CHERYL WATSON

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. doi request reprint Rapid actions of xenoestrogens disrupt normal estrogenic signaling
    Cheryl S Watson
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA Electronic address
    Steroids 81:36-42. 2014
  2. pmc Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT2A or 5-HT2C receptors
    Patricia K Seitz
    Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555, USA
    BMC Neurosci 13:25. 2012
  3. pmc Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I
    Cheryl S Watson
    Dept of Biochemistry and Molecular Biology, Univ of Texas Medical Branch, Galveston, TX 77555 0645, USA
    Steroids 77:424-32. 2012
  4. pmc Combinations of physiologic estrogens with xenoestrogens alter calcium and kinase responses, prolactin release, and membrane estrogen receptor trafficking in rat pituitary cells
    Yow Jiun Jeng
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    Environ Health 9:61. 2010
  5. pmc Membrane estrogen receptor-alpha levels in MCF-7 breast cancer cells predict cAMP and proliferation responses
    Dragoslava Zivadinovic
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas, USA
    Breast Cancer Res 7:R101-12. 2005
  6. pmc Membrane estrogen receptor-alpha levels predict estrogen-induced ERK1/2 activation in MCF-7 cells
    Dragoslava Zivadinovic
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas, USA
    Breast Cancer Res 7:R130-44. 2005
  7. pmc Nongenomic mechanisms of physiological estrogen-mediated dopamine efflux
    Rebecca A Alyea
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
    BMC Neurosci 10:59. 2009
  8. pmc Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspases
    Yow Jiun Jeng
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    BMC Cancer 9:334. 2009
  9. pmc Nongenomic signaling pathways of estrogen toxicity
    Cheryl S Watson
    Biochemistry and Molecular Biology Department, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    Toxicol Sci 115:1-11. 2010
  10. pmc Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells
    Yow Jiun Jeng
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    J Mol Signal 4:2. 2009

Detail Information

Publications38

  1. doi request reprint Rapid actions of xenoestrogens disrupt normal estrogenic signaling
    Cheryl S Watson
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA Electronic address
    Steroids 81:36-42. 2014
    ..Understanding the features of XEs that drive these disruptive mechanisms will allow us to redesign useful chemicals that exclude estrogenic or anti-estrogenic activities. ..
  2. pmc Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT2A or 5-HT2C receptors
    Patricia K Seitz
    Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555, USA
    BMC Neurosci 13:25. 2012
    ..Such profiles are needed to begin to understand the simultaneous contributions from the multiplicity of signaling cascades likely to be initiated by serotonergic ligands...
  3. pmc Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I
    Cheryl S Watson
    Dept of Biochemistry and Molecular Biology, Univ of Texas Medical Branch, Galveston, TX 77555 0645, USA
    Steroids 77:424-32. 2012
    ....
  4. pmc Combinations of physiologic estrogens with xenoestrogens alter calcium and kinase responses, prolactin release, and membrane estrogen receptor trafficking in rat pituitary cells
    Yow Jiun Jeng
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    Environ Health 9:61. 2010
    ..Therefore, we used quantitative medium-throughput screening assays to measure the effects of physiologic estrogens in combination with these xenoestrogens...
  5. pmc Membrane estrogen receptor-alpha levels in MCF-7 breast cancer cells predict cAMP and proliferation responses
    Dragoslava Zivadinovic
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas, USA
    Breast Cancer Res 7:R101-12. 2005
    ....
  6. pmc Membrane estrogen receptor-alpha levels predict estrogen-induced ERK1/2 activation in MCF-7 cells
    Dragoslava Zivadinovic
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas, USA
    Breast Cancer Res 7:R130-44. 2005
    ....
  7. pmc Nongenomic mechanisms of physiological estrogen-mediated dopamine efflux
    Rebecca A Alyea
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
    BMC Neurosci 10:59. 2009
    ..Neurological diseases and neuropsychiatric disorders that vary depending on female life stages suggest that sex hormones may influence the function of neurotransmitter regulatory machinery such as the dopamine transporter (DAT)...
  8. pmc Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspases
    Yow Jiun Jeng
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    BMC Cancer 9:334. 2009
    ..We examined the proliferative effects of phytoestrogens on a rat pituitary tumor cell line, GH3/B6/F10, originally subcloned from GH3 cells based on its ability to express high levels of the membrane estrogen receptor-alpha...
  9. pmc Nongenomic signaling pathways of estrogen toxicity
    Cheryl S Watson
    Biochemistry and Molecular Biology Department, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    Toxicol Sci 115:1-11. 2010
    ....
  10. pmc Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells
    Yow Jiun Jeng
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    J Mol Signal 4:2. 2009
    ..Phytoestrogens bind to nuclear ERs with a much lower affinity and therefore are less potent in mediating genomic responses. However, little is known about their ability to act via mERs to mediate nongenomic effects...
  11. pmc Nongenomic actions of low concentration estrogens and xenoestrogens on multiple tissues
    C S Watson
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
    Mol Cell Endocrinol 274:1-7. 2007
    ....
  12. pmc Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 rats
    Yow Jiun Jeng
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    Nutr Metab (Lond) 7:40. 2010
    ..However, it is unknown if they might themselves establish or exacerbate the growth of estrogen-responsive cancers, such as in pituitary...
  13. pmc Endocrine disruption via estrogen receptors that participate in nongenomic signaling pathways
    Cheryl S Watson
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
    J Steroid Biochem Mol Biol 127:44-50. 2011
    ..Nongenomic actions of xenoestrogens in combination with each other, and with physiologic estrogens, are still largely unexplored from these mechanistic perspectives...
  14. pmc Xenoestrogens are potent activators of nongenomic estrogenic responses
    Cheryl S Watson
    Biochemistry and Molecular Biology Department, University of Texas Medical Branch, Galveston, TX 77555 0645, United States
    Steroids 72:124-34. 2007
    ....
  15. ncbi request reprint Signaling from the membrane via membrane estrogen receptor-alpha: estrogens, xenoestrogens, and phytoestrogens
    Cheryl S Watson
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
    Steroids 70:364-71. 2005
    ..Clearly individual xenoestrogens must be individually investigated for their differing abilities to activate distinct membrane-initiated signal cascades that lead to a variety of cellular functions...
  16. ncbi request reprint Membrane-initiated steroid actions and the proteins that mediate them
    C S Watson
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    Proc Soc Exp Biol Med 220:9-19. 1999
    ..The integration of membrane-initiated effects with genomic mechanisms results in the complete cellular response to steroids...
  17. pmc Membrane oestrogen receptors on rat pituitary tumour cells: immuno-identification and responses to oestradiol and xenoestrogens
    C S Watson
    Human Biological Chemistry and Genetics Department, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
    Exp Physiol 84:1013-22. 1999
    ..Xenoestrogens, which have so far shown weak effects in genomic assay systems, should now be retested for activity in eliciting membrane-initiated oestrogenic responses...
  18. pmc Steadying the boat: integrating mechanisms of membrane and nuclear-steroid-receptor signalling
    Cheryl S Watson
    Human Biological Chemistry and Genetics Department and Center for Interdisciplinary Research in Women s Health, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    EMBO Rep 6:116-9. 2005
  19. ncbi request reprint Membrane estrogen and glucocorticoid receptors--implications for hormonal control of immune function and autoimmunity
    C S Watson
    Human Biological Chemistry and Genetics Department, University of Texas Medical Branch, Route 0645, Galveston, TX 77555 0645, USA
    Int Immunopharmacol 1:1049-63. 2001
    ..Therefore, the study of these forms of steroid receptors may present novel therapeutic opportunities for the use of steroids and steroid analogs...
  20. ncbi request reprint The dynamic and elusive membrane estrogen receptor-alpha
    Cheryl S Watson
    Human Biological Chemistry and Genetics Department, University of Texas Medical Branch, Galveston, TX 77555, USA
    Steroids 67:429-37. 2002
    ..These regulatory phenomena demonstrate that levels of the membrane form of the estrogen receptor are very dynamic...
  21. pmc Proteins of multiple classes may participate in nongenomic steroid actions
    Cheryl S Watson
    Department of Human Biological Chemistry and Genetics, University of Texas, Medical Branch, Galveston, Texas 77555, USA
    Exp Biol Med (Maywood) 228:1272-81. 2003
    ..Resolving such unanswered questions will require future investigative focus on this alternative arm of steroid action, which is likely to yield as many therapeutic opportunities as have nuclear steroid mechanisms...
  22. pmc Quantitative measurement of estrogen-induced ERK 1 and 2 activation via multiple membrane-initiated signaling pathways
    Nataliya N Bulayeva
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA
    Steroids 69:181-92. 2004
    ..Therefore, E2 and other estrogenic compounds can produce rapid ERK phosphorylations via nongenomic pathways, using more than one pathway for signal generation...
  23. pmc Regulation of the membrane estrogen receptor-alpha: role of cell density, serum, cell passage number, and estradiol
    Celeste H Campbell
    Human Biological Chemistry and Genetics Department, University of Texas, Medical Branch, Galveston Texas 77555 0645, USA
    FASEB J 16:1917-27. 2002
    ..That common culturing conditions favor down-regulation of mERalpha may explain the relatively few reports of this protein in other experimental systems...
  24. ncbi request reprint Mechanisms of membrane estrogen receptor-alpha-mediated rapid stimulation of Ca2+ levels and prolactin release in a pituitary cell line
    Nataliya N Bulayeva
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0645, USA
    Am J Physiol Endocrinol Metab 288:E388-97. 2005
    ..Thus rapid exocytosis of PRL is regulated in these cells by mERalpha signaling to specific Ca(2+) channels utilizing extracellular Ca(2+) sources and additional signaling mechanisms...
  25. pmc Alkylphenol xenoestrogens with varying carbon chain lengths differentially and potently activate signaling and functional responses in GH3/B6/F10 somatomammotropes
    Mikhail Y Kochukov
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    Environ Health Perspect 117:723-30. 2009
    ..Their rapid nongenomic effects that depend on structure for cell signaling and resulting functions are unknown...
  26. pmc Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells
    Ann L Wozniak
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    Environ Health Perspect 113:431-9. 2005
    ....
  27. pmc Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways
    Nataliya N Bulayeva
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    Environ Health Perspect 112:1481-7. 2004
    ..However, inhibitors differentially affected each xenoestrogen response examined. These actions may help to explain the distinct abilities of xenoestrogens to disrupt reproductive functions at low concentrations...
  28. pmc Nongenomic actions of estradiol compared with estrone and estriol in pituitary tumor cell signaling and proliferation
    Cheryl S Watson
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
    FASEB J 22:3328-36. 2008
    ..Therefore, the hormones E(1) and E(3), which have been designated "weak" estrogens in genomic actions, are strong estrogens in the nongenomic signaling pathways and functional responses in the pituitary...
  29. ncbi request reprint Intracellular signaling involved in estrogen regulation of serotonin reuptake
    Nina Koldzic-Zivanovic
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1031, USA
    Mol Cell Endocrinol 226:33-42. 2004
    ..In summary, changes in intracellular Ca2+ levels caused by E2 and mediated through ERbeta may be responsible for observed rapid effects of E2 on SERT activity...
  30. pmc The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells
    Rebecca A Alyea
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    J Neurochem 106:1525-33. 2008
    ..Therefore, ERalpha is largely responsible for non-genomic estrogenic effects on DAT activity...
  31. pmc Differential regulation of dopamine transporter function and location by low concentrations of environmental estrogens and 17beta-estradiol
    Rebecca A Alyea
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    Environ Health Perspect 117:778-83. 2009
    ....
  32. pmc Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators
    Shin ichiro Narita
    Department of Pediatrics, Child Health Research Center, University of Texas Medical Branch, Galveston, Texas 77555 0366, USA
    Environ Health Perspect 115:48-52. 2007
    ..These pollutants tend to degrade slowly in the environment and to bioaccumulate and bioconcentrate in the food chain; they also have long biological half-lives...
  33. pmc Cell cycle regulation, neurogenesis, and depression
    Kathryn A Cunningham
    Departments of Pharmacology and Toxicology and Biochemistry and Molecular Biology, Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555 1031, USA
    Proc Natl Acad Sci U S A 105:2259-60. 2008
  34. pmc Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx
    Masafumi Zaitsu
    Department of Pediatrics, Child Health Research Center, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0366, USA
    Mol Immunol 44:1977-85. 2007
    ..A relationship between female hormones and asthma prevalence and severity has been suggested, but the cellular and molecular mechanisms are not understood...
  35. pmc Maternal bisphenol a exposure promotes the development of experimental asthma in mouse pups
    Terumi Midoro-Horiuti
    Department of Pediatrics, Child Health Research Center, University of Texas Medical Branch, Galveston, TX 77555 0366, USA
    Environ Health Perspect 118:273-7. 2010
    ..We recently reported that various environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators in vitro...
  36. ncbi request reprint Correlation of membrane glucocorticoid receptor levels with glucocorticoid-induced apoptotic competence using mutant leukemic and lymphoma cells lines
    Bahiru Gametchu
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Cell Biochem 87:133-46. 2002
    ..These results suggest a better correlation between the quantity and quality of mGRs (rather than total cellular GRs) and the ability of glucocorticoids (GCs) to lyse lymphoid cells...
  37. ncbi request reprint In vitro molecular mechanisms of bisphenol A action
    Yelena B Wetherill
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Reprod Toxicol 24:178-98. 2007
    ....
  38. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007

Research Grants9

  1. Environmental Estrogens Acting via a Membrane Receptor
    CHERYL WATSON; Fiscal Year: 2004
    ..abstract_text> ..
  2. Nongenomic Signaling Mechanisms of Environmental Estrogens
    CHERYL WATSON; Fiscal Year: 2009
    ..breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..
  3. Nongenomic Signaling Mechanisms of Environmental Estrogens
    CHERYL WATSON; Fiscal Year: 2007
    ..The extent and mechanisms by which environmental estrogens contribute to diseases of estrogen overexposure (eg. breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..
  4. Nongenomic Signaling Mechanisms of Environmental Estrogens
    Cheryl S Watson; Fiscal Year: 2011
    ..breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..