Christopher J Watson

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Sleep duration varies as a function of glutamate and GABA in rat pontine reticular formation
    Christopher J Watson
    Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109 5615, USA
    J Neurochem 118:571-80. 2011
  2. pmc Thermal nociception is decreased by hypocretin-1 and an adenosine A1 receptor agonist microinjected into the pontine reticular formation of Sprague Dawley rat
    Sarah L Watson
    Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109 5615, USA
    J Pain 11:535-44. 2010
  3. pmc Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness
    Holly N Brevig
    Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 5615, USA
    Sleep 33:1285-93. 2010
  4. pmc Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia
    Giancarlo Vanini
    Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Anesthesiology 109:978-88. 2008
  5. pmc Pontine reticular formation (PnO) administration of hypocretin-1 increases PnO GABA levels and wakefulness
    Christopher J Watson
    Department ofAnesthesiology, University ofMichigan, Ann Arbor, MI 48109 5615, USA
    Sleep 31:453-64. 2008
  6. ncbi request reprint In vivo neurochemical monitoring by microdialysis and capillary separations
    Robert T Kennedy
    Department of Chemistry and Pharmacology, 930 North University, University of Michigan, Ann Arbor 48109 1055, USA
    Curr Opin Chem Biol 6:659-65. 2002
  7. ncbi request reprint In vivo measurements of neurotransmitters by microdialysis sampling
    Christopher J Watson
    Department of Anesthesiology, University of Michigan, USA
    Anal Chem 78:1391-9. 2006
  8. ncbi request reprint Capillary liquid chromatography with MS3 for the determination of enkephalins in microdialysis samples from the striatum of anesthetized and freely-moving rats
    Holly M Baseski
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109 1055, USA
    J Mass Spectrom 40:146-53. 2005
  9. ncbi request reprint Aptamer affinity chromatography for rapid assay of adenosine in microdialysis samples collected in vivo
    Qing Deng
    Department of Chemistry, University of Michigan, 930 N University Ave, Ann Arbor, MI 48109 1055, USA
    J Chromatogr A 1005:123-30. 2003
  10. ncbi request reprint High-throughput automated post-processing of separation data
    Jonathan G Shackman
    Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109 1055, USA
    J Chromatogr A 1040:273-82. 2004

Collaborators

  • Robert T Kennedy
  • Giancarlo Vanini
  • Jonathan G Shackman
  • Helen A Baghdoyan
  • Sarah L Watson
  • Holly N Brevig
  • Ralph Lydic
  • Holly M Shackman
  • Nicholas A Cellar
  • Holly M Baseski
  • Qing Deng
  • Minshan Shou

Detail Information

Publications11

  1. pmc Sleep duration varies as a function of glutamate and GABA in rat pontine reticular formation
    Christopher J Watson
    Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109 5615, USA
    J Neurochem 118:571-80. 2011
    ..These data provide novel support for the hypothesis that endogenous glutamate and GABA in the PnO contribute to the regulation of sleep duration...
  2. pmc Thermal nociception is decreased by hypocretin-1 and an adenosine A1 receptor agonist microinjected into the pontine reticular formation of Sprague Dawley rat
    Sarah L Watson
    Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109 5615, USA
    J Pain 11:535-44. 2010
    ..These results suggest for the first time that hypocretin receptors in rat PnO modulate nociception...
  3. pmc Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness
    Holly N Brevig
    Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 5615, USA
    Sleep 33:1285-93. 2010
    ..Therefore, this study tested the hypothesis that the increase in wakefulness caused by administration of hypocretin-1 into the PnO occurs via activation of GABAA receptors and hypocretin receptors...
  4. pmc Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia
    Giancarlo Vanini
    Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Anesthesiology 109:978-88. 2008
    ....
  5. pmc Pontine reticular formation (PnO) administration of hypocretin-1 increases PnO GABA levels and wakefulness
    Christopher J Watson
    Department ofAnesthesiology, University ofMichigan, Ann Arbor, MI 48109 5615, USA
    Sleep 31:453-64. 2008
    ..This study also tested the hypothesis that wakefulness is either increased or decreased, respectively, by PnO administration of drugs known to selectively increase or decrease GABA levels...
  6. ncbi request reprint In vivo neurochemical monitoring by microdialysis and capillary separations
    Robert T Kennedy
    Department of Chemistry and Pharmacology, 930 North University, University of Michigan, Ann Arbor 48109 1055, USA
    Curr Opin Chem Biol 6:659-65. 2002
    ..These methods have improved temporal resolution, spatial resolution, multi-analyte capability and potential for compound discovery...
  7. ncbi request reprint In vivo measurements of neurotransmitters by microdialysis sampling
    Christopher J Watson
    Department of Anesthesiology, University of Michigan, USA
    Anal Chem 78:1391-9. 2006
    ..Analytical chemistry has an important role to play in developing our understanding of the brain by providing tools for identification and measurement of the many chemicals involved in neurotransmission...
  8. ncbi request reprint Capillary liquid chromatography with MS3 for the determination of enkephalins in microdialysis samples from the striatum of anesthetized and freely-moving rats
    Holly M Baseski
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109 1055, USA
    J Mass Spectrom 40:146-53. 2005
    ..The method was successfully used to monitor the peptides under basal conditions and with stimulation of peptide secretion by infusion of elevated K+ concentration...
  9. ncbi request reprint Aptamer affinity chromatography for rapid assay of adenosine in microdialysis samples collected in vivo
    Qing Deng
    Department of Chemistry, University of Michigan, 930 N University Ave, Ann Arbor, MI 48109 1055, USA
    J Chromatogr A 1005:123-30. 2003
    ..Total analysis times were short enough that dialysate samples could be injected every 5 min. Basal dialysate concentrations of adenosine stabilized at 87+/-10 nM (n=5) with the probe operated at 0.6 microl/min...
  10. ncbi request reprint High-throughput automated post-processing of separation data
    Jonathan G Shackman
    Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109 1055, USA
    J Chromatogr A 1040:273-82. 2004
    ..Area measurements of deconvoluted peaks were within 3% of the true value of a simulated data set with S/N = 5 and resolution (R(S)) = 1 for equivalent peaks, and within 10% when the ratio of the overlapped peak heights was 10:1...
  11. ncbi request reprint Microdialysis coupled on-line to capillary liquid chromatography with tandem mass spectrometry for monitoring acetylcholine in vivo
    Holly M Shackman
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 1055, USA
    J Neurosci Methods 159:86-92. 2007
    ..Absolute and percent basal levels of ACh from rats receiving different anesthetics were also compared...