J B Watson

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuroscience 159:501-13. 2009
  2. ncbi request reprint Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurosci Res 84:1564-74. 2006
  3. ncbi request reprint Age-related deficits in long-term potentiation are insensitive to hydrogen peroxide: coincidence with enhanced autophosphorylation of Ca2+/calmodulin-dependent protein kinase II
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California, USA
    J Neurosci Res 70:298-308. 2002
  4. ncbi request reprint Adenylyl cyclase activation modulates activity-dependent changes in synaptic strength and Ca2+/calmodulin-dependent kinase II autophosphorylation
    M Makhinson
    Interdepartmental Graduate Program for Neuroscience, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Neurosci 19:2500-10. 1999
  5. ncbi request reprint Functional studies of single-site variants in the calmodulin-binding domain of RC3/neurogranin in Xenopus oocytes
    J B Watson
    Mental Retardation Research Center, UCLA School of Medicine 90024 1759, USA
    Neurosci Lett 219:183-6. 1996
  6. ncbi request reprint Identification of cortexin: a novel, neuron-specific, 82-residue membrane protein enriched in rodent cerebral cortex
    P M Coulter
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles
    J Neurochem 61:756-9. 1993
  7. ncbi request reprint Identification of genes in the oligodendrocyte lineage through the analysis of conditionally immortalized cell lines
    C W Campagnoni
    Mental Retardation Research Center and Neuropsychiatric Institute, UCLA Medical School, Los Angeles, Calif. 90024-1759, USA
    Dev Neurosci 23:452-63. 2001
  8. ncbi request reprint G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine
    J Neurosci Res 39:108-16. 1994
  9. ncbi request reprint Adenylyl cyclase-dependent form of chemical long-term potentiation triggers translational regulation at the elongation step
    J K Chotiner
    Interdepartmental Graduate Program for Neuroscience, University of California Los Angeles School of Medicine, 90095, USA
    Neuroscience 116:743-52. 2003
  10. pmc Localization of the protein kinase C phosphorylation/calmodulin-binding substrate RC3 in dendritic spines of neostriatal neurons
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine 90024
    Proc Natl Acad Sci U S A 89:8581-5. 1992

Collaborators

Detail Information

Publications15

  1. pmc Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuroscience 159:501-13. 2009
    ..ASOTg mice may recapitulate an early stage in PD during which overexpressed alpha-synuclein dampens corticostriatal synaptic transmission and reduces movement...
  2. ncbi request reprint Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurosci Res 84:1564-74. 2006
    ..Overall, the results suggest that dynamic alterations in extracellular H(2)O(2) metabolism affect synaptic plasticity in the hippocampus during aging...
  3. ncbi request reprint Age-related deficits in long-term potentiation are insensitive to hydrogen peroxide: coincidence with enhanced autophosphorylation of Ca2+/calmodulin-dependent protein kinase II
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California, USA
    J Neurosci Res 70:298-308. 2002
    ....
  4. ncbi request reprint Adenylyl cyclase activation modulates activity-dependent changes in synaptic strength and Ca2+/calmodulin-dependent kinase II autophosphorylation
    M Makhinson
    Interdepartmental Graduate Program for Neuroscience, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Neurosci 19:2500-10. 1999
    ..Our results suggest that AC activation facilitates LTP induction by suppressing protein phosphatases and enabling a persistent increase in the levels of autophosphorylated CaMKII...
  5. ncbi request reprint Functional studies of single-site variants in the calmodulin-binding domain of RC3/neurogranin in Xenopus oocytes
    J B Watson
    Mental Retardation Research Center, UCLA School of Medicine 90024 1759, USA
    Neurosci Lett 219:183-6. 1996
    ....
  6. ncbi request reprint Identification of cortexin: a novel, neuron-specific, 82-residue membrane protein enriched in rodent cerebral cortex
    P M Coulter
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles
    J Neurochem 61:756-9. 1993
    ..The function of cortexin may be particularly important to neurons of both the developing and adult cerebral cortex...
  7. ncbi request reprint Identification of genes in the oligodendrocyte lineage through the analysis of conditionally immortalized cell lines
    C W Campagnoni
    Mental Retardation Research Center and Neuropsychiatric Institute, UCLA Medical School, Los Angeles, Calif. 90024-1759, USA
    Dev Neurosci 23:452-63. 2001
    ..In addition to these, beta(10) thymosin and mevalonate kinase clones were also isolated from the screen...
  8. ncbi request reprint G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine
    J Neurosci Res 39:108-16. 1994
    ....
  9. ncbi request reprint Adenylyl cyclase-dependent form of chemical long-term potentiation triggers translational regulation at the elongation step
    J K Chotiner
    Interdepartmental Graduate Program for Neuroscience, University of California Los Angeles School of Medicine, 90095, USA
    Neuroscience 116:743-52. 2003
    ..Taken together, the results suggest that regulation at the elongation step of protein synthesis contributes to persistent forms of long-term potentiation...
  10. pmc Localization of the protein kinase C phosphorylation/calmodulin-binding substrate RC3 in dendritic spines of neostriatal neurons
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine 90024
    Proc Natl Acad Sci U S A 89:8581-5. 1992
    ..We propose that RC3 acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling...
  11. ncbi request reprint Localization of RC3 (neurogranin) in rat brain subcellular fractions
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine 90024
    Brain Res Mol Brain Res 27:323-8. 1994
    ..Solubilization of synaptosomes suggests that RC3 may only be loosely associated with the PSD...
  12. ncbi request reprint Effects of repeated amphetamine treatment on the locomotor activity of the dopamine D1A-deficient mouse
    C A Crawford
    Mental Retardation Research Center, University of California, Los Angeles 90024, USA
    Neuroreport 8:2523-7. 1997
    ..PKA activity also varied depending on genotype, since amphetamine decreased PKA activity in control but not D1A-deficient mice...
  13. ncbi request reprint Chromosomal mapping of mouse genes expressed selectively within the central nervous system
    P E Danielson
    Scripps Research Institute, Department of Molecular Biology, La Jolla, California 92037
    Genomics 19:454-61. 1994
    ....
  14. ncbi request reprint Subtractive cDNA cloning of RC3, a rodent cortex-enriched mRNA encoding a novel 78 residue protein
    J B Watson
    Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California
    J Neurosci Res 26:397-408. 1990
    ....
  15. ncbi request reprint Mouse chromosomal localization of the cortexin (Ctxn) gene
    J B Watson
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles 90024
    Genomics 22:251-2. 1994