Donald L Weaver

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi request reprint Sentinel lymph node biopsy in breast cancer: creating controversy and defining new standards
    D L Weaver
    Department of Pathology, University of Vermont College of Medicine and Vermont Cancer Center, Burlington 05405 0068, USA
    Adv Anat Pathol 8:65-73. 2001
  2. pmc Development of a diagnostic test set to assess agreement in breast pathology: practical application of the Guidelines for Reporting Reliability and Agreement Studies (GRRAS)
    Natalia V Oster
    Department of Medicine, University of Washington, Seattle, WA, USA
    BMC Womens Health 13:3. 2013
  3. pmc Metastasis detection in sentinel lymph nodes: comparison of a limited widely spaced (NSABP protocol B-32) and a comprehensive narrowly spaced paraffin block sectioning strategy
    Donald L Weaver
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Am J Surg Pathol 33:1583-9. 2009
  4. doi request reprint Pathology evaluation of sentinel lymph nodes in breast cancer: protocol recommendations and rationale
    Donald L Weaver
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA
    Mod Pathol 23:S26-32. 2010
  5. pmc Effect of occult metastases on survival in node-negative breast cancer
    Donald L Weaver
    University of Vermont College of Medicine and Vermont Cancer Center, Department of Pathology, Burlington, VT 05405 0068, USA
    N Engl J Med 364:412-21. 2011
  6. ncbi request reprint Sentinel lymph nodes and breast carcinoma: which micrometastases are clinically significant?
    Donald L Weaver
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    Am J Surg Pathol 27:842-5. 2003
  7. pmc Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissection
    Takamaru Ashikaga
    University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Surg Oncol 102:111-8. 2010
  8. ncbi request reprint Detection of occult sentinel lymph node micrometastases by immunohistochemistry in breast cancer. An NSABP protocol B-32 quality assurance study
    Donald L Weaver
    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont 05405 0068, USA
    Cancer 107:661-7. 2006
  9. pmc Surgeon training, protocol compliance, and technical outcomes from breast cancer sentinel lymph node randomized trial
    David N Krag
    Department of Surgery, College of Medicine, University of Vermont, Given Building, Rm E309, 89 Beaumont Ave, Burlington, VT 05405, USA
    J Natl Cancer Inst 101:1356-62. 2009
  10. ncbi request reprint NSABP-32: Phase III, randomized trial comparing axillary resection with sentinal lymph node dissection: a description of the trial
    David N Krag
    Department of Surgery, University of Vermont, Burlington, Vermont, USA
    Ann Surg Oncol 11:208S-10S. 2004

Detail Information

Publications47

  1. ncbi request reprint Sentinel lymph node biopsy in breast cancer: creating controversy and defining new standards
    D L Weaver
    Department of Pathology, University of Vermont College of Medicine and Vermont Cancer Center, Burlington 05405 0068, USA
    Adv Anat Pathol 8:65-73. 2001
    ..Practicing pathologists will need to stay abreast of the issues and facts in order to participate in the debate and shape the future of pathologic management of sentinel nodes...
  2. pmc Development of a diagnostic test set to assess agreement in breast pathology: practical application of the Guidelines for Reporting Reliability and Agreement Studies (GRRAS)
    Natalia V Oster
    Department of Medicine, University of Washington, Seattle, WA, USA
    BMC Womens Health 13:3. 2013
    ..We use the newly developed Guidelines for Reporting Reliability and Agreement Studies (GRRAS) as a basis to report these methods...
  3. pmc Metastasis detection in sentinel lymph nodes: comparison of a limited widely spaced (NSABP protocol B-32) and a comprehensive narrowly spaced paraffin block sectioning strategy
    Donald L Weaver
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Am J Surg Pathol 33:1583-9. 2009
    ..7 to 4.8 mm) and the modal thickness was 2.3 mm. Although more comprehensive sectioning of SLNs detects additional micrometastases, the data suggest diminishing returns and reduced cost effectiveness for the comprehensive strategy...
  4. doi request reprint Pathology evaluation of sentinel lymph nodes in breast cancer: protocol recommendations and rationale
    Donald L Weaver
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA
    Mod Pathol 23:S26-32. 2010
    ..If we ultimately adopt more comprehensive microscopic evaluation of SLNs, the candidate sampling strategies need to be carefully considered in the context of statistically valid sampling strategies...
  5. pmc Effect of occult metastases on survival in node-negative breast cancer
    Donald L Weaver
    University of Vermont College of Medicine and Vermont Cancer Center, Department of Pathology, Burlington, VT 05405 0068, USA
    N Engl J Med 364:412-21. 2011
    ..Prospective data on clinical outcomes from randomized trials according to sentinel-node involvement have been lacking...
  6. ncbi request reprint Sentinel lymph nodes and breast carcinoma: which micrometastases are clinically significant?
    Donald L Weaver
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    Am J Surg Pathol 27:842-5. 2003
    ..Rigorous strategies designed to reliably detect single cells or small cell clusters in sentinel nodes remain time-intensive and cost prohibitive...
  7. pmc Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissection
    Takamaru Ashikaga
    University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Surg Oncol 102:111-8. 2010
    ....
  8. ncbi request reprint Detection of occult sentinel lymph node micrometastases by immunohistochemistry in breast cancer. An NSABP protocol B-32 quality assurance study
    Donald L Weaver
    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont 05405 0068, USA
    Cancer 107:661-7. 2006
    ..2 mm but not larger than 2.0 mm) or isolated tumor cell clusters (< or = 0.2 mm). This study defines the rate at which pathologists miss metastases on CK IHC of sentinel lymph nodes (SLN)...
  9. pmc Surgeon training, protocol compliance, and technical outcomes from breast cancer sentinel lymph node randomized trial
    David N Krag
    Department of Surgery, College of Medicine, University of Vermont, Given Building, Rm E309, 89 Beaumont Ave, Burlington, VT 05405, USA
    J Natl Cancer Inst 101:1356-62. 2009
    ..We evaluated the relationship of surgeon trial preparation, protocol compliance audit, and technical outcomes...
  10. ncbi request reprint NSABP-32: Phase III, randomized trial comparing axillary resection with sentinal lymph node dissection: a description of the trial
    David N Krag
    Department of Surgery, University of Vermont, Burlington, Vermont, USA
    Ann Surg Oncol 11:208S-10S. 2004
    ..A secondary aim of the B32 trial is to evaluate whether patients with "occult" metastases in the SNs have worse survival. Accrual is taking place at 73 institutions in North America, and 217 surgeons are enrolling patients...
  11. ncbi request reprint Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial
    David N Krag
    University of Vermont, College of Medicine, Burlington, VT 05405 0068, USA
    Lancet Oncol 8:881-8. 2007
    ..The aim of this paper is to report the technical success and accuracy of SLN resection plus ALND versus SLN resection alone...
  12. ncbi request reprint Selection of tumor-binding ligands in cancer patients with phage display libraries
    David N Krag
    Department of Surgery and Vermont Cancer Center, University of Vermont College of Medicine, E309 89 Beaumont Avenue, Burlington, VT 05405, USA
    Cancer Res 66:7724-33. 2006
    ..The lack of toxicity and the ability to recover clones with favorable characteristics are a first step for further research with this technology in cancer patients...
  13. ncbi request reprint Cyclin D-1, interleukin-6, HER-2/neu, transforming growth factor receptor-II and prediction of relapse in women with early stage, hormone receptor-positive breast cancer treated with tamoxifen
    Hyman B Muss
    Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont 05401, USA
    Breast J 13:337-45. 2007
    ..In this trial, HER-2 and CD1 proved of borderline significance as predictive factors for recurrence on tamoxifen. An SVM model that included all clinical and biologic variables correctly predicted relapse in >75% of patients...
  14. ncbi request reprint Pathologic findings from the Breast Cancer Surveillance Consortium: population-based outcomes in women undergoing biopsy after screening mammography
    Donald L Weaver
    Department of Pathology, University of Vermont, Burlington, 05405, USA
    Cancer 106:732-42. 2006
    ..To the authors' knowledge, a comprehensive analysis of pathology outcomes after screening mammography, as it is practiced clinically in the U.S. general population, has not been performed...
  15. ncbi request reprint Predicting biopsy outcome after mammography: what is the likelihood the patient has invasive or in situ breast cancer?
    Donald L Weaver
    Department of Pathology, University of Vermont College of Medicine and Vermont Cancer Center, Health Science Complex, 89 Beaumont Avenue, Burlington, Vermont 05405 0068, USA
    Ann Surg Oncol 12:660-73. 2005
    ..Although substantial effort has been devoted to estimating breast cancer risk, there have been no studies to predict outcome in women undergoing breast biopsy...
  16. ncbi request reprint Identification of a small peptide that inhibits the phosphorylation of ErbB2 and proliferation of ErbB2 overexpressing breast cancer cells
    Stephanie C Pero
    Department of Surgery, Vermont Comprehensive Cancer Center, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Int J Cancer 111:951-60. 2004
    ..Continuing research with this peptide includes increasing its affinity to ErbB2, evaluation of pharmacokinetics and evaluation of anti-proliferative effects with conjugate anti-cancer agents...
  17. ncbi request reprint Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology clinical practice guideline update
    Gary H Lyman
    Gary H Lyman, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA Sarah Temin, American Society of Clinical Oncology, Alexandria, VA Stephen B Edge, Baptist Cancer Center, Memphis, TN Lisa A Newman and James Hayman, University of Michigan, Ann Arbor, MI Roderick R Turner, John Wayne Cancer Institute, Santa Monica Linda D Bosserman, Wilshire Oncology Medical Group, Rancho Cucamonga Armando E Giuliano, Cedars Sinai Medical Center, Los Angeles, CA Donald L Weaver, University of Vermont College of Medicine and Vermont Cancer Center, Burlington, VT Al B Benson III, Northwestern University, Chicago, IL Harold J Burstein, Dana Farber Cancer Institute, Boston, MA Hiram Cody III, Memorial Sloan Kettering Cancer Center, New York, NY Cheryl L Perkins, Patient Representative, Dallas and Donald A Podoloff, University of Texas MD Anderson Cancer Center, Houston, TX
    J Clin Oncol 32:1365-83. 2014
    ....
  18. doi request reprint Nodal stage classification for breast carcinoma: improving interobserver reproducibility through standardized histologic criteria and image-based training
    Roderick R Turner
    Department of Pathology, Saint John s Health Center, 1328 Twenty Second St, Santa Monica, CA 90404, USA
    J Clin Oncol 26:258-63. 2008
    ..We sought to determine whether a set of clearly defined histologic criteria could lead to reproducible nodal classification by pathologists...
  19. ncbi request reprint Comparison of pathologist-detected and automated computer-assisted image analysis detected sentinel lymph node micrometastases in breast cancer
    Donald L Weaver
    University of Vermont, Vermont Cancer Center and Fletcher Allen Health Care, Burlington, Vermont 05405 0068, USA
    Mod Pathol 16:1159-63. 2003
    ..Metastases identified exclusively by computer-assisted cell detection tend to be extremely small, and the clinical significance of their identification is currently unknown...
  20. ncbi request reprint Pathological and molecular assessment of sentinel lymph nodes in solid tumors
    David N Krag
    Department of Surgery, Vermont Cancer Center, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Semin Oncol 29:274-9. 2002
    ..It is critical that pathologists and clinicians conduct definitive clinical research directed toward defining the role and impact that SN surgery has on each of these surgical goals...
  21. pmc Impact of mammography screening interval on breast cancer diagnosis by menopausal status and BMI
    Kim Dittus
    Departments of Hematology Oncology, University of Vermont, College of Medicine, Given E 214 89, Beaumont Ave, Burlington, VT, 05405, USA
    J Gen Intern Med 28:1454-62. 2013
    ..Controversy remains regarding the frequency of screening mammography. Women with different risks for developing breast cancer because of body mass index (BMI) may benefit from tailored recommendations...
  22. ncbi request reprint HER-2/neu detection in fine-needle aspirates of breast cancer: fluorescence in situ hybridization and immunocytochemical analysis
    Barbara G Beatty
    Department of Pathology, University of Vermont College of Medicine, Burlington 05405 0068, USA
    Am J Clin Pathol 122:246-55. 2004
    ....
  23. ncbi request reprint The effect of tissue fixation and processing on breast cancer size
    Bobbi Pritt
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Hum Pathol 36:756-60. 2005
    ..One can arguably measure the size of an invasive breast cancer from either the fresh or fixed state without affecting accuracy, but caution should be exercised in relying solely on the microscopic measurements...
  24. ncbi request reprint The detection of isolated tumor cells in bone marrow comparing bright-field immunocytochemistry and multicolor immunofluorescence
    David N Krag
    Department of Surgery, University of Vermont College of Medicine, Given Building, 89 Beaumont Avenue, Burlington, Vermont, 05405, USA
    Ann Surg Oncol 12:753-60. 2005
    ..However, this method can result in false-positive staining events. We used multicolor immunofluorescence (IF) to develop a more specific assay for detecting isolated tumor cells in marrow samples from breast cancer patients...
  25. ncbi request reprint Increased mammography use and its impact on earlier breast cancer detection in Vermont, 1975-1999
    Pamela M Vacek
    Department of Medical Biostatistics, University of Vermont, Burlington, Vermont 05405, USA
    Cancer 94:2160-8. 2002
    ..This study examined the effects of mammography on tumor size and axillary lymph node metastasis in Vermont over 25 years...
  26. ncbi request reprint Influence of breast cancer histology on the relationship between ultrasound and pathology tumor size measurements
    Bobbi Pritt
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Mod Pathol 17:905-10. 2004
    ..Pathologic tumor size can be estimated from the ultrasonographic measurement, particularly if the histologic tumor subtype is known. The results of this study underscore the continued benefit of pretreatment tumor histology...
  27. ncbi request reprint Pathological evaluation of sentinel lymph nodes in breast cancer: a practical academic perspective from America
    D L Weaver
    Department of Pathology, Health Sciences Complex, University of Vermont College of Medicine, Burlington 05405 0068, USA
    Histopathology 46:702-6. 2005
  28. ncbi request reprint Understanding diagnostic variability in breast pathology: lessons learned from an expert consensus review panel
    Kimberly H Allison
    Department of Pathology, University of Washington Medical Center, Seattle, WA, USA
    Histopathology 65:240-51. 2014
    ..To gain a better understanding of the reasons for diagnostic variability, with the aim of reducing the phenomenon...
  29. doi request reprint Carcinoma and atypical hyperplasia in reduction mammaplasty: increased sampling leads to increased detection. A prospective study
    Abiy B Ambaye
    Department of Pathology, Vermont Cancer Center, University of Vermont, Burlington, VT, USA
    Plast Reconstr Surg 124:1386-92. 2009
    ..Systematic sampling of additional tissue sections was instituted to evaluate the hypothesis that increased sampling would identify more significant pathologic findings...
  30. ncbi request reprint Phage-displayed random peptide libraries in mice: toxicity after serial panning
    David N Krag
    Department of Surgery, College of Medicine and the Vermont Comprehensive Cancer Center, Given Bldg Rm E309, Burlington, VT 05405, USA
    Cancer Chemother Pharmacol 50:325-32. 2002
    ..With the ultimate goal of developing similar methods for treating human cancer, we describe an in vivo RPL screening process that, unlike previous in vivo experiments, does not harm the animal being screened...
  31. ncbi request reprint Occult "micrometastases" in ductal carcinoma in situ: investigative implications for sentinel lymph node biopsy
    Donald L Weaver
    Cancer 98:2083-7. 2003
  32. ncbi request reprint American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer
    Gary H Lyman
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Clin Oncol 23:7703-20. 2005
    ..To develop a guideline for the use of sentinel node biopsy (SNB) in early stage breast cancer...
  33. ncbi request reprint Revision of the American Joint Committee on Cancer staging system for breast cancer
    S Eva Singletary
    University of Texas M D Anderson Cancer Center and Baylor College of Medicine, Houston, TX, USA
    J Clin Oncol 20:3628-36. 2002
    ..To revise the American Joint Committee on Cancer staging system for breast carcinoma...
  34. ncbi request reprint Detection of ductal carcinoma in situ in women undergoing screening mammography
    Virginia L Ernster
    Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, USA
    J Natl Cancer Inst 94:1546-54. 2002
    ..We pooled data from seven regional mammography registries to determine the percentage of mammographically detected cancers that are DCIS and the rate of DCIS per 1000 mammograms...
  35. ncbi request reprint Performance of diagnostic mammography for women with signs or symptoms of breast cancer
    William E Barlow
    W E Barlow, Center for Health Studies, Group Health Cooperative, Department of Biostatistics, University of Washington, Seattle 98101 1448, USA
    J Natl Cancer Inst 94:1151-9. 2002
    ..We evaluated whether age, breast density, self-reported breast lump, and previous mammography influence the performance of diagnostic mammography...
  36. ncbi request reprint The TNM staging system and breast cancer
    John R Benson
    Cambridge Breast Unit, Addenbrooke s Hospital, Cambridge, UK
    Lancet Oncol 4:56-60. 2003
  37. ncbi request reprint The frequency of ipsilateral second tumors after breast-conserving surgery for DCIS: a population based analysis
    Joan L Warren
    Health Services and Economics Branch Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892 7344, USA
    Cancer 104:1840-8. 2005
    ..This analysis of women treated with breast-conserving surgery (BCS) evaluated the impact of radiation therapy (RT) in patient outcomes...
  38. ncbi request reprint Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual
    S Eva Singletary
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 106, Houston, TX 77030 4009, USA
    Surg Clin North Am 83:803-19. 2003
    ..By increasing the number of prognostic markers that can give independent information about patient outcome, physicians will be better able to determine optimal treatment approaches for individual patients...
  39. ncbi request reprint Performance benchmarks for screening mammography
    Robert D Rosenberg
    Department of Radiology, University of New Mexico Health Sciences Center, MSC10 5530, USA
    Radiology 241:55-66. 2006
    ..S. radiologists to allow development of performance benchmarks for screening mammography...
  40. ncbi request reprint Prognostic characteristics of breast cancer among postmenopausal hormone users in a screened population
    Karla Kerlikowske
    San Francisco Veterans Affairs Medical Center, General Internal Medicine Section, 111A1, 4150 Clement St, San Francisco, CA 94121, USA
    J Clin Oncol 21:4314-21. 2003
    ..We determined the risk of breast cancer and tumor characteristics among current postmenopausal hormone therapy users compared with nonusers, by duration of use...
  41. ncbi request reprint Effect of breast augmentation on the accuracy of mammography and cancer characteristics
    Diana L Miglioretti
    Center for Health Studies, Group Health Cooperative, Department of Biostatistics, University of Washington, Seattle, Wash 98101, USA
    JAMA 291:442-50. 2004
    ..Breast augmentation is not associated with an increased risk of breast cancer; however, implants may interfere with the detection of breast cancer thereby delaying cancer diagnosis in women with augmentation...
  42. pmc Prerandomization Surgical Training for the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-32 trial: a randomized phase III clinical trial to compare sentinel node resection to conventional axillary dissection in clinically node-negative bre
    Seth P Harlow
    Department of Surgery, University of Vermont College of Medicine and the Vermont Cancer Center, Burlington 05405, USA
    Ann Surg 241:48-54. 2005
    ..To train surgeons in a standardized technique of sentinel lymph node biopsy and to prepare them for the requirements of a prospective randomized surgical trial...
  43. ncbi request reprint Is mode of breast cancer detection associated with cancer treatment in the United States?
    K Robin Yabroff
    Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7344, USA
    Cancer 112:1011-9. 2008
    ..In the current study, the authors explored whether detection by mammography was associated with greater use of guideline-consistent breast cancer treatment among patients with recently diagnosed breast cancer in the United States...
  44. ncbi request reprint Association between breast density and subsequent breast cancer following treatment for ductal carcinoma in situ
    E Shelley Hwang
    Department of Surgery, University of California, San Francisco Cancer Center, 1600 Divisadero Avenue, B606 San Francisco, CA 94115, USA
    Cancer Epidemiol Biomarkers Prev 16:2587-93. 2007
    ..We investigated whether breast density is an independent predictor of subsequent breast events among women treated for DCIS...
  45. ncbi request reprint Assessing the significance of occult micrometastases in axillary lymph nodes from breast cancer patients
    Donald L Weaver
    Breast J 12:291-3. 2006
  46. ncbi request reprint Factors associated with imaging and procedural events used to detect breast cancer after screening mammography
    Patricia A Carney
    Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    AJR Am J Roentgenol 188:385-92. 2007
    ..The purpose of this study was to characterize the type and frequency of diagnostic evaluations after screening mammography and to summarize their association with the likelihood of biopsy and subsequent breast cancer diagnosis...
  47. pmc Comparing screening mammography for early breast cancer detection in Vermont and Norway
    Solveig Hofvind
    Department of Screening based Research, The Cancer Registry of Norway, Oslo, Norway
    J Natl Cancer Inst 100:1082-91. 2008
    ..We examined how these differences affect early detection of breast cancer by comparing performance measures and histopathologic outcomes in women undergoing opportunistic screening in Vermont and organized screening in Norway...