J W Warren

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Urinary symptoms as a prodrome of bladder pain syndrome/interstitial cystitis
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Md Electronic address
    Urology 83:1035-40. 2014
  2. doi request reprint Before the onset of interstitial cystitis/bladder pain syndrome, the presence of multiple non-bladder syndromes is strongly associated with a history of multiple surgeries
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, United States Department of Epidemiology and Public Health, University of Maryland School of Medicine, United States Electronic address
    J Psychosom Res 76:75-9. 2014
  3. doi request reprint Prognostic factors for recent-onset interstitial cystitis/painful bladder syndrome
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BJU Int 111:E92-7. 2013
  4. doi request reprint The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Psychosom Res 74:12-7. 2013
  5. doi request reprint Is there a high incidence of hysterectomy and other nonbladder surgeries before and after onset of interstitial cystitis/bladder pain syndrome?
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Obstet Gynecol 208:77.e1-6. 2013
  6. doi request reprint Functional somatic syndromes: sensitivities and specificities of self-reports of physician diagnosis
    John W Warren
    Department of Medicine and of Epidemiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Psychosom Med 74:891-5. 2012
  7. pmc Dysuria at onset of interstitial cystitis/painful bladder syndrome in women
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 68:477-81. 2006
  8. pmc Using the International Continence Society's definition of painful bladder syndrome
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 67:1138-42; discussion 1142-3. 2006
  9. ncbi request reprint A prospective early history of incident interstitial cystitis/painful bladder syndrome
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Urol 184:2333-8. 2010
  10. doi request reprint Interstitial cystitis/painful bladder syndrome: what do patients mean by "perceived" bladder pain?
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 77:309-12. 2011

Research Grants

  1. A Case Control Study of Interstitial Cystitis
    John Warren; Fiscal Year: 2003
  2. MARYLAND INTERSTITIAL CYSTITIS CLINICAL TRIALS GROUP
    John Warren; Fiscal Year: 2003
  3. A Case Control Study of Interstitial Cystitis
    John Warren; Fiscal Year: 2004
  4. A Case Control Study of Interstitial Cystitis
    John Warren; Fiscal Year: 2005
  5. A Case Control Study of Interstitial Cystitis
    John Warren; Fiscal Year: 2006
  6. Genetics of Interstitial Cystitis
    John Warren; Fiscal Year: 2007

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Urinary symptoms as a prodrome of bladder pain syndrome/interstitial cystitis
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Md Electronic address
    Urology 83:1035-40. 2014
    ..To test the hypothesis that more bladder pain syndrome/interstitial cystitis (BPS/IC) cases than controls report pre-onset urinary symptoms...
  2. doi request reprint Before the onset of interstitial cystitis/bladder pain syndrome, the presence of multiple non-bladder syndromes is strongly associated with a history of multiple surgeries
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, United States Department of Epidemiology and Public Health, University of Maryland School of Medicine, United States Electronic address
    J Psychosom Res 76:75-9. 2014
    ..They also report multiple surgeries. Since pain is a common indication for surgery, we tested the hypothesis that NBSs were associated with surgeries...
  3. doi request reprint Prognostic factors for recent-onset interstitial cystitis/painful bladder syndrome
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BJU Int 111:E92-7. 2013
    ..Mild IC/PBS at baseline was the only variable that was directly associated with a good prognosis...
  4. doi request reprint The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Psychosom Res 74:12-7. 2013
    ..The objective of this study is to test the hypothesis that the number of functional somatic syndromes (FSSs) predicts new, additional FSSs...
  5. doi request reprint Is there a high incidence of hysterectomy and other nonbladder surgeries before and after onset of interstitial cystitis/bladder pain syndrome?
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Obstet Gynecol 208:77.e1-6. 2013
    ..The objective of the study was to compare with controls the incidence of nonbladder pelvic surgeries in the months before and after the onset of interstitial cystitis/bladder pain syndrome (IC/BPS)...
  6. doi request reprint Functional somatic syndromes: sensitivities and specificities of self-reports of physician diagnosis
    John W Warren
    Department of Medicine and of Epidemiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Psychosom Med 74:891-5. 2012
    ..Our objective was to determine the sensitivities and specificities of self-report of physician diagnosis for chronic fatigue syndrome (CFS), fibromyalgia (FM), irritable bowel syndrome (IBS), panic disorder, and migraine...
  7. pmc Dysuria at onset of interstitial cystitis/painful bladder syndrome in women
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 68:477-81. 2006
    ....
  8. pmc Using the International Continence Society's definition of painful bladder syndrome
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 67:1138-42; discussion 1142-3. 2006
    ....
  9. ncbi request reprint A prospective early history of incident interstitial cystitis/painful bladder syndrome
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Urol 184:2333-8. 2010
    ..In a national sample of incident cases we assessed changes in symptoms during the first several years of interstitial cystitis/painful bladder syndrome...
  10. doi request reprint Interstitial cystitis/painful bladder syndrome: what do patients mean by "perceived" bladder pain?
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 77:309-12. 2011
    ..The perception that the bladder is the source of pain is a necessary criterion for many definitions of IC/PBS...
  11. doi request reprint Sexuality and reproductive risk factors for interstitial cystitis/painful bladder syndrome in women
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 77:570-5. 2011
    ..To determine whether interstitial cystitis/painful bladder syndrome (IC/PBS) in women is associated with antecedent sexual and reproductive characteristics...
  12. ncbi request reprint Practice guidelines for the treatment of uncomplicated cystitis
    J W Warren
    Division of Infectious Diseases, University of Maryland School of Medicine, 10 S Pine Street, Room 9 00, MSTF, Baltimore, MD 21201, USA
    Curr Urol Rep 2:326-9. 2001
    ..Clinicians should be alert to patients infected with possibly resistant organisms, eg, patients who have recently been hospitalized or are receiving antibiotics...
  13. ncbi request reprint Interstitial cystitis
    John W Warren
    Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Urol 12:69-74. 2002
    ..One or more promising markers for this disease have been described which may provide a noninvasive means for diagnosis as well as clues to pathogenesis of this disease. Treatment remains empiric...
  14. ncbi request reprint Concordance of interstitial cystitis in monozygotic and dizygotic twin pairs
    J W Warren
    University of Maryland, Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 57:22-5. 2001
    ..There is a greater concordance of IC among monozygotic than dizygotic twin pairs suggesting a genetic susceptibility to IC...
  15. doi request reprint Numbers and types of nonbladder syndromes as risk factors for interstitial cystitis/painful bladder syndrome
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 77:313-9. 2011
    ..In a previously reported case-control study, we confirmed these findings and found that such nonbladder syndromes often preceded the onset of IC/PBS...
  16. doi request reprint Nocturia in interstitial cystitis/painful bladder syndrome
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 77:1308-12. 2011
    ..To explore the roles of pain and urgency in the nocturia of patients with interstitial cystitis/painful bladder syndrome (IC/PBS)...
  17. doi request reprint Sites of pain from interstitial cystitis/painful bladder syndrome
    John W Warren
    Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Urol 180:1373-7. 2008
    ..We hypothesized that a careful and systematic description of the pain of interstitial cystitis/painful bladder syndrome might provide clues to its pathogenesis...
  18. pmc Comparison of Escherichia coli strains recovered from human cystitis and pyelonephritis infections in transurethrally challenged mice
    D E Johnson
    Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 66:3059-65. 1998
    ....
  19. pmc Construction of a flagellum-negative mutant of Proteus mirabilis: effect on internalization by human renal epithelial cells and virulence in a mouse model of ascending urinary tract infection
    H L Mobley
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 64:5332-40. 1996
    ..mirabilis to colonize the urinary tract and cause acute pyelonephritis in an experimental model of ascending urinary tract infection...
  20. pmc Cytotoxicity of hemolytic, cytotoxic necrotizing factor 1-positive and -negative Escherichia coli to human T24 bladder cells
    M D Island
    Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 66:3384-9. 1998
    ..Our results indicate that CNF1 does not have a detectable effect on the ability of hemolytic E. coli to damage human bladder cell monolayers in vitro...
  21. pmc Assessing urgency in interstitial cystitis/painful bladder syndrome
    Christina Diggs
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 69:210-4. 2007
    ..In an ongoing case-control study of recent-onset IC/PBS, we compared the ICSI with a series of questions that addressed the severity of these symptoms...
  22. pmc Effect of Escherichia coli cytotoxic necrotizing factor 1 on repair of human bladder cell monolayers in vitro
    M D Island
    Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 67:3657-61. 1999
    ..coli CNF1...
  23. ncbi request reprint Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor as urine markers for interstitial cystitis
    S K Keay
    Division of Infectious Diseases, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland, USA
    Urology 57:9-14. 2001
    ..These findings confirm the utility of APF, HB-EGF, and EGF as markers for IC. Understanding the reasons for altered levels of these markers may lead to understanding the pathogenesis of this disorder...
  24. pmc Serum immunoglobulin response and protection from homologous challenge by Proteus mirabilis in a mouse model of ascending urinary tract infection
    D E Johnson
    Research Service, VA Medical Center, Baltimore, Maryland 21201, USA
    Infect Immun 67:6683-7. 1999
    ..09), although only a few mice developed significant serum IgA levels. We conclude that prior infection with P. mirabilis does not protect significantly against homologous challenge...
  25. pmc Evidence-based criteria for pain of interstitial cystitis/painful bladder syndrome in women
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 71:444-8. 2008
    ..Its diagnosis is determined by symptoms and the exclusion of mimicking diseases. We hypothesized that certain pain characteristics are sensitive criteria for diagnosing IC/PBS...
  26. doi request reprint Urinary tract infection and inflammation at onset of interstitial cystitis/painful bladder syndrome
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 71:1085-90. 2008
    ..Acute urinary tract infection (UTI) is of high incidence in women, presents as dysuria and urinary symptoms, and is caused by uropathogenic bacteria. We hypothesized that UTI is present at the onset of IC/PBS in some women...
  27. pmc Pathogenicity island sequences of pyelonephritogenic Escherichia coli CFT073 are associated with virulent uropathogenic strains
    J S Kao
    Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 65:2812-20. 1997
    ..When used as probes for DNA hybridization, these sequences were found significantly more often in strains associated with the clinical syndromes of cystitis (82%) and acute pyelonephritis (79%) than in fecal strains (19%; P < 0.001)...
  28. ncbi request reprint Interstitial cystitis/painful bladder syndrome
    John W Warren
    School of Medicine, University of Maryland, Baltimore, MD, USA
    Urol Nurs 27:185-9; quiz 190. 2007
    ..The purpose of this article is to demonstrate that urologic nurses are central to its management, providing sensitive counseling and education as well as therapy...
  29. ncbi request reprint Short interval between symptom onset and medical care as an indication of rapid onset of interstitial cystitis/painful bladder syndrome
    Patty Greenberg
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BJU Int 100:599-602; discussion 602. 2007
    ..To assess how many patients with interstitial cystitis/painful bladder syndrome (IC/PBlS) obtain medical care soon after symptom onset, and to determine how these patients differ from those who have medical care later...
  30. ncbi request reprint Voiding urges perceived by patients with interstitial cystitis/painful bladder syndrome
    Patty Greenberg
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Neurourol Urodyn 27:287-90. 2008
    ..Interstitial cystitis/painful bladder syndrome (IC/PBS) is a symptom-based diagnosis. We studied the IC/PBS symptom commonly referred to as "urgency" and its relationship to IC/PBS pain in a group of women with recent onset of the disease...
  31. ncbi request reprint Catheter-associated urinary tract infections
    J W Warren
    Division of Infectious Diseases, University of Maryland School of Medicine, 10 S. Pine Street, Room 9-00, Baltimore, MD 21201, USA
    Int J Antimicrob Agents 17:299-303. 2001
    ..If the catheter can be removed before bacteriuria develops, postponement becomes prevention...
  32. doi request reprint Pelvic pain and surgeries in women before interstitial cystitis/painful bladder syndrome
    Patricia W Langenberg
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Obstet Gynecol 202:286.e1-6. 2010
    ..The objective of the study was to compare subjects with interstitial cystitis/painful bladder syndrome (IC/PBS) with controls on prior surgeries...
  33. doi request reprint Antecedent nonbladder syndromes in case-control study of interstitial cystitis/painful bladder syndrome
    John W Warren
    Department of Medicine, Epidemiology and Preventive Medicine, and Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Urology 73:52-7. 2009
    ..Probing for clues to the pathogenesis of interstitial cystitis/painful bladder syndrome (IC/PBS), we sought antecedent nonbladder syndromes that distinguished incident IC/PBS cases from matched controls...
  34. ncbi request reprint The role of cytotoxic necrotizing factor-1 in colonization and tissue injury in a murine model of urinary tract infection
    D E Johnson
    Research Service 151, Department of Veterans Affairs, 10 North Greene St, Baltimore, MD 21201, USA
    FEMS Immunol Med Microbiol 28:37-41. 2000
    ..coli UTI isolate and a CNF1-negative mutant of that isolate to colonize and induce histological changes in the urinary tract in a murine model of ascending UTI. We found no evidence that the mutant strain was attenuated...
  35. ncbi request reprint Is interstitial cystitis an infectious disease?
    Susan K Keay
    Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Int J Antimicrob Agents 19:480-3. 2002
    ..Additional research is necessary to determine whether this factor is encoded by the eucaryotic cells themselves or an unidentified intracellular microorganism...
  36. pmc Development of an intranasal vaccine to prevent urinary tract infection by Proteus mirabilis
    Xin Li
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 72:66-75. 2004
    ..Intranasal immunization of CBA mice with MBP-MrpH (residues 23 to 157) conferred effective protection against urinary tract infection by P. mirabilis (P < 0.002)...
  37. ncbi request reprint Prevalence of interstitial cystitis in first-degree relatives of patients with interstitial cystitis
    John W Warren
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Urology 63:17-21. 2004
    ..Often the first evidence that a disease may have a genetic susceptibility is the demonstration of family aggregation of the disease...

Research Grants6

  1. A Case Control Study of Interstitial Cystitis
    John Warren; Fiscal Year: 2003
    ..4) That patients with IC have remissions and that certain clinical features, e.g., bacterial cystitis at disease onset, are prognostic factors for remissions. ..
  2. MARYLAND INTERSTITIAL CYSTITIS CLINICAL TRIALS GROUP
    John Warren; Fiscal Year: 2003
    ..This group will bring to the IC CTG experienced, motivated, and dedicated investigators; a new cadre of IC patients; and a network of referring urologists/gynecologists to study management strategies for this distressing disease. ..
  3. A Case Control Study of Interstitial Cystitis
    John Warren; Fiscal Year: 2004
    ..4) That patients with IC have remissions and that certain clinical features, e.g., bacterial cystitis at disease onset, are prognostic factors for remissions. ..
  4. A Case Control Study of Interstitial Cystitis
    John Warren; Fiscal Year: 2005
    ..4) That patients with IC have remissions and that certain clinical features, e.g., bacterial cystitis at disease onset, are prognostic factors for remissions. ..
  5. A Case Control Study of Interstitial Cystitis
    John Warren; Fiscal Year: 2006
    ..4) That patients with IC have remissions and that certain clinical features, e.g., bacterial cystitis at disease onset, are prognostic factors for remissions. ..
  6. Genetics of Interstitial Cystitis
    John Warren; Fiscal Year: 2007
    ..The identification of alleles of susceptibility to IC may reveal clues to pathogenesis, clinical therapy, preventive strategy, and possibly gene therapies. ..