Jerzy Wegiel

Summary

Affiliation: University at Albany
Country: USA

Publications

  1. pmc The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities IBR, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Acta Neuropathol 119:755-70. 2010
  2. pmc The role of DYRK1A in neurodegenerative diseases
    Jerzy Wegiel
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    FEBS J 278:236-45. 2011
  3. pmc Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 70:36-50. 2011
  4. pmc The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Acta Neuropathol 116:391-407. 2008
  5. pmc Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA
    Acta Neuropathol 113:389-402. 2007
  6. pmc Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, New York 10314, USA
    FASEB J 22:3224-33. 2008
  7. pmc Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome
    Zhihou Liang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
    J Alzheimers Dis 13:295-302. 2008
  8. pmc Gene dosage-dependent association of DYRK1A with the cytoskeleton in the brain and lymphocytes of down syndrome patients
    Karol Dowjat
    Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, NY 10314, USA
    J Neuropathol Exp Neurol 71:1100-12. 2012
  9. pmc Differences between the pattern of developmental abnormalities in autism associated with duplications 15q11.2-q13 and idiopathic autism
    Jerzy Wegiel
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 71:382-97. 2012
  10. doi request reprint Contribution of olivofloccular circuitry developmental defects to atypical gaze in autism
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, United States
    Brain Res 1512:106-22. 2013

Collaborators

Detail Information

Publications32

  1. pmc The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities IBR, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Acta Neuropathol 119:755-70. 2010
    ....
  2. pmc The role of DYRK1A in neurodegenerative diseases
    Jerzy Wegiel
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    FEBS J 278:236-45. 2011
    ....
  3. pmc Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 70:36-50. 2011
    ..These data support the hypothesis that phosphorylation of ASF by overexpressed DYRK1A may contribute to alternative splicing of exon 10, increased expression of 3R tau, and early onset of neurofibrillary degeneration in DS...
  4. pmc The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Acta Neuropathol 116:391-407. 2008
    ....
  5. pmc Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA
    Acta Neuropathol 113:389-402. 2007
    ....
  6. pmc Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, New York 10314, USA
    FASEB J 22:3224-33. 2008
    ..These findings strongly suggest a novel mechanism by which the overexpression of Dyrk1A in DS brain causes neurofibrillary degeneration via hyperphosphorylating tau...
  7. pmc Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome
    Zhihou Liang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
    J Alzheimers Dis 13:295-302. 2008
    ..Our results indicate that PP2A is down-regulated in DS brain and suggest that this down-regulation might be involved in the abnormal hyperphosphorylation and accumulation of tau...
  8. pmc Gene dosage-dependent association of DYRK1A with the cytoskeleton in the brain and lymphocytes of down syndrome patients
    Karol Dowjat
    Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, NY 10314, USA
    J Neuropathol Exp Neurol 71:1100-12. 2012
    ..To our knowledge, this is the first study conducted in human tissue that shows DYRK1A association with the cytoskeleton...
  9. pmc Differences between the pattern of developmental abnormalities in autism associated with duplications 15q11.2-q13 and idiopathic autism
    Jerzy Wegiel
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 71:382-97. 2012
    ..04). The different spectrum and higher prevalence of developmental neuropathologic findings in the dup(15) cohort than in cases with idiopathic autism may contribute to the high risk of early onset of seizures and sudden death...
  10. doi request reprint Contribution of olivofloccular circuitry developmental defects to atypical gaze in autism
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, United States
    Brain Res 1512:106-22. 2013
    ....
  11. pmc Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome
    Wieslaw K Dowjat
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurosci Lett 413:77-81. 2007
    ..It also implies that overexpression of DYRK1A in DS may be potentially relevant to MR status of these individuals during their entire life span...
  12. doi request reprint Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice
    Bozena Mazur-Kolecka
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    J Neurosci Res 90:999-1010. 2012
    ..This study suggests that pharmacological normalization of DYRK1A activity may have a potential role in DS therapy...
  13. pmc Gelsolin levels are increased in the brain as a function of age during normal development in children that are further increased in Down syndrome
    Lina Ji
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    Alzheimer Dis Assoc Disord 23:319-22. 2009
    ..Because cytoplasmic gelsolin has 5 free thiol groups (cysteine), and its levels are increased in response to oxidative stress, we propose that gelsolin may serve as an antioxidant protein...
  14. ncbi request reprint Cells of monocyte/microglial lineage are involved in both microvessel amyloidosis and fibrillar plaque formation in APPsw tg mice
    Jerzy Wegiel
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Brain Res 1022:19-29. 2004
    ....
  15. pmc Abnormal intracellular accumulation and extracellular Aβ deposition in idiopathic and Dup15q11.2-q13 autism spectrum disorders
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
    PLoS ONE 7:e35414. 2012
    ..It has been shown that amyloid ß (Aβ), a product of proteolytic cleavage of the amyloid β precursor protein (APP), accumulates in neuronal cytoplasm in non-affected individuals in a cell type-specific amount...
  16. ncbi request reprint Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain
    Jerzy Wegiel
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Brain Res 1010:69-80. 2004
    ..Differences in the topography and the amount of Mnb/Dyrk1A in neurons, astrocytes, and ependymal and endothelial cells appear to reflect cell type- and brain structure-specific patterns in trafficking and utilization of Mnb/Dyrk1A...
  17. doi request reprint Gelsolin is proteolytically cleaved in the brains of individuals with Alzheimer's disease
    Lina Ji
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Alzheimers Dis 18:105-11. 2009
    ..Taken together, these results suggest that there may be a link among oxidative stress, neuronal apoptosis, and gelsolin cleavage in AD...
  18. ncbi request reprint Binding of trypsin to fibrillar amyloid beta-protein
    Harish Chander
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Brain Res 1082:173-81. 2006
    ..These results suggest that fAbeta and fibrillar amylin have strong affinities for trypsin, and chelation of proteases by abnormal aggregated proteins may be a general mechanism for inflicting pathological conditions in various diseases...
  19. doi request reprint Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A)
    Wojciech Kaczmarski
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York
    J Neurosci Res 92:162-73. 2014
    ..This study supports the hypothesis that intracellular distribution and compartment-specific functions of DYRK1A may depend on its phosphorylation pattern...
  20. ncbi request reprint Kinetic properties of a MNB/DYRK1A mutant suitable for the elucidation of biochemical pathways
    Tatyana Adayev
    Molecular Biology Department, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Biochemistry 45:12011-9. 2006
    ..The K465R mutation apparently transforms the intramolecular interactions required for MNB/DYRK1A catalysis. This mutant would also be valuable for the elucidation of the mechanisms of MNB/DYRK1A-catalyzed reaction...
  21. ncbi request reprint Activity-dependent phosphorylation of dynamin 1 at serine 857
    Wen Xie
    Department of Biology, College of Staten Island, City University of New York, Staten Island, NY 10314, USA
    Biochemistry 51:6786-96. 2012
    ..In summary, our results support the conclusion that S857 phosphorylation is a physiological event and its level is modulated by neuronal activity in nerve terminals...
  22. ncbi request reprint A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations
    Wieslaw K Dowjat
    Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Alzheimers Dis 6:31-43. 2004
    ..Given the high potency in vivo and in vitro of both codon 117 mutations, this site of PS1 must be particularly important for its normal/pathogenic function...
  23. doi request reprint Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism
    Abha Chauhan
    NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Neurochem 117:209-20. 2011
    ..The deficits observed in the levels of ETC complexes in children with autism may readjust to normal levels by adulthood...
  24. pmc Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)
    Tatyana Adayev
    Department of Molecular Biology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Arch Biochem Biophys 507:212-8. 2011
    ..Our results also suggest that harmine will be a good lead compound for further designing of selective ATP-competitive Dyrk1A inhibitors through exploration of the ATP-binding pocket of Dyrk1A...
  25. doi request reprint Relationship between proteolytically cleaved gelsolin and levels of amyloid-β protein in the brains of Down syndrome subjects
    Lina Ji
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Alzheimers Dis 22:609-17. 2010
    ..Since soluble non-fibrillar forms of Aβ are neurotoxic, they may be involved in apoptosis and proteolysis of gelsolin...
  26. doi request reprint High-affinity rabbit monoclonal antibodies specific for amyloid peptides amyloid-β40 and amyloid-β42
    David L Miller
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Alzheimers Dis 23:293-305. 2011
    ..The data indicate that diffuse amyloid deposits contain only minute amounts of Aβ₄₀. Thus these rabbit monoclonal anti-Aβ antibodies can be widely applied in AD and Down syndrome research and diagnosis...
  27. doi request reprint Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection
    Xiaochuan Wang
    Department of Neurochemistry, Inge Grundke Iqbal Research Floor, New York State Institute for Basic Research, in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314 6399, USA
    Acta Neuropathol 127:243-56. 2014
    ..These findings suggest a previously undiscovered etiopathogenic relationship between sporadic forms of AD and ALS that is linked to I2(PP2A) and the potential of I2(PP2A)-based therapeutics for these diseases...
  28. ncbi request reprint Humoral immune response to fibrillar beta-amyloid peptide
    David L Miller
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Biochemistry 42:11682-92. 2003
    ....
  29. ncbi request reprint Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5
    Cheng Xin Gong
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neurochem 88:298-310. 2004
    ..These results suggest that PP5 plays a role in the dephosphorylation of tau and might be involved in the molecular pathogenesis of Alzheimer's disease...
  30. ncbi request reprint Origin and turnover of microglial cells in fibrillar plaques of APPsw transgenic mice
    Jerzy Wegiel
    Department of Pathological Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Acta Neuropathol 105:393-402. 2003
    ..Infiltration of the plaque with cells of blood origin and degeneration of 10-46% of inflammatory cells in large plaques, which is especially frequent at the interface between capillary wall and plaque, suggest their accelerated turnover...
  31. ncbi request reprint Walnut extract inhibits the fibrillization of amyloid beta-protein, and also defibrillizes its preformed fibrils
    Neha Chauhan
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Curr Alzheimer Res 1:183-8. 2004
    ..It is proposed that polyphenolic compounds (such as flavonoids) present in walnuts may be responsible for its anti-amyloidogenic activity...
  32. ncbi request reprint Intracellular oxidation of allopregnanolone by human brain type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Brain Res 1040:29-35. 2005
    ..The elevated level of 17beta-HSD10 in activated astrocytes is a new feature found in brains of people with AD, and it may have important impact on AD pathogenesis...