David J Weber

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint The role of the surface environment in healthcare-associated infections
    David J Weber
    Department of Hospital Epidemiology, University of North Carolina Healthcare, UNC School of Medicine, Chapel Hill, North Carolina 27599 7030, USA
    Curr Opin Infect Dis 26:338-44. 2013
  2. doi request reprint Assessing the risk of disease transmission to patients when there is a failure to follow recommended disinfection and sterilization guidelines
    David J Weber
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Infect Control 41:S67-71. 2013
  3. doi request reprint Self-disinfecting surfaces: review of current methodologies and future prospects
    David J Weber
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Infect Control 41:S31-5. 2013
  4. doi request reprint Role of the environment in the transmission of Clostridium difficile in health care facilities
    David J Weber
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Infect Control 41:S105-10. 2013
  5. ncbi request reprint New antibiotic agents: problems and prospects
    David J Weber
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7030, USA
    Surg Infect (Larchmt) 6:S-97-107. 2005
  6. ncbi request reprint Lessons learned from a norovirus outbreak in a locked pediatric inpatient psychiatric unit
    David J Weber
    Department of Hospital Epidemiology, University of North Carolina Health Care System, USA
    Infect Control Hosp Epidemiol 26:841-3. 2005
  7. doi request reprint Central line-associated bloodstream infections: prevention and management
    David J Weber
    Division of Infectious Diseases, University of North Carolina School of Medicine, 2163 Bioinformatics, 130 Mason Farm Road, Chapel Hill, NC 27599 7030, USA
    Infect Dis Clin North Am 25:77-102. 2011
  8. doi request reprint Assessment of a mandatory tetanus, diphtheria, and pertussis vaccination requirement on vaccine uptake over time
    David J Weber
    Department of Medicine, University of North Carolina Health Care, University of North Carolina, Chapel Hill, North Carolina, USA
    Infect Control Hosp Epidemiol 33:81-3. 2012
  9. ncbi request reprint Immunization of immunocompromised persons
    David J Weber
    Adult Infectious Disease Division, University of North Carolina School of Medicine, CB 7030, Bioinformatics Building, 130 Mason Farm Road, Chapel Hill, NC 27599 7030, USA
    Immunol Allergy Clin North Am 23:605-34, v-vi. 2003
  10. doi request reprint Preventing healthcare-associated Aspergillus infections: review of recent CDC/HICPAC recommendations
    David J Weber
    Division of Infectious Diseases, UNC School of Medicine, Chapel Hill, NC 27599 7030, USA
    Med Mycol 47:S199-209. 2009

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint The role of the surface environment in healthcare-associated infections
    David J Weber
    Department of Hospital Epidemiology, University of North Carolina Healthcare, UNC School of Medicine, Chapel Hill, North Carolina 27599 7030, USA
    Curr Opin Infect Dis 26:338-44. 2013
    ....
  2. doi request reprint Assessing the risk of disease transmission to patients when there is a failure to follow recommended disinfection and sterilization guidelines
    David J Weber
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Infect Control 41:S67-71. 2013
    ..This paper describes a protocol that can guide an institution in managing potential disinfection and sterilization failures...
  3. doi request reprint Self-disinfecting surfaces: review of current methodologies and future prospects
    David J Weber
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Infect Control 41:S31-5. 2013
    ..These methods are under active investigation but to date have not been assessed for their ability to reduce health care-associated infections...
  4. doi request reprint Role of the environment in the transmission of Clostridium difficile in health care facilities
    David J Weber
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Infect Control 41:S105-10. 2013
    ....
  5. ncbi request reprint New antibiotic agents: problems and prospects
    David J Weber
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7030, USA
    Surg Infect (Larchmt) 6:S-97-107. 2005
    ..Management of these infections has become more challenging due to rising rates of multi-drug-resistant organisms and few new antibiotic options...
  6. ncbi request reprint Lessons learned from a norovirus outbreak in a locked pediatric inpatient psychiatric unit
    David J Weber
    Department of Hospital Epidemiology, University of North Carolina Health Care System, USA
    Infect Control Hosp Epidemiol 26:841-3. 2005
    ..Factors contributing to the outbreak included environmental contamination, close staff-patient contact including sharing meals, and inability to confine the index patient with the use of contact precautions...
  7. doi request reprint Central line-associated bloodstream infections: prevention and management
    David J Weber
    Division of Infectious Diseases, University of North Carolina School of Medicine, 2163 Bioinformatics, 130 Mason Farm Road, Chapel Hill, NC 27599 7030, USA
    Infect Dis Clin North Am 25:77-102. 2011
    ....
  8. doi request reprint Assessment of a mandatory tetanus, diphtheria, and pertussis vaccination requirement on vaccine uptake over time
    David J Weber
    Department of Medicine, University of North Carolina Health Care, University of North Carolina, Chapel Hill, North Carolina, USA
    Infect Control Hosp Epidemiol 33:81-3. 2012
    ..Implementation for newly hired employees quickly resulted in complete compliance, but achieving adherence among current workers required setting a termination date for noncompliance...
  9. ncbi request reprint Immunization of immunocompromised persons
    David J Weber
    Adult Infectious Disease Division, University of North Carolina School of Medicine, CB 7030, Bioinformatics Building, 130 Mason Farm Road, Chapel Hill, NC 27599 7030, USA
    Immunol Allergy Clin North Am 23:605-34, v-vi. 2003
    ..This article reviews the benefits of and risks for immunization in immunocompromised persons and provides recommendations for the use of specific vaccines...
  10. doi request reprint Preventing healthcare-associated Aspergillus infections: review of recent CDC/HICPAC recommendations
    David J Weber
    Division of Infectious Diseases, UNC School of Medicine, Chapel Hill, NC 27599 7030, USA
    Med Mycol 47:S199-209. 2009
    ....
  11. ncbi request reprint Risks and prevention of nosocomial transmission of rare zoonotic diseases
    D J Weber
    Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    Clin Infect Dis 32:446-56. 2001
    ..Adherence to recommended isolation precautions will allow for proper patient care while protecting the health care workers who provide care to patients with known or suspected zoonotic infections capable of nosocomial transmission...
  12. ncbi request reprint Comparison of hospitalwide surveillance and targeted intensive care unit surveillance of healthcare-associated infections
    David J Weber
    Department of Hospital Epidemiology, University of North Carolina Health Care System, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    Infect Control Hosp Epidemiol 28:1361-6. 2007
    ..In addition, we assessed whether the infection rates in step-down units more resemble those in wards or ICUs...
  13. pmc Outbreaks associated with contaminated antiseptics and disinfectants
    David J Weber
    Department of Hospital Epidemiology, University of North Carolina Health Care System, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    Antimicrob Agents Chemother 51:4217-24. 2007
  14. ncbi request reprint Microbiology of ventilator-associated pneumonia compared with that of hospital-acquired pneumonia
    David J Weber
    Department of Hospital Epidemiology, University of North Carolina Health Care System, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA
    Infect Control Hosp Epidemiol 28:825-31. 2007
    ..This evaluation assessed whether the currently recommended empirical therapy is appropriate for both ventilator-associated pneumonia (VAP) and HAP by evaluating the infecting flora...
  15. ncbi request reprint Compliance with isolation precautions at a university hospital
    David J Weber
    Department of Hospital Epidemiology, University of North Carolina Health Care System, Chapel Hill, NC 27599, USA
    Infect Control Hosp Epidemiol 28:358-61. 2007
    ..5% (13 observations); contact isolation, 73.3% (165 observations); and protective isolation, 73.6% (72 observations). As with hand hygiene, there is suboptimal compliance with recommended isolation precautions...
  16. doi request reprint Role of hospital surfaces in the transmission of emerging health care-associated pathogens: norovirus, Clostridium difficile, and Acinetobacter species
    David J Weber
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Infect Control 38:S25-33. 2010
    ..Current hand hygiene guidelines and recommendations for surface cleaning/disinfection should be followed in managing outbreaks because of these emerging pathogens...
  17. ncbi request reprint Control of healthcare-associated Staphylococcus aureus: Survey of practices in North Carolina hospitals
    David J Weber
    University of North Carolina, Department of Hospital Epidemiology, Chapel Hill, USA
    Infect Control Hosp Epidemiol 30:909-11. 2009
    ..We report here the results of a survey of 70 hospitals in North Carolina with regard to current management issues surrounding methicillin-resistant S. aureus...
  18. ncbi request reprint Efficacy of selected hand hygiene agents used to remove Bacillus atrophaeus (a surrogate of Bacillus anthracis) from contaminated hands
    David J Weber
    Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill CB 7030, 130 Mason Farm Rd, Chapel Hill, NC 27599 7030, USA
    JAMA 289:1274-7. 2003
    ..However, only limited data are available on the susceptibility of B anthracis to antiseptics...
  19. pmc Approaches to antifungal therapies and their effectiveness among patients with cryptococcosis
    Emily W Bratton
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Antimicrob Agents Chemother 57:2485-95. 2013
    ..Future investigations should consider highlighting the distinction between all-cause mortality and attributable mortality so as not to overestimate the true effect of cryptococcosis on patient death...
  20. ncbi request reprint Nontuberculous mycobacteria. II: nested-cohort study of impact on cystic fibrosis lung disease
    Kenneth N Olivier
    The Cystic Fibrosis Pulmonary Research and Treatment Center, The Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Respir Crit Care Med 167:835-40. 2003
    ..Patients with CF and multiple positive NTM cultures, characteristic HRCT findings, and progression of HRCT changes should be monitored closely and considered for antimycobacterial therapy...
  21. ncbi request reprint Comparative efficacy of hand hygiene agents in the reduction of bacteria and viruses
    Emily E Sickbert-Bennett
    Department of Hospital Epidemiology, University of North Carolina Health Care System, North Carolina, USA
    Am J Infect Control 33:67-77. 2005
    ..Health care-associated infections most commonly result from person-to-person transmission via the hands of health care workers...
  22. pmc Decontamination of targeted pathogens from patient rooms using an automated ultraviolet-C-emitting device
    Deverick J Anderson
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 34:466-71. 2013
    ..Reductions similarly occurred in direct and indirect line of sight. CONCLUSIONS. Our data confirm that automated UV-C-emitting devices can decrease the bioburden of important pathogens in real-world settings such as hospital rooms...
  23. ncbi request reprint Room decontamination with UV radiation
    William A Rutala
    Hospital Epidemiology, University of North Carolina Health Care, and the Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    Infect Control Hosp Epidemiol 31:1025-9. 2010
    ..To determine the effectiveness of a UV-C-emitting device to eliminate clinically important nosocomial pathogens in a contaminated hospital room...
  24. doi request reprint Relative frequency of health care-associated pathogens by infection site at a university hospital from 1980 to 2008
    Jahyun Kang
    University of North Carolina School of Nursing, Chapel Hill, NC 27599, USA
    Am J Infect Control 40:416-20. 2012
    ..We describe the relative frequency of health care-associated pathogens by infection site over 29 years using hospital-wide surveillance data from a large academic hospital...
  25. pmc Clinical outcomes with rapid detection of methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates from routine blood cultures
    Nicole C Nicolsen
    UNC Health Care, Department of Pharmacy, Chapel Hill, North Carolina, USA
    J Clin Microbiol 51:4126-9. 2013
    ..5 h). This study supports the hypothesis that rapid testing plays a role in antimicrobial stewardship by getting patients on targeted therapy faster. ..
  26. pmc Community diarrhea incidence before and after rotavirus vaccine introduction in Nicaragua
    Sylvia Becker-Dreps
    Department of Family Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7595, USA
    Am J Trop Med Hyg 89:246-50. 2013
    ..The adjusted incidence rate ratio was 0.60 (95% confidence interval [CI] 0.40, 0.91) during the vaccine period versus the pre-vaccine period, indicating a lower incidence of watery diarrhea in the community during the vaccine period...
  27. ncbi request reprint Bacterial contamination of keyboards: efficacy and functional impact of disinfectants
    William A Rutala
    Department of Hospital Epidemiology, University of North Carolina Health Care System, 130 Mason Farm Road, Chapel Hill, NC 27599, USA
    Infect Control Hosp Epidemiol 27:372-7. 2006
    ..This study was performed to determine the degree of microbial contamination, the efficacy of different disinfectants, and the cosmetic and functional effects of the disinfectants on the computer keyboards...
  28. doi request reprint Disinfectants used for environmental disinfection and new room decontamination technology
    William A Rutala
    Hospital Epidemiology, University of North Carolina Health Care System, Chapel Hill, NC 27599 7030, USA
    Am J Infect Control 41:S36-41. 2013
    ..Room decontamination units (such as ultraviolet-C and hydrogen peroxide systems) aid in reducing environmental contamination after terminal room cleaning and disinfection...
  29. doi request reprint New developments in reprocessing semicritical items
    William A Rutala
    Hospital Epidemiology, University of North Carolina Health Care System, Chapel Hill, NC 27599 7030, USA
    Am J Infect Control 41:S60-6. 2013
    ..Strict adherence to current guidelines is required because more outbreaks have been linked to inadequately cleaned or disinfected endoscopes undergoing high-level disinfection than any other medical device...
  30. pmc Patient-care practices associated with an increased prevalence of hepatitis C virus infection among chronic hemodialysis patients
    Gayle Shimokura
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Infect Control Hosp Epidemiol 32:415-24. 2011
    ..To identify patient-care practices related to an increased prevalence of hepatitis C virus (HCV) infection among chronic hemodialysis patients...
  31. pmc Completeness of communicable disease reporting, North Carolina, USA, 1995-1997 and 2000-2006
    Emily E Sickbert-Bennett
    Hospital Epidemiology, University of North Carolina Health Care System, Chapel Hill, North Carolina 27514, USA
    Emerg Infect Dis 17:23-9. 2011
    ..Disease-specific reporting completeness proportions ranged from 0% to 82%, but were generally low even for diseases with great public health importance and opportunity for interventions...
  32. ncbi request reprint The effects of test variables on the efficacy of hand hygiene agents
    Emily E Sickbert-Bennett
    Department of Hospital Epidemiology, University of North Carolina Healthcare System, Chapel Hill, NC 27514, USA
    Am J Infect Control 32:69-83. 2004
    ..The purpose of this study was to evaluate the effect of test variables on the efficacy of hand hygiene agents...
  33. doi request reprint Prospective study of etiologic agents of acute gastroenteritis outbreaks in child care centers
    Whitney H Lyman
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, USA
    J Pediatr 154:253-7. 2009
    ..To investigate the etiology of outbreaks of acute gastroenteritis (AGE) in children attending childcare centers (CCCs) in North Carolina between October 2005 and March 2007...
  34. pmc Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study
    Rebekah W Moehring
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, United States of America Department of Medicine, Division of Infectious Diseases, Durham Veterans Affairs Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 8:e76225. 2013
    ..The objective of this study was to estimate the association of prior healthcare exposure on time to appropriate antibiotic therapy in patients with gram-negative BSI...
  35. pmc Statewide costs of health care-associated infections: estimates for acute care hospitals in North Carolina
    Deverick J Anderson
    Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
    Am J Infect Control 41:764-8. 2013
    ..State-specific, health care-associated infection (HAI) cost estimates have not been calculated to guide Department of Public Health efforts and investments...
  36. pmc Bloodstream infections in community hospitals in the 21st century: a multicenter cohort study
    Deverick J Anderson
    Duke University Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, United States of America Duke Infection Control Outreach Network, Durham, North Carolina, United States of America
    PLoS ONE 9:e91713. 2014
    ..While the majority of healthcare in the US is provided in community hospitals, the epidemiology and treatment of bloodstream infections in this setting is unknown...
  37. doi request reprint Hospitalization and skilled nursing care are predictors of influenza vaccination among patients on hemodialysis: evidence of confounding by frailty
    Leah J McGrath
    Departments of Epidemiology, Gillings School of Global Public Health Medicine, Division of Nephrology and Hypertension Medicine, Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC
    Med Care 51:1106-13. 2013
    ..Indicators of health status and frailty suitable for attenuating this bias could be identified in administrative data...
  38. doi request reprint Efficacy of improved hydrogen peroxide against important healthcare-associated pathogens
    William A Rutala
    Hospital Epidemiology, University of North Carolina Health Care, Chapel Hill, North Carolina, USA
    Infect Control Hosp Epidemiol 33:1159-61. 2012
    ..Improved HP is significantly superior to standard HP at the same concentration and can be used for disinfection of environmental surfaces or noncritical patient care items...
  39. doi request reprint Efficacy of different cleaning and disinfection methods against Clostridium difficile spores: importance of physical removal versus sporicidal inactivation
    William A Rutala
    Division of Infectious Diseases, University of North Carolina School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Infect Control Hosp Epidemiol 33:1255-8. 2012
    ..Wiping with sporicidal agents eliminated more than 3.90 log(10) C. difficile spores (physical removal and/or inactivation). Spraying with a sporicide eliminated more than 3.44 log(10) C. difficile spores but would not remove debris...
  40. ncbi request reprint Disinfection of a probe used in ultrasound-guided prostate biopsy
    William A Rutala
    Department of Hospital Epidemiology, University of North Carolina Health Care System, Chapel Hill, NC, USA
    Infect Control Hosp Epidemiol 28:916-9. 2007
    ..Transrectal ultrasound (TRUS)-guided prostate biopsies are among the most common outpatient diagnostic procedures in urology clinics and carry the risk of introducing pathogens that may lead to infection...
  41. doi request reprint A quantitative approach to defining "high-touch" surfaces in hospitals
    Kirk Huslage
    Department of Hospital Epidemiology, UNC Health Care, University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Infect Control Hosp Epidemiol 31:850-3. 2010
    ..Five surfaces were defined as high-touch surfaces: the bed rails, the bed surface, the supply cart, the over-bed table, and the intravenous pump...
  42. ncbi request reprint Lessons learned: protection of healthcare workers from infectious disease risks
    David J Weber
    Department of Medicine, University of North Carolina at Chapel Hill, NC, USA
    Crit Care Med 38:S306-14. 2010
    ..To summarize current concepts on preventing occupationally acquired infections in healthcare workers...
  43. pmc Patterns of rotavirus vaccine uptake and use in privately-insured US infants, 2006-2010
    Catherine A Panozzo
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e73825. 2013
    ..Interventions to increase rotavirus vaccine coverage should consider targeting family physicians and encouraging completion of the vaccine series...
  44. ncbi request reprint Disinfection and sterilization in health care facilities: what clinicians need to know
    William A Rutala
    Hospital Epidemiology, University of North Carolina Health Care System, Chapel Hill, NC 27599 7030, USA
    Clin Infect Dis 39:702-9. 2004
    ..Adherence to these recommendations should improve disinfection and sterilization practices in health care facilities, thereby reducing infections associated with contaminated patient-care items...
  45. doi request reprint Rapid hospital room decontamination using ultraviolet (UV) light with a nanostructured UV-reflective wall coating
    William A Rutala
    Hospital Epidemiology, University of North Carolina Health Care, Chapel Hill, NC, USA
    Infect Control Hosp Epidemiol 34:527-9. 2013
    ....
  46. doi request reprint Disinfection and sterilization: an overview
    William A Rutala
    Hospital Epidemiology, University of North Carolina Health Care System, Chapel Hill, NC 27599 7030, USA
    Am J Infect Control 41:S2-5. 2013
    ..Cleaning must always precede high-level disinfection and sterilization...
  47. ncbi request reprint Pseudomonas aeruginosa-related postoperative endophthalmitis linked to a contaminated phacoemulsifier
    Karen K Hoffmann
    University of North Carolina at Chapel Hill, Campus Box 7030, Burnett Womack, Room 547, Chapel Hill, NC 27599 7030, USA
    Arch Ophthalmol 120:90-3. 2002
  48. ncbi request reprint Microbiologic evaluation of microfiber mops for surface disinfection
    William A Rutala
    Department of Hospital Epidemiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    Am J Infect Control 35:569-73. 2007
    ..Recently, health care facilities have started to use a microfiber mopping technique rather than a conventional, cotton string mop to clean floors...
  49. doi request reprint Sterilization, high-level disinfection, and environmental cleaning
    William A Rutala
    Department of Hospital Epidemiology, University of North Carolina Health Care, Chapel Hill, 101 Manning Drive, NC 27514, USA
    Infect Dis Clin North Am 25:45-76. 2011
    ..In addition, current issues and practices associated with environmental cleaning are reviewed...
  50. ncbi request reprint How to assess risk of disease transmission to patients when there is a failure to follow recommended disinfection and sterilization guidelines
    William A Rutala
    Department of Hospital Epidemiology, University of North Carolina at Chapel Hill, NC 27599, USA
    Infect Control Hosp Epidemiol 28:146-55. 2007
    ..Disinfection and sterilization are critical components of infection control. Unfortunately, breaches of disinfection and sterilization guidelines are not uncommon...
  51. ncbi request reprint Use of germicides in the home and the healthcare setting: is there a relationship between germicide use and antibiotic resistance?
    David J Weber
    Division of Infectious Disease, University of North Carolina School of Medicine, hapel Hill, NC 27599 7030, USA
    Infect Control Hosp Epidemiol 27:1107-19. 2006
    ..The spread of antibiotic-resistant pathogens represents an increasing threat in healthcare facilities. Concern has been expressed that the use of surface disinfectants and antiseptics may select for antibiotic-resistant pathogens...
  52. pmc Efficacy of hospital germicides against adenovirus 8, a common cause of epidemic keratoconjunctivitis in health care facilities
    William A Rutala
    Department of Hospital Epidemiology, University of North Carolina Health Care System, Chapel Hill, NC 27514, USA
    Antimicrob Agents Chemother 50:1419-24. 2006
    ....
  53. ncbi request reprint The benefits of surface disinfection
    William A Rutala
    University of North Carolina Health Care System, Chapel Hill, USA
    Am J Infect Control 32:226-31. 2004
  54. pmc Prevalence and risk factor analysis for methicillin-resistant Staphylococcus aureus nasal colonization in children attending child care centers
    Melissa B Miller
    UNC School of Medicine, Department of Pathology and Laboratory Medicine, Campus Box 7525, Chapel Hill, NC 27599, USA
    J Clin Microbiol 49:1041-7. 2011
    ..The low frequency of colonization observed highlights the need for a large multicenter study to determine risk factors for MRSA colonization and subsequent infection in this highly susceptible population...
  55. ncbi request reprint A comparison of environmental contamination by patients infected or colonized with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a multicenter study
    Lauren P Knelson
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina
    Infect Control Hosp Epidemiol 35:872-5. 2014
    ..Colonized patients had higher median total target colony-forming units (CFU) of MRSA or VRE than did infected patients (median, 25 CFU [interquartile range, 0-106 CFU] vs 0 CFU [interquartile range, 0-29 CFU]; P = .033). ..
  56. ncbi request reprint Factors associated with personal protection equipment use and hand hygiene among hemodialysis staff
    Gayle Shimokura
    Department of Epidemiology, UNC School of Public Health, Chapel Hill, NC, USA
    Am J Infect Control 34:100-7. 2006
    ..In this study, we investigated factors associated with performing these practices as recommended...
  57. pmc Syndromic surveillance for emerging infections in office practice using billing data
    Philip D Sloane
    Department of Family Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Ann Fam Med 4:351-8. 2006
    ..We wanted to evaluate the feasibility of conducting syndromic surveillance in a primary care office using billing data...
  58. ncbi request reprint Changes in childhood pneumonia and infant mortality rates following introduction of the 13-valent pneumococcal conjugate vaccine in Nicaragua
    Sylvia Becker-Dreps
    From the Department of Family Medicine, University of North Carolina School of Medicine, Chapel Hill, NC Department of Microbiology, National Autonomous University of Nicaragua, Leon, Nicaragua Department of Biostatistics, UNC Gillings School of Global Public Health, Chapel Hill, NC Sistemas Locales de Atención Integral a la Salud, León SILAIS León Hospital Epidemiology, Department of Pediatrics, Hospital Escuela Oscar Danilo Rosales Argüello HEODRA, Leon, Nicaragua Division of Infectious Diseases, Duke University School of Medicine, Durham, NC and Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC
    Pediatr Infect Dis J 33:637-42. 2014
    ..We assessed changes in incidence rates of health facility visits for childhood pneumonia and infant mortality after PCV-13 introduction in the Department of León, Nicaragua...
  59. pmc Development of a treatment algorithm for streptococci and enterococci from positive blood cultures identified with the Verigene Gram-positive blood culture assay
    Kevin Alby
    Clinical Microbiology Immunology Laboratories, UNC Health Care, Chapel Hill, North Carolina, USA
    J Clin Microbiol 51:3869-71. 2013
    ..The overall concordance of the assay with culture was 89.7% (70/78 cultures), allowing for the development of a targeted treatment algorithm. ..
  60. pmc Virus transfer from personal protective equipment to healthcare employees' skin and clothing
    Lisa Casanova
    University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Emerg Infect Dis 14:1291-3. 2008
    ..Following this protocol often resulted in virus transfer to hands and clothing. An altered protocol or other measures are needed to prevent healthcare worker contamination...
  61. ncbi request reprint Managing the risk of nosocomial transmission of prion diseases
    David J Weber
    Division of Infectious Diseases, University of North Carolina UNC School of Medicine, Chapel Hill, USA
    Curr Opin Infect Dis 15:421-5. 2002
    ..This paper reviews the recent literature and provides recommendations for the prevention of nosocomial transmission of prion agents...
  62. pmc Economic and microbiologic evaluation of single-dose vial extension for hazardous drugs
    Erinn C Rowe
    University of North Carolina UNC Health Care, Chapel Hill, NC, USA
    J Oncol Pract 8:e45-9. 2012
    ..A study was conducted to evaluate the cost of discarding vials after 6 hours and to further test sterility of vials beyond this time point, subsequently defined as the beyond-use date (BUD)...
  63. ncbi request reprint The use of live attenuated influenza vaccine (LAIV) in healthcare personnel (HCP): guidance from the Society for Healthcare Epidemiology of America (SHEA)
    Thomas R Talbot
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Infect Control Hosp Epidemiol 33:981-3. 2012
    ..This document provides guidance from the Society for Healthcare Epidemiology of America regarding use of LAIV in HCP and the infection control precautions that are recommended with its use in this population...
  64. doi request reprint Disinfection of an infrared coagulation device used to treat hemorrhoids
    William A Rutala
    Department of Hospital Epidemiology, University of North Carolina Health Care System, Chapel Hill, NC 27599 7030, USA
    Am J Infect Control 40:78-9. 2012
    ..We developed and validated a method for disinfecting an infrared coagulation device that cannot be immersed in disinfectant solution...
  65. ncbi request reprint Nontuberculous mycobacteria. I: multicenter prevalence study in cystic fibrosis
    Kenneth N Olivier
    The Cystic Fibrosis Pulmonary Research and Treatment Center, The Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Respir Crit Care Med 167:828-34. 2003
    ..Older age was the most significant predictor for isolation of NTM. The clinical significance of NTM in CF is incompletely defined, but patients with these organisms should be monitored with repeat cultures...
  66. pmc Rotavirus prevalence in the primary care setting in Nicaragua after universal infant rotavirus immunization
    Sylvia Becker-Dreps
    Department of Family Medicine, University of North Carolina School of Medicine, Chapel Hill, 27599 7599, USA
    Am J Trop Med Hyg 85:957-60. 2011
    ..In conclusion, rotavirus was an uncommon cause of childhood diarrhea in this primary care setting after implementation of a rotavirus immunization program...
  67. doi request reprint Utility of International Classification of Diseases, Ninth Revision, Clinical Modification codes for communicable disease surveillance
    Emily E Sickbert-Bennett
    Department of Hospital Epidemiology, University of North Carolina Health Care, Chapel Hill, North Carolina 27514, USA
    Am J Epidemiol 172:1299-305. 2010
    ..6% (95% uncertainty interval: 15.6, 46.5)...
  68. pmc Effects of air temperature and relative humidity on coronavirus survival on surfaces
    Lisa M Casanova
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Appl Environ Microbiol 76:2712-7. 2010
    ..TGEV and MHV could serve as conservative surrogates for modeling exposure, the risk of transmission, and control measures for pathogenic enveloped viruses, such as SARS-CoV and influenza virus, on health care surfaces...
  69. doi request reprint Impact of an oil-based lubricant on the effectiveness of the sterilization processes
    William A Rutala
    Department of Hospital Epidemiology, University of North Carolina Health Care System, Chapel Hill, North Carolina 27599 7030, USA
    Infect Control Hosp Epidemiol 29:69-72. 2008
    ....
  70. doi request reprint Severe postvaccinia encephalitis with acute disseminated encephalomyelitis: recovery with early intravenous immunoglobulin, high-dose steroids, and vaccinia immunoglobulin
    Cornelius N Van Dam
    Department of Internal Medicine Infectious Diseases, University of North Carolina Area Health Education Centers Program, Moses Cone Hospital, Greensboro, NC 27401 1020, USA
    Clin Infect Dis 48:e47-9. 2009
    ..Both affected patients responded dramatically with early intervention of intravenous immunoglobulin. Our patient, who also received concurrent vaccinia immunoglobulin and corticosteroids, demonstrated full recovery...
  71. ncbi request reprint Breakthrough pneumococcal bacteremia in patients being treated with azithromycin and clarithromycin
    M A Kelley
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    Clin Infect Dis 31:1008-11. 2000
    ..Among pneumococci, low-level resistance to macrolides can lead to clinical failure, and resistance to macrolides should be considered during the selection of empiric therapy for patients with presumed pneumococcal infections...
  72. pmc New disinfection and sterilization methods
    W A Rutala
    University of North Carolina UNC Health Care System and UNC School of Medicine, Chapel Hill, North Carolina, USA
    Emerg Infect Dis 7:348-53. 2001
    ....
  73. ncbi request reprint Reprocessing endoscopes: United States perspective
    W A Rutala
    Hospital Epidemiology, University of North Carolina Health Care System, Chapel Hill, NC 27514, USA
    J Hosp Infect 56:S27-39. 2004
    ....
  74. pmc Comparison and temporal trends of three groups with cryptococcosis: HIV-infected, solid organ transplant, and HIV-negative/non-transplant
    Emily W Bratton
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e43582. 2012
    ..However, direct comparisons of management, severity and outcomes of these groups have not been conducted...
  75. doi request reprint Cost-effectiveness analysis of active surveillance screening for methicillin-resistant Staphylococcus aureus in an academic hospital setting
    Jahyun Kang
    School of Nursing, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Infect Control Hosp Epidemiol 33:477-86. 2012
    ....
  76. pmc Influenza vaccine effectiveness in patients on hemodialysis: an analysis of a natural experiment
    Leah J McGrath
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Arch Intern Med 172:548-54. 2012
    ..Observational studies of vaccine effectiveness (VE) are challenging because vaccinated subjects may be healthier than unvaccinated subjects...
  77. ncbi request reprint Influenza vaccination of healthcare workers and vaccine allocation for healthcare workers during vaccine shortages
    Thomas R Talbot
    Department of Medicine, Vanderbilt University School of Medicine, A 2200 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232, USA
    Infect Control Hosp Epidemiol 26:882-90. 2005
    ..These recommendations apply to all types of healthcare facilities, including acute care hospitals, long-term-care facilities, and ambulatory care settings...
  78. ncbi request reprint Virulence associated with outbreak-related strains of Burkholderia cepacia complex among a cohort of patients with bacteremia
    Christopher W Woods
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 38:1243-50. 2004
    ..5; 95% confidence interval, 1.20-25.02). B. cenocepacia is an emerging nosocomial pathogen. Certain strains are associated with an enhanced capacity for interpatient spread and poor outcome...
  79. ncbi request reprint Hand-washing and diapering equipment reduces disease among children in out-of-home child care centers
    Jonathan B Kotch
    Department of Maternal and Child Health, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Pediatrics 120:e29-36. 2007
    ....
  80. pmc Heterotypic humoral and cellular immune responses following Norwalk virus infection
    Lisa C Lindesmith
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Virol 84:1800-15. 2010
    ..1-1968-challenged individuals and highlight a potential complication in the design of efficacious norovirus vaccines...
  81. ncbi request reprint Registration of disinfectants based on relative microbicidal activity
    William A Rutala
    Division of Infectious Disease, University of North Carolina UNC School of Medicine, Department of Hospital Epidemiology, MPH, CB 7030 Bioinformatics Building, 130 Mason Farm Road, Chapel Hill, NC 27599 7030, USA
    Infect Control Hosp Epidemiol 25:333-41. 2004
  82. doi request reprint Survival of surrogate coronaviruses in water
    Lisa Casanova
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA
    Water Res 43:1893-8. 2009
    ..Coronaviruses can remain infectious for long periods in water and pasteurized settled sewage, suggesting contaminated water is a potential vehicle for human exposure if aerosols are generated...
  83. ncbi request reprint Comparative evaluation of the sporicidal activity of new low-temperature sterilization technologies: ethylene oxide, 2 plasma sterilization systems, and liquid peracetic acid
    W A Rutala
    Division of Infectious Diseases, University of North Carolina, Chapel Hill 27599 7030, USA
    Am J Infect Control 26:393-8. 1998
    ..The Steris System 1 is limited by diffusion of the chemical sterilant into the interior of the lumen test unit...
  84. ncbi request reprint Overwhelming disseminated herpes simplex virus type 2 infection in a patient with severe burn injury: case report and literature review
    Amanda Peppercorn
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7215, USA
    J Burn Care Res 31:492-8. 2010
    ..To our knowledge, this is the first report of disseminated visceral HSV-2 infection in a burn patient in the medical literature...
  85. pmc Using hospital antibiogram data to assess regional pneumococcal resistance to antibiotics
    Cheryl R Stein
    The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Emerg Infect Dis 9:211-6. 2003
    ..Aggregating antibiogram data is a feasible and timely method of monitoring regional susceptibility patterns and may also prove beneficial in measuring the effects of interventions to decrease antimicrobial resistance...
  86. ncbi request reprint Community influenza activity and risk of acute influenza-like illness episodes among healthy unvaccinated pregnant and postpartum women
    Lisa Lindsay
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Am J Epidemiol 163:838-48. 2006
    ..Findings estimate that 20-43 pregnant/postpartum women would need to be vaccinated with an 80% effective vaccine to prevent one influenza-like illness episode...
  87. ncbi request reprint Surface disinfection: should we do it?
    W A Rutala
    Division of Infectious Diseases, University of North Carolina Health Care System, UNC School of Medicine, Chapel Hill 27514, USA
    J Hosp Infect 48:S64-8. 2001
    ..It concludes that while non-critical surfaces are uncommonly associated with transmission of infections to patients, one should clean and disinfect surfaces on a regularly scheduled basis...
  88. pmc Uses of inorganic hypochlorite (bleach) in health-care facilities
    W A Rutala
    Division of Infectious Diseases, University of North Carolina School of Medicine, USA
    Clin Microbiol Rev 10:597-610. 1997
    ..Despite the increasing availability of other disinfectants, hypochlorites continue to find wide use in hospitals...
  89. pmc Assessment by meta-analysis of PCR for diagnosis of smear-negative pulmonary tuberculosis
    Olga L Sarmiento
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Microbiol 41:3233-40. 2003
    ....
  90. doi request reprint High-level human herpesvirus-6 viremia associated with onset of Stevens-Johnson syndrome: report of two cases
    Amanda F Peppercorn
    Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill, USA
    J Burn Care Res 31:365-8. 2010
    ....
  91. ncbi request reprint A comparison of height and weight velocity as a part of the composite endpoint in pediatric HIV
    Daniel K Benjamin
    Duke Clinical Research Institute and the Department of Pediatrics, Duke University, Durham, North Carolina, USA
    AIDS 17:2331-6. 2003
    ..However, WAZ and height velocity (HAZ) have not been critically compared for their utility as part of the composite endpoint...
  92. ncbi request reprint Clinical effectiveness of low-temperature sterilization technologies
    W A Rutala
    University of North Carolina School of Medicine, the Department of Hospital Epidemiology, UNC Hospitals, Chapel Hill 27599 7030, USA
    Infect Control Hosp Epidemiol 19:798-804. 1998
    ....
  93. ncbi request reprint Levels of microbial contamination on surgical instruments
    W A Rutala
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, USA
    Am J Infect Control 26:143-5. 1998
    ..This suggests that new low-temperature sterilization technologies are likely to be highly effective in preventing cross-transmission of infection via nonlumen medical instruments...
  94. ncbi request reprint Creutzfeldt-Jakob disease: recommendations for disinfection and sterilization
    W A Rutala
    Division of Infectious Diseases, University of North Carolina (UNC) School of Medicine and the Department of Hospital Epidemiology, UNC Health Care System, Chapel Hill, NC 27599-7030, USA
    Clin Infect Dis 32:1348-56. 2001
    ..g., surgical instruments) and semicritical devices contaminated with high-risk tissue (i.e., brain, spinal cord, and eye tissue) from high-risk patients--those with known or suspected infection with CJD--require special treatment...
  95. ncbi request reprint A review of single-use and reusable gowns and drapes in health care
    W A Rutala
    University of North Carolina, School of Medicine, and the Department of Hospital Epidemiology, Chapel Hill 28599-7030, USA
    Infect Control Hosp Epidemiol 22:248-57. 2001
    ....
  96. ncbi request reprint The emerging nosocomial pathogens Cryptosporidium, Escherichia coli O157:H7, Helicobacter pylori, and hepatitis C: epidemiology, environmental survival, efficacy of disinfection, and control measures
    D J Weber
    Department of Medicine, University of North Carolina at Chapel Hill, 27599-7030, USA
    Infect Control Hosp Epidemiol 22:306-15. 2001
    ....
  97. ncbi request reprint Treatment of tick-borne diseases
    Brian J Donovan
    Infectious Diseases Pharmacotherapy, Department of Pharmacy, University of North Carolina Hospitals, Chapel Hill, NC, USA
    Ann Pharmacother 36:1590-7. 2002
    ..To review the data regarding the pharmacotherapy of Lyme disease, Rocky Mountain spotted fever (RMSF), and the human ehrlichioses...
  98. ncbi request reprint Faucet aerators: A source of patient colonization with Stenotrophomonas maltophilia
    D J Weber
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill 27599 7030, USA
    Am J Infect Control 27:59-63. 1999
    ..If additional clusters of infected or colonized patients are linked to contaminated aerators, consideration should be given to routine disinfection or removal of the aerators...
  99. ncbi request reprint Relative frequency of nosocomial pathogens at a university hospital during the decade 1980 to 1989
    D J Weber
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7030
    Am J Infect Control 20:192-7. 1992
    ..CONCLUSIONS: We conclude that Candida and other yeasts are being isolated increasingly as causative agents of nosocomial infection...
  100. ncbi request reprint Recognition and management of anthrax
    David J Weber
    N Engl J Med 346:943-5; author reply 943-5. 2002
  101. ncbi request reprint Effects of long-term storage on sterility of medical supplies
    William A Rutala
    Am J Infect Control 34:248. 2006