J A Waschek

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma
    Catalina Abad
    1 David Geffen School of Medicine, UCLA, 635 Charles E Young Dr, South, NRB 345, Los Angeles, CA 90095 7332, USA
    J Leukoc Biol 95:357-67. 2014
  2. pmc VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair
    J A Waschek
    Department of Psychiatry and Semel Institute, University of California at Los Angeles, Los Angeles, CA 90095 7332, USA
    Br J Pharmacol 169:512-23. 2013
  3. pmc Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures
    Joseph R Cohen
    Semel Institute Department of Psychiatry and Biobehavioral Sciences, David Geffen, School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 USA
    BMC Cancer 10:676. 2010
  4. ncbi request reprint Hedgehog signaling: new targets for GPCRs coupled to cAMP and protein kinase A
    James A Waschek
    Mental Retardation Research Center, Semel Institute for Neuroscience, Jonsson Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, California 90095, USA
    Ann N Y Acad Sci 1070:120-8. 2006
  5. pmc Neural tube expression of pituitary adenylate cyclase-activating peptide (PACAP) and receptor: potential role in patterning and neurogenesis
    J A Waschek
    Department of Psychiatry, Mental Retardation Research Center, and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90024 1759, USA
    Proc Natl Acad Sci U S A 95:9602-7. 1998
  6. ncbi request reprint PACAP action in nervous system development, regeneration, and neuroblastoma cell proliferation
    J A Waschek
    Department of Psychiatry, Mental Retardation Research Center, and Jonsson Cancer Center, University of California at Los Angeles, Los Angeles, California 90024, USA
    Ann N Y Acad Sci 921:129-36. 2000
  7. ncbi request reprint Developmental actions of natriuretic peptides in the brain and skeleton
    J A Waschek
    Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, 68 225 NPI, 760 Westwood Plaza, Los Angeles, California 90024, USA
    Cell Mol Life Sci 61:2332-42. 2004
  8. ncbi request reprint Multiple actions of pituitary adenylyl cyclase activating peptide in nervous system development and regeneration
    James A Waschek
    Department of Psychiatry and Mental Retardation Research Center, University of California at Los Angeles, Neuropsychiatric Institute, 90024, USA
    Dev Neurosci 24:14-23. 2002
  9. pmc Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide
    B D Armstrong
    Department of Psychiatry, Semel Institute for Neuroscience, Mental Retardation Research Center, University of California at Los Angeles, Los Angeles, CA, USA
    Neuroscience 151:63-73. 2008
  10. ncbi request reprint Embryonic expression of pituitary adenylyl cyclase-activating polypeptide and its selective type I receptor gene in the frog Xenopus laevis neural tube
    Z Hu
    Department of Psychiatry, Mental Retardation Research Center, School of Medicine, University of California at Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024-1759, USA
    J Comp Neurol 441:266-75. 2001

Collaborators

Detail Information

Publications45

  1. doi request reprint Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma
    Catalina Abad
    1 David Geffen School of Medicine, UCLA, 635 Charles E Young Dr, South, NRB 345, Los Angeles, CA 90095 7332, USA
    J Leukoc Biol 95:357-67. 2014
    ..Despite these alterations in immune cells induced by myeloid STAT3 disruption, we found no effect on tumor incidence in Smo* mice with this deletion. ..
  2. pmc VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair
    J A Waschek
    Department of Psychiatry and Semel Institute, University of California at Los Angeles, Los Angeles, CA 90095 7332, USA
    Br J Pharmacol 169:512-23. 2013
    ..The neuroprotective and immunomodulatory actions of VIP and PACAP suggest that receptors for these peptides may be therapeutic targets for neurodegenerative and neuroinflammatory diseases and other forms of CNS injury...
  3. pmc Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures
    Joseph R Cohen
    Semel Institute Department of Psychiatry and Biobehavioral Sciences, David Geffen, School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 USA
    BMC Cancer 10:676. 2010
    ..PACAP/ptch1 double mutant mice exhibit an increased incidence of MB compared to ptch1 mice, indicating that PACAP may regulate HH pathway-mediated MB pathogenesis...
  4. ncbi request reprint Hedgehog signaling: new targets for GPCRs coupled to cAMP and protein kinase A
    James A Waschek
    Mental Retardation Research Center, Semel Institute for Neuroscience, Jonsson Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, California 90095, USA
    Ann N Y Acad Sci 1070:120-8. 2006
    ..It remains to be determined if HH/GPCR antagonistic interactions play additional important roles in development, plasticity, tissue repair, cancer, and other processes...
  5. pmc Neural tube expression of pituitary adenylate cyclase-activating peptide (PACAP) and receptor: potential role in patterning and neurogenesis
    J A Waschek
    Department of Psychiatry, Mental Retardation Research Center, and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90024 1759, USA
    Proc Natl Acad Sci U S A 95:9602-7. 1998
    ..PACAP is thus an early inducer of cAMP levels in the embryo and may act in the neural tube during patterning to control cell proliferation and gene expression...
  6. ncbi request reprint PACAP action in nervous system development, regeneration, and neuroblastoma cell proliferation
    J A Waschek
    Department of Psychiatry, Mental Retardation Research Center, and Jonsson Cancer Center, University of California at Los Angeles, Los Angeles, California 90024, USA
    Ann N Y Acad Sci 921:129-36. 2000
    ..Experiments using a neuroblastoma tumor cell line model indicate that PACAP may execute growth-related functions by activating MAP kinase in addition to cAMP-dependent protein kinase A...
  7. ncbi request reprint Developmental actions of natriuretic peptides in the brain and skeleton
    J A Waschek
    Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, 68 225 NPI, 760 Westwood Plaza, Los Angeles, California 90024, USA
    Cell Mol Life Sci 61:2332-42. 2004
    ..Natriuretic peptides might also have roles in the vascularization of the embryonic brain, establishment of the blood-brain and blood-nerve barriers, and perhaps in nerve regeneration...
  8. ncbi request reprint Multiple actions of pituitary adenylyl cyclase activating peptide in nervous system development and regeneration
    James A Waschek
    Department of Psychiatry and Mental Retardation Research Center, University of California at Los Angeles, Neuropsychiatric Institute, 90024, USA
    Dev Neurosci 24:14-23. 2002
    ..In vivo models now provide additional evidence that PACAP acts in neural development and regeneration...
  9. pmc Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide
    B D Armstrong
    Department of Psychiatry, Semel Institute for Neuroscience, Mental Retardation Research Center, University of California at Los Angeles, Los Angeles, CA, USA
    Neuroscience 151:63-73. 2008
    ....
  10. ncbi request reprint Embryonic expression of pituitary adenylyl cyclase-activating polypeptide and its selective type I receptor gene in the frog Xenopus laevis neural tube
    Z Hu
    Department of Psychiatry, Mental Retardation Research Center, School of Medicine, University of California at Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024-1759, USA
    J Comp Neurol 441:266-75. 2001
    ..These results suggest that PACAP may be involved in the early development of the embryonic Xenopus neural tube...
  11. ncbi request reprint Retinoic acid regulation of the VIP and PACAP autocrine ligand and receptor system in human neuroblastoma cell lines
    J A Waschek
    Department of Psychiatry, University of California at Los Angeles 90024, USA
    Peptides 18:835-41. 1997
    ..The studies indicate that several components of the VIP/PACAP autocrine system are regulated in neuroblastoma cell lines during RA differentiation...
  12. ncbi request reprint Proliferative actions of natriuretic peptides on neuroblastoma cells. Involvement of guanylyl cyclase and non-guanylyl cyclase pathways
    V Lelievre
    Department of Psychiatry and Mental Retardation Research Center, UCLA, Neuropsychiatric Institute, Los Angeles, California 90024, USA
    J Biol Chem 276:43668-76. 2001
    ..Higher concentrations of ANP and CNP exerted a mitogen-activated protein kinase-dependent antiproliferative action mediated by a non-GC receptor that interacts with desANP(4-23) with relatively high affinity...
  13. ncbi request reprint Induction of neuropeptide gene expression and blockade of retrograde transport in facial motor neurons following local peripheral nerve inflammation in severe combined immunodeficiency and BALB/C mice
    B D Armstrong
    University of California at Los Angeles, Psychiatry and Behavioral Sciences, 760 Westwood Plaza, NPI 68 225, Los Angeles, CA 90024, USA
    Neuroscience 129:93-9. 2004
    ....
  14. pmc Circadian rhythm in inhibitory synaptic transmission in the mouse suprachiasmatic nucleus
    Jason Itri
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Science, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    J Neurophysiol 92:311-9. 2004
    ..Overall, these data demonstrate that there is a circadian rhythm in GABAergic transmission in the dorsal region of the mouse SCN and that the VIP is required for expression of this rhythm...
  15. ncbi request reprint VIP gene transcription is regulated by far upstream enhancer and repressor elements
    D Liu
    Department of Psychiatry and Mental Retardation Research Center, University of California at Los Angeles, 760 Westwood Plaza, Room 68-225 NPI, Los Angeles, California, 90024-1759
    Biochem Biophys Res Commun 284:211-8. 2001
    ..The studies provide molecular details of a complex regulatory region on the VIP gene that is likely to be used to finely tune the level of gene transcription in vivo...
  16. ncbi request reprint Selective deficits in the circadian light response in mice lacking PACAP
    C S Colwell
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024 1759, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1194-201. 2004
    ..The results reported here show that the loss of PACAP produced selective deficits in the light response of the circadian system...
  17. ncbi request reprint Molecular cloning of growth hormone-releasing hormone/pituitary adenylyl cyclase-activating polypeptide in the frog Xenopus laevis: brain distribution and regulation after castration
    Z Hu
    Department of Psychiatry, Mental Retardation Research Center, University of California School of Medicine, Los Angeles 90024 1759, USA
    Endocrinology 141:3366-76. 2000
    ..These results provide a molecular basis for studying the physiological functions of PACAP in frog brain and suggest that PACAP may be involved in the feedback regulation of hypothalamic-pituitary-gonadal axis...
  18. ncbi request reprint Paradoxical antagonism of PACAP receptor signaling by VIP in Xenopus oocytes via the type-C natriuretic peptide receptor
    V Lelievre
    Department of Psychiatry and Mental Retardation Research Center, The David Geffen School of Medicine, University of California at Los Angeles, 635 Charles E Young Drive, Los Angeles, CA 90095, USA
    Cell Signal 18:2013-21. 2006
    ..These results suggest that VIP and natriuretic peptides can potentially modulate the action of PACAP in cells where these receptors are co-expressed...
  19. doi request reprint The role of the neuropeptides PACAP and VIP in the photic regulation of gene expression in the suprachiasmatic nucleus
    Joanna M Dragich
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Eur J Neurosci 31:864-75. 2010
    ..Furthermore, VIP, but not PACAP, is required for the appropriate temporal gating of light-induced gene expression within the SCN...
  20. ncbi request reprint Fibroblast growth factor-2 converts PACAP growth action on embryonic hindbrain precursors from stimulation to inhibition
    Vincent Lelievre
    Department of Psychiatry and Mental Retardation Research Center, Neuropsychiatric Institute, University of California at Los Angeles, Los Angeles, California 90024, USA
    J Neurosci Res 67:566-73. 2002
    ..We hypothesize that the actions of PACAP in the specific parts of the developing nervous system are determined in part by the presence or absence of FGFs and other growth factors...
  21. pmc PACAP deficiency sensitizes nigrostriatal dopaminergic neurons to paraquat-induced damage and modulates central and peripheral inflammatory activation in mice
    M B Watson
    Semel Institute for Neuroscience and Human Behavior, Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles UCLA, Los Angeles, CA 90095 1769, USA
    Neuroscience 240:277-86. 2013
    ..The results indicate that endogenous PACAP acts to maintain the integrity of DA neurons during exposure to PQ, an action that may be linked to its ability to regulate microglia and/or other immune cells...
  22. ncbi request reprint Disrupted circadian rhythms in VIP- and PHI-deficient mice
    Christopher S Colwell
    Mental Retardation Res Ctr, Univ of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Am J Physiol Regul Integr Comp Physiol 285:R939-49. 2003
    ..Together, the observations suggest that VIP/PHI peptides are critically involved in both the generation of circadian oscillations as well as the normal synchronization of these rhythms to light...
  23. pmc Vasoactive intestinal peptide is critical for circadian regulation of glucocorticoids
    Dawn H Loh
    Semel Institute for Neuroscience, Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Calif 90024 1759, USA
    Neuroendocrinology 88:246-55. 2008
    ..The aim of our study was to examine the possible role of VIP in driving circadian rhythms in the hypothalamic-pituitary-adrenal axis...
  24. ncbi request reprint Local action of estrogen and thyroid hormone on vasoactive intestinal peptide (VIP) and galanin gene expression in the rat anterior pituitary
    A Degerman
    Department of Psychiatry and Mental Retardation Research Center, University of California at Los Angeles, CA 90024, USA
    Neuropeptides 36:50-7. 2002
    ..The bovine galanin gene fragment used in these studies contains a potential pituitary cell-type specific enhancer, but appears to lack strong E2-and T(3)-responsive sequences...
  25. ncbi request reprint Embryonic expression of vasoactive intestinal peptide (VIP) and VIP receptor genes
    J A Waschek
    Department of Psychiatry and Mental Retardation Research Center, University of California at Los Angeles, USA
    J Neurochem 66:1762-5. 1996
    ..Expression of the VIP2 receptor gene was also detected by northern analysis in E14 mouse brains. These studies support the hypothesis that VIP produced by the embryo exerts important effects on embryonic nervous system development...
  26. doi request reprint Mice deficient in both pituitary adenylyl cyclase-activating polypeptide and vasoactive intestinal peptide survive, but display growth retardation and sex-dependent early death
    Pawel Niewiadomski
    Semel Institute Department of Psychiatry and Biobehavioral Research and Mental Retardation Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    J Mol Neurosci 36:200-7. 2008
    ....
  27. pmc Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis
    Catalina Abad
    The Semel Institute and Department of Psychiatry, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:19555-60. 2010
    ....
  28. ncbi request reprint Lack of vasoactive intestinal peptide reduces testosterone levels and reproductive aging in mouse testis
    Arnaud Lacombe
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Gonda Center, University of California, Room 6357, 695 Charles Young Drive South, Los Angeles, California 90095 7088, USA
    J Endocrinol 194:153-60. 2007
    ..All together, these results suggest that 1) VIP is an important factor for regulating testosterone biosynthesis and FSH secretion and 2) VIP may influence testicular aging...
  29. ncbi request reprint Lymphocyte regulation of neuropeptide gene expression after neuronal injury
    Brian D Armstrong
    Mental Retardation Research Center, Neuropsychiatric Institute, The David Geffen School of Medicine, University of California at Los Angeles, Los Angeles 90024 1759, USA
    J Neurosci Res 74:240-7. 2003
    ..The data suggest that an inflammatory response, most likely involving T lymphocytes, is necessary for the axotomy-induced increase in PACAP but not in VIP. LIF, IL-6, and TNFalpha, however, are not required for this response to injury...
  30. pmc Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis
    Yossan Var Tan
    Semel Institute Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 106:2012-7. 2009
    ..These results demonstrate that endogenous PACAP provides protection in EAE and identify PACAP as an intrinsic regulator of Treg abundance after inflammation...
  31. ncbi request reprint Restoration of axotomy-induced PACAP gene induction in SCID mice with CD4+ T-lymphocytes
    Brian D Armstrong
    University of California at Los Angeles, 760 Westwood Plaza, NPI 68 225, Los Angeles, CA 90024, USA
    Neuroreport 15:2647-50. 2004
    ..The CD4+ cell-dependent induction of PACAP in motor neurons may thus be a factor in the cascade of events triggered by immune cells that ultimately lead to nerve regeneration...
  32. ncbi request reprint Neuropeptide mimetics and antagonists in the treatment of inflammatory disease: focus on VIP and PACAP
    Catalina Abad
    Mental Retardation Research Center, Semel Institute for Neuroscience, The David Geffen School of Medicine, University of California at Los Angeles, CA 90024, USA
    Curr Top Med Chem 6:151-63. 2006
    ....
  33. pmc Delayed testicular aging in pituitary adenylate cyclase-activating peptide (PACAP) null mice
    Arnaud Lacombe
    Department of Human Genetics, University of California, Gonda Center, 695 Charles Young Drive South, Los Angeles, CA 90095 7088, USA
    Proc Natl Acad Sci U S A 103:3793-8. 2006
    ....
  34. ncbi request reprint Immunomodulatory roles of VIP and PACAP in models of multiple sclerosis
    Catalina Abad
    The Semel Institute for Neuroscience and Human and Department of Psychiatry, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Curr Pharm Des 17:1025-35. 2011
    ..In this review, the immunomodulatory actions of VIP and PACAP will be discussed, with particular emphasis on their potential significance in MS...
  35. pmc Induction of colitis and rapid development of colorectal tumors in mice deficient in the neuropeptide PACAP
    Nicole Nemetz
    Department of Laboratory Animal Medicine, David Geffen School of Medicine, Semel Institute for Neuroscience and Mental Retardation Research Center, University of California at Los Angeles, CA 90095, USA
    Int J Cancer 122:1803-9. 2008
    ..Consistent with published data, DSS-treated WT mice did not develop such tumors. The results demonstrate a new mouse model which rapidly develops inflammation-associated colorectal cancer in the absence of a carcinogen...
  36. pmc Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice
    Vincent Lelievre
    Department of Psychiatry and Biobehavioral Research Mental Retardation Research Center, University of California at Los Angeles, CA 90095, USA
    Dev Biol 313:359-70. 2008
    ..The results provide genetic evidence that PACAP acts as a physiological factor that regulates the pathogenesis of Hh pathway-associated MB tumors...
  37. pmc Negative regulation of Hedgehog signaling by liver X receptors
    Woo Kyun Kim
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Mol Endocrinol 23:1532-43. 2009
    ..Given the importance of modulating Hh signaling in various physiological and pathological settings, our findings suggest that pharmacological targeting of LXRs may be a novel strategy for Hh pathway modulation...
  38. ncbi request reprint Comparative distributions of pituitary adenylyl cyclase-activating polypeptide and its selective type I receptor mRNA in the frog (Xenopus laevis) brain
    Zhongting Hu
    Department of Psychiatry, Mental Retardation Research Center, School of Medicine, University of California at Los Angeles, Los Angeles, CA 90024 1759, USA
    Regul Pept 109:15-26. 2002
    ..These localized patterns of ligand and receptor gene expression suggest possible PACAP projection and target fields in the frog brain...
  39. ncbi request reprint Mice lacking the VIP gene show airway hyperresponsiveness and airway inflammation, partially reversible by VIP
    Anthony M Szema
    Department of Medicine, State University of New York at Stony Brook, NY 11794 8172, USA
    Am J Physiol Lung Cell Mol Physiol 291:L880-6. 2006
    ....
  40. ncbi request reprint Noncompensation in peptide/receptor gene expression and distinct behavioral phenotypes in VIP- and PACAP-deficient mice
    Beatrice A Girard
    Department of Anatomy, University of Vermont College of Medicine, Burlington, 05405, USA
    J Neurochem 99:499-513. 2006
    ..These results suggest that the PACAP and VIP have evolved to possess distinct biological activities and intimate that the respective knockout phenotypes represent deficits unmitigated by the actions of the complementary related peptide...
  41. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation
    Arnaud Nicot
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 22:9244-54. 2002
    ..These observations suggest that G-protein-coupled receptors, such as PAC1, serve as sensors of environmental cues, coordinating diverse neurogenetic signals...
  42. ncbi request reprint Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene
    Sami I Said
    Departments of Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA
    Circulation 115:1260-8. 2007
    ..We have tested the hypothesis that targeted deletion of the VIP gene may lead to PAH with pulmonary vascular remodeling...
  43. pmc Vasoactive intestinal peptide induction by ciliary neurotrophic factor in donor human corneal endothelium in situ
    Shay Whey M Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, United States
    Neurosci Lett 423:89-94. 2007
    ....
  44. pmc Regardless of genotype, offspring of VIP-deficient female mice exhibit developmental delays and deficits in social behavior
    Maria A Lim
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Int J Dev Neurosci 26:423-34. 2008
    ....
  45. pmc Deficits in social behavior and reversal learning are more prevalent in male offspring of VIP deficient female mice
    Conor M Stack
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Neurol 211:67-84. 2008
    ....

Research Grants16

  1. Regulation of Neural Precursors: Role of Neuropeptides
    James Waschek; Fiscal Year: 2006
    ..The work may lead to new strategies for the diagnosis and treatment of diseases of brain development, degenerative diseases and brain tumors. ..
  2. Gene Targeting to Study Light-induced Circadian Changes
    James Waschek; Fiscal Year: 2003
    ..Moreover, the same targeting system should have utility in investigating individual components of the clock, such as PER, CRY, BMAL and CLOCK proteins. ..
  3. REGULATION OF NEURAL PRECURSORS: ROLE OF NEUROPEPTIDES
    James Waschek; Fiscal Year: 2000
    ..The results are expected to provide important mechanistic information on how these neuropeptides play important roles in CNS development, as well as in nerve injury, neurological tumors, and degenerative diseases of the nervous system. ..
  4. PKA modulation of hedgehog: a mouse medulloblastoma model
    James Waschek; Fiscal Year: 2009
    ..abstract_text> ..