Research Topics
| CHERYL WATSONSummaryAffiliation: University of Texas Medical Branch Country: USA Publications
Research Grants
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Detail Information
Publications
Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT2A or 5-HT2C receptorsPatricia K Seitz
Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555, USA
BMC Neurosci 13:25. 2012..Such profiles are needed to begin to understand the simultaneous contributions from the multiplicity of signaling cascades likely to be initiated by serotonergic ligands...- Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin ICheryl S Watson
Dept of Biochemistry and Molecular Biology, Univ of Texas Medical Branch, Galveston, TX 77555 0645, USA
Steroids 77:424-32. 2012.... - Combinations of physiologic estrogens with xenoestrogens alter calcium and kinase responses, prolactin release, and membrane estrogen receptor trafficking in rat pituitary cellsYow Jiun Jeng
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
Environ Health 9:61. 2010..Therefore, we used quantitative medium-throughput screening assays to measure the effects of physiologic estrogens in combination with these xenoestrogens... - Membrane estrogen receptor-alpha levels in MCF-7 breast cancer cells predict cAMP and proliferation responsesDragoslava Zivadinovic
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas, USA
Breast Cancer Res 7:R101-12. 2005.... - Membrane estrogen receptor-alpha levels predict estrogen-induced ERK1/2 activation in MCF-7 cellsDragoslava Zivadinovic
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas, USA
Breast Cancer Res 7:R130-44. 2005.... - Nongenomic mechanisms of physiological estrogen-mediated dopamine effluxRebecca A Alyea
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
BMC Neurosci 10:59. 2009..Neurological diseases and neuropsychiatric disorders that vary depending on female life stages suggest that sex hormones may influence the function of neurotransmitter regulatory machinery such as the dopamine transporter (DAT)... - Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspasesYow Jiun Jeng
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
BMC Cancer 9:334. 2009..We examined the proliferative effects of phytoestrogens on a rat pituitary tumor cell line, GH3/B6/F10, originally subcloned from GH3 cells based on its ability to express high levels of the membrane estrogen receptor-alpha... - Nongenomic signaling pathways of estrogen toxicityCheryl S Watson
Biochemistry and Molecular Biology Department, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
Toxicol Sci 115:1-11. 2010.... - Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cellsYow Jiun Jeng
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
J Mol Signal 4:2. 2009..Phytoestrogens bind to nuclear ERs with a much lower affinity and therefore are less potent in mediating genomic responses. However, little is known about their ability to act via mERs to mediate nongenomic effects... - Nongenomic actions of low concentration estrogens and xenoestrogens on multiple tissuesC S Watson
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
Mol Cell Endocrinol 274:1-7. 2007.... 
Membrane-initiated steroid actions and the proteins that mediate themC S Watson
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
Proc Soc Exp Biol Med 220:9-19. 1999..The integration of membrane-initiated effects with genomic mechanisms results in the complete cellular response to steroids...- Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 ratsYow Jiun Jeng
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
Nutr Metab (Lond) 7:40. 2010..However, it is unknown if they might themselves establish or exacerbate the growth of estrogen-responsive cancers, such as in pituitary... - Endocrine disruption via estrogen receptors that participate in nongenomic signaling pathwaysCheryl S Watson
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
J Steroid Biochem Mol Biol 127:44-50. 2011..Nongenomic actions of xenoestrogens in combination with each other, and with physiologic estrogens, are still largely unexplored from these mechanistic perspectives... - Xenoestrogens are potent activators of nongenomic estrogenic responsesCheryl S Watson
Biochemistry and Molecular Biology Department, University of Texas Medical Branch, Galveston, TX 77555 0645, United States
Steroids 72:124-34. 2007.... - Signaling from the membrane via membrane estrogen receptor-alpha: estrogens, xenoestrogens, and phytoestrogensCheryl S Watson
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
Steroids 70:364-71. 2005..Clearly individual xenoestrogens must be individually investigated for their differing abilities to activate distinct membrane-initiated signal cascades that lead to a variety of cellular functions... - The dynamic and elusive membrane estrogen receptor-alphaCheryl S Watson
Human Biological Chemistry and Genetics Department, University of Texas Medical Branch, Galveston, TX 77555, USA
Steroids 67:429-37. 2002..These regulatory phenomena demonstrate that levels of the membrane form of the estrogen receptor are very dynamic... - Membrane oestrogen receptors on rat pituitary tumour cells: immuno-identification and responses to oestradiol and xenoestrogensC S Watson
Human Biological Chemistry and Genetics Department, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
Exp Physiol 84:1013-22. 1999..Xenoestrogens, which have so far shown weak effects in genomic assay systems, should now be retested for activity in eliciting membrane-initiated oestrogenic responses... - Steadying the boat: integrating mechanisms of membrane and nuclear-steroid-receptor signallingCheryl S Watson
Human Biological Chemistry and Genetics Department and Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch, Galveston, Texas 77555-0645, USA
EMBO Rep 6:116-9. 2005 - Membrane estrogen and glucocorticoid receptors--implications for hormonal control of immune function and autoimmunityC S Watson
Human Biological Chemistry and Genetics Department, University of Texas Medical Branch, Route 0645, Galveston, TX 77555 0645, USA
Int Immunopharmacol 1:1049-63. 2001..Therefore, the study of these forms of steroid receptors may present novel therapeutic opportunities for the use of steroids and steroid analogs... - Proteins of multiple classes may participate in nongenomic steroid actionsCheryl S Watson
Department of Human Biological Chemistry and Genetics, University of Texas, Medical Branch, Galveston, Texas 77555, USA
Exp Biol Med (Maywood) 228:1272-81. 2003..Resolving such unanswered questions will require future investigative focus on this alternative arm of steroid action, which is likely to yield as many therapeutic opportunities as have nuclear steroid mechanisms... - Mechanisms of membrane estrogen receptor-alpha-mediated rapid stimulation of Ca2+ levels and prolactin release in a pituitary cell lineNataliya N Bulayeva
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0645, USA
Am J Physiol Endocrinol Metab 288:E388-97. 2005..Thus rapid exocytosis of PRL is regulated in these cells by mERalpha signaling to specific Ca(2+) channels utilizing extracellular Ca(2+) sources and additional signaling mechanisms... - Quantitative measurement of estrogen-induced ERK 1 and 2 activation via multiple membrane-initiated signaling pathwaysNataliya N Bulayeva
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA
Steroids 69:181-92. 2004..Therefore, E2 and other estrogenic compounds can produce rapid ERK phosphorylations via nongenomic pathways, using more than one pathway for signal generation... - Regulation of the membrane estrogen receptor-alpha: role of cell density, serum, cell passage number, and estradiolCeleste H Campbell
Human Biological Chemistry and Genetics Department, University of Texas, Medical Branch, Galveston Texas 77555-0645, USA
FASEB J 16:1917-27. 2002..That common culturing conditions favor down-regulation of mERalpha may explain the relatively few reports of this protein in other experimental systems... - Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cellsAnn L Wozniak
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-0645, USA
Environ Health Perspect 113:431-9. 2005.... - Alkylphenol xenoestrogens with varying carbon chain lengths differentially and potently activate signaling and functional responses in GH3/B6/F10 somatomammotropesMikhail Y Kochukov
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
Environ Health Perspect 117:723-30. 2009..Their rapid nongenomic effects that depend on structure for cell signaling and resulting functions are unknown... - Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathwaysNataliya N Bulayeva
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-0645, USA
Environ Health Perspect 112:1481-7. 2004..However, inhibitors differentially affected each xenoestrogen response examined. These actions may help to explain the distinct abilities of xenoestrogens to disrupt reproductive functions at low concentrations... - Nongenomic actions of estradiol compared with estrone and estriol in pituitary tumor cell signaling and proliferationCheryl S Watson
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
FASEB J 22:3328-36. 2008..Therefore, the hormones E(1) and E(3), which have been designated "weak" estrogens in genomic actions, are strong estrogens in the nongenomic signaling pathways and functional responses in the pituitary... - Intracellular signaling involved in estrogen regulation of serotonin reuptakeNina Koldzic-Zivanovic
Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-1031, USA
Mol Cell Endocrinol 226:33-42. 2004..In summary, changes in intracellular Ca2+ levels caused by E2 and mediated through ERbeta may be responsible for observed rapid effects of E2 on SERT activity... - The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cellsRebecca A Alyea
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
J Neurochem 106:1525-33. 2008..Therefore, ERalpha is largely responsible for non-genomic estrogenic effects on DAT activity... - Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediatorsShin ichiro Narita
Department of Pediatrics, Child Health Research Center, University of Texas Medical Branch, Galveston, Texas 77555 0366, USA
Environ Health Perspect 115:48-52. 2007..These pollutants tend to degrade slowly in the environment and to bioaccumulate and bioconcentrate in the food chain; they also have long biological half-lives... - Differential regulation of dopamine transporter function and location by low concentrations of environmental estrogens and 17beta-estradiolRebecca A Alyea
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
Environ Health Perspect 117:778-83. 2009.... - Cell cycle regulation, neurogenesis, and depressionKathryn A Cunningham
Departments of Pharmacology and Toxicology and Biochemistry and Molecular Biology, Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555-1031, USA
Proc Natl Acad Sci U S A 105:2259-60. 2008 - Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influxMasafumi Zaitsu
Department of Pediatrics, Child Health Research Center, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0366, USA
Mol Immunol 44:1977-85. 2007..A relationship between female hormones and asthma prevalence and severity has been suggested, but the cellular and molecular mechanisms are not understood... - Maternal bisphenol a exposure promotes the development of experimental asthma in mouse pupsTerumi Midoro-Horiuti
Department of Pediatrics, Child Health Research Center, University of Texas Medical Branch, Galveston, TX 77555 0366, USA
Environ Health Perspect 118:273-7. 2010..We recently reported that various environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators in vitro... - Correlation of membrane glucocorticoid receptor levels with glucocorticoid-induced apoptotic competence using mutant leukemic and lymphoma cells linesBahiru Gametchu
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Cell Biochem 87:133-46. 2002..These results suggest a better correlation between the quantity and quality of mGRs (rather than total cellular GRs) and the ability of glucocorticoids (GCs) to lyse lymphoid cells... - Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposureFrederick S vom Saal
Reprod Toxicol 24:131-8. 2007 - In vitro molecular mechanisms of bisphenol A actionYelena B Wetherill
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Reprod Toxicol 24:178-98. 2007....
Research Grants
- Environmental Estrogens Acting via a Membrane ReceptorCHERYL WATSON; Fiscal Year: 2004..abstract_text> ..
- Nongenomic Signaling Mechanisms of Environmental EstrogensCHERYL WATSON; Fiscal Year: 2007..The extent and mechanisms by which environmental estrogens contribute to diseases of estrogen overexposure (eg. breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..
- Nongenomic Signaling Mechanisms of Environmental EstrogensCHERYL WATSON; Fiscal Year: 2009..breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..
- Nongenomic Signaling Mechanisms of Environmental EstrogensCheryl S Watson; Fiscal Year: 2011..breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..