Lawrence R Wechsler

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Innovative Strategies in the Management of Acute Stroke
    Lawrence R Wechsler
    UPMC Stroke Institute, University of Pittsburgh School of Medicine, C 426 PUH, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Curr Treat Options Cardiovasc Med 4:421-428. 2002
  2. ncbi request reprint Innovative strategies in the management of acute stroke
    Lawrence R Wechsler
    UPMC Stroke Institute, University of Pittsburgh School of Medicine, C 426 PUH, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Curr Cardiol Rep 4:135-40. 2002
  3. ncbi request reprint PFO and stroke: what are the data?
    Lawrence R Wechsler
    Department of Neurology, UPMC Stroke Institute, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213 2582, USA
    Cardiol Rev 16:53-7. 2008
  4. ncbi request reprint Does the Merci Retriever work? Against
    Lawrence R Wechsler
    University of Pittsburgh Medical Center Stroke Institute, Pittsburgh, PA 15213, USA
    Stroke 37:1341-2; discussion 1342-3. 2006
  5. ncbi request reprint Factors influencing outcome and treatment effect in PROACT II
    Lawrence R Wechsler
    University of Pittsburgh, Pittsburgh, PA, USA
    Stroke 34:1224-9. 2003
  6. ncbi request reprint Stem cell transplantation for stroke
    Lawrence R Wechsler
    UPMC Stroke Institute, University of Pittsburgh Medical School, Pittsburgh, PA 15217, USA
    Cleve Clin J Med 71:S40-1. 2004
  7. ncbi request reprint Cell therapy: replacement
    Lawrence R Wechsler
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Stroke 34:2081-2. 2003
  8. doi request reprint Impact of telemedicine implementation in thrombolytic use for acute ischemic stroke: the University of Pittsburgh Medical Center telestroke network experience
    Edilberto Amorim
    Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Stroke Cerebrovasc Dis 22:527-31. 2013
  9. ncbi request reprint Reduced pretreatment ipsilateral middle cerebral artery cerebral blood flow is predictive of symptomatic hemorrhage post-intra-arterial thrombolysis in patients with middle cerebral artery occlusion
    Rishi Gupta
    Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Stroke 37:2526-30. 2006
  10. ncbi request reprint Multimodal reperfusion therapy for acute ischemic stroke: factors predicting vessel recanalization
    Rishi Gupta
    Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, Pennsylvania, USA
    Stroke 37:986-90. 2006

Detail Information

Publications37

  1. ncbi request reprint Innovative Strategies in the Management of Acute Stroke
    Lawrence R Wechsler
    UPMC Stroke Institute, University of Pittsburgh School of Medicine, C 426 PUH, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Curr Treat Options Cardiovasc Med 4:421-428. 2002
    ..For the millions of stroke survivors, investigations are now underway into the possibility of improvement of function through neuronal transplantation...
  2. ncbi request reprint Innovative strategies in the management of acute stroke
    Lawrence R Wechsler
    UPMC Stroke Institute, University of Pittsburgh School of Medicine, C 426 PUH, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Curr Cardiol Rep 4:135-40. 2002
    ..For the millions of stroke survivors, investigations are now underway into the possibility of improvement of function through neuronal transplantation...
  3. ncbi request reprint PFO and stroke: what are the data?
    Lawrence R Wechsler
    Department of Neurology, UPMC Stroke Institute, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213 2582, USA
    Cardiol Rev 16:53-7. 2008
    ..Endovascular closure is technically feasible, but not without the possibility of periprocedural complications. Comparison of medical and endovascular closure of PFOs in patients with stroke is ongoing in 2 major randomized trials...
  4. ncbi request reprint Does the Merci Retriever work? Against
    Lawrence R Wechsler
    University of Pittsburgh Medical Center Stroke Institute, Pittsburgh, PA 15213, USA
    Stroke 37:1341-2; discussion 1342-3. 2006
  5. ncbi request reprint Factors influencing outcome and treatment effect in PROACT II
    Lawrence R Wechsler
    University of Pittsburgh, Pittsburgh, PA, USA
    Stroke 34:1224-9. 2003
    ..The purpose of the current study was to examine baseline factors to determine predictors of good outcome and response to treatment...
  6. ncbi request reprint Stem cell transplantation for stroke
    Lawrence R Wechsler
    UPMC Stroke Institute, University of Pittsburgh Medical School, Pittsburgh, PA 15217, USA
    Cleve Clin J Med 71:S40-1. 2004
  7. ncbi request reprint Cell therapy: replacement
    Lawrence R Wechsler
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Stroke 34:2081-2. 2003
  8. doi request reprint Impact of telemedicine implementation in thrombolytic use for acute ischemic stroke: the University of Pittsburgh Medical Center telestroke network experience
    Edilberto Amorim
    Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Stroke Cerebrovasc Dis 22:527-31. 2013
    ..The use of telemedicine in stroke makes it possible to bring the expertise of academic stroke centers to underserved areas, potentially increasing the quality of stroke care...
  9. ncbi request reprint Reduced pretreatment ipsilateral middle cerebral artery cerebral blood flow is predictive of symptomatic hemorrhage post-intra-arterial thrombolysis in patients with middle cerebral artery occlusion
    Rishi Gupta
    Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Stroke 37:2526-30. 2006
    ..We hypothesized that patients with lower prethrombolysis cerebral blood flow (CBF) were at a higher risk of symptomatic ICH (sICH)...
  10. ncbi request reprint Multimodal reperfusion therapy for acute ischemic stroke: factors predicting vessel recanalization
    Rishi Gupta
    Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, Pennsylvania, USA
    Stroke 37:986-90. 2006
    ..Endovascular therapies using mechanical and pharmacological modalities for large vessel occlusions in acute stroke are rapidly evolving. Our aim was to determine whether one modality is associated with higher recanalization rates...
  11. doi request reprint Endovascular treatment of tandem extracranial/intracranial anterior circulation occlusions: preliminary single-center experience
    Amer M Malik
    UPMC Stroke Institute, 200 Lothrop Street, Suite C400, Pittsburgh, PA 15213, USA
    Stroke 42:1653-7. 2011
    ..We aimed to evaluate our single-center experience with endovascular treatment of this unique stroke population...
  12. doi request reprint Protocol adherence and safety of intravenous thrombolysis after telephone consultation with a stroke center
    Ken Uchino
    University of Pittsburgh Medical Center Stroke Institute, Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Stroke Cerebrovasc Dis 19:417-23. 2010
    ..Our findings indicate the need for improved protocol adherence for stroke thrombolysis in patients presenting to small community hospitals...
  13. doi request reprint Telestroke-guided intravenous tissue-type plasminogen activator treatment achieves a similar clinical outcome as thrombolysis at a comprehensive stroke center
    Syed F Zaidi
    University of Pittsburgh Medical Center Stroke Institute, Pittsburgh, PA, USA
    Stroke 42:3291-3. 2011
    ..Telestroke networks offer an opportunity to increase tissue-type plasminogen activator use in community hospitals...
  14. pmc Cell therapy for stroke
    Sean I Savitz
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    NeuroRx 1:406-14. 2004
    ..We emphasize the current, limited knowledge about the biology of implant sources and discuss special conditions in stroke that will impact the potential success of neurotransplantation in clinical trials...
  15. doi request reprint Extensive brainstem ischemia on neuroimaging does not preclude meaningful recovery from locked-in syndrome: two cases of endovascularly managed basilar thrombosis
    Nestor D Tomycz
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Neuroimaging 18:15-7. 2008
    ..Following aggressive supportive care and rehabilitation, outcomes obtained prospectively revealed that both patients made a remarkable recovery, becoming fully independent with Barthel scores of 20 and modified Rankin scores of 2...
  16. doi request reprint A 5-item scale to predict stroke outcome after cortical middle cerebral artery territory infarction: validation from results of the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) Study
    Nirav A Vora
    Department of Neurology, St Louis University, St Louis, MO, USA
    Stroke 42:645-9. 2011
    ..The purpose of this study was to combine these parameters into a validated scale for outcome prognostication in patients with a middle cerebral artery territory infarction...
  17. doi request reprint Mechanical approaches combined with intra-arterial pharmacological therapy are associated with higher recanalization rates than either intervention alone in revascularization of acute carotid terminus occlusion
    Ridwan Lin
    Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, Pittsburgh, PA 15213, USA
    Stroke 40:2092-7. 2009
    ..Historically, pharmacological thrombolysis alone has low recanalization rates. We sought to determine whether adjunctive mechanical approaches achieve better vessel recanalization and functional outcome...
  18. doi request reprint Comparison of safety and clinical and radiographic outcomes in endovascular acute stroke therapy for proximal middle cerebral artery occlusion with intubation and general anesthesia versus the nonintubated state
    Mouhammad A Jumaa
    Center for Neuroendovascular Therapy, UPMC Stroke Institute, Suite C424, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Stroke 41:1180-4. 2010
    ..We sought to compare clinical and radiographic outcomes between these 2 sedation modalities...
  19. doi request reprint Bioengineering solutions for neural repair and recovery in stroke
    Michel Modo
    aMcGowan Institute for Regenerative Medicine bDepartment of Radiology cDepartment of Bioengineering dDepartment of Physical Medicine and Rehabilitation eDepartment of Neurological Surgery fDepartment of Surgery gDepartment of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Opin Neurol 26:626-31. 2013
    ..This review discusses emerging bioengineering opportunities for the treatment of stroke and their potential to build on current rehabilitation protocols...
  20. ncbi request reprint The cortical ischemic core and not the consistently present penumbra is a determinant of clinical outcome in acute middle cerebral artery occlusion
    Tudor G Jovin
    Department of Neurology, University of Pittsburgh Medical Center, Presbyterian University Hospital, 200 Lothrop, Pittsburgh, PA 15213, USA
    Stroke 34:2426-33. 2003
    ..This approach requires early determination of both irreversible (core) and reversible (penumbra) ischemia in acute stroke...
  21. ncbi request reprint Emergent stenting of extracranial internal carotid artery occlusion in acute stroke has a high revascularization rate
    Tudor G Jovin
    Department of Neurology, University of Pittsburgh Medical Center Stroke Institute, Pittsburgh, PA 15213, USA
    Stroke 36:2426-30. 2005
    ..In selected cases, revascularization with carotid artery stenting has been reported, but the safety, recanalization rate, and clinical outcomes in consecutive case series are not known...
  22. ncbi request reprint Intracranial hemorrhage associated with revascularization therapies
    Pooja Khatri
    University of Cincinnati, Department of Neurology, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
    Stroke 38:431-40. 2007
    ..This review discusses the state of our current knowledge on hemorrhagic transformation (HT) and summarizes key factors to be considered when comparing risk associated with various approaches to revascularization...
  23. doi request reprint Imaging evaluation of acute ischemic stroke
    Lawrence R Wechsler
    Department of Neurology, University of Pittsburgh Medical School, Pittsburgh, PA, USA
    Stroke 42:S12-5. 2011
    ..Imaging is an important aspect of decisions regarding treatment for acute stroke. New imaging techniques using MRI and CT enable estimation of tissue viability. This information may be useful to select patients for acute stroke therapies...
  24. pmc Teleneurology applications: Report of the Telemedicine Work Group of the American Academy of Neurology
    Lawrence R Wechsler
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 80:670-6. 2013
    ..To review current literature on neurology telemedicine and to discuss its application to patient care, neurology practice, military medicine, and current federal policy...
  25. ncbi request reprint Cell transplantation for stroke
    Sean I Savitz
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Ann Neurol 52:266-75. 2002
    ..The survival, integration, and efficacy of neural transplants in stroke patients will depend on the type, severity, chronicity, adequacy of circulation, and location of the stroke lesion...
  26. doi request reprint Management of patent foramen ovale and stroke
    Mouhammad A Jumaa
    Department of Neurology, UPMC Stroke Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, C400, Pittsburgh, PA, 15213, USA
    Curr Treat Options Neurol 12:483-91. 2010
    ..Until these data is available, antiplatelet therapy remains the first-line treatment and endovascular closure should be considered in selected cases...
  27. doi request reprint Neuroimaging in ischemia and infarction
    Maxim D Hammer
    The Stroke Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Semin Neurol 28:446-52. 2008
    ..Techniques for measuring cerebral blood flow, to quantify tissue at risk, are detailed and compared. The quantification of cerebral blood flow is discussed in detail. Methods of visualizing the cerebral circulation are illustrated...
  28. ncbi request reprint Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 37:2322-5. 2006
    ..In a combined analysis of the tissue plasminogen activator clinical trials, a sex-by-treatment interaction was observed. We sought to confirm that observation in an independent data set...
  29. ncbi request reprint Computed tomographic findings in patients undergoing intra-arterial thrombolysis for acute ischemic stroke due to middle cerebral artery occlusion: results from the PROACT II trial
    Heidi C Roberts
    Department of Radiology, University of California, San Francisco, USA
    Stroke 33:1557-65. 2002
    ..The purpose of this study was to evaluate the role of noncontrast CT in the selection of patients to receive thrombolytic therapy for acute ischemic stroke and to predict radiological and clinical outcomes...
  30. pmc Optimal definition for PWI/DWI mismatch in acute ischemic stroke patients
    Wataru Kakuda
    Department of Rehabilitation Medicine, Jikei University School of Medicine, Minato ku, Tokyo, Japan
    J Cereb Blood Flow Metab 28:887-91. 2008
    ..Defining mismatch with a larger PWI/DWI ratio may provide greater power for detecting beneficial effects of reperfusion...
  31. ncbi request reprint Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Calgary, Alberta, Canada
    Stroke 34:1925-31. 2003
    ....
  32. ncbi request reprint Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable
    Marc Fisher
    UMass Memorial Healthcare Center, 119 Belmont St, Worcester, MA 01605, USA
    Stroke 36:1808-13. 2005
    ..A fourth (STAIR-IV) was held to discuss relevant issues related to acute stroke drug development and regulatory approval...
  33. ncbi request reprint Cryptogenic stroke in relation to genetic variation in clotting factors and other genetic polymorphisms among young men and women
    Harland Austin
    Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA, USA
    Stroke 33:2762-8. 2002
    ....
  34. pmc The MRA-DWI mismatch identifies patients with stroke who are likely to benefit from reperfusion
    Maarten G Lansberg
    Stanford Stroke Center, 701 Welch Road, Suite B325, Palo Alto, CA 94304 9705, USA
    Stroke 39:2491-6. 2008
    ....
  35. ncbi request reprint Training, competency, and credentialing standards for diagnostic cervicocerebral angiography, carotid stenting, and cerebrovascular intervention: a joint statement from the American Academy of Neurology, the American Association of Neurological Surgeons,
    John J Connors
    Baptist Cardiac and Vascular Institute, Baptist Hospital Miami, 8900 N Kendall Avenue, Miami, FL 33133, USA
    Neurology 64:190-8. 2005
  36. ncbi request reprint Absence of a diastolic velocity notch does not indicate hyperemia in traumatic brain injured patients without elevated cerebral blood flow velocity
    Barbara B Weber
    University of Pittsburgh School of Nursing, Pennsylvania, USA
    J Neurosurg Anesthesiol 14:279-86. 2002
    ..7% and 57.9% respectively. The results showed that relative hyperemia was present without an elevation in blood flow velocities, and that the lack of a diastolic notch did not detect the presence of hyperemia in the TBI patient...
  37. pmc Patients with acute stroke treated with intravenous tPA 3-6 hours after stroke onset: correlations between MR angiography findings and perfusion- and diffusion-weighted imaging in the DEFUSE study
    Michael P Marks
    Department of Radiology, Neurosurgery, Stanford University Medical Center, Stanford, CA 94305 5105, USA
    Radiology 249:614-23. 2008
    ..To study magnetic resonance (MR) angiography findings in patients with acute stroke treated with intravenous tissue plasminogen activator (tPA) in relationship to perfusion- and diffusion-weighted imaging changes and clinical outcome...