JEANNE WEHNER

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi request reprint Quantitative trait locus analysis of contextual fear conditioning in mice
    J M Wehner
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
    Nat Genet 17:331-4. 1997
  2. ncbi request reprint Microarray analysis of the effects of a gamma-protein kinase C null mutation on gene expression in striatum: a role for transthyretin in mutant phenotypes
    Amy M Smith
    Institute for Behavioral Genetics, University of Colorado, 447, UCB, Boulder, CO 80309, USA
    Behav Genet 36:869-81. 2006
  3. ncbi request reprint The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibition
    Isabel R Schlaepfer
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA, and Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Addict Biol 12:200-9. 2007
  4. pmc Microarray analysis identifies cerebellar genes sensitive to chronic ethanol treatment in PKCgamma mice
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Alcohol 40:19-33. 2006
  5. pmc Regulation of 5-HT2A/C receptors and DOI-induced behaviors by protein kinase Cgamma
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Pharmacol Biochem Behav 85:441-7. 2006
  6. ncbi request reprint Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task
    Jason J Keller
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Behav Brain Res 162:143-52. 2005
  7. ncbi request reprint Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado at Boulder, 447 UCB, Boulder, CO 80309, USA
    Alcohol Clin Exp Res 29:295-302. 2005
  8. ncbi request reprint Alpha 4 beta 2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response
    Jeremy C Owens
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Alcohol Clin Exp Res 27:1867-75. 2003
  9. pmc Acetylcholine-stimulated [3H]GABA release from mouse brain synaptosomes is modulated by alpha4beta2 and alpha4alpha5beta2 nicotinic receptor subtypes
    Tristan D McClure-Begley
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Mol Pharmacol 75:918-26. 2009
  10. ncbi request reprint Inbred mouse strain differences in the establishment of long-term fear memory
    Seth A Balogh
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder 80309 0447, USA
    Behav Brain Res 140:97-106. 2003

Research Grants

  1. QTL MAPPING OF COMPLEX LEARNING IN MICE
    JEANNE WEHNER; Fiscal Year: 2001
  2. ETHANOLS ACTIONS IN GAMMA PKC NULL MUTANTS
    JEANNE WEHNER; Fiscal Year: 2001
  3. QTL MAPPING OF COMPLEX LEARNING IN MICE
    JEANNE WEHNER; Fiscal Year: 2000
  4. Role of Nicotinic Receptors in Effects of Alcohol
    JEANNE WEHNER; Fiscal Year: 2006

Detail Information

Publications20

  1. ncbi request reprint Quantitative trait locus analysis of contextual fear conditioning in mice
    J M Wehner
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
    Nat Genet 17:331-4. 1997
    ..QTLs for conditioning to the auditory cue (lod score > 4.3) were localized to chromosomes 1 and 10. Suggestive QTLs (lod score = 2.8-4.1) for contextual conditioning were detected on chromosomes 1, 2 and 3...
  2. ncbi request reprint Microarray analysis of the effects of a gamma-protein kinase C null mutation on gene expression in striatum: a role for transthyretin in mutant phenotypes
    Amy M Smith
    Institute for Behavioral Genetics, University of Colorado, 447, UCB, Boulder, CO 80309, USA
    Behav Genet 36:869-81. 2006
    ..Ethanol treatment of mutants reversed the dramatic increase in transthyretin expression seen in naïve and control-diet treated mutants, but did not affect transthyretin expression in wild types...
  3. ncbi request reprint The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibition
    Isabel R Schlaepfer
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA, and Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Addict Biol 12:200-9. 2007
    ..This study provides the first exploration of the PRKCG gene and its association with behavioral disinhibition and warrants further study in other larger population samples...
  4. pmc Microarray analysis identifies cerebellar genes sensitive to chronic ethanol treatment in PKCgamma mice
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Alcohol 40:19-33. 2006
    ..2 and Th, were found to be sensitive to chronic ethanol and were added to the transcription factors, JunB and Nur77, confirmed by qRT-PCR, as a subset of genes that respond to chronic ethanol...
  5. pmc Regulation of 5-HT2A/C receptors and DOI-induced behaviors by protein kinase Cgamma
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Pharmacol Biochem Behav 85:441-7. 2006
    ..These data support a role for 5-HT(2A/C) receptors in the PFC in mediating some of the behavioral differences observed between PKCgamma mutant and wild-type mice...
  6. ncbi request reprint Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task
    Jason J Keller
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Behav Brain Res 162:143-52. 2005
    ..These results support a role of the alpha7 nicotinic receptor in mediating appetitive learning and suggest a potential role for the alpha7 nAChRs in the regulation of behavioral disinhibition...
  7. ncbi request reprint Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado at Boulder, 447 UCB, Boulder, CO 80309, USA
    Alcohol Clin Exp Res 29:295-302. 2005
    ..The studies outlined here used alpha7 gene knockout (null mutant) mice to evaluate the potential role of alpha7 nAChRs in modulating selected behavioral and physiological effects produced by ethanol...
  8. ncbi request reprint Alpha 4 beta 2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response
    Jeremy C Owens
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Alcohol Clin Exp Res 27:1867-75. 2003
    ..Ethanol also alters the acoustic startle response. Thus, we evaluated the potential role of alpha4beta2 nAChRs in modulating ethanol's effects on acoustic startle...
  9. pmc Acetylcholine-stimulated [3H]GABA release from mouse brain synaptosomes is modulated by alpha4beta2 and alpha4alpha5beta2 nicotinic receptor subtypes
    Tristan D McClure-Begley
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Mol Pharmacol 75:918-26. 2009
    ....
  10. ncbi request reprint Inbred mouse strain differences in the establishment of long-term fear memory
    Seth A Balogh
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder 80309 0447, USA
    Behav Brain Res 140:97-106. 2003
    ..The utility of the 14-day hyper responsiveness phenotype as a potential model for fear-related psychopathology is also discussed...
  11. doi request reprint Cued and contextual fear conditioning in mice
    Jeanne M Wehner
    University of Colorado, Boulder, Colorado, USA
    Curr Protoc Neurosci . 2004
    ..Clinically, it is has relevance to human behavior in that fear conditioning can be produced in humans, and damage to the amygdala prevents fear conditioning...
  12. ncbi request reprint Aniracetam improves contextual fear conditioning and increases hippocampal gamma-PKC activation in DBA/2J mice
    Amy M Smith
    Institute for Behavioral Genetics and Department of Psychology, University of Colorado, Boulder 80309, USA
    Hippocampus 12:76-85. 2002
    ..No increase in learning or gamma-PKC was found 5 min after training. These results suggest an altered time course of activation of gamma-PKC in response to treatment with aniracetam, which improves learning in D2 mice...
  13. ncbi request reprint Contextual and cued fear conditioning in C57BL/6J and DBA/2J mice: context discrimination and the effects of retention interval
    Seth A Balogh
    Institute for Behavioral Genetics, University of Colorado at Boulder, 80309 0447, USA
    Behav Neurosci 116:947-57. 2002
    ..The acoustic startle response in B6 mice was also enhanced at 14 days after training. D2 mice did not show this pattern of generalized freezing. B6, but not D2, mice retained contextual memories for at least 60 days...
  14. ncbi request reprint Animal models as a tool for studying mechanisms of co-abuse of alcohol and tobacco
    Seth A Balogh
    University of Colorado, Institute for Behavioral Genetics, Boulder 80309 0447, USA
    Alcohol Clin Exp Res 26:1911-4. 2002
  15. ncbi request reprint Gene expression in brain: a window on ethanol dependence, neuroadaptation, and preference
    Paula L Hoffman
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Alcohol Clin Exp Res 27:155-68. 2003
    ..Gene expression profiling related to initial sensitivity and tolerance in gamma-protein kinase C mutants, by Jeanne Wehner; and (6) Gene expression patterns in human alcoholic brain: from microarrays to protein profiles, by Joanne ..
  16. ncbi request reprint The pathophysiology of traumatic brain injury in alpha7 nicotinic cholinergic receptor knockout mice
    Matthew L Kelso
    College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Brain Res 1083:204-10. 2006
    ..However, when null mutant mice develop in the absence of central alpha7 expression, it is possible that compensatory changes occur that confound the results obtained...
  17. ncbi request reprint Decreased anxiety-like behavior in beta3 nicotinic receptor subunit knockout mice
    T K Booker
    Salk Institute for Biological Studies, La Jolla, CA 92037 USA
    Pharmacol Biochem Behav 87:146-57. 2007
    ..These findings strongly suggest that beta3-containing nicotinic receptors influence anxiety and may be critical for the continuation of smoking behaviors...
  18. ncbi request reprint Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice
    W R Proctor
    Department of Veterans Affairs Medical Center, Research Service, Denver, Colorado, USA
    J Pharmacol Exp Ther 305:264-70. 2003
    ..These results suggest that PKCgamma and PKCepsilon signaling pathways reciprocally modulate both ethanol enhancement of GABA(A) receptor function and hypnotic sensitivity to ethanol...
  19. ncbi request reprint Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action
    Henry A Lester
    California Institute of Technology, Division of Biology, Pasadena, CA 91125, USA
    Curr Opin Drug Discov Devel 6:633-9. 2003
    ..These strains are helping to define the occurrence of these important receptor subtypes, and their role in the acute and chronic actions of nicotine. The hypersensitive strains may be useful for the development of nicotinic drug therapy...
  20. ncbi request reprint Guidelines on nicotine dose selection for in vivo research
    Shannon G Matta
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 190:269-319. 2007
    ..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...

Research Grants14

  1. QTL MAPPING OF COMPLEX LEARNING IN MICE
    JEANNE WEHNER; Fiscal Year: 2001
    ..Studies of this form of learning are not only applicable to normal complex learning processes but also to certain psychopathologies like post-traumatic stress syndrome. ..
  2. ETHANOLS ACTIONS IN GAMMA PKC NULL MUTANTS
    JEANNE WEHNER; Fiscal Year: 2001
    ..The results of these studies will establish whether y-PKC plays a role in the pharmacological actions of ethanol that underlie the determination of ethanol sensitivity and tolerance. ..
  3. QTL MAPPING OF COMPLEX LEARNING IN MICE
    JEANNE WEHNER; Fiscal Year: 2000
    ..Studies of this form of learning are not only applicable to normal complex learning processes but also to certain psychopathologies like post-traumatic stress syndrome. ..
  4. Role of Nicotinic Receptors in Effects of Alcohol
    JEANNE WEHNER; Fiscal Year: 2006
    ..The results of these studies should provide a better understanding of the potential interactions and mechanisms underlying the co-administration of ethanol with nicotine. ..