JYOTI WATTERS

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Chronic intermittent hypoxia exerts CNS region-specific effects on rat microglial inflammatory and TLR4 gene expression
    Stephanie M C Smith
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 8:e81584. 2013
  2. pmc Efficient isolation of live microglia with preserved phenotypes from adult mouse brain
    Maria Nikodemova
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Neuroinflammation 9:147. 2012
  3. pmc Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia
    Jessica M Crain
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Neuroinflammation 6:24. 2009
  4. ncbi request reprint Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor beta
    Ann E Baker
    Department of Comparative Biosciences, 2015 Linden Drive, Madison, Wisconsin 53706, USA
    Endocrinology 145:5021-32. 2004
  5. ncbi request reprint Purinergic receptor modulation of BV-2 microglial cell activity: potential involvement of p38 MAP kinase and CREB
    Vielska M Brautigam
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Neuroimmunol 166:113-25. 2005
  6. ncbi request reprint The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho
    Zachary A Pfeiffer
    Department of Biomecular Chemistry, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706 0450, USA
    J Leukoc Biol 75:1173-82. 2004
  7. ncbi request reprint Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-kappa B signaling pathways in murine RAW 264.7 macrophages
    Mini Aga
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706, USA
    Am J Physiol Cell Physiol 286:C923-30. 2004
  8. ncbi request reprint A differential role for the mitogen-activated protein kinases in lipopolysaccharide signaling: the MEK/ERK pathway is not essential for nitric oxide and interleukin 1beta production
    Jyoti J Watters
    Department of Biomolecular Chemistry and Program in Molecular and Cellular Pharmacology, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA
    J Biol Chem 277:9077-87. 2002
  9. doi request reprint Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxia
    Julia E R Wilkerson
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 28:2949-58. 2008
  10. ncbi request reprint Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII
    Maria Nikodemova
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:15208-16. 2007

Research Grants

  1. Microglia adenine nucleotides and hypoxia
    JYOTI WATTERS; Fiscal Year: 2005
  2. Microglia adenine nucleotides and hypoxia
    JYOTI WATTERS; Fiscal Year: 2006
  3. Microglia adenine nucleotides and hypoxia
    JYOTI WATTERS; Fiscal Year: 2007
  4. Microglia adenine nucleotides and hypoxia
    JYOTI WATTERS; Fiscal Year: 2009

Collaborators

Detail Information

Publications19

  1. pmc Chronic intermittent hypoxia exerts CNS region-specific effects on rat microglial inflammatory and TLR4 gene expression
    Stephanie M C Smith
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 8:e81584. 2013
    ..Together, these data indicate that microglial-specific neuroinflammation may play distinct roles in the effects of intermittent hypoxia in different CNS regions. ..
  2. pmc Efficient isolation of live microglia with preserved phenotypes from adult mouse brain
    Maria Nikodemova
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Neuroinflammation 9:147. 2012
    ..However, other cell types in the CNS can also synthesize inflammatory molecules. Hence, to enable direct analysis of microglial activities ex vivo, an efficient, reliable, and reproducible method of microglial isolation is needed...
  3. pmc Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia
    Jessica M Crain
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Neuroinflammation 6:24. 2009
    ..These data represent the first complete and systematic report of changes in purinergic receptor expression of microglia with age and sex, and provide important information necessary for accurate in vitro modeling of healthy animals...
  4. ncbi request reprint Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor beta
    Ann E Baker
    Department of Comparative Biosciences, 2015 Linden Drive, Madison, Wisconsin 53706, USA
    Endocrinology 145:5021-32. 2004
    ..In addition, we show that E(2) alters LPS-stimulated MAPK pathway activation, supporting the idea that alterations in the MAPKs may be a potential mechanism by which ERbeta mediates decreased microglial activation...
  5. ncbi request reprint Purinergic receptor modulation of BV-2 microglial cell activity: potential involvement of p38 MAP kinase and CREB
    Vielska M Brautigam
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Neuroimmunol 166:113-25. 2005
    ..Together, these data suggest that ATP may exert neuroprotective effects in the brain via a mechanism involving augmented activation of the p38/CREB pathway...
  6. ncbi request reprint The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho
    Zachary A Pfeiffer
    Department of Biomecular Chemistry, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706 0450, USA
    J Leukoc Biol 75:1173-82. 2004
    ..These data support a model wherein p38- and Rho-dependent pathways are critical for P2X7-dependent actin reorganization and membrane blebbing, thereby facilitating P2X7 involvement in macrophage inflammatory responses...
  7. ncbi request reprint Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-kappa B signaling pathways in murine RAW 264.7 macrophages
    Mini Aga
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706, USA
    Am J Physiol Cell Physiol 286:C923-30. 2004
    ....
  8. ncbi request reprint A differential role for the mitogen-activated protein kinases in lipopolysaccharide signaling: the MEK/ERK pathway is not essential for nitric oxide and interleukin 1beta production
    Jyoti J Watters
    Department of Biomolecular Chemistry and Program in Molecular and Cellular Pharmacology, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA
    J Biol Chem 277:9077-87. 2002
    ..These data support the idea that ERK activation is not a required function of LPS-mediated signaling events and illustrate that alternative/additional pathways for LPS action exist in these cell types...
  9. doi request reprint Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxia
    Julia E R Wilkerson
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 28:2949-58. 2008
    ..The specific okadaic acid-sensitive phosphatase(s) constraining pLTF and their spatiotemporal dynamics during and/or after IH and SH remain to be determined...
  10. ncbi request reprint Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII
    Maria Nikodemova
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:15208-16. 2007
    ..Such a fundamental mechanism may underlie the pleiotropic effects of minocycline in CNS inflammatory disorders...
  11. ncbi request reprint Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microglia
    Maria Nikodemova
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurochem 96:314-23. 2006
    ..In addition, minocycline attenuated lipopolysaccharide-stimulated degradation of IkappaBalpha implying a possible inhibitory role on NF-kappaB transcriptional activity...
  12. pmc Prolactin and estrogen enhance the activity of activating protein 1 in breast cancer cells: role of extracellularly regulated kinase 1/2-mediated signals to c-fos
    Jennifer H Gutzman
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Mol Endocrinol 19:1765-78. 2005
    ..The enhanced AP-1 activity resulting from the interaction of these hormones may increase expression of many target genes that are critical for oncogenesis and may contribute to neoplastic progression...
  13. pmc Multiple kinase cascades mediate prolactin signals to activating protein-1 in breast cancer cells
    Jennifer H Gutzman
    Molecular and Environmental Toxicology Program, University of Wisconsin, 2015 Linden Drive, Madison, Wisconsin 53706, USA
    Mol Endocrinol 18:3064-75. 2004
    ..These active AP-1 dimers may direct expression of multiple target genes, mediating some of PRL's actions in mammary disease...
  14. pmc Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation
    Scott A Friedle
    Program in Cellular and Molecular Biology and Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    Recent Pat CNS Drug Discov 5:35-45. 2010
    ....
  15. ncbi request reprint BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia
    Tracy L Baker-Herman
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Nat Neurosci 7:48-55. 2004
    ..These experiments also illustrate the potential use of RNAi to investigate functional consequences of gene expression in the mammalian nervous system in vivo...
  16. ncbi request reprint Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors
    David D Fuller
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA
    J Neurotrauma 22:203-13. 2005
    ..05). Our data are consistent with the hypothesis that spontaneous increase in 5-HT2A receptor expression on or near phrenic motoneurons contributes to strengthened crossed-spinal synaptic pathways to phrenic motoneurons following C2HS...
  17. ncbi request reprint Microglia function in brain tumors
    Jyoti J Watters
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53792 3232, USA
    J Neurosci Res 81:447-55. 2005
    ..A better understanding of microglia and macrophage function is essential for the development of immune-based treatment strategies against malignant brain tumors...
  18. doi request reprint Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation
    Francis J Golder
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 28:2033-42. 2008
    ....
  19. ncbi request reprint Purinergic receptors modulate MAP kinases and transcription factors that control microglial inflammatory gene expression
    Yvonne D Potucek
    Department of Comparative Biosciences and Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53706, United States
    Neurochem Int 49:204-14. 2006
    ..Together, these data indicate that ATP may be an endogenous inhibitor or neuroprotective molecule decreasing the inflammatory capacity of microglia...

Research Grants5

  1. Microglia adenine nucleotides and hypoxia
    JYOTI WATTERS; Fiscal Year: 2005
    ..Results of this work will aid in the identification of new pharmacologic targets that may be exploited therapeutically to control microglial activation in response to several stimuli including hypoxia. ..
  2. Microglia adenine nucleotides and hypoxia
    JYOTI WATTERS; Fiscal Year: 2006
    ..Results of this work will aid in the identification of new pharmacologic targets that may be exploited therapeutically to control microglial activation in response to several stimuli including hypoxia. ..
  3. Microglia adenine nucleotides and hypoxia
    JYOTI WATTERS; Fiscal Year: 2007
    ..Results of this work will aid in the identification of new pharmacologic targets that may be exploited therapeutically to control microglial activation in response to several stimuli including hypoxia. ..
  4. Microglia adenine nucleotides and hypoxia
    JYOTI WATTERS; Fiscal Year: 2009
    ..Results of this work will aid in the identification of new pharmacologic targets that may be exploited therapeutically to control microglial activation in response to several stimuli including hypoxia. ..