Jon Watchko

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Common hematologic problems in the newborn nursery
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, Magee Womens Hospital, 300 Halket Street and Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15213, USA Electronic address
    Pediatr Clin North Am 62:509-24. 2015
  2. doi request reprint Are the neuromotor disabilities of bilirubin-induced neurologic dysfunction disorders related to the cerebellum and its connections?
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Electronic address
    Semin Fetal Neonatal Med 20:47-51. 2015
  3. doi request reprint The enigma of low bilirubin kernicterus in premature infants: why does it still occur, and is it preventable?
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA Electronic address
    Semin Perinatol 38:397-406. 2014
  4. ncbi request reprint Vigintiphobia revisited
    Jon F Watchko
    Division of Neonatology and Developmental Biology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 115:1747-53. 2005
  5. ncbi request reprint Myofibrillar or mitochondrial creatine kinase deficiency alone does not impair mouse diaphragm isotonic function
    J F Watchko
    Department of Pediatrics, Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Appl Physiol (1985) 88:973-80. 2000
  6. ncbi request reprint Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, PA, USA
    Neuromolecular Med 8:513-29. 2006
  7. ncbi request reprint Hyperbilirubinemia and bilirubin toxicity in the late preterm infant
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin Perinatol 33:839-52; abstract ix. 2006
  8. doi request reprint Identification of neonates at risk for hazardous hyperbilirubinemia: emerging clinical insights
    Jon F Watchko
    Department of Pediatrics, Division of Newborn Medicine, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Magee Womens Hospital, Pittsburgh, PA 15213, USA
    Pediatr Clin North Am 56:671-87, Table of Contents. 2009
  9. doi request reprint Hyperbilirubinemia in African American neonates: clinical issues and current challenges
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Semin Fetal Neonatal Med 15:176-82. 2010
  10. doi request reprint Exploring the genetic architecture of neonatal hyperbilirubinemia
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, Magee Women s Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Semin Fetal Neonatal Med 15:169-75. 2010

Research Grants

Collaborators

Detail Information

Publications32

  1. doi request reprint Common hematologic problems in the newborn nursery
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, Magee Womens Hospital, 300 Halket Street and Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15213, USA Electronic address
    Pediatr Clin North Am 62:509-24. 2015
    ..A less frequent clinically relevant hematologic issue in newborns to be covered herein is thrombocytopenia." ..
  2. doi request reprint Are the neuromotor disabilities of bilirubin-induced neurologic dysfunction disorders related to the cerebellum and its connections?
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Electronic address
    Semin Fetal Neonatal Med 20:47-51. 2015
    ..Future study using advanced magnetic resonance neuroimaging techniques have the potential to shed new insights into bilirubin's effect on neural network topology via both structural and functional brain connectivity measurements. ..
  3. doi request reprint The enigma of low bilirubin kernicterus in premature infants: why does it still occur, and is it preventable?
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA Electronic address
    Semin Perinatol 38:397-406. 2014
    ..While efforts to refine and improve current treatment guidelines are certainly needed, such revision(s) will also have to take into account the risks and benefits of any intervention, including phototherapy. ..
  4. ncbi request reprint Vigintiphobia revisited
    Jon F Watchko
    Division of Neonatology and Developmental Biology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 115:1747-53. 2005
    ....
  5. ncbi request reprint Myofibrillar or mitochondrial creatine kinase deficiency alone does not impair mouse diaphragm isotonic function
    J F Watchko
    Department of Pediatrics, Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Appl Physiol (1985) 88:973-80. 2000
    ..We conclude that Dia power and work output are not absolutely dependent on the presence of either M-CK or ScCKmit, whereas the complete absence of CK acutely impairs Dia shortening capacity during repetitive activation...
  6. ncbi request reprint Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, PA, USA
    Neuromolecular Med 8:513-29. 2006
    ..An enhanced understanding of the molecular pathogenesis of bilirubin-induced neuronal injury will lead to the identification of potential novel interventional strategies to protect the CNS against kernicterus...
  7. ncbi request reprint Hyperbilirubinemia and bilirubin toxicity in the late preterm infant
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin Perinatol 33:839-52; abstract ix. 2006
    ....
  8. doi request reprint Identification of neonates at risk for hazardous hyperbilirubinemia: emerging clinical insights
    Jon F Watchko
    Department of Pediatrics, Division of Newborn Medicine, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Magee Womens Hospital, Pittsburgh, PA 15213, USA
    Pediatr Clin North Am 56:671-87, Table of Contents. 2009
    ....
  9. doi request reprint Hyperbilirubinemia in African American neonates: clinical issues and current challenges
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Semin Fetal Neonatal Med 15:176-82. 2010
    ..Parental education at the time of birth hospitalization discharge combined with timely follow-up may help to reduce the risk of developing hazardous hyperbilirubinemia...
  10. doi request reprint Exploring the genetic architecture of neonatal hyperbilirubinemia
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, Magee Women s Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Semin Fetal Neonatal Med 15:169-75. 2010
    ..Variant gene co-expression including compound and synergistic heterozygosity enhances hyperbilirubinemia risk, contributing to the etiologic heterogeneity and complex nature of neonatal jaundice...
  11. doi request reprint Enduring controversies in the management of hyperbilirubinemia in preterm neonates
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Magee Women s Research Institute, Pittsburgh, Pennsylvania, USA
    Semin Fetal Neonatal Med 15:136-40. 2010
    ..Additional study is needed to further clarify the risk posed by hyperbilirubinemia in premature neonates and to frame guidelines for phototherapy and exchange transfusion that are more evidence-based...
  12. ncbi request reprint Bilirubin induced apoptosis in vitro: insights for kernicterus: commentary on the article by Hankø et al. on page 179
    Jon F Watchko
    Division of Neonatology and Developmental Biology, Department of Pediatrics, University of Pittsburgh School of Medicine, Room 4230, Magee Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA
    Pediatr Res 57:177-8. 2005
  13. ncbi request reprint Genetics and the risk of neonatal hyperbilirubinemia: commentary on the article by Huang et al. on page 682
    Jon F Watchko
    Division of Neonatology and Developmental Biology, Department of Pediatrics, Room 4407, Magee Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA
    Pediatr Res 56:677-8. 2004
  14. ncbi request reprint Understanding neonatal hyperbilirubinaemia in the era of genomics
    Jon F Watchko
    Division of Neonatology and Developmental Biology, Department of Pediatrics, University of Pittsburgh School of Medicine, Magee Womens Hospital, 300 Halket Street, Pittsburgh, Pennsylvania 15213, USA
    Semin Neonatol 7:143-52. 2002
    ..Expanded study using the tools of genomics will shed insights into the genetics of newborn jaundice and the pathogenesis of hyperbilirubinaemic encephalopathy...
  15. ncbi request reprint Functional characteristics of dystrophic skeletal muscle: insights from animal models
    Jon F Watchko
    Department of Pediatrics, Magee Women s Research Institute, Duchenne Muscular Dystrophy Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Appl Physiol (1985) 93:407-17. 2002
    ..It is likely that changes in muscle structure and function, downstream of the specific, primary biochemical deficiency, may alter muscle contractile properties...
  16. pmc Jaundice in low birthweight infants: pathobiology and outcome
    J F Watchko
    Division of Neonatology and Developmental Biology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Dis Child Fetal Neonatal Ed 88:F455-8. 2003
    ..Hyperbilirubinaemia in preterm infants is more prevalent, more severe, and its course more protracted than in term neonates...
  17. doi request reprint Complex multifactorial nature of significant hyperbilirubinemia in neonates
    Jon F Watchko
    Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 124:e868-77. 2009
    ....
  18. ncbi request reprint Regulation of FasL/Fas in human trophoblasts: possible implications for chorioamnionitis
    Dhruv R Balkundi
    Department of Pediatrics, Division of Neonatology and Developmental Biology, University of Pittsburgh, Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Biol Reprod 69:718-24. 2003
    ..These mechanisms may be important in perpetuating inflammation in the placental microenvironment and may contribute to the pathogenesis of chorioamnionitis...
  19. ncbi request reprint Adeno-associated virus vector-mediated minidystrophin gene therapy improves dystrophic muscle contractile function in mdx mice
    Jon Watchko
    Division of Neonatology and Developmental Biology, Department of Pediatrics, Magee Women s Research Institute, Pittsburgh, PA 15213, USA
    Hum Gene Ther 13:1451-60. 2002
    ..We conclude that AAV-minidystrophin gene treatment is effective in improving mdx muscle contractile function...
  20. ncbi request reprint Skeletal muscle glucose transporter protein responses to antenatal glucocorticoids in the ovine fetus
    Susan Gray
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    J Endocrinol 189:219-29. 2006
    ....
  21. ncbi request reprint Effect of injecting primary myoblasts versus putative muscle-derived stem cells on mass and force generation in mdx mice
    Gunhild M Mueller
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hum Gene Ther 13:1081-90. 2002
    ..This may, in part, explain the failure of cellular therapy to alter the contractile properties of murine dystrophic muscle...
  22. doi request reprint Coexpression of gene polymorphisms involved in bilirubin production and metabolism
    Zhili Lin
    Pediatrix Screening, Inc, Bridgeville, Pennsylvania, USA
    Pediatrics 122:e156-62. 2008
    ....
  23. ncbi request reprint Unconjugated bilirubin efflux by bovine brain microvascular endothelial cells in vitro
    Deryk Sequeira
    Department of Pediatrics, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, PA, USA
    Pediatr Crit Care Med 8:570-5. 2007
    ..The objective of the current study was to characterize the passage of UCB across primary bovine brain microvascular endothelial cell (BBMVEC) monolayers in vitro...
  24. ncbi request reprint Calculated in vivo free bilirubin levels in the central nervous system of Gunn rat pups
    Monica J Daood
    Department of Pediatrics, Division of Newborn Medicine, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Res 60:44-9. 2006
    ....
  25. ncbi request reprint Sex-specific regional brain bilirubin content in hyperbilirubinemic Gunn rat pups
    Carrie Cannon
    Division of Newborn Medicine, Department of Pediatrics, Magee Women s Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Biol Neonate 90:40-5. 2006
    ..Despite evidence that the cerebellar region and males are predisposed to bilirubin-induced brain injury in this animal model, there are limited regional and no sex-specific brain bilirubin content data...
  26. ncbi request reprint P-glycoprotein expression in mouse brain increases with maturation
    Catherine E Tsai
    Department of Pediatrics, Magee Womens Hospital Research Institute, University of Pittsburgh School of Medicine, 300 Halket Street, Pittsburgh, PA 15213, USA
    Biol Neonate 81:58-64. 2002
    ....
  27. ncbi request reprint IUGR alters postnatal rat skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a fiber specific manner
    Robert H Lane
    David Geffen School of Medicine at UCLA, Mattel Children s Hospital at UCLA, Department of Pediatrics, Los Angles CA 90095 1752, USA
    Pediatr Res 53:994-1000. 2003
    ..Down stream targets of PGC-1 followed a similar pattern of expression. We conclude that PGC-1 expression is altered in rat IUGR skeletal muscle and speculate that it contributes to the pathogenesis of insulin resistance in the IUGR rat...
  28. ncbi request reprint Neonatal hyperbilirubinemia--what are the risks?
    Jon F Watchko
    N Engl J Med 354:1947-9. 2006
  29. ncbi request reprint Effect of predischarge bilirubin screening on subsequent hyperbilirubinemia
    M Jeffrey Maisels
    Pediatrics 118:1796; author reply 1976-7. 2006
  30. ncbi request reprint Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain
    Erik Hankø
    Department of Pediatrics, Rikshospitalet, N 0027 Oslo, Norway
    Pediatr Res 54:441-5. 2003
    ..We speculate that drugs known to inhibit P-gp function may increase the risk of bilirubin encephalopathy in the hyperbilirubinemic infant...
  31. ncbi request reprint Postnatal dexamethasone for lung disease of prematurity
    Jon F Watchko
    N Engl J Med 350:2715-8; author reply 2715-8. 2004
  32. doi request reprint Management of jaundice and prevention of severe neonatal hyperbilirubinemia in infants >or=35 weeks gestation
    Vinod K Bhutani
    School of Medicine at Stanford University, Stanford, CA, USA
    Neonatology 94:63-7. 2008
    ..Translational research is needed to better understand the mechanisms of bilirubin neurotoxicity and potential therapeutic interventions...

Research Grants1

  1. NEONATAL BILIRUBIN NEUROTOXICITY AND P-GLYCOPROTEIN
    Jon Watchko; Fiscal Year: 2007
    ..abstract_text> ..