L Wecker

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint Cyclic AMP-dependent protein kinase (PKA) and protein kinase C phosphorylate sites in the amino acid sequence corresponding to the M3/M4 cytoplasmic domain of alpha4 neuronal nicotinic receptor subunits
    L Wecker
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, Florida, USA
    J Neurochem 76:711-20. 2001
  2. ncbi request reprint Phosphorylation sites within alpha4 subunits of alpha4beta2 neuronal nicotinic receptors: a comparison of substrate specificities for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC)
    Lynn Wecker
    Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida 33612 4799, USA
    Neurochem Res 28:431-6. 2003
  3. ncbi request reprint Developmental differences in nicotine place conditioning
    Tracy A Torrella
    Department of Pharmacology and Therapeutics, USFCOM, MDC Box 9, 12901 Bruce B Downs Boulevard, Tampa, FL 33612 4799, USA
    Ann N Y Acad Sci 1021:399-403. 2004
  4. pmc Nicotine-induced up regulation of α4β2 neuronal nicotinic receptors is mediated by the protein kinase C-dependent phosphorylation of α4 subunits
    L Wecker
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Neurosciences, University of South Florida College of Medicine, Tampa, FL, USA
    Neuroscience 171:12-22. 2010
  5. pmc Cyclic AMP-dependent protein kinase A and protein kinase C phosphorylate alpha4beta2 nicotinic receptor subunits at distinct stages of receptor formation and maturation
    V V Pollock
    Department of Psychiatry and Behavioral Medicine, USF College of Medicine, Tampa, FL 33613, USA
    Neuroscience 158:1311-25. 2009
  6. ncbi request reprint Identification of three cAMP-dependent protein kinase (PKA) phosphorylation sites within the major intracellular domain of neuronal nicotinic receptor alpha4 subunits
    Xiang Guo
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, Florida 33612 4799, USA
    J Neurochem 82:439-47. 2002
  7. ncbi request reprint Phosphorylation of the alpha4 subunit of human alpha4beta2 nicotinic receptors: role of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC)
    Mary A Pacheco
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612 4799, USA
    Brain Res Mol Brain Res 114:65-72. 2003
  8. doi request reprint Repeated ethanol exposure during adolescence alters the developmental trajectory of dopaminergic output from the nucleus accumbens septi
    Rex M Philpot
    Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    Int J Dev Neurosci 27:805-15. 2009
  9. ncbi request reprint The controversy concerning plasma homocysteine in Parkinson disease patients treated with levodopa alone or with entacapone: effects of vitamin status
    Theresa A Zesiewicz
    Parkinson s Disease and Movement Disorders Center, University of South Florida, Tampa, 33612, USA
    Clin Neuropharmacol 29:106-11. 2006
  10. ncbi request reprint Cyclic AMP-dependent protein kinase (PKA) phosphorylates Ser362 and 467 and protein kinase C phosphorylates Ser550 within the M3/M4 cytoplasmic domain of human nicotinic receptor alpha4 subunits
    Veronica V Pollock
    Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, USA
    J Neurochem 103:456-66. 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Cyclic AMP-dependent protein kinase (PKA) and protein kinase C phosphorylate sites in the amino acid sequence corresponding to the M3/M4 cytoplasmic domain of alpha4 neuronal nicotinic receptor subunits
    L Wecker
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, Florida, USA
    J Neurochem 76:711-20. 2001
    ..The phosphorylation of alpha4(356-371) by both PKA and PKC was saturable with K(m)s of 15.3 +/- 3.3 microM and 160.8 +/- 26.8 microM, respectively, suggesting that Ser(368) was a better substrate for PKA than PKC...
  2. ncbi request reprint Phosphorylation sites within alpha4 subunits of alpha4beta2 neuronal nicotinic receptors: a comparison of substrate specificities for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC)
    Lynn Wecker
    Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida 33612 4799, USA
    Neurochem Res 28:431-6. 2003
    ....
  3. ncbi request reprint Developmental differences in nicotine place conditioning
    Tracy A Torrella
    Department of Pharmacology and Therapeutics, USFCOM, MDC Box 9, 12901 Bruce B Downs Boulevard, Tampa, FL 33612 4799, USA
    Ann N Y Acad Sci 1021:399-403. 2004
    ....
  4. pmc Nicotine-induced up regulation of α4β2 neuronal nicotinic receptors is mediated by the protein kinase C-dependent phosphorylation of α4 subunits
    L Wecker
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Neurosciences, University of South Florida College of Medicine, Tampa, FL, USA
    Neuroscience 171:12-22. 2010
    ..Because up regulation of these receptors has been implicated to mediate tolerance, locomotor sensitization and addiction to nicotine, results identify a potential new target for modulating the effects of nicotine on the brain...
  5. pmc Cyclic AMP-dependent protein kinase A and protein kinase C phosphorylate alpha4beta2 nicotinic receptor subunits at distinct stages of receptor formation and maturation
    V V Pollock
    Department of Psychiatry and Behavioral Medicine, USF College of Medicine, Tampa, FL 33613, USA
    Neuroscience 158:1311-25. 2009
    ....
  6. ncbi request reprint Identification of three cAMP-dependent protein kinase (PKA) phosphorylation sites within the major intracellular domain of neuronal nicotinic receptor alpha4 subunits
    Xiang Guo
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, Florida 33612 4799, USA
    J Neurochem 82:439-47. 2002
    ..Results indicate that Ser365, Ser472 and Ser491 on neuronal nicotinic receptor alpha4 subunits are phosphorylated by PKA and are likely to represent post-translational regulatory sites on the receptor...
  7. ncbi request reprint Phosphorylation of the alpha4 subunit of human alpha4beta2 nicotinic receptors: role of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC)
    Mary A Pacheco
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612 4799, USA
    Brain Res Mol Brain Res 114:65-72. 2003
    ..1 microM). These findings indicate that the alpha4 subunit of human alpha4beta2 nicotinic receptors is phosphorylated in situ by PKA and PKC...
  8. doi request reprint Repeated ethanol exposure during adolescence alters the developmental trajectory of dopaminergic output from the nucleus accumbens septi
    Rex M Philpot
    Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    Int J Dev Neurosci 27:805-15. 2009
    ..This alteration may explain the increased addiction vulnerability observed in individuals who initiate alcohol use during early adolescence...
  9. ncbi request reprint The controversy concerning plasma homocysteine in Parkinson disease patients treated with levodopa alone or with entacapone: effects of vitamin status
    Theresa A Zesiewicz
    Parkinson s Disease and Movement Disorders Center, University of South Florida, Tampa, 33612, USA
    Clin Neuropharmacol 29:106-11. 2006
    ..In patients with low or low-normal folate levels, levodopa administration is associated with a greater increase in homocysteine and concomitant entacapone administration is associated with a greater reduction in homocysteine...
  10. ncbi request reprint Cyclic AMP-dependent protein kinase (PKA) phosphorylates Ser362 and 467 and protein kinase C phosphorylates Ser550 within the M3/M4 cytoplasmic domain of human nicotinic receptor alpha4 subunits
    Veronica V Pollock
    Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, USA
    J Neurochem 103:456-66. 2007
    ....
  11. doi request reprint Dependence of adolescent novelty-seeking behavior on response phenotype and effects of apparatus scaling
    Rex M Philpot
    Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa, FL 33613, USA
    Behav Neurosci 122:861-75. 2008
    ..Results confirm that novelty-seeking by adolescents is greater than by adults, a behavior attributed primarily to the response magnitude exhibited by adolescents with the HR phenotype...
  12. ncbi request reprint The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels
    Emily G Severance
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, MDC 9, Tampa, FL 33612 4799, USA
    Mol Pharmacol 66:420-9. 2004
    ..Furthermore, the distribution of the alpha7-2 isoform is not limited to peripheral neurons...
  13. pmc Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia
    L Wecker
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Neurosciences, University of South Florida, USA Department of Molecular Pharmacology and Physiology, University of South Florida, USA Department of Neurology, University of South Florida, USA Electronic address
    Neuropharmacology 73:75-86. 2013
    ..Results provide evidence that nicotinic agonists are of benefit for alleviating some of the behavioral deficits in olivocerebellar ataxia and warrant further studies to elucidate the specific mechanism(s) involved. ..
  14. doi request reprint A randomized trial of varenicline (Chantix) for the treatment of spinocerebellar ataxia type 3
    T A Zesiewicz
    Department of Neurology, Ataxia Research Center, University of South Florida, Tampa, USA
    Neurology 78:545-50. 2012
    ....
  15. pmc Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610 0267, USA
    J Pharmacol Exp Ther 333:501-18. 2010
    ..Hexamethonium was a relatively nonselective antagonist with mixed competitive and noncompetitive activity...
  16. ncbi request reprint Transdermal selegiline: targeted effects on monoamine oxidases in the brain
    Lynn Wecker
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, Florida 33612 4799, USA
    Biol Psychiatry 54:1099-104. 2003
    ..These studies determined whether the transdermal administration of selegiline has differential effects on MAOs in brain versus the gastrointestinal system...