S J Watson

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Marijuana and medicine: assessing the science base: a summary of the 1999 Institute of Medicine report
    S J Watson
    Department of Psychiatry, Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA
    Arch Gen Psychiatry 57:547-52. 2000
  2. ncbi request reprint Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala
    H E Day
    Mental Health Research Institute and Psychology Department, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 21:732-40. 2001
  3. ncbi request reprint Environmental context modulates the ability of cocaine and amphetamine to induce c-fos mRNA expression in the neocortex, caudate nucleus, and nucleus accumbens
    J Uslaner
    Biopsychology Programs, Department of Psychology, University of Michigan, East Hall, 525 East University Street, Ann Arbor, MI 48019-1109, USA
    Brain Res 920:106-16. 2001
  4. pmc Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders
    M P Vawter
    Department of Psychiatry, University of California, Irvine, USA
    Mol Psychiatry 11:615, 663-79. 2006
  5. ncbi request reprint Expression of orphanin FQ and the opioid receptor-like (ORL1) receptor in the developing human and rat brain
    C R Neal
    Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, 48109-0720, Ann Arbor, MI, USA
    J Chem Neuroanat 22:219-49. 2001
  6. ncbi request reprint Temporal and anatomical distribution of nitric oxide synthase mRNA expression and nitric oxide production during central nervous system inflammation
    M O Lopez-Figueroa
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA
    Brain Res 852:239-46. 2000
  7. ncbi request reprint Maternal deprivation regulates serotonin 1A and 2A receptors in the infant rat
    D M Vazquez
    Endocrine Division, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Brain Res 855:76-82. 2000
  8. ncbi request reprint Connections of some auditory-responsive posterior thalamic nuclei putatively involved in activation of the hypothalamo-pituitary-adrenocortical axis in response to audiogenic stress in rats: an anterograde and retrograde tract tracing study combined with
    S Campeau
    Mental Health Research Institute, The University of Michigan, Ann Arbor 48109 0720, USA
    J Comp Neurol 423:474-91. 2000
  9. ncbi request reprint Direct evidence of nitric oxide presence within mitochondria
    M O Lopez-Figueroa
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720, USA
    Biochem Biophys Res Commun 272:129-33. 2000
  10. ncbi request reprint Expression of alpha(1b) adrenoceptor mRNA in corticotropin-releasing hormone-containing cells of the rat hypothalamus and its regulation by corticosterone
    H E Day
    Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 19:10098-106. 1999

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Marijuana and medicine: assessing the science base: a summary of the 1999 Institute of Medicine report
    S J Watson
    Department of Psychiatry, Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA
    Arch Gen Psychiatry 57:547-52. 2000
    ..Finally, the report evaluates the abuse potential, tolerance, withdrawal, and gateway risks of medical use of cannabinoid drugs...
  2. ncbi request reprint Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala
    H E Day
    Mental Health Research Institute and Psychology Department, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 21:732-40. 2001
    ..These data suggest that the context in which psychostimulants are given powerfully and differentially alters the response of limbic structures that have been functionally implicated in drug reinforcement and emotional behaviors...
  3. ncbi request reprint Environmental context modulates the ability of cocaine and amphetamine to induce c-fos mRNA expression in the neocortex, caudate nucleus, and nucleus accumbens
    J Uslaner
    Biopsychology Programs, Department of Psychology, University of Michigan, East Hall, 525 East University Street, Ann Arbor, MI 48019-1109, USA
    Brain Res 920:106-16. 2001
    ..The ability of environmental context to modulate psychostimulant drug-induced immediate early gene expression may be related to its ability to modulate forms of drug experience-dependent plasticity, such as behavioral sensitization...
  4. pmc Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders
    M P Vawter
    Department of Psychiatry, University of California, Irvine, USA
    Mol Psychiatry 11:615, 663-79. 2006
    ..Genes with the least sensitivity to agonal-pH could present a starting point for candidate gene search in neuropsychiatric disorders...
  5. ncbi request reprint Expression of orphanin FQ and the opioid receptor-like (ORL1) receptor in the developing human and rat brain
    C R Neal
    Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, 48109-0720, Ann Arbor, MI, USA
    J Chem Neuroanat 22:219-49. 2001
    ..The influence of early orphanin expression on maturation of stress and pain circuitry in the developing brain remains unknown...
  6. ncbi request reprint Temporal and anatomical distribution of nitric oxide synthase mRNA expression and nitric oxide production during central nervous system inflammation
    M O Lopez-Figueroa
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA
    Brain Res 852:239-46. 2000
    ..While the mRNA is degraded by 24 h post treatment, the enzyme remains active. We propose that the DAF-2/DA method can be used as a potential marker in the diagnosis of CNS inflammation...
  7. ncbi request reprint Maternal deprivation regulates serotonin 1A and 2A receptors in the infant rat
    D M Vazquez
    Endocrine Division, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Brain Res 855:76-82. 2000
    ..Because hippocampal 5-HT1A gene expressions are known to decrease in the adult animal after chronic glucocorticoid elevation, this data also suggests that other mechanisms, perhaps central, predominate during development...
  8. ncbi request reprint Connections of some auditory-responsive posterior thalamic nuclei putatively involved in activation of the hypothalamo-pituitary-adrenocortical axis in response to audiogenic stress in rats: an anterograde and retrograde tract tracing study combined with
    S Campeau
    Mental Health Research Institute, The University of Michigan, Ann Arbor 48109 0720, USA
    J Comp Neurol 423:474-91. 2000
    ....
  9. ncbi request reprint Direct evidence of nitric oxide presence within mitochondria
    M O Lopez-Figueroa
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720, USA
    Biochem Biophys Res Commun 272:129-33. 2000
    ..Our results provide a new tool to directly study the modulatory role of NO in mitochondrial respiration and membrane potential, in vivo...
  10. ncbi request reprint Expression of alpha(1b) adrenoceptor mRNA in corticotropin-releasing hormone-containing cells of the rat hypothalamus and its regulation by corticosterone
    H E Day
    Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 19:10098-106. 1999
    ..Because activation of the alpha(1B) adrenoceptor is predominantly excitatory within the brain, we predict that this receptor plays an important role in facilitation of the HPA axis response...
  11. ncbi request reprint Characterization of basal nitric oxide production in living cells
    M O Lopez-Figueroa
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA
    Biochim Biophys Acta 1540:253-64. 2001
    ..Conversely, increasing concentrations of a NO donor, or incident light, increased the fluorescence intensity. Our observation of NO production and distribution using the DAF-2 method has a direct impact on studies using these cell lines...
  12. ncbi request reprint Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons
    A Badiani
    Biopsychology, Department of Psychology, The University of Michigan, Ann Arbor 48109 1109, USA
    Behav Brain Res 103:203-9. 1999
    ..We conclude that the neural populations engaged by amphetamine vary as a function of the circumstances surrounding its administration...
  13. ncbi request reprint Impact of cocaine on adult hippocampal neurogenesis in an animal model of differential propensity to drug abuse
    M J García-Fuster
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA
    Eur J Neurosci 31:79-89. 2010
    ..This latter effect in bHRs could contribute to their enhanced degree of cocaine-induced psychomotor behavioral sensitization...
  14. ncbi request reprint [Use of the technology of the genetic chip to study of the nitric oxide synthase]
    A L López-Figueroa
    Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Rev Neurol 33:555-60. 2001
    ..The end of our century has been characterized by a quick scientific and technological growth. Among other, the brain, the human genome project and the computer science, they are some of the numerous fields that characterize this revolution...
  15. pmc Differential responses to morphine-induced analgesia in the tail-flick test
    M Cecchi
    Molecular and Behavioral Neuroscience Institute, The University of Michigan School of Medicine, Ann Arbor, MI 48109 0720, USA
    Behav Brain Res 194:146-51. 2008
    ..Such variability is dependent upon activation of mu opioid receptors, but does not correlate with mu opioid receptor expression in LC, vPAG or ventral medulla...
  16. pmc Female CREBalphadelta- deficient mice show earlier age-related cognitive deficits than males
    E K Hebda-Bauer
    Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Neuroscience 150:260-72. 2007
    ..Thus, a genetic predisposition to cognitive impairment may render females more vulnerable than males to such deficits with age...
  17. ncbi request reprint The 5-HT7 receptor: role in novel object discrimination and relation to novelty-seeking behavior
    S J Ballaz
    Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Neuroscience 149:192-202. 2007
    ..Scopolamine inhibited object discrimination in HR rats more efficiently than it did in LR rats. Taken together, these results suggest that 5-HT7 may mediate attentional and memory processes relevant to novelty-induced arousal...
  18. pmc Dysregulation of the fibroblast growth factor system in major depression
    S J Evans
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 101:15506-11. 2004
    ..We also make available the gene-expression profile of all of the other growth factors and growth factor receptors detected in these postmortem samples...
  19. pmc Forebrain glucocorticoid receptor overexpression increases environmental reactivity and produces a stress-induced spatial discrimination deficit
    E K Hebda-Bauer
    University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Neuroscience 169:645-53. 2010
    ..They implicate forebrain glucocorticoid receptor (GR) in fine-tuning interactions with the environment and the interplay of emotional salience, coping abilities, and cognitive function...
  20. ncbi request reprint Estrogen receptor beta in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone
    C Isgor
    Mental Health Research Institute, The University of Michigan School of Medicine, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Neuroscience 121:837-45. 2003
    ..These data suggest that ERbeta in the PVN may critically modulate the HPA axis response to stress and is, in turn, regulated by circulating CORT...
  21. pmc DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles
    S J Evans
    Pritzker Consortium for Severe Psychiatric Disorders, San Francisco, CA, USA
    Neurobiol Dis 14:240-50. 2003
    ....
  22. ncbi request reprint Orphanin FQ-induced hyperphagia is mediated by corticosterone and central glucocorticoid receptors
    J R Nicholson
    Mental Health Research Institute, University of Michigan School of Medicine, 205 Zina Pitcher Place, Ann Arbor 48109 0720, USA
    Neuroscience 115:637-43. 2002
    ....
  23. ncbi request reprint Stress during adolescence alters behavioral sensitization to amphetamine
    M Kabbaj
    Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Neuroscience 113:395-400. 2002
    ..We conclude that our chronic variable social stress protocol during adolescence inhibits behavioral sensitization to amphetamine during adulthood...
  24. ncbi request reprint Social defeat alters the acquisition of cocaine self-administration in rats: role of individual differences in cocaine-taking behavior
    M Kabbaj
    Mental Health Research Institute, The University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720, USA
    Psychopharmacology (Berl) 158:382-7. 2001
    ..CONCLUSION The unique patterns of responsiveness in the HR and LR animals suggest that social defeat plays a role of equalizer of individual differences in drug-taking behavior...
  25. ncbi request reprint Distinct neurochemical populations in the rat central nucleus of the amygdala and bed nucleus of the stria terminalis: evidence for their selective activation by interleukin-1beta
    H E Day
    Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Comp Neurol 413:113-28. 1999
    ....
  26. ncbi request reprint Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding
    C R Neal
    Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0720, USA
    J Comp Neurol 412:563-605. 1999
    ....
  27. ncbi request reprint Pattern of c-fos mRNA induction in rat brain by acute morphine
    H B Gutstein
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720, USA
    Can J Physiol Pharmacol 76:294-303. 1998
    ..These findings are considered in the context of the effects of opioids on neural circuitry as well as direct, receptor-mediated effects of morphine on neural cells...
  28. pmc Cloning and pharmacological characterization of a rat kappa opioid receptor
    F Meng
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109
    Proc Natl Acad Sci U S A 90:9954-8. 1993
    ..These observations indicate that we have cloned a cDNA encoding a rat kappa receptor of the kappa 1 subtype...
  29. ncbi request reprint Analysis of 5-HT6 and 5-HT7 receptor gene expression in rats showing differences in novelty-seeking behavior
    S J Ballaz
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Neuroscience 147:428-38. 2007
    ..Taken together, these results provide new insight into the potential contribution of 5-HT to novelty-seeking behavior and associated behaviors such as substance abuse...
  30. ncbi request reprint Moving from the orphanin FQ receptor to an opioid receptor using four point mutations
    F Meng
    Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 271:32016-20. 1996
    ..This suggests that the Orphanin FQ receptor has developed features that specifically exclude the opioids and that these features are distinct from those required for the high affinity binding of its own endogenous ligand...
  31. ncbi request reprint Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia
    J H Meador-Woodruff
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Arch Gen Psychiatry 54:1089-95. 1997
    ..We determined the expression of transcripts encoding the dopamine receptors in the brains of schizophrenic patients...
  32. ncbi request reprint Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Am J Psychiatry 155:207-13. 1998
    ..The present investigation tested the hypothesis that brain serotonin transporter function is altered in chronic users of ethanol and cocaine, which might be related to a common serotonin transporter promoter polymorphism...
  33. ncbi request reprint Creating a functional opioid alkaloid binding site in the orphanin FQ receptor through site-directed mutagenesis
    F Meng
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA
    Mol Pharmacol 53:772-7. 1998
    ..These findings may be helpful to medicinal chemists in designing ligands for the orphanin FQ receptor based on the structure of the opiate alkaloids...
  34. ncbi request reprint Regulation of 5-HT receptors and the hypothalamic-pituitary-adrenal axis. Implications for the neurobiology of suicide
    J F Lopez
    Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, USA
    Ann N Y Acad Sci 836:106-34. 1997
    ..These data may also provide a biological understanding of how stressful events may increase the risk for suicide in vulnerable individuals and may help us elucidate the neurobiological underpinnings of treatment resistance...
  35. ncbi request reprint Differential expression of c-fos mRNA within neurocircuits of male hamsters exposed to acute or chronic defeat
    S Kollack-Walker
    Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    J Neuroendocrinol 11:547-59. 1999
    ..In contrast, brain areas that maintain relatively high levels of c-fos mRNA following repeated defeat may reflect processes less likely to adapt such as defensive behaviour...
  36. ncbi request reprint Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat
    C R Neal
    Mental Health Research Institute, Department of Pediatrics, University of Michigan Medical Center, Ann Arbor 48109 0720, USA
    J Comp Neurol 406:503-47. 1999
    ....
  37. ncbi request reprint Brain dopamine transporter messenger RNA and binding sites in cocaine users: a postmortem study
    K Y Little
    Department of Psychiatry, University of Michigan, and Ann Arbor Veterans Affairs Medical Center, 48105, USA
    Arch Gen Psychiatry 55:793-9. 1998
    ..The present experiment tested the hypothesis in cocaine-using humans that synthesis of midbrain DAT messenger RNA increases parallel with increased striatal DAT binding sites...
  38. ncbi request reprint The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humans
    E A Young
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA
    J Clin Endocrinol Metab 83:3339-45. 1998
    ..These data suggest that MR appear to play a clear role in HPA axis regulation during the time of the circadian peak as well as the trough. Furthermore, MR blockade may affect the sensitivity of the adrenal to ACTH...
  39. ncbi request reprint The effect of stressor controllability on stress-induced neuropeptide mRNA expression within the paraventricular nucleus of the hypothalamus
    D L Helmreich
    University of Michigan, Ann Arbor, USA
    J Neuroendocrinol 11:121-8. 1999
    ..These results suggest that physical attributes of a stress, rather than psychological, may be the more important factors in determining the PVN mRNA response...
  40. pmc Primary structure and functional expression of a guinea pig kappa opioid (dynorphin) receptor
    G X Xie
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109
    Proc Natl Acad Sci U S A 91:3779-83. 1994
    ..Species differences in the pharmacology and mRNA distribution between the cloned guinea pig and rat kappa receptors may be worthy of further examination...
  41. ncbi request reprint Crucial role of c-Jun NH2-terminal kinase 1 (JNK1) in cold-restraint stress-induced gastric lesions in mice
    K Kasugai
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0682, USA
    Dig Dis Sci 52:1698-705. 2007
    ..JNK1 plays a key role in the development of cold-restraint stress-induced gastric lesions in mice through the activation of cholinergic, atropine sensitive pathways...
  42. ncbi request reprint Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study
    A Mansour
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720, USA
    J Neurochem 68:344-53. 1997
    ....
  43. ncbi request reprint Nucleotide sequence and tissue-specific expression of the rat melanin concentrating hormone gene
    R C Thompson
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720
    DNA Cell Biol 9:637-45. 1990
    ..We also characterize the central nervous system distribution of expression of the MCH gene by Northern blot analysis, demonstrating that the MCH mRNA is found predominantly if not exclusively within the hypothalamus...
  44. ncbi request reprint Cloning and characterization of a pharmacologically distinct A1 adenosine receptor from guinea pig brain
    F Meng
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109
    Brain Res Mol Brain Res 26:143-55. 1994
    ..Northern blotting for different guinea pig tissues and in situ hybridization for guinea pig brain sections reveal an abundant and broad distribution of mRNA of this A1 subtype receptor in the brain...
  45. ncbi request reprint Molecular cloning of a mineralocorticoid (type I) receptor complementary DNA from rat hippocampus
    P D Patel
    Mental Health Research Institute, University of Michigan Medical School, Ann Arbor 48109
    Mol Endocrinol 3:1877-85. 1989
    ..These data provide evidence to support the contention that a single gene gives rise to the MR in renal tissues and type I receptors in the brain...
  46. ncbi request reprint Cloning and expression of the A2a adenosine receptor from guinea pig brain
    F Meng
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109
    Neurochem Res 19:613-21. 1994
    ....
  47. ncbi request reprint Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132)
    X Y Lu
    University of Michigan School of Medicine, Mental Health Research Institute, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720, USA
    Neuroreport 12:1281-4. 2001
    ..These time course profiles indicate the complexity of the mechanisms involved in AGRP-induced feeding...
  48. ncbi request reprint Cloning and pharmacological characterization of a rat mu opioid receptor
    R C Thompson
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720
    Neuron 11:903-13. 1993
    ..Based upon these observations, we conclude that pRMuR-12 encodes a mu opioid receptor...
  49. ncbi request reprint The fibroblast growth factor family and mood disorders
    H Akil
    University of Michigan, Mental Health Research Institute, Ann Arbor 48109, USA
    Novartis Found Symp 289:94-6; discussion 97-100, 193-5. 2008
    ..This paper is focused on a group of growth factors, the fibroblast growth factor (FGF) family and their potential role in mood disorders...
  50. ncbi request reprint Differential expression of protein phosphatase 1 isoforms in mammalian brain
    E F da Cruz e Silva
    Rockefeller University, New York, New York 10021, USA
    J Neurosci 15:3375-89. 1995
    ..PP1 beta appeared to be relatively less abundant in the same cells, as judged both by "in situ" hybridization and by the apparent absence of PP1 beta clones from the striatal cDNA libraries used...
  51. ncbi request reprint Stress-induced changes in primate prefrontal profiles of gene expression
    A M Karssen
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305 5485, USA
    Mol Psychiatry 12:1089-102. 2007
    ....
  52. ncbi request reprint Environmental context and drug history modulate amphetamine-induced c-fos mRNA expression in the basal ganglia, central extended amygdala, and associated limbic forebrain
    M M Ostrander
    Biopsychology and Neuroscience Programs, Department of Psychology, The University of Michigan, 525 East University Avenue, Ann Arbor, MI 48109 1109, USA
    Neuroscience 120:551-71. 2003
    ....
  53. pmc Inter-individual differences in novelty-seeking behavior in rats predict differential responses to desipramine in the forced swim test
    A Jama
    St Elizabeths Hospital, 2700 M L King Ave SE, Barton Hall, 2nd Floor, Washington, DC 20032, USA
    Psychopharmacology (Berl) 198:333-40. 2008
    ..Antidepressant medications are effective only in a subpopulation of patients with depression, and some patients respond to certain drugs, but not others. The biological bases for these clinical observations remain unexplained...
  54. pmc Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
    P V Choudary
    Center for Neuroscience and Department of Psychiatry and Behavioral Sciences, University of California Davis, 1544 Newton Court, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 102:15653-8. 2005
    ..These findings point to previously undiscovered molecular underpinnings of the pathophysiology of major depression and offer potentially new pharmacological targets for treating depression...
  55. ncbi request reprint Relation between the hypothalamic-pituitary-thyroid (HPT) axis and the hypothalamic-pituitary-adrenal (HPA) axis during repeated stress
    Dana L Helmreich
    Department of Biology and Neuroscience Program, Middlebury College, Middlebury, VT, USA
    Neuroendocrinology 81:183-92. 2005
    ..These results suggest that repeated exposure to mild-electric foot-shock causes a decrease in peripheral thyroid hormone levels, and that components of the HPA axis and hypothalamic AGRP may be involved in stress regulation of the HPT...
  56. ncbi request reprint Estrogen receptor alpha and beta mRNA expressions by proliferating and differentiating cells in the adult rat dentate gyrus and subventricular zone
    C Isgor
    Department of Biomedical Science, Charles E Schmidt Biomedical Center, Florida Atlantic University, Boca Raton, FL 33431 0991, USA
    Neuroscience 134:847-56. 2005
    ....
  57. ncbi request reprint The search for the neurobiological basis of vulnerability to drug abuse: using microarrays to investigate the role of stress and individual differences
    M Kabbaj
    Department of Biomedical Sciences, College of Medicine, Florida State University, 520 Building 127, Tallahassee, FL 32306 4300, USA
    Neuropharmacology 47:111-22. 2004
    ..The power and limits of this approach, and its future directions, are discussed within this general framework...
  58. ncbi request reprint Molecular cloning of a novel melanocortin receptor
    I Gantz
    Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109 0386
    J Biol Chem 268:8246-50. 1993
    ..These findings may yield insight into the physiology of peptides derived from pro-opiomelanocortin post-translational processing...
  59. ncbi request reprint Amphetamine and cocaine induce different patterns of c-fos mRNA expression in the striatum and subthalamic nucleus depending on environmental context
    J Uslaner
    Biopsychology and Neuroscience Programs, Department of Psychology, The University of Michigan, East Hall, 525 E. University St, Ann Arbor, MI 48019-1109, USA
    Eur J Neurosci 13:1977-83. 2001
    ..This may be related to the ability of environmental novelty to facilitate psychostimulant drug-induced neuroplasticity...
  60. ncbi request reprint Physiological and anatomical circuitry between Agouti-related protein and leptin signaling
    B D Wilson
    Department of Pediatrics, and Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5428, USA
    Endocrinology 140:2387-97. 1999
    ..These results suggest that in the fed state, AGRP is normally suppressed by leptin, and that release of this suppression during fasting leads to increased ingestive behavior...
  61. ncbi request reprint Molecular analysis of the X11-mLin-2/CASK complex in brain
    J P Borg
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Neurosci 19:1307-16. 1999
    ..Together, our data demonstrate that the X11alpha-mLin-2 complex contacts many partners, creating a macrocomplex suitable for receptor targeting at the neuronal plasma membrane...
  62. pmc Primary structure and tissue distribution of the orphanin FQ precursor
    H P Nothacker
    Central Nervous System Research, Pharma Division, Hoffmann La Roche AG, Basel, Switzerland
    Proc Natl Acad Sci U S A 93:8677-82. 1996
    ..These data confirm that the OFQ system differs from the opioid system at the molecular level, although the OFQ and opioid precursors may have arisen from a common ancestral gene...
  63. ncbi request reprint Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis
    S Erb
    Centre for the Neurobiology of Stress, Department of Life Science and Psychology, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario M1C 1A4, Canada
    Neuroscience 123:1003-9. 2004
    ....
  64. ncbi request reprint Regulatory mechanisms of corticotropin-releasing hormone and vasopressin gene expression in the hypothalamus
    K Itoi
    Laboratory of Information Biology, Graduate School of Information Sciences, Tohoku University, Sendai, Japan
    J Neuroendocrinol 16:348-55. 2004
    ..Expression profiles of the CRH and vasopressin genes are not uniform after stress exposure, and the vasopressin gene appears to be more sensitive to glucocorticoid suppression...