Affiliation: University of Florida
- Concurrent calpain and caspase-3 mediated proteolysis of alpha II-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injuryMatthew W Warren
University of Florida Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
Life Sci 78:301-9. 2005..Use of calpain and caspase proteolytic inhibitors may be useful in preventing methamphetamine-induced neurotoxicity...
- Ecstasy toxicity: a comparison to methamphetamine and traumatic brain injuryMatthew W Warren
College of Medicine, University of Florida, Gainsville, FL 32610, USA
J Addict Dis 25:115-23. 2006..Neurotoxicity is still evident after 72 hours. Furthermore, apoptosis of the liver is seen 72 hours after ecstasy use. Use of protease inhibitors may be useful in preventing ecstasy-induced toxicity...
- Body mass index and marijuana useMatthew Warren
College of Medicine, University of Florida, PO Box 100183, Gainesville, FL, 32610, USA
J Addict Dis 24:95-100. 2005..Linear regression revealed a negative correlation between BMI group and percent marijuana use (R-squared = 0.96; P = 0.0173). These findings provide support for overeating as competition for drugs and alcohol in brain reward sites...
- Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMAMatthew W Warren
Center for Traumatic Brain Injury Studies, Department of Neuroscience, McKnight Brain Institute of the University of Florida, Gainesville, FL 32610, USA
Acta Neuropathol 114:277-86. 2007..These findings support the hypothesis that calpains and caspases mediate PCD in cortical neurons following club drug abuse and, more importantly, appear to contribute to the neuropathology suffered by abusers...
- Calpain- and caspase-mediated alphaII-spectrin and tau proteolysis in rat cerebrocortical neuronal cultures after ecstasy or methamphetamine exposureMatthew W Warren
Center for Traumatic Brain Injury Studies, Department of Neuroscience, McKnight Brain Institute of the University of Florida, Gainesville, FL, USA
Int J Neuropsychopharmacol 10:479-89. 2007..The ability of the protease inhibitors to reduce the damage caused by these drugs suggests that the treatment arsenal could include similar drugs as possible tools to combat the drug-induced neurotoxicity in vivo...
- Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in ratsFiras H Kobeissy
University of Florida College of Medicine, Gainesville, FL 32610, USA
Addict Biol 13:15-25. 2008..Future studies should be performed to see how chronic, low dose drug administration would affect hormone levels and try to answer questions about the physiological mechanisms involved in the anorexic paradigm observed in drug use...
- Psychoproteomic analysis of rat cortex following acute methamphetamine exposureFiras H Kobeissy
Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, College of Medicine, McKnight Brain Institute of the University of Florida, Gainesville, Florida 32610, USA
J Proteome Res 7:1971-83. 2008..Lastly, we used these differentially expressed protein subsets to construct a "psychoproteomic" spectrum map in an effort to uncover potential protein interactions relevant to acute METH neurotoxicity...
- The relationship between obesity and drug useMatthew W Warren
Am J Psychiatry 164:1268; author reply 1268-9. 2007