R L Watts
Affiliation: University of Alabama at Birmingham
- The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD studyJeanne C Latourelle
Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
BMC Med 6:32. 2008..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
- Onset of dyskinesia with adjunct ropinirole prolonged-release or additional levodopa in early Parkinson's diseaseRay L Watts
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
Mov Disord 25:858-66. 2010..Ropinirole prolonged-release delayed the onset of dyskinesia with comparable efficacy to increased doses of levodopa in early PD patients not optimally controlled with levodopa...
- Randomized, blind, controlled trial of transdermal rotigotine in early Parkinson diseaseR L Watts
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35233 0017, USA
Neurology 68:272-6. 2007....
- Randomized, double-blind, placebo-controlled, short-term trial of ropinirole in restless legs syndromeD L Bliwise
Department of Neurology, Emory University Medical School, WMRB, Suite 6000, 1639 Pierce Drive, Atlanta, GA 30322, USA
Sleep Med 6:141-7. 2005..The purpose of this study was to test the clinical efficacy of ropinirole, a D2/D3 agonist, in the treatment of RLS in a double-blind, short-term, placebo-controlled clinical trial...
- Genome-wide scan for Parkinson's disease: the GenePD StudyA L DeStefano
Department of Neurology, Boston University Schools of Medicine and of Public Health, Boston, MA 02118, USA
Neurology 57:1124-6. 2001..The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others...
- Ophthalmologic features of Parkinson's diseaseV Biousse
Department of Ophthalmology, Emory University, Atlanta, USA
Neurology 62:177-80. 2004..These findings likely account for many of the visual difficulties commonly encountered by PD patients. These ocular abnormalities frequently respond to treatment...
- Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's diseaseJ M van der Walt
Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
Neurology 60:1189-91. 2003..The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals)...
- Occupation and parkinsonism in three movement disorders clinicsS M Goldman
The University of California, San Francisco, CA, USA
Neurology 65:1430-5. 2005..The aim of the present study was to investigate occupational associations with PD or parkinsonism drawing from three different movement disorders clinics...
- Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson diseaseE R Martin
Center for Human Genetics, Box 2903, Duke University Medical Center, Durham, NC 27710, USA
JAMA 286:2245-50. 2001..001) was detected between 4 of the 5 SNPs (SNPs 3, 9i, 9ii, and 11). CONCLUSIONS: This integrated approach of genetic linkage and positional association analyses implicates tau as a susceptibility gene for idiopathic PD...
- Complete genomic screen in Parkinson disease: evidence for multiple genesW K Scott
Center for Human Genetics, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
JAMA 286:2239-44. 2001..CONCLUSIONS: Our data suggest that the parkin gene is important in early-onset PD and that multiple genetic factors may be important in the development of idiopathic late-onset PD...