C G Wasterlain

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Trafficking of NMDA receptors during status epilepticus: therapeutic implications
    Claude G Wasterlain
    Department of Neurology, Veterans Administration Greater Los Angeles Healthcare System West Los Angeles, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, U S A
    Epilepsia 54:78-80. 2013
  2. doi request reprint Epileptogenesis in the developing brain
    Claude G Wasterlain
    Department of Neurology, VA Greater Los Angeles Health Care System, and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Electronic address
    Handb Clin Neurol 111:427-39. 2013
  3. pmc The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus
    Claude G Wasterlain
    Department of Neurology, and Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Epilepsy Res 94:10-7. 2011
  4. ncbi request reprint Self-sustaining status epilepticus: a condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators
    C G Wasterlain
    Department of Neurology, VA Greater Los Angeles Health Care System, California 90073, USA
    Epilepsia 41:S134-43. 2000
  5. pmc Brain energy metabolism during experimental neonatal seizures
    Claude G Wasterlain
    Epilepsy Research Laboratory, VA Greater Los Angeles Health Care System, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, USA
    Neurochem Res 35:2193-8. 2010
  6. doi request reprint Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs
    Claude G Wasterlain
    Epilepsy Research Laboratories, Department of Neurology, David Gefen School of Medicine at UCLA, Los Angeles, California, USA
    Epilepsia 49:63-73. 2008
  7. doi request reprint Rational polytherapy in the treatment of acute seizures and status epilepticus
    Claude G Wasterlain
    Epilepsy Research Laboratory, VA Greater Los Angeles Health Care System, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, USA
    Epilepsia 52:70-1. 2011
  8. ncbi request reprint Seizure-induced neuronal death in the immature brain
    Claude G Wasterlain
    Epilepsy Research Laboratory, VA Greater Los Angeles Healthcare System, Department of Neurology Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Prog Brain Res 135:335-53. 2002
  9. ncbi request reprint Patterns of status epilepticus-induced substance P expression during development
    H Liu
    Epilepsy Research Laboratory, Veteran Administration Medical Center, Sepulveda, CA 91343, USA
    Neuroscience 101:297-304. 2000
  10. ncbi request reprint Granule cell neurogenesis after status epilepticus in the immature rat brain
    R Sankar
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1752, USA
    Epilepsia 41:S53-6. 2000

Research Grants

  1. BRAIN DEVELOPMENT IN EXPERIMENTAL EPILEPSY
    Claude Wasterlain; Fiscal Year: 2002
  2. BRAIN DEVELOPMENT IN EXPERIMENTAL EPILEPSY
    Claude Wasterlain; Fiscal Year: 2006
  3. BRAIN DEVELOPMENT IN EXPERIMENTAL EPILEPSY
    Claude Wasterlain; Fiscal Year: 1980
  4. BRAIN DEVELOPMENT IN EXPERIMENTAL EPILEPSY
    Claude Wasterlain; Fiscal Year: 1993

Detail Information

Publications50

  1. doi request reprint Trafficking of NMDA receptors during status epilepticus: therapeutic implications
    Claude G Wasterlain
    Department of Neurology, Veterans Administration Greater Los Angeles Healthcare System West Los Angeles, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, U S A
    Epilepsia 54:78-80. 2013
    ..The therapeutic implications of these results are discussed. ..
  2. doi request reprint Epileptogenesis in the developing brain
    Claude G Wasterlain
    Department of Neurology, VA Greater Los Angeles Health Care System, and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Electronic address
    Handb Clin Neurol 111:427-39. 2013
    ..Further research is needed to elucidate the molecular mechanisms of epileptogenesis and of seizure- or drug-induced neuronal injury, in order to prevent their long-term consequences...
  3. pmc The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus
    Claude G Wasterlain
    Department of Neurology, and Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Epilepsy Res 94:10-7. 2011
    ..The results presented here suggest that lacosamide deserves investigation for the clinical treatment of SE. Potential for disease modification in this rat model of self-sustaining SE will require further studies...
  4. ncbi request reprint Self-sustaining status epilepticus: a condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators
    C G Wasterlain
    Department of Neurology, VA Greater Los Angeles Health Care System, California 90073, USA
    Epilepsia 41:S134-43. 2000
    ..These changes and those in other limbic peptides may contribute to the maintenance of SSSE and to the modulation of hippocampal excitability during epileptic seizures. NMDA..
  5. pmc Brain energy metabolism during experimental neonatal seizures
    Claude G Wasterlain
    Epilepsy Research Laboratory, VA Greater Los Angeles Health Care System, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, USA
    Neurochem Res 35:2193-8. 2010
    ..These results suggest that the metabolic challenge imposed on the brain by this model of experimental neonatal seizures is milder than that seen at older ages, but can become critical when associated with other types of metabolic stress...
  6. doi request reprint Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs
    Claude G Wasterlain
    Epilepsy Research Laboratories, Department of Neurology, David Gefen School of Medicine at UCLA, Los Angeles, California, USA
    Epilepsia 49:63-73. 2008
    ..have seen renewed interest. A rapidly increasing but largely anecdotal body of literature reports success in seizure control at the price of relatively few complications with the clinical use of those agents in refractory SE...
  7. doi request reprint Rational polytherapy in the treatment of acute seizures and status epilepticus
    Claude G Wasterlain
    Epilepsy Research Laboratory, VA Greater Los Angeles Health Care System, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, USA
    Epilepsia 52:70-1. 2011
    ..Combinations of a benzodiazepine with ketamine and valproate, or with ketamine and brivaracetam, were more effective and less toxic than benzodiazepine monotherapy in this model of SE...
  8. ncbi request reprint Seizure-induced neuronal death in the immature brain
    Claude G Wasterlain
    Epilepsy Research Laboratory, VA Greater Los Angeles Healthcare System, Department of Neurology Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Prog Brain Res 135:335-53. 2002
    ..Seizure-induced necrosis has many of the biochemical features of apoptosis, with early cytochrome release from mitochondria and capase activation. We speculate that this form of necrosis is associated with seizure-induced energy failure...
  9. ncbi request reprint Patterns of status epilepticus-induced substance P expression during development
    H Liu
    Epilepsy Research Laboratory, Veteran Administration Medical Center, Sepulveda, CA 91343, USA
    Neuroscience 101:297-304. 2000
    ..These results indicate that seizure activity selectively evokes age-dependent and region-selective expression of substance P...
  10. ncbi request reprint Granule cell neurogenesis after status epilepticus in the immature rat brain
    R Sankar
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1752, USA
    Epilepsia 41:S53-6. 2000
    ..We investigated seizure-induced granule cell neurogenesis in developing rat pups to study the association between hilar injury, granule cell neurogenesis, and epilepsy...
  11. ncbi request reprint Ontogeny of self-sustaining status epilepticus
    R Sankar
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Dev Neurosci 21:345-51. 1999
    ..This model of SE differs from in vitro models of SE, in which immature animals show an increased susceptibility to epileptogenic stimuli, and provides us with a novel method to study epileptogenicity in the developing brain...
  12. ncbi request reprint N-methyl-D-asparate receptor antagonists abolish the maintenance phase of self-sustaining status epilepticus in rat
    A M Mazarati
    Department of Neurology and Brain Research Institute, UCLA School of Medicine, Los Angeles, CA, USA
    Neurosci Lett 265:187-90. 1999
    ..We suggest that the maintenance phase of SSSE depends on activation of NMDA receptors and that NMDA receptor blockers may be a promising class of compounds for the treatment of status epilepticus...
  13. ncbi request reprint Self-sustaining status epilepticus after brief electrical stimulation of the perforant path
    A M Mazarati
    Veteran Administration Medical Center, Neurology Service, UCLA School of Medicine, Sepulveda, USA
    Brain Res 801:251-3. 1998
    ..The animals killed 3 days after SSSE showed extensive neuronal damage. Those which were allowed to survive for 6 weeks after SSSE displayed spontaneous seizures...
  14. pmc Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage
    Maria Leonor Lopez-Meraz
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neurobiol Dis 37:394-402. 2010
    ..The regional level of neuronal maturity may be a determining factor in the execution of a specific death program...
  15. ncbi request reprint GABA metabolism during status epilepticus in the developing rat brain
    R Sankar
    Department of Neurology, UCLA School of Medicine 90095 1752, USA
    Brain Res Dev Brain Res 98:60-4. 1997
    ..Our data describe an aspect of developmental GABA neurochemistry which may in part explain the relative resistance of the immature hippocampus to seizure spread and of certain types of seizure-induced damage...
  16. ncbi request reprint Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain
    H I Kornblum
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Brain Res Mol Brain Res 44:219-28. 1997
    ..Furthermore, BDNF may be capable of playing a role in the development of seizure susceptibility in the immature brain...
  17. ncbi request reprint Blockers of NMDA receptor restore paired-pulse inhibition in the rat dentate gyrus lesioned by perforant path stimulation
    A M Mazarati
    Department of Neurology, UCLA School of Medicine, USA
    Neurosci Lett 234:135-8. 1997
    ....
  18. pmc Substance P is expressed in hippocampal principal neurons during status epilepticus and plays a critical role in the maintenance of status epilepticus
    H Liu
    Epilepsy Research Laboratory, Veteran Administration Medical Center, Sepulveda, CA 91343, USA
    Proc Natl Acad Sci U S A 96:5286-91. 1999
    ..Enhanced expression of SP during SSSE may modulate hippocampal excitability and contribute to the maintenance of SSSE. Thus, SPR antagonists may constitute a novel category of drugs in antiepileptic therapy...
  19. ncbi request reprint Modulation of hippocampal excitability and seizures by galanin
    A M Mazarati
    Department of Neurology, University of California Los Angeles, School of Medicine, Los Angeles, California 90095 1769, USA mailto mazarati ucla edu
    J Neurosci 20:6276-81. 2000
    ....
  20. ncbi request reprint Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus
    A M Mazarati
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA
    Brain Res 814:179-85. 1998
    ..SSSE induced by PPS is an advantageous animal model of refractory status epilepticus, which may be used in preclinical studies of novel antiepileptic drugs...
  21. pmc Distinct caspase pathways mediate necrosis and apoptosis in subpopulations of hippocampal neurons after status epilepticus
    Maria Leonor Lopez-Meraz
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Epilepsia 51:56-60. 2010
    ....
  22. ncbi request reprint Mitochondrial pathways of neuronal necrosis
    J Niquet
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biochem Soc Trans 34:1347-51. 2006
    ..We called this form of necrosis 'programmed necrosis'. We discuss in this paper the contribution of another mitochondrial death factor, apoptosis-inducing factor...
  23. ncbi request reprint Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus
    Zhiqun Tan
    Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street MCH 142, Los Angeles, CA 90033, USA
    Brain Res 928:187-93. 2002
    ..This was supported by colocalization of activated caspase 3 in some cells with damaged DNA. These results provide additional evidence for a critical role for the p53 pathway in excitotoxic neuronal cell death due to status epilepticus...
  24. ncbi request reprint Advances in the pathophysiology of status epilepticus
    J W Y Chen
    Department of Neurology and Brain Research Institute, Geffen School of Medicine at UCLA, CA, USA
    Acta Neurol Scand Suppl 186:7-15. 2007
    ..Finally, SE-induced neuronal injury and epileptogenesis are briefly discussed...
  25. ncbi request reprint Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia
    M R Pulera
    Department of Neurology, Veteran s Affairs Medical Center, Sepulveda, Calif, USA
    Stroke 29:2622-30. 1998
    ..In addition to necrosis, apoptotic cell death may occur. The purpose of this study was to determine whether an established model of cerebral hypoxia-ischemia in the neonatal rat demonstrates any features of apoptosis...
  26. ncbi request reprint Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus
    Zhiqun Tan
    Department of Neurology, USC Keck School of Medicine, Los Angeles, CA 90033, USA
    Brain Res 929:129-38. 2002
    ..The data indicate that p53 induction following LPSE may activate downstream pro-apoptotic genes leading to neurodegeneration...
  27. pmc Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene
    H Liu
    Epilepsy Research Laboratory, Veterans Administration Medical Center, Sepulveda, CA 91343, USA
    Proc Natl Acad Sci U S A 96:12096-101. 1999
    ..They suggest that these neurokinins are critical to the control of hippocampal excitability, hippocampal seizures, and hippocampal vulnerability...
  28. ncbi request reprint Selective facilitation of kindled seizures from the amygdala after hippocampal lesions induced by perforant path stimulation
    A M Mazarati
    Department of Neurology, UCLA School of Medicine, USA
    Neurosci Lett 224:165-8. 1997
    ..After amygdala kindling, some animals showed spontaneous seizures. PPS may recruit amygdala into the epileptogenic circuit, resulting in "latent' kindling and development of spontaneous seizures...
  29. ncbi request reprint Serum neuron-specific enolase is a marker for neuronal damage following status epilepticus in the rat
    R Sankar
    Department of Neurology, UCLA School of Medicine, USA
    Epilepsy Res 28:129-36. 1997
    ..4 +/- 0.4 in the control animals to 30.4 +/- 1.3 after SE. The different brain regions examined had distinctive ontogenic profiles for SE-induced damage. Elevation of s-NSE after SE correlated with overall histologic evidence for damage...
  30. ncbi request reprint Reverse transport of glutamate during depolarization in immature hippocampal slices
    H Katsumori
    Epilepsy Research Laboratory, Veterans Affairs Medical Center, Sepulveda, CA, USA
    Brain Res 819:160-4. 1999
    ....
  31. ncbi request reprint Intravenously administered cell-permeant calcium buffer decreases evoked synaptic potentials in rat dentate gyrus in vivo
    I Spigelman
    Section of Oral Biology, UCLA School of Dentistry, Los Angeles CA 90095 1668, USA
    Brain Res 810:269-73. 1998
    ..These results indicate that the cell-permeant Ca2+ buffer, APTRA-AM, attenuates hippocampal excitability in vivo, most likely by decreasing synaptic neurotransmission...
  32. ncbi request reprint Posttraumatic epilepsy and treatment
    James W Y Chen
    West Los Angeles VA Healthcare Center, Neurology MC 127, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    J Rehabil Res Dev 46:685-96. 2009
    ..Optimal seizure control is essential to the physical and emotional health of veterans with TBI and to their ability to lead productive lives...
  33. ncbi request reprint Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain
    Jerome Niquet
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Epilepsia 48:1203-6. 2007
    ..Caspase-3 was activated in injured (acidophilic) neurons 24 hours following SE, raising the possibility that they died by caspase-dependent "programmed" necrosis...
  34. ncbi request reprint Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus
    Andrey M Mazarati
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Seizure 11:423-30. 2002
    ..To examine the seizure-protective properties of fluorofelbamate, a felbamate analog, on acute and chronic seizures in an experimental model of self-sustaining status epilepticus (SSSE)...
  35. ncbi request reprint Epileptogenesis after self-sustaining status epilepticus
    Andrey Mazarati
    Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Epilepsia 43:74-80. 2002
    ..To describe the natural history of chronic epilepsy after experimental self-sustaining status epilepticus (SSSE) and to correlate patterns of SSSE with ictal, interictal, and plastic changes that characterize chronic epilepsy...
  36. ncbi request reprint Short-term plasticity of hippocampal neuropeptides and neuronal circuitry in experimental status epilepticus
    Claude G Wasterlain
    Department of Neurology, VA Greater Los Angeles Healthcare System 127, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, USA
    Epilepsia 43:20-9. 2002
    ....
  37. ncbi request reprint Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus
    Andrey Mazarati
    Department of Neurology and Brain Research Institute, University of California, Los Angeles, USA
    Neurosci Lett 331:123-7. 2002
    ....
  38. pmc Hypoxic neuronal necrosis: protein synthesis-independent activation of a cell death program
    Jerome Niquet
    Epilepsy Research, Research 151, Veterans Affairs Greater Los Angeles Healthcare System and Department of Neurology David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:2825-30. 2003
    ..Hypoxic neuronal necrosis may be an active process in which the direct effect of hypoxia on mitochondria may lead to the final common pathway of caspase-3-mediated neuronal death...
  39. ncbi request reprint Evidence of caspase-3 activation in hyposmotic stress-induced necrosis
    Jerome Niquet
    Epilepsy Research, Research 151, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, USA
    Neurosci Lett 356:225-7. 2004
    ..Caspase-3(a) immunoreactivity appears as early as 1 min after hyposmotic treatment, when some neurons are still alive, suggesting that caspase-3(a) may contribute to further necrotic cell death...
  40. ncbi request reprint Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects
    Lucie Suchomelova
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    Pediatr Res 59:237-43. 2006
    ..Diazepam, on the other hand, was a better anticonvulsant than an antiepileptogenic agent in the P15 animals at the dose tested. Such effects were not seen in the older animals...
  41. ncbi request reprint Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus
    David E Naylor
    Department of Neurology, Veterans Administration Greater Los Angeles Healthcare System, University of California, Los Angeles, California 90073, USA
    J Neurosci 25:7724-33. 2005
    ..Novel therapies for SE might be directed toward prevention or reversal of these losses...
  42. ncbi request reprint GABA synapses and the rapid loss of inhibition to dentate gyrus granule cells after brief perforant-path stimulation
    David E Naylor
    Department of Neurology, Veterans Administration Greater Los Angeles Healthcare Center and University of California at Los Angeles, Los Angeles, California 90073, USA
    Epilepsia 46:142-7. 2005
    ..To study the pharmacologic and synaptic basis for the early loss of paired-pulse inhibition that occurs in the perforant-path stimulation model of status epilepticus...
  43. ncbi request reprint Programmed neuronal necrosis and status epilepticus
    Jerome Niquet
    Epilepsy Research Laboratory, VA Greater Los Angeles Healthcare System, West Los Angeles, CA 90073, USA
    Epilepsia 46:43-8. 2005
    ....
  44. pmc Bim, Bad, and Bax: a deadly combination in epileptic seizures
    Jerome Niquet
    Epilepsy Research Laboratory, Veteran s Administration Greater Los Angeles Healthcare System, West Los Angeles, California 90073, USA
    J Clin Invest 113:960-2. 2004
    ..In this issue of the JCI, Shinoda and collaborators show the key role of Bim in epileptic seizure-induced neuronal injury and identify the contribution of transcription factors responsible for seizure-induced Bim upregulation...
  45. ncbi request reprint Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus
    Andrey M Mazarati
    Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Epilepsy Res 58:167-74. 2004
    ..We conclude that LEV deserves further evaluation in the treatment of status epilepticus...
  46. ncbi request reprint Hypoxia in presence of blockers of excitotoxicity induces a caspase-dependent neuronal necrosis
    J Niquet
    Epilepsy Research Laboratory 151, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, USA
    Neuroscience 141:77-86. 2006
    ..Caspase inhibitors were neuroprotective. These results suggest that "non-excitotoxic hypoxic neuronal death" requires the activation in many neurons of a cell death program originating in mitochondria and leading to necrosis...
  47. ncbi request reprint Advances in the pathophysiology of status epilepticus
    J W Y Chen
    Department of Neurology and Brain Research Institute, Geffen School of Medicine at UCLA, and VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Acta Neurol Scand 115:7-15. 2007
    ..Finally, SE-induced neuronal injury and epileptogenesis are briefly discussed...
  48. ncbi request reprint Urethane anesthesia produces selective damage in the piriform cortex of the developing brain
    K W Thompson
    VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Building 114, Rm 137, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Brain Res Dev Brain Res 130:167-71. 2001
    ..It will be important to determine if anesthetics used in pregnant women and young children may have similar effects...
  49. ncbi request reprint Status epilepticus: pathophysiology and management in adults
    James W Y Chen
    Department of Neurology and Brain Research Institute, Geffen School of Medicine at UCLA, and VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Lancet Neurol 5:246-56. 2006
    ..We comment on our preference for drugs with a short elimination half-life and discuss some therapeutic choices...
  50. ncbi request reprint Development of temporal lobe epilepsy in 21-day-old rats
    Raman Sankar
    Epilepsia 44:872; author reply 872-3. 2003

Research Grants34

  1. BRAIN DEVELOPMENT IN EXPERIMENTAL EPILEPSY
    Claude Wasterlain; Fiscal Year: 2002
    ..We will chronically administer anticonvulsants after the end of status epilepticus, and study their effects on the development of spontaneous seizures. ..
  2. BRAIN DEVELOPMENT IN EXPERIMENTAL EPILEPSY
    Claude Wasterlain; Fiscal Year: 2006
    ..This will be of great relevance to the problem of seizure-induced brain damage, since a better understanding of the mechanisms involved in seizure induced neuronal necrosis could help to prevent or minimize that damage. ..
  3. BRAIN DEVELOPMENT IN EXPERIMENTAL EPILEPSY
    Claude Wasterlain; Fiscal Year: 1980
    ..We hope our results will suggest measures directed toward the prevention of mental retardation and of epileptic brain damage in the convulsing neonate. ..
  4. BRAIN DEVELOPMENT IN EXPERIMENTAL EPILEPSY
    Claude Wasterlain; Fiscal Year: 1993
    ..We expect those studies to significantly advance our understanding of the mechanism of damage resulting from seizures in the immature brain...