Marian Waterman

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression
    LAURA ARCE
    Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA 92697 4025, USA
    BMC Cancer 9:159. 2009
  2. ncbi request reprint Lymphoid enhancer factor/T cell factor expression in colorectal cancer
    Marian L Waterman
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, USA
    Cancer Metastasis Rev 23:41-52. 2004
  3. pmc Wnt activation and alternative promoter repression of LEF1 in colon cancer
    Tony W H Li
    Department of Microbiology and Molecular Genetics, Rm B240, Medical Sciences I, University of California, Irvine, Irvine, CA 92697 4025, USA
    Mol Cell Biol 26:5284-99. 2006
  4. pmc An internal ribosome entry site mediates translation of lymphoid enhancer factor-1
    Judith Jimenez
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, CA 92697 4025, USA
    RNA 11:1385-99. 2005
  5. pmc A unique DNA binding domain converts T-cell factors into strong Wnt effectors
    Fawzia A Atcha
    Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA
    Mol Cell Biol 27:8352-63. 2007
  6. ncbi request reprint IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes
    Bert L Semler
    Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA
    Trends Microbiol 16:1-5. 2008
  7. pmc The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation
    Baoan Li
    Department of Biological Chemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 99:6064-9. 2002
  8. ncbi request reprint A new beta-catenin-dependent activation domain in T cell factor
    Fawzia A Atcha
    Microbiology and Molecular Genetics Department, School of Medicine, University of California, Irvine, CA 92697 4025, USA
    J Biol Chem 278:16169-75. 2003
  9. pmc Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2
    Steve P Crampton
    Department of Molecular Biology and Biochemistry, UCI Institute for Immunology, University of California Irvine, Irvine, California, USA
    PLoS ONE 4:e7841. 2009
  10. pmc A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer
    Noriko N Yokoyama
    Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA
    Nucleic Acids Res 38:6375-88. 2010

Research Grants

  1. Wnt signaling in Colon Cancer
    Marian Waterman; Fiscal Year: 2009
  2. LEF/TCF Expression in Colon Cancer
    Marian Waterman; Fiscal Year: 2007
  3. ACTIVITIES OF BETA CATENIN AND LEF/TCF COMPLEXES
    Marian Waterman; Fiscal Year: 2004
  4. LEF/TCF Expression in Colon Cancer
    Marian L Waterman; Fiscal Year: 2010

Collaborators

  • BERT SEMLER
  • STEVEN MONROE LIPKIN
  • Robert Andrew Edwards
  • LAURA ARCE
  • Noriko N Yokoyama
  • Fawzia A Atcha
  • Tony W H Li
  • Nate P Hoverter
  • Kira T Pate
  • Shaheen S Sikandar
  • Steve P Crampton
  • Beibei Wu
  • Min Yang
  • Ju Hui T Ting
  • Jesus E Munguia
  • Judith Jimenez
  • Baoan Li
  • Stephanie Sprowl
  • Scott Anderson
  • Diana Dizon
  • Candice Solomon
  • Christopher C W Hughes
  • Edward J Park
  • Jai Hyun Kim
  • Rainer K Brachmann
  • Adeela Syed
  • Harry J Mangalam
  • J Lawrence Marsh
  • Alla Bernstein
  • Marc van de Wetering
  • Gwendolyn M Jang
  • Karine Hovanes
  • Magid Fallahi
  • Christopher P Schonbaum
  • Qian Dai
  • Elaine Fuchs
  • Judith Fantes
  • Xing Dai
  • Anthony P Mahowald
  • Mahalakshmi Nair
  • Douglas R Mackay

Detail Information

Publications13

  1. pmc Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression
    LAURA ARCE
    Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA 92697 4025, USA
    BMC Cancer 9:159. 2009
    ..The molecular events involved in this competitive interaction are not defined and the actions of Groucho/TLEs within the context of Wnt-linked cancer are unknown...
  2. ncbi request reprint Lymphoid enhancer factor/T cell factor expression in colorectal cancer
    Marian L Waterman
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, USA
    Cancer Metastasis Rev 23:41-52. 2004
    ..While the underlying mechanism for a change in the LEF/TCF isoform expression is not yet known, recent evidence implicates the Wnt signaling pathway itself as a potential modulator...
  3. pmc Wnt activation and alternative promoter repression of LEF1 in colon cancer
    Tony W H Li
    Department of Microbiology and Molecular Genetics, Rm B240, Medical Sciences I, University of California, Irvine, Irvine, CA 92697 4025, USA
    Mol Cell Biol 26:5284-99. 2006
    ..We conclude that the biological outcome of aberrant LEF1 activation in colon cancer is directed by differential promoter activation and repression...
  4. pmc An internal ribosome entry site mediates translation of lymphoid enhancer factor-1
    Judith Jimenez
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, CA 92697 4025, USA
    RNA 11:1385-99. 2005
    ....
  5. pmc A unique DNA binding domain converts T-cell factors into strong Wnt effectors
    Fawzia A Atcha
    Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA
    Mol Cell Biol 27:8352-63. 2007
    ..Thus, E-tail isoforms of TCFs utilize two DNA binding activities to access a subset of Wnt targets important for cell growth...
  6. ncbi request reprint IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes
    Bert L Semler
    Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA
    Trends Microbiol 16:1-5. 2008
    ....
  7. pmc The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation
    Baoan Li
    Department of Biological Chemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 99:6064-9. 2002
    ....
  8. ncbi request reprint A new beta-catenin-dependent activation domain in T cell factor
    Fawzia A Atcha
    Microbiology and Molecular Genetics Department, School of Medicine, University of California, Irvine, CA 92697 4025, USA
    J Biol Chem 278:16169-75. 2003
    ..This study thus identifies a new and unique set of motifs used by the Wnt pathway for target gene regulation...
  9. pmc Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2
    Steve P Crampton
    Department of Molecular Biology and Biochemistry, UCI Institute for Immunology, University of California Irvine, Irvine, California, USA
    PLoS ONE 4:e7841. 2009
    ..Both rac1 and c-jun have recently been implicated in wnt signaling, however their upstream activators have not been identified...
  10. pmc A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer
    Noriko N Yokoyama
    Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA
    Nucleic Acids Res 38:6375-88. 2010
    ..We also show that induced expression of dnLEF-1 in colon cancer cells slows their rate of proliferation. We propose that YY1 plays an important role in preventing dnLEF-1 expression and growth inhibition in colon cancer...
  11. ncbi request reprint hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin
    Min Yang
    Department of Medicine, University of California, Irvine, California, USA
    Cancer Biol Ther 7:120-8. 2008
    ..Our studies identify hADA2a and hADA3 as crucial cofactors of beta-catenin that are likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes...
  12. doi request reprint A Wnt-fall for gene regulation: repression
    Nate P Hoverter
    Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA
    Sci Signal 1:pe43. 2008
    ..A recent study uncovered a new mode of repression of Wnt target genes in which recognition of a novel DNA element by TCF specifies that beta-catenin acts as a transcriptional repressor...
  13. doi request reprint NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer
    Shaheen S Sikandar
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, California, USA
    Cancer Res 70:1469-78. 2010
    ..Our findings describe a novel human cell system to study NOTCH signaling in CRC tumor initiation and suggest that inhibition of NOTCH signaling may improve CRC chemoprevention and chemotherapy...

Research Grants18

  1. Wnt signaling in Colon Cancer
    Marian Waterman; Fiscal Year: 2009
    ..Collectively, the work proposed will address important unknowns about the role that TCF proteins play in directing Wnt signals toward cell transformation and cancer progression. ..
  2. LEF/TCF Expression in Colon Cancer
    Marian Waterman; Fiscal Year: 2007
    ..To test this hypothesis, two strategies will be used to disrupt LEF/TCF function in colon cancer cells. Effects will be assessed by global gene expression profiles and cell growth and viability assays (Specific Aim 4). ..
  3. ACTIVITIES OF BETA CATENIN AND LEF/TCF COMPLEXES
    Marian Waterman; Fiscal Year: 2004
    ..Aim 3 describes experiments to assess the role of LEF/TCF DNA binding domain in the recruitment of beta catenin and, paradoxically, an antagonizing nuclear co-activator to promoters. ..
  4. LEF/TCF Expression in Colon Cancer
    Marian L Waterman; Fiscal Year: 2010
    ..This project examines how two such collaborating pathways (Notch and Calmodulin Kinase II) modify Wnt signals in colon cancer and in newly established colon cancer stem cell lines. ..