Richard Watanabe

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose
    Xia Li
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Diabetes 58:2946-53. 2009
  2. pmc A principal-components-based clustering method to identify multiple variants associated with rheumatoid arthritis and arthritis-related autoantibodies
    Mary Helen Black
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP 222 V, Los Angeles, California 90089, USA
    BMC Proc 3:S129. 2009
  3. pmc Inherited destiny? Genetics and gestational diabetes mellitus
    Richard M Watanabe
    Department of Preventive Medicine, Keck School of Medicine of USC, 1540 Alcazar St, CHP 220, Los Angeles, CA 90089 9011, USA
    Genome Med 3:18. 2011
  4. pmc Genetics of gestational diabetes mellitus and type 2 diabetes
    Richard M Watanabe
    Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089 9011, USA
    Diabetes Care 30:S134-40. 2007
  5. pmc Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans
    Richard M Watanabe
    Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine, The University of Southern California, Los Angeles, California 90089 9011, USA
    Diabetes 56:1481-5. 2007
  6. pmc The genetics of insulin resistance: Where's Waldo?
    Richard M Watanabe
    Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089 9011, USA
    Curr Diab Rep 10:476-84. 2010
  7. doi request reprint Statistical issues in gene association studies
    Richard M Watanabe
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 700:17-36. 2011
  8. doi request reprint Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans
    Xia Li
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine of USC, Los Angeles, California, USA
    Obesity (Silver Spring) 17:729-36. 2009
  9. ncbi request reprint Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin
    Richard N Bergman
    Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Diabetes 52:2168-74. 2003
  10. ncbi request reprint Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans
    Mary Helen Black
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar St, CHP 220, Los Angeles, CA 90089 9011, USA
    Diabetes 57:1048-56. 2008

Research Grants

  1. Pharmacogenetics of Diabetes Prevention
    Richard Watanabe; Fiscal Year: 2007
  2. Pharmacogenetics of Diabetes Prevention
    Richard Watanabe; Fiscal Year: 2009

Detail Information

Publications34

  1. pmc Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose
    Xia Li
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Diabetes 58:2946-53. 2009
    ..GCK rs1799884 and G6PC2 rs560887 have been independently associated with fasting glucose, but their interaction on glucose-insulin relationships is not well characterized...
  2. pmc A principal-components-based clustering method to identify multiple variants associated with rheumatoid arthritis and arthritis-related autoantibodies
    Mary Helen Black
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP 222 V, Los Angeles, California 90089, USA
    BMC Proc 3:S129. 2009
    ..Using the orthoblique PC-based clustering method, we identified new clusters of SNPs across the MHC region associated with RA and RFUW, and replicated known SNP cluster associations with RA, such as those in the HLA-DRB region...
  3. pmc Inherited destiny? Genetics and gestational diabetes mellitus
    Richard M Watanabe
    Department of Preventive Medicine, Keck School of Medicine of USC, 1540 Alcazar St, CHP 220, Los Angeles, CA 90089 9011, USA
    Genome Med 3:18. 2011
    ..Finally, I examine how the study of susceptibility loci can be used to influence clinical care, one of the great promises of the new era of human genome analysis...
  4. pmc Genetics of gestational diabetes mellitus and type 2 diabetes
    Richard M Watanabe
    Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089 9011, USA
    Diabetes Care 30:S134-40. 2007
  5. pmc Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans
    Richard M Watanabe
    Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine, The University of Southern California, Los Angeles, California 90089 9011, USA
    Diabetes 56:1481-5. 2007
    ..We examined variation in a 0.1-Mb region surrounding marker DG10S478 for association with diabetes-related quantitative traits in 132 Mexican-American families of a proband with previous gestational diabetes mellitus (GDM)...
  6. pmc The genetics of insulin resistance: Where's Waldo?
    Richard M Watanabe
    Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089 9011, USA
    Curr Diab Rep 10:476-84. 2010
    ....
  7. doi request reprint Statistical issues in gene association studies
    Richard M Watanabe
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 700:17-36. 2011
    ..We draw examples from the type 2 diabetes genetics literature to illustrate some of the issues discussed...
  8. doi request reprint Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans
    Xia Li
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine of USC, Los Angeles, California, USA
    Obesity (Silver Spring) 17:729-36. 2009
    ..066) and disposition index (DI) (Bonferroni P = 0.072). We conclude that rs11705701 in IGF2BP2 is associated with body fat and this effect on body fat influences insulin resistance which may contribute to T2DM risk...
  9. ncbi request reprint Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin
    Richard N Bergman
    Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Diabetes 52:2168-74. 2003
    ..Thus S(I), a direct measure of insulin sensitivity, is determined more by genetic factors rather than measures such as HOMA, which reflect fasting insulin...
  10. ncbi request reprint Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans
    Mary Helen Black
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar St, CHP 220, Los Angeles, CA 90089 9011, USA
    Diabetes 57:1048-56. 2008
    ....
  11. pmc Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans
    Yu Hsiang Shu
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 94:4094-102. 2009
    ..Acid phosphatase locus 1 (ACP1) is a low molecular weight tyrosine phosphatase that has been shown to be an important regulator of insulin receptor signaling...
  12. ncbi request reprint What is gestational diabetes?
    Thomas A Buchanan
    Departments of Medicine, Obstetrics and Gynecology, and Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Diabetes Care 30:S105-11. 2007
  13. ncbi request reprint Insulin resistance and associated compensatory responses in african-american and Hispanic children
    Michael I Goran
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Diabetes Care 25:2184-90. 2002
    ..The objective of this study was to compare insulin resistance relative to body fat and the associated compensatory responses in 57 healthy children living in Los Angeles, California (14 Caucasians, 15 African-Americans, and 28 Hispanics)...
  14. pmc OGTT-derived measures of insulin sensitivity are confounded by factors other than insulin sensitivity itself
    Katrin Hucking
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Obesity (Silver Spring) 16:1938-45. 2008
    ....
  15. pmc Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q
    Corina Shtir
    Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089, USA
    Hum Hered 63:17-25. 2007
    ..The purpose of this study was to examine carefully heterogeneity underlying evidence for linkage to type 2 diabetes (T2DM) on chromosome 6q from two sets of FUSION families...
  16. ncbi request reprint Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes
    Cristen J Willer
    Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor 48109 2029, USA
    Diabetes 56:256-64. 2007
    ..03), although we also replicated 4 of 58 SNPs from genes that had only one previous report of association...
  17. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  18. ncbi request reprint Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes
    Kaisa Silander
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Diabetes 53:1141-9. 2004
    ....
  19. ncbi request reprint Acute alcohol consumption improves insulin action without affecting insulin secretion in type 2 diabetic subjects
    Angelo Avogaro
    Dipartimento Medicina Sperimentale Policlinico, University of Padua Medical School, Via Giustiniani 2, 35128 Padua, Italy
    Diabetes Care 27:1369-74. 2004
    ..The aim of the present study was to assess the role of acute moderate alcohol intake on insulin sensitivity and insulin secretion in comparable subjects with and without type 2 diabetes...
  20. ncbi request reprint Glucose tolerance during moderate alcohol intake: insights on insulin action from glucose/lactate dynamics
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, University of Padova Medical School, 35128 Padova, Italy
    J Clin Endocrinol Metab 87:1233-8. 2002
    ..Because ETOH at moderate doses has a marked antilipolytic action, it might improve insulin action by improving substrate competition. The present findings suggest that moderate alcohol consumption in the diet should not be discouraged...
  21. ncbi request reprint Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort
    Tasha E Fingerlin
    Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Diabetes 51:1644-8. 2002
    ..We conclude that variation in these three SNPs in the calpain-10 gene is unlikely to confer susceptibility to type 2 diabetes in this Finnish cohort...
  22. ncbi request reprint Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns
    Karen L Mohlke
    Department of Genetics, University of North Carolina, 4109 F Neurosciences Research Building, 103 Mason Farm Road, CB 7264, 27599 7264, Chapel Hill, NC, USA
    Hum Genet 118:245-54. 2005
    ..Furthermore, our data do not support a reported maternal inheritance pattern of T2DM but instead show a strong effect of recall bias...
  23. pmc A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Science 316:1341-5. 2007
    ..This brings the number of T2D loci now confidently identified to at least 10...
  24. pmc Sequence variation in PPARG may underlie differential response to troglitazone
    Johanna K Wolford
    Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona, USA
    Diabetes 54:3319-25. 2005
    ..05). Three variants were also associated with changes in Si as a continuous variable. Our results suggest that PPARG variation may underlie response to TZD therapy in women at risk for type 2 diabetes...
  25. ncbi request reprint A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14
    Kaisa Silander
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Diabetes 53:821-9. 2004
    ....
  26. pmc Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of Diabe
    Soren Snitker
    Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland, Baltimore School of Medicine, 660 W Redwood St, Howard Hall Rm 598 B, Baltimore, MD 21201 1596, USA
    Diabetes Care 27:1365-8. 2004
    ....
  27. ncbi request reprint MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test
    Ray C Boston
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Diabetes Technol Ther 5:1003-15. 2003
    ..In contrast to earlier versions of MINMOD and some other minimal model programs, Millennium provides identified estimates of insulin sensitivity and glucose effectiveness for almost every subject...
  28. pmc Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    Wei Min Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 118:2620-8. 2008
    ....
  29. pmc Common variants in the GDF5-UQCC region are associated with variation in human height
    Serena Sanna
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:198-203. 2008
    ..44 cm (overall P < 10(-15)). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development...
  30. ncbi request reprint Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
    ..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...
  31. pmc Prioritized subset analysis: improving power in genome-wide association studies
    Chun Li
    Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hum Hered 65:129-41. 2008
    ..Traditional approaches for assessing the overall statistical significance of GWAS results ignore such information by inherently treating all markers equally...
  32. ncbi request reprint Variants in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes
    Meredith P Millis
    Translational Genomics Research Institute, 445 North Fifth St, Phoenix, AZ 85004, USA
    Diabetes 56:3027-32. 2007
    ..The objective of this study was to evaluate the extent to which these variants mediate susceptibility in other populations...
  33. ncbi request reprint Ordered subset analysis in genetic linkage mapping of complex traits
    Elizabeth R Hauser
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 27:53-63. 2004
    ..We illustrate this method by analyzing data on breast cancer age of onset and chromosome 17q [Hall et al., 1990, Science 250:1684-1689]. We evaluate OSA using simulation studies under a variety of genetic models...
  34. ncbi request reprint Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns
    Lori L Bonnycastle
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 2152, USA
    Diabetes 55:2534-40. 2006
    ..Our data suggest that common variants in several MODY genes play a modest role in type 2 diabetes susceptibility...

Research Grants3

  1. Pharmacogenetics of Diabetes Prevention
    Richard Watanabe; Fiscal Year: 2007
    ..This will help clinicians to avoid interventions that have a low probability of success in a given patient with T2DM. ..
  2. Pharmacogenetics of Diabetes Prevention
    Richard Watanabe; Fiscal Year: 2009
    ..This will help clinicians to avoid interventions that have a low probability of success in a given patient with T2DM. ..