Research Topics
Species | W S WatkinsSummaryAffiliation: University of Utah Country: USA Publications
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Publications
Genetic variation in South Indian castes: evidence from Y-chromosome, mitochondrial, and autosomal polymorphismsW S Watkins
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
BMC Genet 9:86. 2008..An understanding of these influences is increasingly important as gene mapping and case-control studies are initiated in South Indian populations...
Diversity and divergence among the tribal populations of IndiaW S Watkins
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Ann Hum Genet 69:680-92. 2005....- The distribution of human genetic diversity: a comparison of mitochondrial, autosomal, and Y-chromosome dataL B Jorde
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, UT, 84112, USA
Am J Hum Genet 66:979-88. 2000..These results are reassuring in their consistency and offer broad support for an African origin of modern human populations... - Multiple origins of the mtDNA 9-bp deletion in populations of South IndiaW S Watkins
Department of Human Genetics, University of Utah, Salt Lake City 84112 0533, USA
Am J Phys Anthropol 109:147-58. 1999..These results demonstrate varying genetic affinities of different South Indian tribes to continental populations and underscore the complex histories of the tribal populations living in South Asia... - Genetic evidence on the origins of Indian caste populationsM Bamshad
Department of Pediatrics, University of Utah, Salt Lake City, Utah 84112, USA
Genome Res 11:994-1004. 2001..We conclude that Indian castes are most likely to be of proto-Asian origin with West Eurasian admixture resulting in rank-related and sex-specific differences in the genetic affinities of castes to Asians and Europeans... - Genetic similarities within and between human populationsD J Witherspoon
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
Genetics 176:351-9. 2007..This provides empirical justification for caution when using population labels in biomedical settings, with broad implications for personalized medicine, pharmacogenetics, and the meaning of race... - Population genomics: a bridge from evolutionary history to genetic medicineL B Jorde
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
Hum Mol Genet 10:2199-207. 2001..We review some of the general patterns of human genetic variation, and we show how our knowledge of these patterns can aid in the mapping and cloning of disease-causing genes... - Human population genetic structure and diversity inferred from polymorphic L1(LINE-1) and Alu insertionsD J Witherspoon
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, UT 84112 5330, USA
Hum Hered 62:30-46. 2006..L1 elements drive replication of Alu elements, and both have had far-reaching impacts on the human genome. We use L1 and Alu insertion polymorphisms to analyze human population structure... - DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selectionS P Wooding
Department of Human Genetics, University of Utah, Salt Lake City, UT, 84112, USA
Am J Hum Genet 71:528-42. 2002..90) frequencies in human populations, a trend consistent with the action of positive natural selection. These patterns have a number of implications for disease-association studies in CYP1A2 and other genes... - Mitochondrial mismatch analysis is insensitive to the mutational processA R Rogers
Department of Anthropology, University of Utah, Salt Lake City 84112, USA
Mol Biol Evol 13:895-902. 1996..01. In addition, we evaluate and reject the proposition that mismatch waves are produced by pooling data from several subdivisions of a structured population... - Microsatellite diversity and the demographic history of modern humansL B Jorde
Eccles Institute of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
Proc Natl Acad Sci U S A 94:3100-3. 1997..A comparison of continental diversity differences in microsatellites and mtDNA sequences suggests earlier demographic expansion of the ancestors of Africans... - The spectrum of mutations in TBX3: Genotype/Phenotype relationship in ulnar-mammary syndromeM Bamshad
Department of Pediatrics, Eccles Institute of Human Genetics, 15 North 2030 East, Room 2100, University of Utah, Salt Lake City, UT 84112 5330, USA
Am J Hum Genet 64:1550-62. 1999..We found no obvious phenotypic differences between those who have missense mutations and those who have deletions or frameshifts... - A variant of Freeman-Sheldon syndrome maps to 11p15.5-pterP A Krakowiak
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
Am J Hum Genet 60:426-32. 1997..5-6.5-cM region between the marker TH and the telomere. Analysis of additional families improves the LOD score to 6.45 at theta = 0 and suggests linkage homogeneity for DA2B... - Large-scale analysis of the Alu Ya5 and Yb8 subfamilies and their contribution to human genomic diversityM L Carroll
Departments of Pathology, Genetics Biochemistry and Molecular Biology Stanley S. Scott Cancer Center Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans 70112, USA
J Mol Biol 311:17-40. 2001..The newly identified Alu insertion polymorphisms will be useful tools for the study of human genomic diversity... - Mitochondrial DNA variation in Nicobarese IslandersB V Prasad
Department of Anthropology, Andhra University, Visakhapatnam, Andhra Pradesh, India
Hum Biol 73:715-25. 2001..g., Cambodians). Thus, the dispersal of southern Chinese into mainland Southeast Asia may have included a westward expansion and colonization of the islands of the Andaman Sea... - Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: implications for gene mappingL B Jorde
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84112
Am J Hum Genet 53:1038-50. 1993..These are discussed, and guidelines for linkage disequilibrium studies are suggested... - A gene for distal arthrogryposis type I maps to the pericentromeric region of chromosome 9M Bamshad
Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City 84132 1001
Am J Hum Genet 55:1153-8. 1994..Analysis of an additional family demonstrated no linkage to the same locus, indicating likely locus heterogeneity. Of the autosomal congenital contracture disorders causing positional foot deformities, this is the first to be mapped... - The exuperantia gene is required for Drosophila spermatogenesis as well as anteroposterior polarity of the developing oocyte, and encodes overlapping sex-specific transcriptsT Hazelrigg
Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112
Genetics 126:607-17. 1990..1 kb in the female. We also show that these two transcripts are limited in expression to the germline. We demonstrate that one allele, exuVL57, is a deletion of about 700 bp which results in a loss of both transcripts...