D E Weeks

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc PedCheck: a program for identification of genotype incompatibilities in linkage analysis
    J R O'Connell
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Hum Genet 63:259-66. 1998
  2. pmc GWAS of dental caries patterns in the permanent dentition
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 92:38-44. 2013
  3. pmc A whole genome linkage scan identifies multiple chromosomal regions influencing adiposity-related traits among Samoans
    F Dai
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Hum Genet 72:780-92. 2008
  4. pmc Genome-wide Association Studies of Pit-and-Fissure- and Smooth-surface Caries in Permanent Dentition
    Z Zeng
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Dent Res 92:432-7. 2013
  5. pmc High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12
    R H Duerr
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Hum Genet 66:1857-62. 2000
  6. ncbi request reprint Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions
    D E Weeks
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Ophthalmol 132:682-92. 2001
  7. pmc A survey of affected-sibship statistics for nonparametric linkage analysis
    H Sengul
    Department of Human Genetics, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Am J Hum Genet 69:179-90. 2001
  8. pmc Linkage and association between inflammatory bowel disease and a locus on chromosome 12
    R H Duerr
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Hum Genet 63:95-100. 1998
  9. pmc Clustering tooth surfaces into biologically informative caries outcomes
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 92:32-7. 2013
  10. pmc An optimal algorithm for automatic genotype elimination
    J R O'Connell
    University of Pittsburgh, Department of Human Genetics, Pittsburgh, PA 15261, USA
    Am J Hum Genet 65:1733-40. 1999

Collaborators

Detail Information

Publications16

  1. pmc PedCheck: a program for identification of genotype incompatibilities in linkage analysis
    J R O'Connell
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Hum Genet 63:259-66. 1998
    ..We use various real data sets to illustrate the power and effectiveness of our program...
  2. pmc GWAS of dental caries patterns in the permanent dentition
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 92:38-44. 2013
    ..Suggestive genetic associations were also observed for ABCG2, PKD2, the dentin/bone SCPP sub-family, EDNRA, TJFBR1, NKX2-3, IFT88, TWSG1, IL17D, and SMAD7 (p values < 7e-6). We nominate these novel genes for future study...
  3. pmc A whole genome linkage scan identifies multiple chromosomal regions influencing adiposity-related traits among Samoans
    F Dai
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Hum Genet 72:780-92. 2008
    ..64) for %BFAT, 2q13 for adiponectin (LOD = 2.05) and 19q12 for BMI-adjusted leptin (LOD = 2.03). Further fine mapping of these regions may help identify the genetic variants contributing to the development of obesity in Samoan adults...
  4. pmc Genome-wide Association Studies of Pit-and-Fissure- and Smooth-surface Caries in Permanent Dentition
    Z Zeng
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Dent Res 92:432-7. 2013
    ..g., CXCR1 and CXCR2, p value = 1.9E-6). This study supports the notion that genes differentially affect cariogenesis across the surfaces of the permanent dentition, and nominates several novel genes for investigation...
  5. pmc High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12
    R H Duerr
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Hum Genet 66:1857-62. 2000
    ..8) satisfies criteria for confirmed linkage, so we propose that the region of interest on chromosome 14q11-12 should be designated the IBD4 locus...
  6. ncbi request reprint Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions
    D E Weeks
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Ophthalmol 132:682-92. 2001
    ..There was no evidence that other known macular or retinal dystrophy candidate gene regions are major contributors to the genetics of age-related maculopathy...
  7. pmc A survey of affected-sibship statistics for nonparametric linkage analysis
    H Sengul
    Department of Human Genetics, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Am J Hum Genet 69:179-90. 2001
    ..For the most part, the same statistics performed well for all sibship sizes. We also used our results to give some suggestions regarding how to weight sibships of different sizes, in forming an overall statistic...
  8. pmc Linkage and association between inflammatory bowel disease and a locus on chromosome 12
    R H Duerr
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Hum Genet 63:95-100. 1998
    ..012). In conclusion, we have independently confirmed linkage of IBD to the chromosome 12 region that we investigated. A positive TDT at D12S83 suggests that we have greatly narrowed the chromosome 12 region that contains an IBD locus...
  9. pmc Clustering tooth surfaces into biologically informative caries outcomes
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 92:32-7. 2013
    ....
  10. pmc An optimal algorithm for automatic genotype elimination
    J R O'Connell
    University of Pittsburgh, Department of Human Genetics, Pittsburgh, PA 15261, USA
    Am J Hum Genet 65:1733-40. 1999
    ..In this paper we present a new recursive loop breaker-elimination algorithm that solves this problem and illustrate its effectiveness on a pedigree with six loops...
  11. ncbi request reprint Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees
    E Sobel
    Department of Human Genetics, University of California, Los Angeles, CA, USA
    Hum Hered 52:121-31. 2001
    ..In addition, our testing has validated our algorithm for estimating IBD probabilities at arbitrary positions on general pedigrees...
  12. pmc Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association
    H J Tsai
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Hum Genet 69:1236-44. 2001
    ....
  13. ncbi request reprint Comparison of allele-sharing statistics for general pedigrees
    E Feingold
    Department of Human Genetics, University of Pittsburgh, Graduate School of Public Health, Pennsylvania 15261, USA
    Genet Epidemiol 19:S92-8. 2000
    ..In particular, pedigree structure and the degree of recessiveness of the trait appear to be critical factors in determining which statistics are most powerful...
  14. pmc Genome-wide association scan for childhood caries implicates novel genes
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Dent Res 90:1457-62. 2011
    ..Verification/replication of suggestive loci may highlight biological mechanisms and/or pathways leading to a fuller understanding of the genetic risks for dental caries...
  15. ncbi request reprint Genome-wide scan for adiposity-related phenotypes in adults from American Samoa
    F Dai
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 02912, USA
    Int J Obes (Lond) 31:1832-42. 2007
    ....
  16. pmc A juvenile-onset, progressive cataract locus on chromosome 3q21-q22 is associated with a missense mutation in the beaded filament structural protein-2
    Y P Conley
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Hum Genet 66:1426-31. 2000
    ..This is the first example of a mutation in a noncrystallin structural gene that leads to a juvenile-onset, progressive cataract...