of California, Davis, California 95618, USA
    J Biol Chem 285:34699-707. 2010
    ..Thus, this study provides evidence of the cellular etiology and mechanisms of SGN degeneration in DFNA2...
  6. pmc Regeneration of the mammalian inner ear sensory epithelium
    Dongguang Wei
    Center for Neuroscience, Program in Communication Science, Department of Anesthesiology and Pain Medicine, University of California, Davis, California 95618, USA
    Curr Opin Otolaryngol Head Neck Surg 17:373-80. 2009
    ..This review will focus on 'self-repair' of the mammalian inner ear sensory epithelium, including recruiting the in-situ proliferation and differentiation of endogenous cells at the damaged site and the autologous transplantation..
  7. ncbi request reprint Developmental expression and localization of KCNJ10 K+ channels in the guinea pig inner ear
    Zhe Jin
    Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroreport 17:475-9. 2006
    ..Differential expression of KCNJ10 channel protein suggests roles for KCNJ10 channels in inner ear development and onset of auditory function...
  8. pmc Release and elementary mechanisms of nitric oxide in hair cells
    Ping Lv
    Center for Neuroscience, Department of Anesthesiology and Pain Medicine, Program in Communication Sciences, University of California, Davis, Davis, CA 95616, USA
    J Neurophysiol 103:2494-505. 2010
    ..Finally, NO increases the magnitude of Ca(2+)-activated K(+) currents via direct NO nitrosylation. We conclude that NO-mediated inhibition serves as a component of efferent nerve modulation of hair cells...
  9. pmc Conservation of hearing by simultaneous mutation of Na,K-ATPase and NKCC1
    Rodney C Diaz
    Department of Otolaryngology Head and Neck Surgery, University of California Davis School of Medicine, 1515 Newton Court, Davis, CA 95618, USA
    J Assoc Res Otolaryngol 8:422-34. 2007
    ..These observations provide insight into the detailed mechanisms of EP generation, and results of combination-knockout experiments may have important implications in the future treatment of drug-induced and age-related hearing losses...
  10. ncbi request reprint Roles of alternative splicing in the functional properties of inner ear-specific KCNQ4 channels
    Tonghui Xu
    Center for Neuroscience and Communication Science Program, University of California, Davis, California 95618, USA
    J Biol Chem 282:23899-909. 2007
    ..Furthermore, the dominant negative KCNQ4 mutant stifles the activity of KCNQ2-5, raising the possibility of a global disruption of KCNQ channel activity and the ensuing auditory phenotype...
  11. pmc Endogenous electric currents might guide rostral migration of neuroblasts
    Lin Cao
    Department of Dermatology, University of California, Davis, 3301 C Street, Sacramento, California 95816, USA
    EMBO Rep 14:184-90. 2013
    ..The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration...
  12. pmc Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia
    Hong Qiu
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Cardiovasc Res 95:336-45. 2012
    ..However, the key question that remains unanswered is whether cardiac-generated eicosanoids are the cause or the consequence of cardiac cell damage in MI...