Valerie M Weaver

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    Valerie M Weaver
    Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 2:205-16. 2002
  2. ncbi request reprint Tensional homeostasis and the malignant phenotype
    Matthew J Paszek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 8:241-54. 2005
  3. pmc Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate
    Matthew J Paszek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Comput Biol 5:e1000604. 2009
  4. pmc Matrix crosslinking forces tumor progression by enhancing integrin signaling
    Kandice R Levental
    Department of Bioengineering and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell 139:891-906. 2009
  5. pmc Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion
    Alaina K Fournier
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    J Cell Sci 121:226-33. 2008
  6. ncbi request reprint Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard
    Yuan Yan
    Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Proteome Res 4:2007-14. 2005
  7. pmc Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors
    Nastaran Zahir
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 163:1397-407. 2003
  8. ncbi request reprint alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini
    Julie C Friedland
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Sci 120:3700-12. 2007
  9. pmc Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis
    Kandice R Johnson
    Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Methods Cell Biol 83:547-83. 2007
  10. pmc HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype
    Penney M Gilbert
    Department of Pathology, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Clin Invest 120:1535-50. 2010

Collaborators

Detail Information

Publications21

  1. pmc beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    Valerie M Weaver
    Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 2:205-16. 2002
    ..These results indicate that integrin-induced polarity may drive tumor cell resistance to apoptosis-inducing agents via effects on NFkappaB...
  2. ncbi request reprint Tensional homeostasis and the malignant phenotype
    Matthew J Paszek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 8:241-54. 2005
    ..Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype...
  3. pmc Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate
    Matthew J Paszek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Comput Biol 5:e1000604. 2009
    ..We thus demonstrate how integrins themselves could function as sensory molecules that begin sensing matrix properties even before large multi-molecular adhesion complexes are assembled...
  4. pmc Matrix crosslinking forces tumor progression by enhancing integrin signaling
    Kandice R Levental
    Department of Bioengineering and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell 139:891-906. 2009
    ..These data show how collagen crosslinking can modulate tissue fibrosis and stiffness to force focal adhesions, growth factor signaling and breast malignancy...
  5. pmc Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion
    Alaina K Fournier
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    J Cell Sci 121:226-33. 2008
    ..Our results identify Rac signaling to cyclin D1 as a crucial pro-proliferative effect of E-cadherin-mediated cell-cell adhesion...
  6. ncbi request reprint Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard
    Yuan Yan
    Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Proteome Res 4:2007-14. 2005
    ..These results suggest that the malignant T4-2 cells have acquired more resistance to H(2)O(2)-induced apoptosis than the nonmalignant S-1 cells...
  7. pmc Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors
    Nastaran Zahir
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 163:1397-407. 2003
    ..Therefore, epithelial tumors could survive in the absence of exogenous basement membrane through autocrine LM-5-alpha6beta4 integrin-RAC-NFkappaB signaling...
  8. ncbi request reprint alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini
    Julie C Friedland
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Sci 120:3700-12. 2007
    ....
  9. pmc Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis
    Kandice R Johnson
    Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Methods Cell Biol 83:547-83. 2007
    ..We end by discussing technical limitations of currently available systems and by presenting opportunities for improvement...
  10. pmc HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype
    Penney M Gilbert
    Department of Pathology, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Clin Invest 120:1535-50. 2010
    ....
  11. ncbi request reprint Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin
    Chengfeng Yang
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Biol Chem 280:24363-70. 2005
    ....
  12. ncbi request reprint The tension mounts: mechanics meets morphogenesis and malignancy
    Matthew J Paszek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6383, USA
    J Mammary Gland Biol Neoplasia 9:325-42. 2004
    ..Additionally, it will be critical to identify the key molecular elements regulating tensional-homeostasis of the mammary gland and thereafter to characterize their associated mechanotransduction pathways...
  13. ncbi request reprint Death in the third dimension: apoptosis regulation and tissue architecture
    Nastaran Zahir
    Department of Bioengineering and Institute for Medicine and Engineering, 1170 Vagelos Research Laboratory, 3340 Smith Walk, Philadelphia, PA 19104 6383, USA
    Curr Opin Genet Dev 14:71-80. 2004
    ....
  14. pmc Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression
    Karen D Cowden Dahl
    Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Mol Biol Cell 16:1901-12. 2005
    ..Together, these data suggest that HIF and O(2) tension influence placental invasion and tumor migration by increasing cell surface expression of alphavbeta3 integrin...
  15. ncbi request reprint Watch thy neighbor: cancer is a communal affair
    Valerie M Weaver
    Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA
    J Cell Sci 117:1287-90. 2004
    ..New work reported in this issue of Journal of Cell Science now provides compelling evidence that alterations in the stroma are necessary and also sufficient for induction of malignant behavior by genetically normal cells...
  16. ncbi request reprint The tissue microenvironment as an epigenetic tumor modifier
    Meredith Unger
    Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 223:315-47. 2003
  17. ncbi request reprint The ultrastructure of MCF-10A acini
    Jean M Underwood
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 208:141-8. 2006
    ..Electron microscopy has the resolution required to survey features of MCF-10A cell and acinus architecture that may change with manipulations designed to induce malignant phenotypes...
  18. ncbi request reprint Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures
    Christy Hebner
    Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, CA, USA
    Annu Rev Pathol 3:313-39. 2008
    ..We review how 3D models are being used to investigate fundamental cellular and biophysical mechanisms associated with breast cancer progression that have not been readily amenable to traditional genetic or biochemical analysis...
  19. pmc A human breast cell model of preinvasive to invasive transition
    Aylin Rizki
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Res 68:1378-87. 2008
    ..This model provides a new tool for dissection of mechanisms by which preinvasive breast cells could acquire invasiveness in a metaplastic context...
  20. pmc Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis
    Laura Kass
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Int J Biochem Cell Biol 39:1987-94. 2007
    ....
  21. pmc The organizing principle: microenvironmental influences in the normal and malignant breast
    Mina J Bissell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Differentiation 70:537-46. 2002
    ..How this context determines functional integrity, and how its loss can lead to malignancy, appears to have much to do with tissue structure and polarity...