Thomas Wassink

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophrenia
    T H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242, USA
    Mol Psychiatry 5:678-82. 2000
  2. doi request reprint Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Gen Psychiatry 69:885-92. 2012
  3. pmc Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
    Peg Nopoulos
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Behav Brain Funct 7:45. 2011
  4. doi request reprint Posterior probability of linkage analysis of autism dataset identifies linkage to chromosome 16
    Thomas H Wassink
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Psychiatr Genet 18:85-91. 2008
  5. ncbi request reprint Systematic screening for subtelomeric anomalies in a clinical sample of autism
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Autism Dev Disord 37:703-8. 2007
  6. ncbi request reprint Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 136:36-44. 2005
  7. ncbi request reprint A case of autism and uniparental disomy of chromosome 1
    Thomas H Wassink
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hum Genet 117:200-6. 2005
  8. ncbi request reprint The search for autism disease genes
    Thomas H Wassink
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Ment Retard Dev Disabil Res Rev 10:272-83. 2004
  9. ncbi request reprint Examination of AVPR1a as an autism susceptibility gene
    T H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Mol Psychiatry 9:968-72. 2004
  10. ncbi request reprint NOTCH4 and the frontal lobe in schizophrenia
    Thomas H Wassink
    Department of Psychiatry, Psychiatry Research MEB, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 118:1-7. 2003

Research Grants

  1. A MULTI-FACETED SEARCH FOR AUTISM DISEASE GENES
    Thomas Wassink; Fiscal Year: 2004
  2. MOLECULAR GENETICS OF AUTISM
    Thomas Wassink; Fiscal Year: 2006
  3. Genetic Determinants of Brain Structure and Disease Risk in Schizophrenia
    Thomas H Wassink; Fiscal Year: 2010

Detail Information

Publications25

  1. ncbi request reprint Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophrenia
    T H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242, USA
    Mol Psychiatry 5:678-82. 2000
    ..We found no support, therefore, for TNF-RII as a disease susceptibility gene for schizophrenia. The gene may, however, modify phenotypic aspects of the disease such as brain morphology and age of onset of illness...
  2. doi request reprint Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Gen Psychiatry 69:885-92. 2012
    ..Our study supports this assertion by finding that specific genotypes of the polymorphism are associated with brain structure volumes in individuals with schizophrenia and healthy volunteers and with symptom severity in schizophrenia...
  3. pmc Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
    Peg Nopoulos
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Behav Brain Funct 7:45. 2011
    ..The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating...
  4. doi request reprint Posterior probability of linkage analysis of autism dataset identifies linkage to chromosome 16
    Thomas H Wassink
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Psychiatr Genet 18:85-91. 2008
    ..To apply phenotypic and statistical methods designed to account for heterogeneity to linkage analyses of the autism Collaborative Linkage Study of Autism (CLSA) affected sibling pair families...
  5. ncbi request reprint Systematic screening for subtelomeric anomalies in a clinical sample of autism
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Autism Dev Disord 37:703-8. 2007
    ..2 in subgroups of our sample. We conclude that while karyotyping may be more broadly indicated for autism than previously supposed, subtelomere FISH appears less likely to be a useful screening tool for unselected PDD populations...
  6. ncbi request reprint Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 136:36-44. 2005
    ..We conclude, therefore, that 2q37.3 continues to be a region of interest for autism susceptibility, and that CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism...
  7. ncbi request reprint A case of autism and uniparental disomy of chromosome 1
    Thomas H Wassink
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hum Genet 117:200-6. 2005
    ..In agreement with this, one of the regions of isodisomy overlaps an emerging chromosome 1 region of interest in autism located at 150-160 Mb...
  8. ncbi request reprint The search for autism disease genes
    Thomas H Wassink
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Ment Retard Dev Disabil Res Rev 10:272-83. 2004
    ....
  9. ncbi request reprint Examination of AVPR1a as an autism susceptibility gene
    T H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Mol Psychiatry 9:968-72. 2004
    ..Given the emerging biological, animal model, and now genetic data, AVPR1a and genes in the AVP system remain strong candidates for involvement in autism susceptibility and deserve continued scrutiny...
  10. ncbi request reprint NOTCH4 and the frontal lobe in schizophrenia
    Thomas H Wassink
    Department of Psychiatry, Psychiatry Research MEB, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 118:1-7. 2003
    ..These findings may reflect the interaction of NOTCH4 with the underlying genetic and phenotypic complexity that characterizes both schizophrenia and normal cognition and brain development...
  11. ncbi request reprint Heritability of BDNF alleles and their effect on brain morphology in schizophrenia
    T H Wassink
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa
    Am J Med Genet 88:724-8. 1999
    ..We did not find support for BDNF as a disease gene for schizophrenia. Allelic variability of the gene may, however, influence brain morphology in these same subjects. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:724-728, 1999...
  12. ncbi request reprint Prevalence of depressive symptoms early in the course of schizophrenia
    T H Wassink
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa College of Medicine, Iowa City 52242, USA
    Am J Psychiatry 156:315-6. 1999
    ..The rate of depressive symptoms early in the course of schizophrenia was determined...
  13. ncbi request reprint Evidence supporting WNT2 as an autism susceptibility gene
    T H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Med Genet 105:406-13. 2001
    ....
  14. ncbi request reprint Chromosomal abnormalities in a clinic sample of individuals with autistic disorder
    T H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, USA
    Psychiatr Genet 11:57-63. 2001
    ..These data support the contribution of chromosomal abnormalities to a small but significant number of cases of autism, and highlight the involvement of chromosome 15 and the sex chromosomes...
  15. ncbi request reprint Evaluation of FOXP2 as an autism susceptibility gene
    Thomas H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Med Genet 114:566-9. 2002
    ..We conclude that FOXP2 is unlikely to contribute significantly to autism susceptibility...
  16. pmc Cerebral cortex structure in prodromal Huntington disease
    Peggy C Nopoulos
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA 52242, USA
    Neurobiol Dis 40:544-54. 2010
    ..Early in the course of HD, the cortex shows changes that are manifest as cortical thinning and are most robust in the posterior and superior regions of the cerebrum...
  17. ncbi request reprint Population-based association analyses of the HOPA12bp polymorphism for schizophrenia and hypothyroidism
    R A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City 52242 1000, USA
    Am J Med Genet 105:130-4. 2001
    ....
  18. ncbi request reprint Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow
    B C Ho
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52252, USA
    Mol Psychiatry 10:229, 287-98. 2005
    ..Age-related changes and phenotypic heterogeneity of schizophrenia may influence the complex relationships between COMT genotype and cognition...
  19. pmc Pax6 3' deletion results in aniridia, autism and mental retardation
    L K Davis
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Hum Genet 123:371-8. 2008
    ..3 Mb deletion that disrupts PAX6 transcriptional activity and deletes additional genes expressed in the brain. Our findings provide continued evidence for the role of PAX6 in neural phenotypes associated with aniridia...
  20. pmc Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Psychiatry 164:1890-9. 2007
    ..Factors underlying progressive brain volume changes in schizophrenia remain poorly understood. The authors investigated whether a gene polymorphism influencing neuroplasticity may contribute to longitudinal brain volume alterations...
  21. ncbi request reprint Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism
    Thomas H Wassink
    Department of Psychiatry, The University of Iowa, USA
    Arch Gen Psychiatry 64:709-17. 2007
    ..Autism is a heritable neurodevelopmental disorder characterized biologically by enlargement of the head and brain and abnormalities of serotonin neurotransmission...
  22. pmc Cortical enlargement in autism is associated with a functional VNTR in the monoamine oxidase A gene
    Lea K Davis
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1145-51. 2008
    ..Future studies will determine if there is a more severe clinical phenotype associated with both the "low activity" genotype and the larger brain volumes in our sample...
  23. pmc Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers
    Beng Choon Ho
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
    Arch Gen Psychiatry 63:731-40. 2006
    ..Its role in determining cognitive deficits in schizophrenia has also not been systematically studied...
  24. ncbi request reprint An association study of PCQAP polymorphisms and schizophrenia
    Harinder K Sandhu
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa 52242 1000, USA
    Psychiatr Genet 14:169-72. 2004
    ..Recently, DeLuca and colleagues reported that polymorphisms in a trinucleotide repeat in exon 7 of PCQAP were associated with schizophrenia in a case-control study of Italian schizophrenics...
  25. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...

Research Grants8

  1. A MULTI-FACETED SEARCH FOR AUTISM DISEASE GENES
    Thomas Wassink; Fiscal Year: 2004
    ..Taken together, the training plan and research proposal provide for a breadth of training, the potential for meaningful discovery, and support for the establishment of an independent research career. ..
  2. MOLECULAR GENETICS OF AUTISM
    Thomas Wassink; Fiscal Year: 2006
    ..The WNT2 findings will be further examined in two-independent patient samples. ..
  3. Genetic Determinants of Brain Structure and Disease Risk in Schizophrenia
    Thomas H Wassink; Fiscal Year: 2010
    ....