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Genomes and Genes | Valerie M WeaverSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epitheliumValerie M Weaver
Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Cancer Cell 2:205-16. 2002..These results indicate that integrin-induced polarity may drive tumor cell resistance to apoptosis-inducing agents via effects on NFkappaB...
Tensional homeostasis and the malignant phenotypeMatthew J Paszek
Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
Cancer Cell 8:241-54. 2005..Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype...- Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrateMatthew J Paszek
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS Comput Biol 5:e1000604. 2009..We thus demonstrate how integrins themselves could function as sensory molecules that begin sensing matrix properties even before large multi-molecular adhesion complexes are assembled... - Matrix crosslinking forces tumor progression by enhancing integrin signalingKandice R Levental
Department of Bioengineering and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell 139:891-906. 2009..These data show how collagen crosslinking can modulate tissue fibrosis and stiffness to force focal adhesions, growth factor signaling and breast malignancy... - Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesionAlaina K Fournier
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
J Cell Sci 121:226-33. 2008..Our results identify Rac signaling to cyclin D1 as a crucial pro-proliferative effect of E-cadherin-mediated cell-cell adhesion... - Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standardYuan Yan
Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA
J Proteome Res 4:2007-14. 2005..These results suggest that the malignant T4-2 cells have acquired more resistance to H(2)O(2)-induced apoptosis than the nonmalignant S-1 cells... - Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumorsNastaran Zahir
Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Cell Biol 163:1397-407. 2003..Therefore, epithelial tumors could survive in the absence of exogenous basement membrane through autocrine LM-5-alpha6beta4 integrin-RAC-NFkappaB signaling... - alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary aciniJulie C Friedland
Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Cell Sci 120:3700-12. 2007.... - Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesisKandice R Johnson
Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Methods Cell Biol 83:547-83. 2007..We end by discussing technical limitations of currently available systems and by presenting opportunities for improvement... - HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotypePenney M Gilbert
Department of Pathology, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Clin Invest 120:1535-50. 2010.... - Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerinChengfeng Yang
Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
J Biol Chem 280:24363-70. 2005.... - The tension mounts: mechanics meets morphogenesis and malignancyMatthew J Paszek
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6383, USA
J Mammary Gland Biol Neoplasia 9:325-42. 2004..Additionally, it will be critical to identify the key molecular elements regulating tensional-homeostasis of the mammary gland and thereafter to characterize their associated mechanotransduction pathways... - Death in the third dimension: apoptosis regulation and tissue architectureNastaran Zahir
Department of Bioengineering and Institute for Medicine and Engineering, 1170 Vagelos Research Laboratory, 3340 Smith Walk, Philadelphia, PA 19104-6383, USA
Curr Opin Genet Dev 14:71-80. 2004.... - Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expressionKaren D Cowden Dahl
Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
Mol Biol Cell 16:1901-12. 2005..Together, these data suggest that HIF and O(2) tension influence placental invasion and tumor migration by increasing cell surface expression of alphavbeta3 integrin... - Watch thy neighbor: cancer is a communal affairValerie M Weaver
Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA
J Cell Sci 117:1287-90. 2004..New work reported in this issue of Journal of Cell Science now provides compelling evidence that alterations in the stroma are necessary and also sufficient for induction of malignant behavior by genetically normal cells... - The tissue microenvironment as an epigenetic tumor modifierMeredith Unger
Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, PA, USA
Methods Mol Biol 223:315-47. 2003 - The ultrastructure of MCF-10A aciniJean M Underwood
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Cell Physiol 208:141-8. 2006..Electron microscopy has the resolution required to survey features of MCF-10A cell and acinus architecture that may change with manipulations designed to induce malignant phenotypes... - Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial culturesChristy Hebner
Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, CA, USA
Annu Rev Pathol 3:313-39. 2008..We review how 3D models are being used to investigate fundamental cellular and biophysical mechanisms associated with breast cancer progression that have not been readily amenable to traditional genetic or biochemical analysis... - A human breast cell model of preinvasive to invasive transitionAylin Rizki
Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Cancer Res 68:1378-87. 2008..This model provides a new tool for dissection of mechanisms by which preinvasive breast cells could acquire invasiveness in a metaplastic context... - Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesisLaura Kass
Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
Int J Biochem Cell Biol 39:1987-94. 2007.... - The organizing principle: microenvironmental influences in the normal and malignant breastMina J Bissell
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Differentiation 70:537-46. 2002..How this context determines functional integrity, and how its loss can lead to malignancy, appears to have much to do with tissue structure and polarity...