Felix W Wehrli

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Time-Resolved MRI Oximetry for Quantifying CMRO2 and Vascular Reactivity
    Felix W Wehrli
    Laboratory for Structural Nuclear Magnetic Resonance Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania Medical Center, 1 Founders, 3400 Spruce St, Philadelphia, PA 19104 Electronic address
    Acad Radiol 21:207-14. 2014
  2. pmc Vessel-wall imaging and quantification of flow-mediated dilation using water-selective 3D SSFP-echo
    Michael C Langham
    Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, USA
    J Cardiovasc Magn Reson 15:100. 2013
  3. pmc Combined measurement of perfusion, venous oxygen saturation, and skeletal muscle T2* during reactive hyperemia in the leg
    Erin K Englund
    Department of Radiology, Laboratory of Structural NMR Imaging, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Cardiovasc Magn Reson 15:70. 2013
  4. doi request reprint Magnetic resonance of calcified tissues
    Felix W Wehrli
    Laboratory for Structural NMR Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, USA
    J Magn Reson 229:35-48. 2013
  5. pmc Mechanical implications of estrogen supplementation in early postmenopausal women
    Felix W Wehrli
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Bone Miner Res 25:1406-14. 2010
  6. pmc Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD
    Glenn A Ladinsky
    Division of Renal, Electrolytes and Hypertension, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Bone Miner Res 23:64-74. 2008
  7. pmc Quantitative CMR markers of impaired vascular reactivity associated with age and peripheral artery disease
    Michael C Langham
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Cardiovasc Magn Reson 15:17. 2013
  8. pmc In vivo magnetic resonance detects rapid remodeling changes in the topology of the trabecular bone network after menopause and the protective effect of estradiol
    Felix W Wehrli
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Bone Miner Res 23:730-40. 2008
  9. doi request reprint 3D fast spin echo with out-of-slab cancellation: a technique for high-resolution structural imaging of trabecular bone at 7 Tesla
    Jeremy F Magland
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 63:719-27. 2010
  10. ncbi request reprint Effect of testosterone replacement on trabecular architecture in hypogonadal men
    Maria Benito
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6149, USA
    J Bone Miner Res 20:1785-91. 2005

Research Grants

Collaborators

Detail Information

Publications88

  1. pmc Time-Resolved MRI Oximetry for Quantifying CMRO2 and Vascular Reactivity
    Felix W Wehrli
    Laboratory for Structural Nuclear Magnetic Resonance Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania Medical Center, 1 Founders, 3400 Spruce St, Philadelphia, PA 19104 Electronic address
    Acad Radiol 21:207-14. 2014
    ....
  2. pmc Vessel-wall imaging and quantification of flow-mediated dilation using water-selective 3D SSFP-echo
    Michael C Langham
    Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, USA
    J Cardiovasc Magn Reson 15:100. 2013
    ..To introduce a new, efficient method for vessel-wall imaging of carotid and peripheral arteries by means of a flow-sensitive 3D water-selective SSFP-echo pulse sequence...
  3. pmc Combined measurement of perfusion, venous oxygen saturation, and skeletal muscle T2* during reactive hyperemia in the leg
    Erin K Englund
    Department of Radiology, Laboratory of Structural NMR Imaging, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Cardiovasc Magn Reson 15:70. 2013
    ..The purpose of this work is to develop and evaluate a magnetic resonance (MR) technique for simultaneous measurement of perfusion, SvO2, and skeletal muscle T2*...
  4. doi request reprint Magnetic resonance of calcified tissues
    Felix W Wehrli
    Laboratory for Structural NMR Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, USA
    J Magn Reson 229:35-48. 2013
    ....
  5. pmc Mechanical implications of estrogen supplementation in early postmenopausal women
    Felix W Wehrli
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Bone Miner Res 25:1406-14. 2010
    ..The data further highlight the anabolic effect of short-term estrogen supplementation...
  6. pmc Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD
    Glenn A Ladinsky
    Division of Renal, Electrolytes and Hypertension, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Bone Miner Res 23:64-74. 2008
    ....
  7. pmc Quantitative CMR markers of impaired vascular reactivity associated with age and peripheral artery disease
    Michael C Langham
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Cardiovasc Magn Reson 15:17. 2013
    ....
  8. pmc In vivo magnetic resonance detects rapid remodeling changes in the topology of the trabecular bone network after menopause and the protective effect of estradiol
    Felix W Wehrli
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Bone Miner Res 23:730-40. 2008
    ....
  9. doi request reprint 3D fast spin echo with out-of-slab cancellation: a technique for high-resolution structural imaging of trabecular bone at 7 Tesla
    Jeremy F Magland
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 63:719-27. 2010
    ....
  10. ncbi request reprint Effect of testosterone replacement on trabecular architecture in hypogonadal men
    Maria Benito
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6149, USA
    J Bone Miner Res 20:1785-91. 2005
    ..After 2 years, microMRI parameters of trabecular connectivity improved significantly, suggesting the possibility that testosterone improves trabecular architecture...
  11. pmc Implications of resolution and noise for in vivo micro-MRI of trabecular bone
    Charles Q Li
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Med Phys 35:5584-94. 2008
    ....
  12. pmc Simultaneous mapping of temporally-resolved blood flow velocity and oxygenation in femoral artery and vein during reactive hyperemia
    Michael C Langham
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Cardiovasc Magn Reson 13:66. 2011
    ..Here we demonstrate the feasibility of a simultaneous measurement of blood flow and HbO2 in the femoral circulation as part of a single procedure...
  13. ncbi request reprint Spatial autocorrelation and mean intercept length analysis of trabecular bone anisotropy applied to in vivo magnetic resonance imaging
    Michael J Wald
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Med Phys 34:1110-20. 2007
    ..There was good agreement between the two techniques as far as the eigenvectors of the fabric ellipsoids were concerned, which parallel the bone's macroscopic axis...
  14. ncbi request reprint Implications of pulse sequence in structural imaging of trabecular bone
    Aranee Techawiboonwong
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Magn Reson Imaging 22:647-55. 2005
    ....
  15. pmc Method for cortical bone structural analysis from magnetic resonance images
    Bryon R Gomberg
    Department of Radiology, Laboratory for Structural NMR Imaging, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Acad Radiol 12:1320-32. 2005
    ..The aim of this study is to develop MR acquisition and analysis methods optimized for the detection of cortical boundaries in such complex geometries as the femoral neck...
  16. pmc Accuracy and precision of MR blood oximetry based on the long paramagnetic cylinder approximation of large vessels
    Michael C Langham
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Magn Reson Med 62:333-40. 2009
    ..In conclusion, the data suggest that %HbO(2) can be measured reproducibly in vivo in large vessels of the peripheral circulation on the basis of the paramagnetic cylinder approximation of the incremental field...
  17. pmc MRI estimation of global brain oxygen consumption rate
    Varsha Jain
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Cereb Blood Flow Metab 30:1598-607. 2010
    ..In addition, the short acquisition time (approximately 30 seconds) makes the technique suitable for studying the temporal variations in CMRO(2) in response to physiologic challenges...
  18. pmc Magnetic resonance microimaging of intraaxonal water diffusion in live excised lamprey spinal cord
    Masaya Takahashi
    Departments of Radiology and Neurology, University of Pennsylvania Medical Center, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104 USA
    Proc Natl Acad Sci U S A 99:16192-6. 2002
    ..These findings support the hypothesis that the cell membrane is the primary source of diffusion anisotropy in fiber tracts of the central nervous system...
  19. pmc Skeletal muscle microvascular flow in progressive peripheral artery disease: assessment with continuous arterial spin-labeling perfusion magnetic resonance imaging
    Wen Chau Wu
    Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 53:2372-7. 2009
    ..We present the novel application of continuous arterial spin-labeling (CASL) magnetic resonance imaging (MRI) for the measurement of calf muscle perfusion in subjects with progressive peripheral arterial disease (PAD)...
  20. pmc Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRI
    Wen Chau Wu
    Department of Radiology, The Hospital of University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Physiol Heart Circ Physiol 294:H2129-36. 2008
    ..These results demonstrate that CASL is sensitive to flow heterogeneity between diverse muscle groups and that nonuniform hyperemic flow patterns following an ischemic paradigm correlate with relative fiber-type predominance...
  21. pmc 31P NMR relaxation of cortical bone mineral at multiple magnetic field strengths and levels of demineralization
    Alan C Seifert
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
    NMR Biomed 26:1158-66. 2013
    ..Despite the steep decrease in the T2 */T1 ratio, SNR should increase with field strength as B0 (0.4) for sample-dominated noise and as B0 (1.1) for coil-dominated noise. This was confirmed by imaging experiments...
  22. pmc Time-resolved absolute velocity quantification with projections
    Michael C Langham
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 64:1599-606. 2010
    ..In conclusion, the proposed method provides temporally resolved arterial velocity with a temporal resolution of 20 ms with minimal post processing...
  23. doi request reprint Accuracy of the cylinder approximation for susceptometric measurement of intravascular oxygen saturation
    Cheng Li
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 67:808-13. 2012
    ..In conclusion, the simulation results provide a significant level of confidence for the validity of the cylinder approximation underlying MR susceptometry-based oximetry of large vessels...
  24. pmc Implications of noise and resolution on mechanical properties of trabecular bone estimated by image-based finite-element analysis
    Chamith S Rajapakse
    Department of Radiology, Laboratory for Structural NMR Imaging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Orthop Res 27:1263-71. 2009
    ..Systematic errors manifesting in significant deviations of the slopes from unity are caused by higher apparent bone-volume fraction of the MR images but can potentially be corrected with appropriate histogram-standardization techniques...
  25. ncbi request reprint Image metric-based correction (autofocusing) of motion artifacts in high-resolution trabecular bone imaging
    Wei Lin
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Magn Reson Imaging 26:191-7. 2007
    ..To evaluate the performance of the autofocusing (AF) motion correction technique in high-resolution trabecular bone imaging where image signal-to noise ratio (SNR) is limited...
  26. pmc Indirect measurement of regional axon diameter in excised mouse spinal cord with q-space imaging: simulation and experimental studies
    Henry H Ong
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neuroimage 40:1619-32. 2008
    ..QSI may be able to quantify nondestructively changes in WM axon architecture due to pathology or injury at the cellular level...
  27. pmc Retrospective 3D registration of trabecular bone MR images for longitudinal studies
    Jeremy F Magland
    Department of Radiology, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
    J Magn Reson Imaging 29:118-26. 2009
    ..To evaluate an automatic 3D registration algorithm for serial high-resolution images of trabecular bone (TB) in studies designed to evaluate the response of the trabecular architecture to intervention or disease progression...
  28. ncbi request reprint Retrospective correction for induced magnetic field inhomogeneity in measurements of large-vessel hemoglobin oxygen saturation by MR susceptometry
    Michael C Langham
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 61:626-33. 2009
    ....
  29. pmc Non-triggered quantification of central and peripheral pulse-wave velocity
    Michael C Langham
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Cardiovasc Magn Reson 13:81. 2011
    ..We extended a previous non-triggered projection-based cardiovascular MR method and demonstrate its feasibility by mapping the PWV of the aortic arch, thoraco-abdominal aorta and iliofemoral arteries in a cohort of healthy adults...
  30. pmc Deuterium nuclear magnetic resonance unambiguously quantifies pore and collagen-bound water in cortical bone
    Henry H Ong
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Bone Miner Res 27:2573-81. 2012
    ..91). Our method provides means for direct validation of emerging relaxation-based measurements of cortical bone porosity by proton MRI...
  31. ncbi request reprint Deterioration of trabecular architecture in hypogonadal men
    Maria Benito
    Department of Medicine, University of Pennsylvania, Phyladelphia 19104, USA
    J Clin Endocrinol Metab 88:1497-502. 2003
    ..We conclude that male hypogonadism is associated with marked deterioration of trabecular architecture and to a greater degree than bone densitometry of the spine and hip suggests...
  32. pmc Micro-MR imaging-based computational biomechanics demonstrates reduction in cortical and trabecular bone strength after renal transplantation
    Chamith S Rajapakse
    Department of Radiology, University of Pennsylvania, 1 Founders, 3400 Spruce St, Philadelphia, PA 19104, USA
    Radiology 262:912-20. 2012
    ....
  33. pmc Predicting trabecular bone elastic properties from measures of bone volume fraction and fabric on the basis of micromagnetic resonance images
    Michael J Wald
    Department of Radiology, Laboratory for Structural NMR Imaging, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States of America
    Magn Reson Med 68:463-73. 2012
    ..98 and 0.82 (in vivo). The results show that fabric, an important predictor of bone mechanical properties, can be assessed in the limited resolution and signal-to-noise ratio regime of micromagnetic resonance images...
  34. pmc On the significance of motion degradation in high-resolution 3D μMRI of trabecular bone
    Yusuf A Bhagat
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    Acad Radiol 18:1205-16. 2011
    ..In this work, the effects of translational and rotational motion displacements were evaluated qualitatively and quantitatively...
  35. pmc Computational biomechanics of the distal tibia from high-resolution MR and micro-CT images
    Chamith S Rajapakse
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Bone 47:556-63. 2010
    ..0.71+/-0.11) when correlated with reference subregional elastic and shear moduli. This work suggests that elastic properties of distal tibia can be reliably estimated by microFE analysis from microMRIs obtainable at in vivo resolution...
  36. pmc Assessment of trabecular bone yield and post-yield behavior from high-resolution MRI-based nonlinear finite element analysis at the distal radius of premenopausal and postmenopausal women susceptible to osteoporosis
    Ning Zhang
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce St, Philadelphia, PA 19104
    Acad Radiol 20:1584-91. 2013
    ..To assess the performance of a nonlinear microfinite element model on predicting trabecular bone yield and post-yield behavior based on high-resolution in vivo magnetic resonance images via the serial reproducibility...
  37. pmc Evaluation of cuff-induced ischemia in the lower extremity by magnetic resonance oximetry
    Michael C Langham
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 55:598-606. 2010
    ....
  38. pmc Potential of in vivo MRI-based nonlinear finite-element analysis for the assessment of trabecular bone post-yield properties
    Ning Zhang
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Med Phys 40:052303. 2013
    ....
  39. pmc Classification of trabeculae into three-dimensional rodlike and platelike structures via local inertial anisotropy
    Branimir Vasilic
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Med Phys 36:3280-91. 2009
    ..Finally, the method is applied to data acquired in a previous translational pilot study showing that the trabecular bone of untreated hypogonadal men is less platelike than that of their eugonadal peers...
  40. ncbi request reprint A new approach for simultaneous measurement of ADC and T2 from echoes generated via multiple coherence transfer pathways
    Henry Ong
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Magn Reson 173:153-9. 2005
    ..The regional SMART derived T2 and ADC agree well with those obtained with conventional double-spin-echo and pulsed gradient spin-echo methods...
  41. ncbi request reprint A novel local thresholding algorithm for trabecular bone volume fraction mapping in the limited spatial resolution regime of in vivo MRI
    Branimir Vasilic
    Department of Radiology, The University of Pennsylvania Medical Center, 3400 Spruce Street, 1st Floor Founders, MRI Leaming Center, Philadelphia, PA 19104 USA
    IEEE Trans Med Imaging 24:1574-85. 2005
    ..Finally, we demonstrate that the LTA is superior in preserving connectivity by showing for 75 in vivo images that the genus of the trabecular bone surface is always higher than when processed with the HDA...
  42. ncbi request reprint Measurement of trabecular bone thickness in the limited resolution regime of in vivo MRI by fuzzy distance transform
    Punam K Saha
    Medical Image Processing Group, Department of Radiology, University of Pennsylvania, Fourth Floor, Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    IEEE Trans Med Imaging 23:53-62. 2004
    ..Finally, with in vivo micro-MR images from a prior study in rabbits subjected to corticosteroid exposure, it is demonstrated that short-term treatment resulting in trabecular thinning can be quantified with the new method...
  43. pmc Performance of the MRI-based virtual bone biopsy in the distal radius: serial reproducibility and reliability of structural and mechanical parameters in women representative of osteoporosis study populations
    Shing Chun Benny Lam
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Bone 49:895-903. 2011
    ..The underlying technology is portable and should be compatible with all general-purpose MRI scanners, which is appealing considering the very large installed base of this modality...
  44. pmc Comparison of optimized soft-tissue suppression schemes for ultrashort echo time MRI
    Cheng Li
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    Magn Reson Med 68:680-9. 2012
    ..IR-UTE has the lowest short-T(2) SNR efficiency but provides highly uniform short-T(2) contrast and is well suited for imaging short-T(2) species with relatively short T(1) such as bone water...
  45. pmc Computationally-optimized bone mechanical modeling from high-resolution structural images
    Jeremy F Magland
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e35525. 2012
    ..In conclusion, the system described should enable image-based finite-element bone simulations in practical computation times on high-end desktop computers with applications to laboratory studies and clinical imaging...
  46. pmc High temporal resolution MRI quantification of global cerebral metabolic rate of oxygen consumption in response to apneic challenge
    Zachary B Rodgers
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 33:1514-22. 2013
    ....
  47. ncbi request reprint Assessment of axonal fiber tract architecture in excised rat spinal cord by localized NMR q-space imaging: simulations and experimental studies
    Chih Liang Chin
    University of Pennsylvania Medical Center, Department of Radiology, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 52:733-40. 2004
    ..The data suggest the NMR q-space approach has potential for nondestructive analysis of the axonal architecture in the mammalian spinal cord...
  48. ncbi request reprint Water content measured by proton-deuteron exchange NMR predicts bone mineral density and mechanical properties
    Maria A Fernandez-Seara
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Bone Miner Res 19:289-96. 2004
    ..Water content showed an inverse relationship with mineral content, suggesting it could serve as a surrogate measure for the bone's degree of mineralization...
  49. ncbi request reprint Structural and functional assessment of trabecular and cortical bone by micro magnetic resonance imaging
    Felix W Wehrli
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Magn Reson Imaging 25:390-409. 2007
    ..Current data suggest that noninvasive assessment of cortical and trabecular bone (TB) architecture by mu-MRI may provide new surrogate endpoints to assess the efficacy of intervention in osteoporosis treatment and prevention...
  50. pmc Cortical bone water: in vivo quantification with ultrashort echo-time MR imaging
    Aranee Techawiboonwong
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce St, 1 Founders, MRI Education Center, Philadelphia, PA 19104, USA
    Radiology 248:824-33. 2008
    ..To develop and evaluate a method based on ultrashort echo-time radial magnetic resonance (MR) imaging to quantify bone water (BW) concentration as a new metric of bone quality in human cortical bone in vivo...
  51. pmc Quantifying cortical bone water in vivo by three-dimensional ultra-short echo-time MRI
    Hamidreza Saligheh Rad
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    NMR Biomed 24:855-64. 2011
    ..The data thus show conclusively that the method quantifies water even though, in vivo, no distinction can be made between various fractions, such as collagen-bound vs pore-resident water...
  52. ncbi request reprint Fast prospective registration of in vivo MR images of trabecular bone microstructure in longitudinal studies
    Chamith S Rajapakse
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Magn Reson Med 59:1120-6. 2008
    ..Based on phantom and human subject studies it is shown that prospective registration yields very close matching between baseline and follow-up imaging volumes...
  53. pmc Helmholtz-pair transmit coil with integrated receive array for high-resolution MRI of trabecular bone in the distal tibia at 7T
    Alexander C Wright
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Magn Reson 210:113-22. 2011
    ..9× for imaging at 7T compared to 3T and 1.5T, respectively. The results thus display an approximately linear dependence of SNR with field strength and enable the practical utility of 7T scanners for micro-MRI of trabecular bone...
  54. ncbi request reprint Quantitative MRI for the assessment of bone structure and function
    Felix W Wehrli
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    NMR Biomed 19:731-64. 2006
    ..Key clinical applications targeted involve fracture risk prediction and evaluation of the effect of therapeutic intervention...
  55. ncbi request reprint Correcting bulk in-plane motion artifacts in MRI using the point spread function
    Wei Lin
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    IEEE Trans Med Imaging 24:1170-6. 2005
    ..Rotation is detected by analyzing the relative displacements of two such markers. The technique was evaluated with simulations, phantom and in vivo experiments...
  56. pmc Longitudinal reproducibility and accuracy of pseudo-continuous arterial spin-labeled perfusion MR imaging in typically developing children
    Varsha Jain
    Department of Radiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Radiology 263:527-36. 2012
    ..To evaluate the longitudinal repeatability and accuracy of cerebral blood flow (CBF) measurements by using pseudo-continuous arterial spin-labeled (pCASL) perfusion magnetic resonance (MR) imaging in typically developing children...
  57. pmc Trabecular bone structure analysis in the limited spatial resolution regime of in vivo MRI
    Jeremy F Magland
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Acad Radiol 15:1482-93. 2008
    ....
  58. pmc Quantifying axon diameter and intra-cellular volume fraction in excised mouse spinal cord with q-space imaging
    Henry H Ong
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neuroimage 51:1360-6. 2010
    ..92, p<0.05) with measurements from histology (0.68+/-0.07). These methods may provide insight into axonal architecture in normal and abnormal WM tissue but additional validation with more samples will be needed...
  59. pmc Rapid magnetic resonance measurement of global cerebral metabolic rate of oxygen consumption in humans during rest and hypercapnia
    Varsha Jain
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 31:1504-12. 2011
    ..44, P=0.052). A CVR value of 6.1%±1.6%/mm Hg was determined using a linear-fit model. Additionally, an average undershoot of 6.7%±4% and 17.1%±7% was observed in S(v)O(2) and tCBF upon recovery from hypercapnia in six subjects...
  60. pmc Performance of μMRI-Based virtual bone biopsy for structural and mechanical analysis at the distal tibia at 7T field strength
    Yusuf A Bhagat
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, MRI Education Center, Philadelphia, Pennsylvania 19104, USA
    J Magn Reson Imaging 33:372-81. 2011
    ..0t...
  61. ncbi request reprint MR susceptometry for measuring global brain oxygen extraction
    Maria A Fernandez-Seara
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 55:967-73. 2006
    ..Unlike alternative methods, the susceptometric technique does not require calibration...
  62. pmc Bone mineral (31)P and matrix-bound water densities measured by solid-state (31)P and (1)H MRI
    Alan C Seifert
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
    NMR Biomed 27:739-48. 2014
    ..This work establishes the feasibility of image-based quantification of bone mineral and bound water densities using clinical hardware...
  63. pmc Nontriggered MRI quantification of aortic pulse-wave velocity
    Michael C Langham
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 65:750-5. 2011
    ..Key benefits of the proposed method are simplicity in both data acquisition and processing requiring only computation of the complex difference between the velocity-encoded projections rather than absolute velocity...
  64. ncbi request reprint Topology-based orientation analysis of trabecular bone networks
    Bryon R Gomberg
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Med Phys 30:158-68. 2003
    ..16, 1520 (2001)] shows that the mean orientation and anisotropy at the medial and lateral sides in the distal radius mataphyseal trabecular network are consistent with the mechanical stresses acting on the radius during common tasks...
  65. ncbi request reprint Quantitative high-resolution magnetic resonance imaging reveals structural implications of renal osteodystrophy on trabecular and cortical bone
    Felix W Wehrli
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Magn Reson Imaging 20:83-9. 2004
    ....
  66. pmc Direct magnetic resonance detection of myelin and prospects for quantitative imaging of myelin density
    Michael J Wilhelm
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:9605-10. 2012
    ..Last, the integrated signal from myelin suspensions is shown, both spectroscopically and by imaging, to scale with concentration, suggesting the potential for quantitative determination of myelin density...
  67. pmc Mineral volume and morphology in carotid plaque specimens using high-resolution MRI and CT
    Ronald L Wolf
    Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce St, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 25:1729-35. 2005
    ..The purpose of this study was to assess the performance of high-resolution MRI in evaluation of the quantity and pattern of mineral deposition in carotid endarterectomy (CEA) specimens, with quantitative micro-CT as the gold standard...
  68. ncbi request reprint Skeletal effects of short-term exposure to dexamethasone and response to risedronate treatment studied in vivo in rabbits by magnetic resonance micro-imaging and spectroscopy
    Masaya Takahashi
    Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Bone Miner Metab 24:467-75. 2006
    ..The data lend support to a protective effect of risedronate on trabecular architecture during GC exposure. The improvement in trabecular network parameters beyond baseline values further suggest a therapeutic effect of risedronate...
  69. ncbi request reprint Quantitative magnetic resonance imaging in the calcaneus and femur of women with varying degrees of osteopenia and vertebral deformity status
    Felix W Wehrli
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Bone Miner Res 17:2265-73. 2002
    ..01). The data suggest the calcaneus to be suited as a surrogate site to assess vertebral osteoporosis and that R2* is sensitive to alterations in bone quality not captured by density...
  70. pmc Investigating the magnetic susceptibility properties of fresh human blood for noninvasive oxygen saturation quantification
    Varsha Jain
    Department of Radiology, Laboratory of Structural NMR Imaging, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Magn Reson Med 68:863-7. 2012
    ..Regression analysis yielded 0.273 ± 0.006 and -0.008 ± 0.003 ppm (cgs) respectively, for Δχ(do) and Δχ(oxy) , in excellent agreement with previous work by Spees et al. (Magn Reson Med 2001;45:533-542)...
  71. ncbi request reprint Role of magnetic resonance for assessing structure and function of trabecular bone
    Felix W Wehrli
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, 1 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Top Magn Reson Imaging 13:335-55. 2002
    ..The method currently is confined to peripheral skeletal sites, and its extension to typical fracture sites such as the proximal femur hinges on further advances in detection sensitivity...
  72. ncbi request reprint Reference-scan-free method for automated correction of Nyquist ghost artifacts in echoplanar brain images
    Yan Zhang
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 51:621-4. 2004
    ..In vivo data demonstrate the effectiveness of the algorithm showing ghost suppression comparable to that achievable with the reference-scan method...
  73. ncbi request reprint Multislice double inversion pulse sequence for efficient black-blood MRI
    Hee Kwon Song
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Magn Reson Med 47:616-20. 2002
    ..It is demonstrated in vivo with examples from carotid and coronary arteries that one can acquire multiple slices with sufficient nulling of blood, following a single set of inversion pulses...
  74. ncbi request reprint Visualization of individual axons in excised lamprey spinal cord by magnetic resonance microscopy
    Alexander C Wright
    Laboratory for Structural NMR Imaging, Department of Radiology, 1 Silverstein, Hospital of the University of Pennsylvania, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neurosci Methods 114:9-15. 2002
    ..Although the lamprey previously has not been the subject of MR microscopy investigations, these results demonstrate the method's potential for imaging this axon system, which is an important model of spinal cord injury and regeneration...
  75. ncbi request reprint Nuclear magnetic resonance studies of bone water
    Felix W Wehrli
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Ann Biomed Eng 33:79-86. 2005
    ..Finally, whereas isotope exchange is not feasible in vivo, it is shown that bone water can be imaged by proton MRI...
  76. ncbi request reprint Noninvasive assessment of bone microarchitecture by MRI
    Glenn A Ladinsky
    Division of Renal, Electrolytes and Hypertension, University of Pennsylvania, 700 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104 4218, USA
    Curr Osteoporos Rep 4:140-7. 2006
    ..This technique is noninvasive, involving no contrast or ionizing radiation, and provides useful clinical information independent of bone mineral density, thereby allowing for better classification of those at high risk for fracture...
  77. pmc Diffusion of exchangeable water in cortical bone studied by nuclear magnetic resonance
    Maria A Fernandez-Seara
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Biophys J 82:522-9. 2002
    ..Finally, the data reveal a water component (approximately 30%) diffusing four orders of magnitude more slowly, which is ascribed to water tightly bound to the organic matrix and mineral phase...
  78. ncbi request reprint The role of stress-induced cortisol in the relationship between depression and decreased bone mineral density
    Patricia M Furlan
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 57:911-7. 2005
    ..This study was designed to test the hypothesis that cortisol mediates the relationship between bone density and depression in postmenopausal women...
  79. pmc In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure
    Masaya Takahashi
    Department of Radiology, University of Pennsylvania Medical Center, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:4574-9. 2002
    ..Finally, this work, which was performed on a clinical scanner, has implications for evaluating patients on high-dose steroid treatment...
  80. ncbi request reprint Coherence-induced artifacts in large-flip-angle steady-state spin-echo imaging
    Branimir Vasilic
    Laboratory for Structural NMR Imaging, University of Pennsylvania Medical Center, Department of Radiology, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 52:346-53. 2004
    ..The results of the simulations were in exact agreement with the experiments and the proposed remedy was found to eliminate the artifact...
  81. ncbi request reprint Relationships between MR transverse relaxation parameters R*(2), R(2) and R'(2) and hepatic iron content in thalassemic mice at 1.5 T and 3 T
    Ruitian Song
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    NMR Biomed 21:574-80. 2008
    ..It can be concluded that the three rates could all be effective for assessing hepatic iron concentration and that imaging at higher fields may not offer any advantages over that at lower fields...
  82. ncbi request reprint Subvoxel processing: a method for reducing partial volume blurring with application to in vivo MR images of trabecular bone
    Scott N Hwang
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 47:948-57. 2002
    ..The subvoxel-processed images are shown to have architectural features characteristic of images acquired at higher spatial resolution...
  83. ncbi request reprint Biexponential diffusion attenuation in the rat spinal cord: computer simulations based on anatomic images of axonal architecture
    Chih Liang Chin
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 47:455-60. 2002
    ....
  84. pmc High-resolution black-blood MRI of the carotid vessel wall using phased-array coils at 1.5 and 3 Tesla
    Seshasailaja Anumula
    Department of Radiology, Laboratory for Structural NMR Imaging, University of Pennsylvania Health System, Philadelphia, PA, USA
    Acad Radiol 12:1521-6. 2005
    ..5 and 3 Tesla (T) and determine the extent to which the improved SNR at the higher field can be traded for improved spatial resolution...
  85. ncbi request reprint A theoretical and experimental investigation of the tagging efficiency of pseudocontinuous arterial spin labeling
    Wen Chau Wu
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 58:1020-7. 2007
    ..These improvements provide a better balance between tagging efficiency and SNR...
  86. ncbi request reprint In vivo MRI of submillisecond T(2) species with two-dimensional and three-dimensional radial sequences and applications to the measurement of cortical bone water
    Aranee Techawiboonwong
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    NMR Biomed 21:59-70. 2008
    ..With the use of an external reference, the water volume fraction of cortical bone in four subjects (mean +/- SD age 32.25 +/- 5.3 years) was found to be 22.5 +/- 2.7%, in good agreement with literature values...
  87. ncbi request reprint Isolating quantum coherences in structural imaging using intermolecular double-quantum coherence MRI
    Chih Liang Chin
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104 4283, USA
    J Magn Reson 165:309-14. 2003
    ..Finally, preliminary data suggest the method to be able to provide information on trabecular bone architecture such as regional mean trabecular plate separation...
  88. ncbi request reprint Spatially-confined arterial spin-labeling with FAIR
    Yan Zhang
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Magn Reson Imaging 22:119-24. 2005
    ..To investigate the effectiveness of slab-selective inversion in pulsed arterial spin labeling with body coil excitation as a means to reduce large vessel contamination of the perfusion signal...

Research Grants43

  1. IN VIVO ASSESSMENT OF STEROID-INDUCED OSTEOPENIA
    Felix Wehrli; Fiscal Year: 2001
    ..4) Supplementation of corticosteroid treatment with gonadal steroids alleviates bone loss. (5) The corticosteroid-induced changes in trabecular microarchitecture are accompanied by a predictable reduction in the bone's elastic modulus. ..
  2. MRI-Based Virtual Bone Biopsy
    Felix Wehrli; Fiscal Year: 2005
    ..abstract_text> ..
  3. Bone Water and Mineralization Measured by Nuclear Magnetic Resonance
    Felix W Wehrli; Fiscal Year: 2010
    ..The proposed approach, based on quantification of bone water with a new magnetic resonance imaging technique provides noninvasive surrogate measurement of cortical bone porosity as a new metric of bone quality. ..
  4. NMR IMAGING AND STEREOLOGIC ANALYSIS OF TRABECULAR BONE
    Felix Wehrli; Fiscal Year: 2002
    ....
  5. IN VIVO ASSESSMENT OF STEROID INDUCED OSTEOPENIA
    Felix Wehrli; Fiscal Year: 1999
    ..4) Supplementation of corticosteroid treatment with gonadal steroids alleviates bone loss. (5) The corticosteroid-induced changes in trabecular microarchitecture are accompanied by a predictable reduction in the bone's elastic modulus. ..
  6. NMR IMAGING AND STEREOLOGIC ANALYSIS OF TRABECULAR BONE
    Felix Wehrli; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. NMR IMAGING AND STEREOLOGIC ANALYSIS OF TRABECULAR BONE
    Felix Wehrli; Fiscal Year: 2008
    ..abstract_text> ..
  8. Structural MRI of trabecular bone for therapy response monitoring
    Felix Wehrli; Fiscal Year: 2008
    ..Already established Penn-internal partnerships with Dr. Charles Epstein (Department of Mathematics) and Dr. Peter Snyder (Department of Medicine, Division of Endocrinology) will be further expanded and strengthened. ..
  9. MRI-Based Virtual Bone Biopsy
    Felix Wehrli; Fiscal Year: 2002
    ..abstract_text> ..
  10. MRI-Based Virtual Bone Biopsy
    Felix Wehrli; Fiscal Year: 2004
    ..abstract_text> ..
  11. Bone Water & Mineralization: Nuclear Magnetic Resonance
    Felix Wehrli; Fiscal Year: 2005
    ..The long-term goal of this project is to provide a noninvasive method for probing the intrinsic properties of bone in laboratory animals and ultimately in humans. ..
  12. MRI of trabecular bone for therapy response monitoring
    Felix Wehrli; Fiscal Year: 2005
    ..Already established Penn-internal partnerships with Dr. Charles Epstein (Department of Mathematics) and Dr. Peter Snyder (Department of Medicine, Division of Endocrinology) will be further expanded and strengthened. ..
  13. Osteoporosis Treatment Response Assessed by Micromechanical Modeling of MRI Data
    Felix Wehrli; Fiscal Year: 2009
    ....
  14. Structural MRI of trabecular bone for therapy response monitoring
    Felix Wehrli; Fiscal Year: 2009
    ..Already established Penn-internal partnerships with Dr. Charles Epstein (Department of Mathematics) and Dr. Peter Snyder (Department of Medicine, Division of Endocrinology) will be further expanded and strengthened. ..
  15. Structural MRI of trabecular bone for therapy response monitoring
    Felix Wehrli; Fiscal Year: 2007
    ..Already established Penn-internal partnerships with Dr. Charles Epstein (Department of Mathematics) and Dr. Peter Snyder (Department of Medicine, Division of Endocrinology) will be further expanded and strengthened. ..
  16. NMR IMAGING AND STEREOLOGIC ANALYSIS OF TRABECULAR BONE
    Felix Wehrli; Fiscal Year: 2009
    ..abstract_text> ..
  17. Bone Water and Mineralization Measured by Nuclear Magnetic Resonance
    Felix Wehrli; Fiscal Year: 2009
    ..The proposed approach, based on quantification of bone water with a new magnetic resonance imaging technique provides noninvasive surrogate measurement of cortical bone porosity as a new metric of bone quality. ..
  18. IN VIVO ASSESSMENT OF STEROID-INDUCED OSTEOPENIA
    Felix Wehrli; Fiscal Year: 1999
    ..4) Supplementation of corticosteroid treatment with gonadal steroids alleviates bone loss. (5) The corticosteroid-induced changes in trabecular microarchitecture are accompanied by a predictable reduction in the bone's elastic modulus. ..
  19. IN VIVO ASSESSMENT OF STEROID-INDUCED OSTEOPENIA
    Felix Wehrli; Fiscal Year: 2000
    ..4) Supplementation of corticosteroid treatment with gonadal steroids alleviates bone loss. (5) The corticosteroid-induced changes in trabecular microarchitecture are accompanied by a predictable reduction in the bone's elastic modulus. ..
  20. Structure-Function Assessment of Carotid Disease by MR
    Felix Wehrli; Fiscal Year: 2002
    ....
  21. Osteoporosis Treatment Response Assessed by Micromechanical Modeling of MRI Data
    Felix Wehrli; Fiscal Year: 2008
    ....
  22. Bone Water and Mineralization Measured by Nuclear Magnetic Resonance
    Felix Wehrli; Fiscal Year: 2008
    ..The proposed approach, based on quantification of bone water with a new magnetic resonance imaging technique provides noninvasive surrogate measurement of cortical bone porosity as a new metric of bone quality. ..
  23. Osteoporosis Treatment Response Assessed by Micromechanical Modeling of MRI Data
    Felix W Wehrli; Fiscal Year: 2010
    ....
  24. Structural MRI of trabecular bone for therapy response monitoring
    Felix Wehrli; Fiscal Year: 2006
    ..Already established Penn-internal partnerships with Dr. Charles Epstein (Department of Mathematics) and Dr. Peter Snyder (Department of Medicine, Division of Endocrinology) will be further expanded and strengthened. ..
  25. Bone Water & Mineralization: Nuclear Magnetic Resonance
    Felix Wehrli; Fiscal Year: 2006
    ..The long-term goal of this project is to provide a noninvasive method for probing the intrinsic properties of bone in laboratory animals and ultimately in humans. ..
  26. NMR IMAGING AND STEREOLOGIC ANALYSIS OF TRABECULAR BONE
    Felix Wehrli; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  27. NMR IMAGING AND STEREOLOGIC ANALYSIS OF TRABECULAR BONE
    Felix Wehrli; Fiscal Year: 2001
    ....
  28. Structure-Function Assessment of Carotid Disease by MR
    Felix Wehrli; Fiscal Year: 2003
    ....
  29. NMR IMAGING AND STEREOLOGIC ANALYSIS OF TRABECULAR BONE
    Felix Wehrli; Fiscal Year: 2003
    ....
  30. MRI-Based Virtual Bone Biopsy
    Felix Wehrli; Fiscal Year: 2003
    ..abstract_text> ..
  31. Structure-Function Assessment of Carotid Disease by MR
    Felix Wehrli; Fiscal Year: 2004
    ....
  32. Bone Water & Mineralization: Nuclear Magnetic Resonance
    Felix Wehrli; Fiscal Year: 2004
    ..The long-term goal of this project is to provide a noninvasive method for probing the intrinsic properties of bone in laboratory animals and ultimately in humans. ..
  33. CT DEVICE FOR MICROIMAGING OF TISSUE SPECIMENS IN VIVO
    Felix Wehrli; Fiscal Year: 2001
    ..abstract_text> ..
  34. IN VIVO ASSESSMENT OF STEROID-INDUCED OSTEOPENIA
    Felix Wehrli; Fiscal Year: 2000
    ..4) Supplementation of corticosteroid treatment with gonadal steroids alleviates bone loss. (5) The corticosteroid-induced changes in trabecular microarchitecture are accompanied by a predictable reduction in the bone's elastic modulus. ..
  35. Bone Water & Mineralization: Nuclear Magnetic Resonance
    Felix Wehrli; Fiscal Year: 2003
    ..The long-term goal of this project is to provide a noninvasive method for probing the intrinsic properties of bone in laboratory animals and ultimately in humans. ..
  36. NMR IMAGING AND STEREOLOGIC ANALYSIS OF TRABECULAR BONE
    Felix Wehrli; Fiscal Year: 2000
    ....